riluzole has been researched along with Allodynia in 13 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immediate treatment of spinal root avulsion injuries with minocycline or riluzole prevents the onset of evoked pain hypersensitivity by reducing microglial cell activation." | 7.80 | The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. ( Carlstedt, T; Chew, DJ; Shortland, PJ, 2014) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "The burns produced significant hyperalgesia, but riluzole had no acute analgesic effects in normal or hyperalgesic skin." | 6.69 | Effect of riluzole on acute pain and hyperalgesia in humans. ( Hammer, NA; Kehlet, H; Lillesø, J; Pedersen, JL, 1999) |
| "Cervical spondylotic myelopathy (CSM) is the commonest cause of spinal cord impairment worldwide and despite surgical treatment, it is commonly associated with chronic neuropathic pain and neurological impairment." | 5.40 | Riluzole attenuates neuropathic pain and enhances functional recovery in a rodent model of cervical spondylotic myelopathy. ( Austin, JW; Fehlings, MG; Karadimas, SK; Moon, ES; Yu, WR, 2014) |
| "Immediate treatment of spinal root avulsion injuries with minocycline or riluzole prevents the onset of evoked pain hypersensitivity by reducing microglial cell activation." | 3.80 | The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. ( Carlstedt, T; Chew, DJ; Shortland, PJ, 2014) |
| "Even though riluzole was administered after the onset of behavioral sensitivity at Day 1, its administration resulted in immediate resolution of mechanical allodynia and thermal hyperalgesia (p < 0." | 3.80 | Riluzole effects on behavioral sensitivity and the development of axonal damage and spinal modifications that occur after painful nerve root compression. ( Gilliland, TM; Nicholson, KJ; Winkelstein, BA; Zhang, S, 2014) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "The burns produced significant hyperalgesia, but riluzole had no acute analgesic effects in normal or hyperalgesic skin." | 2.69 | Effect of riluzole on acute pain and hyperalgesia in humans. ( Hammer, NA; Kehlet, H; Lillesø, J; Pedersen, JL, 1999) |
| "Neuropathic pain is becoming an intractable health threat, with its profound effect on quality of life, thus posing a major challenge to clinical therapy." | 1.43 | Effects of riluzole on P2X7R expression in the spinal cord in rat model of neuropathic pain. ( Chen, H; Ge, AQ; Jiang, K; Miao, B; Sun, L; Yan, M; Zhuang, Y, 2016) |
| "Cervical spondylotic myelopathy (CSM) is the commonest cause of spinal cord impairment worldwide and despite surgical treatment, it is commonly associated with chronic neuropathic pain and neurological impairment." | 1.40 | Riluzole attenuates neuropathic pain and enhances functional recovery in a rodent model of cervical spondylotic myelopathy. ( Austin, JW; Fehlings, MG; Karadimas, SK; Moon, ES; Yu, WR, 2014) |
| "However, MK-801 (0." | 1.35 | The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine. ( Böhmer, AE; Crestana, RH; Dalmaz, C; Elisabetsky, E; Hansel, G; Knorr, L; Lara, DR; Schallenberger, C; Schmidt, AP; Silveira, PP; Souza, DO; Tort, AB, 2009) |
| "All three drugs decreased hyperalgesia when administered prior to carrageenan injection." | 1.31 | Neurochemical changes after morphine, dizocilpine or riluzole in the ventral posterolateral thalamic nuclei of rats with hyperalgesia. ( Abarca, C; Contreras, E; Oliva, P; Sepúlveda, MJ; Silva, E, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamoto, S | 1 |
| Ushio, S | 1 |
| Egashira, N | 1 |
| Kawashiri, T | 1 |
| Mitsuyasu, S | 1 |
| Higuchi, H | 1 |
| Ozawa, N | 1 |
| Masuguchi, K | 1 |
| Ono, Y | 1 |
| Masuda, S | 1 |
| Moon, ES | 1 |
| Karadimas, SK | 1 |
| Yu, WR | 1 |
| Austin, JW | 1 |
| Fehlings, MG | 1 |
| Chew, DJ | 1 |
| Carlstedt, T | 1 |
| Shortland, PJ | 1 |
| Nicholson, KJ | 1 |
| Zhang, S | 1 |
| Gilliland, TM | 1 |
| Winkelstein, BA | 1 |
| Jiang, K | 1 |
| Zhuang, Y | 1 |
| Yan, M | 1 |
| Chen, H | 1 |
| Ge, AQ | 1 |
| Sun, L | 1 |
| Miao, B | 1 |
| Schmidt, AP | 1 |
| Tort, AB | 1 |
| Silveira, PP | 1 |
| Böhmer, AE | 1 |
| Hansel, G | 1 |
| Knorr, L | 1 |
| Schallenberger, C | 1 |
| Dalmaz, C | 1 |
| Elisabetsky, E | 1 |
| Crestana, RH | 1 |
| Lara, DR | 1 |
| Souza, DO | 1 |
| Hama, A | 1 |
| Sagen, J | 1 |
| Xie, RG | 1 |
| Zheng, DW | 1 |
| Xing, JL | 1 |
| Zhang, XJ | 1 |
| Song, Y | 1 |
| Xie, YB | 1 |
| Kuang, F | 1 |
| Dong, H | 1 |
| You, SW | 1 |
| Xu, H | 1 |
| Hu, SJ | 1 |
| Hobo, S | 1 |
| Eisenach, JC | 1 |
| Hayashida, K | 1 |
| Sung, B | 1 |
| Lim, G | 1 |
| Mao, J | 1 |
| Coderre, TJ | 1 |
| Kumar, N | 1 |
| Lefebvre, CD | 1 |
| Yu, JS | 1 |
| Hammer, NA | 1 |
| Lillesø, J | 1 |
| Pedersen, JL | 1 |
| Kehlet, H | 1 |
| Abarca, C | 1 |
| Silva, E | 1 |
| Sepúlveda, MJ | 1 |
| Oliva, P | 1 |
| Contreras, E | 1 |
1 trial available for riluzole and Allodynia
| Article | Year |
|---|---|
Effect of riluzole on acute pain and hyperalgesia in humans.
Topics: Acute Disease; Adult; Anesthetics; Burns; Cross-Over Studies; Double-Blind Method; Female; Humans; H | 1999 |
12 other studies available for riluzole and Allodynia
| Article | Year |
|---|---|
Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug.
Topics: Animals; Antineoplastic Agents; Biological Transport; Chemoprevention; Disease Models, Animal; Excit | 2017 |
Riluzole attenuates neuropathic pain and enhances functional recovery in a rodent model of cervical spondylotic myelopathy.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Gait; Hyperalgesia; Neur | 2014 |
The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats.
Topics: Animals; Disease Models, Animal; Functional Laterality; Hyperalgesia; Male; Minocycline; Neurons; Ne | 2014 |
Riluzole effects on behavioral sensitivity and the development of axonal damage and spinal modifications that occur after painful nerve root compression.
Topics: Animals; Axons; Hyperalgesia; Immunohistochemistry; Male; Neck Injuries; Neck Pain; Nerve Compressio | 2014 |
Effects of riluzole on P2X7R expression in the spinal cord in rat model of neuropathic pain.
Topics: Animals; Constriction, Pathologic; Hyperalgesia; Male; Microglia; Neuralgia; Purinergic P2X Receptor | 2016 |
The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine.
Topics: Animals; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Antagonist | 2009 |
Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain.
Topics: Animals; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal | 2011 |
Blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured DRG neurons.
Topics: Animals; Ganglia, Spinal; Hyperalgesia; Ion Channel Gating; Membrane Potentials; Nerve Fibers; Neuro | 2011 |
Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Transp | 2011 |
Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.
Topics: Amino Acid Transport System X-AG; Animals; Behavior, Animal; Biological Transport; Carbazoles; Const | 2003 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |
Neurochemical changes after morphine, dizocilpine or riluzole in the ventral posterolateral thalamic nuclei of rats with hyperalgesia.
Topics: Analysis of Variance; Animals; Arginine; Aspartic Acid; Carrageenan; Citrulline; Dialysis Solutions; | 2000 |