7-nitroindazole has been researched along with Allodynia in 21 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
| Excerpt | Relevance | Reference |
|---|---|---|
| ", twice a week) caused mechanical allodynia in the fourth week, which was reversed by intrathecal injection of MK-801 (10 nmol) and memantine (1 μmol), NMDA receptor antagonists." | 3.77 | Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. ( Egashira, N; Ikesue, H; Kawashiri, T; Mihara, Y; Oishi, R; Sada, H; Ushio, S; Yano, T, 2011) |
| "In a diabetic neuropathic pain model, pretreatment with celecoxib, L-NIL and 7-Ni, significantly increased the antihyperalgesic activity of both Met-F-AEA and AM 1241." | 1.42 | Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy. ( Bujalska-Zadrożny, M; de Cordé, A; Pawlik, K, 2015) |
| "Modafinil was administered in the doses of 50, 100 or 200 mg/kg once in acute study and it showed significantly increased tail-flick latency (tfl) and paw-licking latency." | 1.40 | Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole. ( Bhattacharya, SK; Gupta, LK; Gupta, R, 2014) |
| "IANX induced mechanical allodynia, which was diminished by intra-TG administration of selective nNOS inhibitors." | 1.39 | Nitric oxide signaling contributes to ectopic orofacial neuropathic pain. ( Echizenya, S; Honda, K; Ito, R; Iwata, K; Kaji, K; Lee, J; Ohara, K; Shinoda, M; Sugiyama, T; Takahashi, O; Urata, K; Watase, T, 2013) |
| "Compound 16 was shown to reverse thermal hyperalgesia in vivo in the Chung model of neuropathic pain." | 1.37 | Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. ( Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D, 2011) |
| "In streptozotocin-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway." | 1.35 | Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. ( Bujalska, M; Makulska-Nowak, H, 2009) |
| "Herpetic allodynia was significantly inhibited by i." | 1.34 | Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice. ( Andoh, T; Ito, S; Kuraishi, Y; Mabuchi, T; Sasaki, A; Serizawa, K; Shiraki, K; Takasaki, I, 2007) |
| "Agmatine is an endogenous decarboxylation product of arginine that has been previously shown to antagonize the N-methyl-d-aspartate (NMDA) receptor and inhibit nitric-oxide synthase." | 1.33 | Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse. ( Fairbanks, CA; Grocholski, BM; Kitto, KF; Roberts, JC, 2005) |
| "In contrast, the PAR-2-triggered thermal hyperalgesia in rats was blocked by both agents." | 1.31 | Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats. ( Itoh, H; Kataoka, K; Kawabata, A; Kawao, N; Kuroda, R; Masuko, T; Ogawa, S; Shimada, C; Takebe, K, 2002) |
| "Magnesium (Mg)-deficient rats develop a mechanical hyperalgesia which is reversed by a N-Methyl-D-Aspartate (NMDA) receptor antagonist." | 1.31 | Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats. ( Begon, S; Dubray, C; Eschalier, A; Mazur, A; Pickering, G; Rayssiguier, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Annedi, SC | 1 |
| Maddaford, SP | 1 |
| Mladenova, G | 1 |
| Ramnauth, J | 1 |
| Rakhit, S | 1 |
| Andrews, JS | 1 |
| Lee, DK | 1 |
| Zhang, D | 1 |
| Porreca, F | 1 |
| Bunton, D | 1 |
| Christie, L | 1 |
| Quiñonez-Bastidas, GN | 1 |
| Cervantes-Durán, C | 1 |
| Rocha-González, HI | 1 |
| Murbartián, J | 1 |
| Granados-Soto, V | 1 |
| Sugiyama, T | 1 |
| Shinoda, M | 1 |
| Watase, T | 1 |
| Honda, K | 1 |
| Ito, R | 1 |
| Kaji, K | 1 |
| Urata, K | 1 |
| Lee, J | 1 |
| Ohara, K | 1 |
| Takahashi, O | 1 |
| Echizenya, S | 1 |
| Iwata, K | 1 |
| Gupta, R | 1 |
| Gupta, LK | 1 |
| Bhattacharya, SK | 1 |
| Bujalska-Zadrożny, M | 1 |
| de Cordé, A | 1 |
| Pawlik, K | 1 |
| Bujalska, M | 1 |
| Makulska-Nowak, H | 1 |
| Kunori, S | 1 |
| Matsumura, S | 1 |
| Okuda-Ashitaka, E | 1 |
| Katano, T | 1 |
| Audoly, LP | 1 |
| Urade, Y | 1 |
| Ito, S | 2 |
| Mihara, Y | 1 |
| Egashira, N | 1 |
| Sada, H | 1 |
| Kawashiri, T | 1 |
| Ushio, S | 1 |
| Yano, T | 1 |
| Ikesue, H | 1 |
| Oishi, R | 1 |
| Tjong, YW | 1 |
| Ip, SP | 1 |
| Lao, L | 1 |
| Wu, J | 1 |
| Fong, HH | 1 |
| Sung, JJ | 1 |
| Berman, B | 1 |
| Che, CT | 1 |
| Wang, W | 2 |
| Mei, XP | 1 |
| Wei, YY | 1 |
| Zhang, MM | 1 |
| Zhang, T | 1 |
| Xu, LX | 1 |
| Wu, SX | 1 |
| Li, YQ | 1 |
| Kawabata, A | 2 |
| Kawao, N | 2 |
| Itoh, H | 1 |
| Shimada, C | 1 |
| Takebe, K | 1 |
| Kuroda, R | 1 |
| Masuko, T | 1 |
| Kataoka, K | 1 |
| Ogawa, S | 1 |
| Picolo, G | 1 |
| Cury, Y | 2 |
| Sekiguchi, F | 1 |
| Mita, Y | 1 |
| Kamanaka, Y | 1 |
| Matsuya, H | 1 |
| Taga, C | 1 |
| Zanchet, EM | 1 |
| Longo, I | 1 |
| Tao, F | 1 |
