Compounds > isobrucein b
Page last updated: 2024-12-07

isobrucein b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

isobrucein B: structure given in first source; isolated from Cedronia granatensis [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Cedroniagenus[no description available]SimaroubaceaeA plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. Leaves are alternate and compound. Most have small flowers, bitter bark, and fleshy fruits that are sometimes winged. Members contain QUASSINS.[MeSH]
Cedronia granatensisspecies[no description available]SimaroubaceaeA plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. Leaves are alternate and compound. Most have small flowers, bitter bark, and fleshy fruits that are sometimes winged. Members contain QUASSINS.[MeSH]

Cross-References

ID SourceID
PubMed CID99530
CHEMBL ID475082
CHEBI ID5988
MeSH IDM0205366

Synonyms (12)

Synonym
isobruceine b
nsc-238181
isobrucein b
C08770
53663-03-9
AC1L40YM ,
chebi:5988 ,
CHEMBL475082 ,
nsc 238181
picras-3-en-21-oic acid, 15-(acetyloxy)-13,20-epoxy-1,11,12-trihydroxy-2,16-dioxo-, methyl ester, (1beta,11beta,12alpha,15beta)-
Q27106964
methyl (1r,2s,3r,6r,8s,12s,13s,14r,15r,16s,17s)-3-acetyloxy-12,15,16-trihydroxy-9,13-dimethyl-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate

Research Excerpts

Overview

Isobrucein B is a quassinoid isolated from the Amazonian medicinal plant Picrolemma sprucei.

ExcerptReferenceRelevance
"Isobrucein B (1) is a quassinoid isolated from the Amazonian medicinal plant Picrolemma sprucei. "( The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
Amorim, RC; Cunha, FQ; Cunha, TM; França, RO; Lopes, AH; Pohlit, AM; Silva, EC; Silva, RL; Vieira, SM, 2015)		2.21
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (80)

Assay IDTitleYearJournalArticle
AID335062Cytotoxicity against human DMS273 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335076Cytotoxicity against human SNB78 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204982Inhibition of PGN-induced NF-kappaB activation in mouse RAW264.7 cells assessed as reduction luminescence emission at 0.001 to 10 uM pretreated 30 mins before LPS challenge measured after 4 hrs by luciferase reporter gene assay2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335327Cytotoxicity against human OVCAR4 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335322Cytotoxicity against human SK-MEL-5 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335050Cytotoxicity against human A549 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335051Cytotoxicity against human EKVX cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335328Cytotoxicity against human OVCAR5 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335058Cytotoxicity against human NCI-H460 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335069Cytotoxicity against human KM20L2 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335331Cytotoxicity against human 786-O cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204985Effect on luciferase (unknown origin) activity in LPS-induced in mouse RAW264.7 cells at 10 uM pretreated 30 mins before LPS challenge measured after 4 hrs2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335066Cytotoxicity against human HCT15 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335319Cytotoxicity against human M14 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335323Cytotoxicity against human UACC257 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335045Cytotoxicity against human HL-60(TB) cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335333Cytotoxicity against human ACHN cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335044Cytotoxicity against human CCRF-CEM cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335049Cytotoxicity against human SR cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335075Cytotoxicity against human SNB75 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335054Cytotoxicity against human HOP92 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335061Cytotoxicity against human DMS114 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204974Antiinflammatory activity in carrageenan-induced mechanical inflammatory hyperalgesia male C57BL/6 mouse model assessed as inhibition of KC/CXCL1 production in inflamed tissue at 5 mg/kg, sc pretreated 30 mins after carrageenan challenge and measured afte2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335330Cytotoxicity against human SKOV3 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335341Cytotoxicity against human RXF631 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204975Antiinflammatory activity in carrageenan-induced mechanical inflammatory hyperalgesia male C57BL/6 mouse model assessed as inhibition of TNF level production in inflamed tissue at 5 mg/kg, sc pretreated 30 mins after carrageenan challenge and measured aft2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID1204973Antiinflammatory activity in carrageenan-induced mechanical inflammatory hyperalgesia male C57BL/6 mouse model assessed as inhibition of IL-1beta production in inflamed tissue at 5 mg/kg, sc pretreated 30 mins after carrageenan challenge and measured afte2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335339Cytotoxicity against human DLD1 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335070Cytotoxicity against human SW620 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204987Inhibition of LPS-induced NF-kappaB p65 translocation into nucleus in mouse RAW264.7 cells at 10 uM treated 30 mins before LPS challenge by Western blot analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335046Cytotoxicity against human K562 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204979Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 0.001 to 10 uM pretreated 30 mins by MTT assay in presence of LPS2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID1204977Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced IL-1beta production compound pretreated 30 mins of LPS challenge measured after 4 hrs by ELISA2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335337Cytotoxicity against human TK10 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204984Inhibition of PMA-induced NF-kappaB activation in mouse RAW264.7 cells assessed as reduction luminescence emission at 0.001 to 10 uM pretreated 30 mins before LPS challenge measured after 4 hrs by luciferase reporter gene assay2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335325Cytotoxicity against human IGROV1 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335052Cytotoxicity against human HOP18 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335071Cytotoxicity against human SF268 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335332Cytotoxicity against human A498 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335065Cytotoxicity against human HCT116 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335074Cytotoxicity against human SNB19 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335057Cytotoxicity against human NCI-H322 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204990Inhibition of luminescence emission in mouse RAW264.7 cells transfected with luciferase plasmid containing universal promoter PKG at 0.1 to 10 uM after 6 hrs by luciferase reporter gene assay2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335067Cytotoxicity against human HT-29 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335336Cytotoxicity against human SN12C cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335073Cytotoxicity against human SF539 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335068Cytotoxicity against human KM12 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335064Cytotoxicity against human HCC2998 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335335Cytotoxicity against human RXF393 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335317Cytotoxicity against human LOXIMVI cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204978Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced KC/CXCL1 production compound pretreated 30 mins of LPS challenge measured after 4 hrs by ELISA2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335326Cytotoxicity against human OVCAR-3 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335060Cytotoxicity against human LXFL 529L cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335048Cytotoxicity against human RPMI8226 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335340Cytotoxicity against human M19-MEL cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335324Cytotoxicity against human UACC62 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204981Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells assessed as reduction luminescence emission at 0.001 to 10 uM pretreated 30 mins before LPS challenge measured after 4 hrs by luciferase reporter gene assay2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID1204983Inhibition of TNF-induced NF-kappaB activation in mouse RAW264.7 cells assessed as reduction luminescence emission at 0.001 to 10 uM pretreated 30 mins before LPS challenge measured after 4 hrs by luciferase reporter gene assay2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335055Cytotoxicity against human NCI-H226 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335338Cytotoxicity against human UO31 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335056Cytotoxicity against human NCI-H23 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335320Cytotoxicity against human SK-MEL-2 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335063Cytotoxicity against human COLO205 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID422119Growth inhibition of human NCI60 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
AID1204972Antihyperalgesic activity in male C57BL/6 mouse assessed as reduction in carrageenan-induced mechanical inflammatory hyperalgesia at 5 mg/kg, sc pretreated 30 mins after carrageenan challenge and measured after 3 hrs2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID1204971Antihyperalgesic activity in sc dosed male C57BL/6 mouse assessed as reduction in carrageenan-induced mechanical inflammatory hyperalgesia pretreated 30 mins after carrageenan challenge and measured after 3 hrs2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335315Cytotoxicity against human U251 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335072Cytotoxicity against human SF295 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204986Inhibition of NF-kappaB-mediated IkappaBalpha degradation in LPS-induced mouse RAW264.7 cells at 10 uM treated 30 mins before LPS challenge by Western blot analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335316Cytotoxicity against human XF498 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204976Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced TNF production compound pretreated 30 mins of LPS challenge measured after 4 hrs by ELISA2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID335318Cytotoxicity against human MALME-3M cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335059Cytotoxicity against human NCI-H522 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335334Cytotoxicity against human Caki1 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335321Cytotoxicity against human SK-MEL-28 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335047Cytotoxicity against human MOLT4 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335329Cytotoxicity against human OVCAR8 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID335053Cytotoxicity against human HOP62 cells1992Journal of natural products, May, Volume: 55, Issue:5
Cytotoxic quassinoids from Cedronia granatensis.
AID1204988Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced TNF mRNA expression cells at 10 uM treated 30 mins before LPS challenge measured after 3 hrs by qRT-PCR analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
AID1204980Cytotoxicity against mouse RAW264.7 cells at 0.001 to 10 uM pretreated 30 mins by LDH activity assay in presence of LPS2015Journal of natural products, Feb-27, Volume: 78, Issue:2
The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.110aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		2.1110antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
pyrrolidine dithiocarbamate
pyrrolidine dithiocarbamic acid: spelled pyrolidine in J Nutr 1979 reference; RN given refers to parent cpd. pyrrolidine dithiocarbamate : A member of the class of dithiocarbamic acids that is the N-dithiocarboxy derivative of pyrrolidine.		2.1110dithiocarbamic acids;
pyrrolidines		anticonvulsant;
antineoplastic agent;
geroprotector;
neuroprotective agent;
NF-kappaB inhibitor;
radical scavenger
quassin
quassin: article discusses quassinoid principle; structure		2.0510triterpenoid
glaucarubinone
[no description available]		2.0510carboxylic ester;
organic heteropentacyclic compound;
quassinoid;
secondary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone;
tetrol		antimalarial;
antineoplastic agent;
geroprotector;
plant metabolite
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.5120prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
bruceantin
[no description available]		2.0510triterpenoid
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		2.1110aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
simalikalactone D
[no description available]		2.0510cyclic ether;
delta-lactone;
enone;
organic heteropentacyclic compound;
quassinoid;
secondary alcohol;
secondary alpha-hydroxy ketone;
triol		antimalarial;
antineoplastic agent;
antiviral agent;
metabolite
glaucarubin
Glaucarubin: (1 beta,2 alpha,11 beta,12 alpha,15 beta(S))-11,20-Epoxy-1,2,11,12-tetrahydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)picras-3-en-16-one. A quassinoid (Simaroubolide) from Simaruba glauca, a tropical shrub. It has been used as an antiamebic agent and is found to be cytotoxic. It may be of use in cancer chemotherapy.		2.3920
ConditionIndicatedRelationship StrengthStudiesTrials
Allodynia
[description not available]		02.1110
Innate Inflammatory Response
[description not available]		02.1110
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.1110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.110
Gastritis
Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.		02.110
Extravascular Hemolysis
[description not available]		02.0510
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.0510