nitroglycerin has been researched along with Allodynia in 71 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nimesulide was compared with vehicle in groups of 4-10 rats that were randomly tested with different models of pain." | 9.10 | Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2003) |
| " Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CM-associated molecules in the trigeminal nucleus caudalis (TNC)." | 8.31 | GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. ( Jing, F; Pu, Y; Zou, Q, 2023) |
| " The aim of this study was to analyze the sensitivity of rats with prenatal hyperhomocysteinemia (hHCY) in respect of the development of behavioral correlates of headache and spreading cortical depolarization (CSD) in a migraine model induced by the administration of the nitric oxide (NO) donor nitroglycerin." | 8.12 | Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats. ( Bogatova, K; Enikeev, D; Gerasimova, E; Giniatullin, R; Hermann, A; Sitdikova, G; Yakovleva, O, 2022) |
| "This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats." | 8.12 | Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. ( Alam, A; Almalki, HS; Alqarni, MH; Devi, S; Foudah, AI; Kumar, M; Salkini, MA, 2022) |
| "Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia." | 7.74 | Role of calcitonin gene-related peptide and substance P in different models of pain. ( Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2008) |
| "Surprisingly, a single topical application of a nitroglycerin (NTG) gel in humans has been shown to cause analgesia and to reduce oedema in thrombophlebitis." | 7.68 | Blockade of hyperalgesia and neurogenic oedema by topical application of nitroglycerin. ( Faccioli, LH; Ferreira, SH; Lorenzetti, BB, 1992) |
| "Using nitroglycerine to trigger migraine attacks, we investigated whether cranial allodynia could be triggered experimentally, observing its response to treatment." | 6.90 | Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2019) |
| "This study shows that the antimigraine effects of DOR agonists can be separated from their proconvulsant effects." | 5.62 | A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia. ( Asif, S; Bertels, Z; Pradhan, AA; Siegersma, K; van Rijn, RM; Witkowski, WD, 2021) |
| "Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20% of the population worldwide." | 5.62 | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ( He, Y; Kashyap, Y; Messing, RO; Shi, Z; Wang, ZJ, 2021) |
| "Chronic migraine was modeled by injection (10 mg/kg, i." | 5.48 | Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats. ( Erfani, M; Farajdokht, F; Karimi, P; Mahmoudi, J; Mohaddes, G; Rajabi, M; Reyhani-Rad, S; Sadigh-Eteghad, S, 2018) |
| "By contrast, cold allodynia, but not mechanical hypersensitivity, occurred in the facial region." | 5.48 | Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents. ( Beitz, AJ; Kim, SJ; Kwon, SG; Lee, JH; Roh, DH; Yeo, JH; Yoon, SY, 2018) |
| "Nimesulide was compared with vehicle in groups of 4-10 rats that were randomly tested with different models of pain." | 5.10 | Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2003) |
| " Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CM-associated molecules in the trigeminal nucleus caudalis (TNC)." | 4.31 | GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. ( Jing, F; Pu, Y; Zou, Q, 2023) |
| " The aim of this study was to analyze the sensitivity of rats with prenatal hyperhomocysteinemia (hHCY) in respect of the development of behavioral correlates of headache and spreading cortical depolarization (CSD) in a migraine model induced by the administration of the nitric oxide (NO) donor nitroglycerin." | 4.12 | Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats. ( Bogatova, K; Enikeev, D; Gerasimova, E; Giniatullin, R; Hermann, A; Sitdikova, G; Yakovleva, O, 2022) |
| "Repeated administration of nitroglycerin (NTG) or levcromakalim (LEV) was conducted to stimulate human migraine-like pain and establish two types of CMMs in mice." | 4.12 | A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine. ( Li, Z; Liu, X; Ren, X; Wang, W; Wang, Y; Wu, S; Zhang, K; Zhu, C, 2022) |
| "This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats." | 4.12 | Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. ( Alam, A; Almalki, HS; Alqarni, MH; Devi, S; Foudah, AI; Kumar, M; Salkini, MA, 2022) |
| " Then, nitroglycerin (NTG) (5 mg/kg/IP) was used to induce migraine and pain-related symptoms were recorded for 90 min." | 3.96 | Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats. ( Abbasnejad, M; Askari-Zahabi, K; Esmaeili-Mahani, S; Kooshki, R; Raoof, M; Shamsizadeh, A, 2020) |
| " Results VL-102-evoked acute and chronic mechanical cephalic and hind-paw allodynia in a dose-dependent manner, which was blocked by the migraine medications sumatriptan, propranolol, and topiramate." | 3.88 | Soluble guanylyl cyclase is a critical regulator of migraine-associated pain. ( Ben Aissa, M; Bennett, BM; Bertels, Z; Gaisina, IN; Gandhi, R; Lee, SH; Litosh, V; Moye, LS; Novack, M; Pradhan, AA; Thatcher, GR; Tipton, AF; Wang, Y, 2018) |
| "Systemic administration of nitroglycerin (NTG) consistently provokes spontaneous-like migraine attacks in migraine sufferers, and in rat it induces hyperalgesia and allodynia." | 3.83 | Ghrelin attenuates hyperalgesia and light aversion-induced by nitroglycerin in male rats. ( Babri, S; Farajdokht, F; Karimi, P; Mohaddes, G, 2016) |
| "The NO donors nitroglycerin and sodium nitroprusside (SNP) induced allodynia (cold plate test) and hyperalgesia (hot plate test)." | 3.79 | St. John's wort relieves pain in an animal model of migraine. ( Galeotti, N; Ghelardini, C, 2013) |
| "Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia." | 3.74 | Role of calcitonin gene-related peptide and substance P in different models of pain. ( Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2008) |
| "Surprisingly, a single topical application of a nitroglycerin (NTG) gel in humans has been shown to cause analgesia and to reduce oedema in thrombophlebitis." | 3.68 | Blockade of hyperalgesia and neurogenic oedema by topical application of nitroglycerin. ( Faccioli, LH; Ferreira, SH; Lorenzetti, BB, 1992) |
| "Using nitroglycerine to trigger migraine attacks, we investigated whether cranial allodynia could be triggered experimentally, observing its response to treatment." | 2.90 | Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2019) |
| "Migraine is a recurrent primary headache disorder with moderate to severe disability; however, the pathophysiology is not fully understood." | 1.91 | Multi-region local field potential signatures and brain coherence alternations in response to nitroglycerin-induced migraine attacks. ( Lin, Q; Peng, YB; Wang, Z, 2023) |
| "In the acute migraine model, rats received CBD (15 mg or 30 mg/kg, i." | 1.91 | Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine. ( Demartini, C; Facchetti, S; Francavilla, M; Franco, V; Greco, R; Pacchetti, B; Palmisani, M; Sodergren, MH; Tassorelli, C; Zanaboni, AM, 2023) |
| "In the nitroglycerin-induced chronic migraine model, the microglial response to extracellular stimuli leads to the activation of surface purine receptors P2X4、P2X7、P2Y12, which mediate signal transduction through intracellular signalling cascades, such as the BDNF/TrkB, NLRP3/IL-1β and RhoA/ROCK signalling pathways, and release inflammatory mediators and cytokines that enhance pain by increasing the excitability of nearby neurons." | 1.91 | The status of knowledge on migraines: The role of microglia. ( He, W; Wang, Y; Zhang, Y; Zhou, J, 2023) |