| Tao, YX | 1 |
| Zhao, C | 1 |
| Doré, S | 1 |
| Liaw, WJ | 1 |
| Raja, SN | 1 |
| Johns, RA | 1 |
| Roberts, JC | 1 |
| Grocholski, BM | 1 |
| Kitto, KF | 1 |
| Fairbanks, CA | 1 |
| Sasaki, A | 1 |
| Mabuchi, T | 1 |
| Serizawa, K | 1 |
| Takasaki, I | 1 |
| Andoh, T | 1 |
| Shiraki, K | 1 |
| Kuraishi, Y | 1 |
| Lawand, NB | 1 |
| Willis, WD | 1 |
| Westlund, KN | 1 |
| Osborne, MG | 1 |
| Coderre, TJ | 1 |
| Sugimoto, Y | 1 |
| Yamada, J | 1 |
| Yoshikawa, T | 1 |
| Begon, S | 1 |
| Pickering, G | 1 |
| Eschalier, A | 1 |
| Mazur, A | 1 |
| Rayssiguier, Y | 1 |
| Dubray, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura[NCT00877838] | Phase 2 | 40 participants (Anticipated) | Interventional | 2009-05-31 | Recruiting | ||
| The Effect of Magnesium Sulfate Infusion on the Quality of Recovery of Ambulatory Patients[NCT01433081] | 50 participants (Actual) | Interventional | 2011-02-28 | Completed | |||
| Does Magnesium Sulfate as a Supplement in Adductor Canal Blocks Improve Pain Control After Total Knee Arthroplasty?[NCT02581683] | Phase 4 | 130 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Opioid consumption after discharge (NCT01433081)
Timeframe: 24 hours
| Intervention | miligram morphine equivalents (Median) |
|---|---|
| Magnesium Sulfate Infusion | 10 |
| Placebo | 30 |
Quality of recovery scores post operative. Scored on a scale of 40 (poor recovery) to 200 (good recovery). (NCT01433081)
Timeframe: 24 hours post operative
| Intervention | units on scale 40 (low) - 200 (high) (Mean) |
|---|---|
| Magnesium Sulfate Infusion | 183 |
| Placebo | 159 |
21 other studies available for 7-nitroindazole and Allodynia
| Article | Year |
|---|---|
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalge | 2011 |
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Re | 2013 |
Nitric oxide signaling contributes to ectopic orofacial neuropathic pain.
Topics: Animals; Arginine; Enzyme Inhibitors; Enzyme Precursors; Facial Pain; Hyperalgesia; Indazoles; Lip; | 2013 |
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Form | 2014 |
Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy.
Topics: Animals; Arachidonic Acids; Cannabinoids; Celecoxib; Cyclooxygenase Inhibitors; Diabetic Neuropathie | 2015 |
Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Diabetes Mellitus, Experimental; Diabetic Neur | 2009 |
A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord.
Topics: Adenosine Triphosphate; Animals; Cell Movement; Cerebral Cortex; Cinnamates; Dinoprostone; Disease M | 2011 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles | 2011 |
Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats.
Topics: Animals; Animals, Newborn; Colon; Colonic Diseases; Disease Models, Animal; Electromyography; Gastro | 2011 |
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain.
Topics: Animals; Astrocytes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hype | 2011 |
Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperalgesia; In | 2002 |
Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a delta- and kappa-opioid receptor agonist.
Topics: Analgesics; Animals; Crotalid Venoms; Crotalus; Dinoprostone; Drug Antagonism; Enzyme Inhibitors; Hy | 2004 |
The potent inducible nitric oxide synthase inhibitor ONO-1714 inhibits neuronal NOS and exerts antinociception in rats.
Topics: Amidines; Analgesics; Animals; Carrageenan; Cerebellum; Heating; Heterocyclic Compounds, 2-Ring; Hum | 2004 |
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide Receptor Antagonists; Celecoxib; Citrates; Cycl | 2004 |
Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.
Topics: Animals; Blotting, Western; Calcium; Carrageenan; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2004 |
Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse.
Topics: Agmatine; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Indazoles; I | 2005 |
Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Enzyme Inhibitors; Female; Ganglia, Spinal; Herpesvirus 1, | 2007 |
Blockade of joint inflammation and secondary hyperalgesia by L-NAME, a nitric oxide synthase inhibitor.
Topics: Analgesics; Animals; Arthritis; Carrageenan; Hyperalgesia; Indazoles; Inflammation; Injections, Intr | 1997 |
Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Hyperalgesia; | 1999 |
A neuronal nitric oxide synthase inhibitor 7-nitroindazole reduces the 5-HT1A receptor against 8-OH-DPAT-elicited hyperphagia in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Arginine; Autoreceptors; Enzyme Inhibitors; Feeding | 1999 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |