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riluzole and Allodynia

riluzole has been researched along with Allodynia in 13 studies

Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Research Excerpts

ExcerptRelevanceReference
"Immediate treatment of spinal root avulsion injuries with minocycline or riluzole prevents the onset of evoked pain hypersensitivity by reducing microglial cell activation."7.80The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. ( Carlstedt, T; Chew, DJ; Shortland, PJ, 2014)
"The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain."7.74A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007)
"The burns produced significant hyperalgesia, but riluzole had no acute analgesic effects in normal or hyperalgesic skin."6.69Effect of riluzole on acute pain and hyperalgesia in humans. ( Hammer, NA; Kehlet, H; Lillesø, J; Pedersen, JL, 1999)
"Cervical spondylotic myelopathy (CSM) is the commonest cause of spinal cord impairment worldwide and despite surgical treatment, it is commonly associated with chronic neuropathic pain and neurological impairment."5.40Riluzole attenuates neuropathic pain and enhances functional recovery in a rodent model of cervical spondylotic myelopathy. ( Austin, JW; Fehlings, MG; Karadimas, SK; Moon, ES; Yu, WR, 2014)
"Immediate treatment of spinal root avulsion injuries with minocycline or riluzole prevents the onset of evoked pain hypersensitivity by reducing microglial cell activation."3.80The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. ( Carlstedt, T; Chew, DJ; Shortland, PJ, 2014)
"Even though riluzole was administered after the onset of behavioral sensitivity at Day 1, its administration resulted in immediate resolution of mechanical allodynia and thermal hyperalgesia (p < 0."3.80Riluzole effects on behavioral sensitivity and the development of axonal damage and spinal modifications that occur after painful nerve root compression. ( Gilliland, TM; Nicholson, KJ; Winkelstein, BA; Zhang, S, 2014)
"The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain."3.74A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007)
"The burns produced significant hyperalgesia, but riluzole had no acute analgesic effects in normal or hyperalgesic skin."2.69Effect of riluzole on acute pain and hyperalgesia in humans. ( Hammer, NA; Kehlet, H; Lillesø, J; Pedersen, JL, 1999)
"Neuropathic pain is becoming an intractable health threat, with its profound effect on quality of life, thus posing a major challenge to clinical therapy."1.43Effects of riluzole on P2X7R expression in the spinal cord in rat model of neuropathic pain. ( Chen, H; Ge, AQ; Jiang, K; Miao, B; Sun, L; Yan, M; Zhuang, Y, 2016)
"Cervical spondylotic myelopathy (CSM) is the commonest cause of spinal cord impairment worldwide and despite surgical treatment, it is commonly associated with chronic neuropathic pain and neurological impairment."1.40Riluzole attenuates neuropathic pain and enhances functional recovery in a rodent model of cervical spondylotic myelopathy. ( Austin, JW; Fehlings, MG; Karadimas, SK; Moon, ES; Yu, WR, 2014)
"However, MK-801 (0."1.35The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine. ( Böhmer, AE; Crestana, RH; Dalmaz, C; Elisabetsky, E; Hansel, G; Knorr, L; Lara, DR; Schallenberger, C; Schmidt, AP; Silveira, PP; Souza, DO; Tort, AB, 2009)
"All three drugs decreased hyperalgesia when administered prior to carrageenan injection."1.31Neurochemical changes after morphine, dizocilpine or riluzole in the ventral posterolateral thalamic nuclei of rats with hyperalgesia. ( Abarca, C; Contreras, E; Oliva, P; Sepúlveda, MJ; Silva, E, 2000)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's4 (30.77)29.6817
2010's8 (61.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yamamoto, S1
Ushio, S1
Egashira, N1
Kawashiri, T1
Mitsuyasu, S1
Higuchi, H1
Ozawa, N1
Masuguchi, K1
Ono, Y1
Masuda, S1
Moon, ES1
Karadimas, SK1
Yu, WR1
Austin, JW1
Fehlings, MG1
Chew, DJ1
Carlstedt, T1
Shortland, PJ1
Nicholson, KJ1
Zhang, S1
Gilliland, TM1
Winkelstein, BA1
Jiang, K1
Zhuang, Y1
Yan, M1
Chen, H1
Ge, AQ1
Sun, L1
Miao, B1
Schmidt, AP1
Tort, AB1
Silveira, PP1
Böhmer, AE1
Hansel, G1
Knorr, L1
Schallenberger, C1
Dalmaz, C1
Elisabetsky, E1
Crestana, RH1
Lara, DR1
Souza, DO1
Hama, A1
Sagen, J1
Xie, RG1
Zheng, DW1
Xing, JL1
Zhang, XJ1
Song, Y1
Xie, YB1
Kuang, F1
Dong, H1
You, SW1
Xu, H1
Hu, SJ1
Hobo, S1
Eisenach, JC1
Hayashida, K1
Sung, B1
Lim, G1
Mao, J1
Coderre, TJ1
Kumar, N1
Lefebvre, CD1
Yu, JS1
Hammer, NA1
Lillesø, J1
Pedersen, JL1
Kehlet, H1
Abarca, C1
Silva, E1
Sepúlveda, MJ1
Oliva, P1
Contreras, E1