| "The mechanism of SGD in remedying migraine was studied through transcriptome sequencing (RNA-seq), which was further validated utilizing Elisa, Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting (WB) experiments." | 1.91 | Shaoyao Gancao decoction alleviates the central hyperalgesia of recurrent NTG-induced migraine in rats by regulating the NGF/TRPV1/COX-2 signal pathway. ( Hou, J; Ji, X; Li, R; Liu, Z; Luo, Y; Qiu, Y; Song, H; Tao, X; Wang, T; Yang, F; Zhang, S; Zhang, Y; Zhou, R, 2023) |
| "Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and other associated symptoms." | 1.72 | Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2022) |
| "Migraine is a common brain-disorder that affects 15% of the population." | 1.72 | Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine. ( Campolo, M; Casili, G; Cuzzocrea, S; Esposito, E; Filippone, A; Giuffrè, L; Lanza, M; Paterniti, I; Scuderi, SA, 2022) |
| "We established a mouse model of chronic migraine with intermittent injections of clinically-relevant dose of nitroglycerin (0." | 1.72 | CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. ( Chen, SP; Chou, TM; Lee, ZF; Lien, CC; Wang, SJ, 2022) |
| "Moreover, significant hyperalgesia was induced by nitroglycerin administration in GFC mice." | 1.72 | The gut microbiome modulates nitroglycerin-induced migraine-related hyperalgesia in mice. ( Kang, L; Kong, S; Li, Y; Liu, J; Tang, W; Yu, S; Zhang, M; Zhang, Y; Zhao, D, 2022) |
| "Nitroglycerin induced activation of migraine-like central trigeminocervical neurons, and intracranial and extracranial neuronal hypersensitivity." | 1.62 | Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2021) |
| "Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20% of the population worldwide." | 1.62 | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ( He, Y; Kashyap, Y; Messing, RO; Shi, Z; Wang, ZJ, 2021) |
| "This study shows that the antimigraine effects of DOR agonists can be separated from their proconvulsant effects." | 1.62 | A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia. ( Asif, S; Bertels, Z; Pradhan, AA; Siegersma, K; van Rijn, RM; Witkowski, WD, 2021) |
| "5-BDBD or ANA-12 prevented hyperalgesia induced by NTG, which was associated with a significant inhibition of the NTG-induced increase in phosphorylated extracellular regulated protein kinases (p-ERK) and calcitonin gene related peptide (CGRP) release in the TNC." | 1.56 | Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. ( Chen, L; He, W; Long, T; Pan, Q; Qin, G; Zhang, D; Zhang, S; Zhou, J, 2020) |
| "This study showed that EVO inhibits the migraine-like pain response and that this beneficial effect might be attributed to the regulation of nNOS and suppression of the AMPA receptor GluA1." | 1.56 | Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response. ( Chen, J; Li, C; Li, Z; Lin, J; Lu, H; Wu, Z; Yang, X; Zhang, X; Zhang, Y, 2020) |
| "Vestibular migraine has recently been recognized as a novel subtype of migraine." | 1.56 | Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine. ( Chen, L; Fan, X; Pan, Q; Qin, G; Tian, K; Wang, Y; Zhang, D; Zhang, Y; Zhou, J, 2020) |
| "In a model of chronic migraine-associated pain using the human migraine trigger, nitroglycerin, we observed increased expression of DOR in cortex, hippocampus, and striatum; suggesting a role for these forebrain regions in the regulation of migraine." | 1.56 | Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia. ( Baca, SM; Bertels, Z; Dripps, IJ; Kieffer, BL; Moye, LS; Pradhan, AA; Siegersma, K; Tipton, AF, 2020) |
| "Pretreatment with PL ameliorated migraine headache behaviors in the NTG-induced migraine rat model, suggesting pretreatment with PL is beneficial for migraine headache treatment." | 1.51 | Effect of Paeonia lactiflora, a traditional Chinese herb, on migraines based on clinical application and animal behavior analyses. ( Chen, CH; Hsieh, CL; Li, JM; Liao, CC; Lin, CL, 2019) |
| "Allodynia was absent in TRPA1-deficient mice and was reversed by TRPA1 antagonists." | 1.48 | TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. ( Benemei, S; Bunnett, NW; De Carvalho Goncalves, M; De Logu, F; Ferreira, J; Geppetti, P; Jain, P; Li Puma, S; Marone, IM; Materazzi, S; Nassini, R, 2018) |
| "By contrast, cold allodynia, but not mechanical hypersensitivity, occurred in the facial region." | 1.48 | Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents. ( Beitz, AJ; Kim, SJ; Kwon, SG; Lee, JH; Roh, DH; Yeo, JH; Yoon, SY, 2018) |
| "Migraine is the third most common disease worldwide; however, the mechanisms underlying migraine headache are still not fully understood." | 1.48 | AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain. ( Liu, S; Shu, H; Tang, Y; Tao, F; Xing, Y, 2018) |
| "Chronic migraine was modeled by injection (10 mg/kg, i." | 1.48 | Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats. ( Erfani, M; Farajdokht, F; Karimi, P; Mahmoudi, J; Mohaddes, G; Rajabi, M; Reyhani-Rad, S; Sadigh-Eteghad, S, 2018) |
| "The mechanism underlying migraine chronification remains unclear." | 1.48 | Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation. ( Chen, L; He, W; Liu, C; Liu, Q; Long, T; Pan, Q; Qin, G; Zhang, S; Zhang, Y; Zhou, J, 2018) |
| " In addition, chronic administration of nitroglycerin produces a progressive and sustained decrease in basal mechanical responses, and this hypersensitivity is blocked by migraine preventatives such as topiramate." | 1.46 | Animal Model of Chronic Migraine-Associated Pain. ( Moye, LS; Pradhan, AAA, 2017) |
| "BAI could alleviate the migraine-like headache induced by NTG, which is related to the regulation of vasoactive substances." | 1.46 | Analgesia effect of baicalein against NTG-induced migraine in rats. ( Bao, Y; Dong, CL; Guo, CR; Hu, WL; Sun, YY; Wang, CZ; Yuan, CS; Zhang, CF; Zhang, WJ; Zhang, XF, 2017) |
| "In rats bearing nitroglycerin-induced hyperalgesia, ADM_12 showed an anti-hyperalgesic effect in the second phase of the orofacial formalin test." | 1.46 | The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model. ( Demartini, C; Francesconi, O; Greco, R; Nativi, C; Tassorelli, C; Tonsi, G; Zanaboni, AM, 2017) |
| "Results KYNA-A1 abolished NTG-induced hyperalgesia in both pain models; NTG alone or associated to formalin injection induced an increased mRNA expression of CGRP, nNOS and cytokines in the trigeminal ganglia and central areas, which was reduced by KYNA-A1." | 1.46 | Effects of kynurenic acid analogue 1 (KYNA-A1) in nitroglycerin-induced hyperalgesia: Targets and anti-migraine mechanisms. ( Blandini, F; Demartini, C; Fülöp, F; Greco, R; Nappi, G; Pampalone, S; Redavide, E; Sandrini, G; Tassorelli, C; Toldi, J; Vécsei, L; Zanaboni, AM, 2017) |
| "The presentation of spontaneous tactile allodynia was observed in the nitroglycerin group by the 5th episode." | 1.46 | The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification. ( Black, JR; Carpenter, JM; Harris, HM; Smitherman, TA; Sufka, KJ, 2017) |
| "This hyperalgesia was greater in females, was prevented by pretreatment with the anti-migraine drug, sumatriptan, as well as by chronic pretreatment with the mast cell degranulator, compound 48/80." | 1.43 | Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat. ( Ferrari, LF; Green, PG; Levine, JD, 2016) |