Trials

1 trial available for riluzole and Allodynia

ArticleYear
Effect of riluzole on acute pain and hyperalgesia in humans.
    British journal of anaesthesia, 1999, Volume: 82, Issue:5

    Topics: Acute Disease; Adult; Anesthetics; Burns; Cross-Over Studies; Double-Blind Method; Female; Humans; H

1999

Other Studies

12 other studies available for riluzole and Allodynia

ArticleYear
Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug.
    Scientific reports, 2017, 08-29, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Transport; Chemoprevention; Disease Models, Animal; Excit

2017
Riluzole attenuates neuropathic pain and enhances functional recovery in a rodent model of cervical spondylotic myelopathy.
    Neurobiology of disease, 2014, Volume: 62

    Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Gait; Hyperalgesia; Neur

2014
The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats.
    The journal of pain, 2014, Volume: 15, Issue:6

    Topics: Animals; Disease Models, Animal; Functional Laterality; Hyperalgesia; Male; Minocycline; Neurons; Ne

2014
Riluzole effects on behavioral sensitivity and the development of axonal damage and spinal modifications that occur after painful nerve root compression.
    Journal of neurosurgery. Spine, 2014, Volume: 20, Issue:6

    Topics: Animals; Axons; Hyperalgesia; Immunohistochemistry; Male; Neck Injuries; Neck Pain; Nerve Compressio

2014
Effects of riluzole on P2X7R expression in the spinal cord in rat model of neuropathic pain.
    Neuroscience letters, 2016, Apr-08, Volume: 618

    Topics: Animals; Constriction, Pathologic; Hyperalgesia; Male; Microglia; Neuralgia; Purinergic P2X Receptor

2016
The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:4

    Topics: Animals; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Antagonist

2009
Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain.
    Journal of neurotrauma, 2011, Volume: 28, Issue:1

    Topics: Animals; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal

2011
Blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured DRG neurons.
    PloS one, 2011, Apr-25, Volume: 6, Issue:4

    Topics: Animals; Ganglia, Spinal; Hyperalgesia; Ion Channel Gating; Membrane Potentials; Nerve Fibers; Neuro

2011
Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
    Neuroscience letters, 2011, Sep-08, Volume: 502, Issue:1

    Topics: Analgesics; Animals; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Transp

2011
Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Apr-01, Volume: 23, Issue:7

    Topics: Amino Acid Transport System X-AG; Animals; Behavior, Animal; Biological Transport; Carbazoles; Const

2003
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
    Journal of neurochemistry, 2007, Volume: 100, Issue:5

    Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease

2007
Neurochemical changes after morphine, dizocilpine or riluzole in the ventral posterolateral thalamic nuclei of rats with hyperalgesia.
    European journal of pharmacology, 2000, Sep-01, Volume: 403, Issue:1-2

    Topics: Analysis of Variance; Animals; Arginine; Aspartic Acid; Carrageenan; Citrulline; Dialysis Solutions;

2000