| "Antioxidants have been proven to weaken hyperalgesia in neuropathic pain." | 1.43 | Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats. ( Di, W; Fang, Y; Li, Z; Liu, J; Lv, H; Shi, X; Zhang, H, 2016) |
| "NTG-induced hyperalgesia in rats has been extensively used as a migraine model for pre-clinical research." | 1.42 | Pregabalin alleviates the nitroglycerin-induced hyperalgesia in rats. ( Di, W; Ding, MH; Fang, YN; Lin, JW; Luo, N; Qi, WW; Shi, XL; Xiao, ZJ; Zhang, AW; Zheng, ZY, 2015) |
| "We found that nitroglycerin-induced mechanical allodynia and neuronal activation of the trigeminal nucleus were completely abolished in FAAH-deficient mice." | 1.42 | Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. ( Markert, A; Nozaki, C; Zimmer, A, 2015) |
| "This chronic basal hyperalgesia occurred in a dose-dependent fashion and persisted for days after cessation of NTG administration." | 1.40 | Characterization of a novel model of chronic migraine. ( Charles, A; Evans, CJ; McGuire, B; Pradhan, AA; Smith, ML; Tarash, I, 2014) |
| "Migraine is an extraordinarily common brain disorder for which treatment options continue to be limited." | 1.40 | δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. ( Charles, A; Pradhan, AA; Smith, ML; Zyuzin, J, 2014) |
| "Migraine is a common disabling disorder with a significant genetic component, characterized by severe headache and often accompanied by nausea, vomiting, and light sensitivity." | 1.39 | Casein kinase iδ mutations in familial migraine and advanced sleep phase. ( Bates, EA; Brennan, KC; Charles, AC; Fu, YH; Hallows, WC; Huang, Y; Jones, CR; Lee, HY; Ptáček, LJ; Shapiro, RE; Zyuzin, J, 2013) |
| "Nitroglycerin-induced hyperalgesia can be detected as an increase in the nociceptive behavior evoked by the formalin test." | 1.33 | Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D, 2006) |
| "Nitroglycerin is a nitric oxide (NO) donor which activates nuclei involved in nociceptive transmission following systemic administration." | 1.32 | Nitroglycerin induces hyperalgesia in rats--a time-course study. ( Greco, R; Nappi, G; Sandrini, G; Sandrini, M; Tassorelli, C; Wang, D, 2003) |
| "Spinal NMDA receptors are involved in hyperalgesia and chronic pain." | 1.30 | [Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord]. ( Kuno, Y; Sato, E; Sato, I; Takano, M; Takano, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (4.23) | 18.2507 |
| 2000's | 6 (8.45) | 29.6817 |
| 2010's | 34 (47.89) | 24.3611 |
| 2020's | 28 (39.44) | 2.80 |
| Authors | Studies |
|---|---|
| Biava, M | 1 |
| Porretta, GC | 1 |
| Poce, G | 1 |
| Battilocchio, C | 1 |
| Alfonso, S | 1 |
| Rovini, M | 1 |
| Valenti, S | 1 |
| Giorgi, G | 1 |
| Calderone, V | 1 |
| Martelli, A | 1 |
| Testai, L | 1 |
| Sautebin, L | 1 |
| Rossi, A | 1 |
| Papa, G | 1 |
| Ghelardini, C | 2 |
| Di Cesare Mannelli, L | 1 |
| Giordani, A | 1 |
| Anzellotti, P | 1 |
| Bruno, A | 1 |
| Patrignani, P | 1 |
| Anzini, M | 1 |
| Kang, L | 1 |
| Tang, W | 1 |
| Zhang, Y | 11 |
| Zhang, M | 1 |
| Liu, J | 2 |
| Li, Y | 1 |
| Kong, S | 1 |
| Zhao, D | 1 |
| Yu, S | 1 |
| Lanza, M | 2 |
| Filippone, A | 2 |
| Ardizzone, A | 1 |
| Casili, G | 2 |
| Paterniti, I | 2 |
| Esposito, E | 2 |
| Campolo, M | 2 |
| Pan, Q | 5 |
| Wang, Y | 5 |
| Tian, R | 1 |
| Wen, Q | 1 |
| Qin, G | 5 |
| Zhang, D | 4 |
| Chen, L | 5 |
| Zhou, J | 6 |
| Giuffrè, L | 1 |
| Scuderi, SA | 1 |
| Cuzzocrea, S | 1 |
| Gerasimova, E | 1 |
| Yakovleva, O | 1 |
| Enikeev, D | 1 |
| Bogatova, K | 1 |
| Hermann, A | 1 |
| Giniatullin, R | 1 |
| Sitdikova, G | 1 |
| Greco, R | 18 |
| Demartini, C | 11 |
| Zanaboni, AM | 10 |
| Francavilla, M | 8 |
| Reggiani, A | 1 |
| Realini, N | 1 |
| Scarpelli, R | 1 |
| Piomelli, D | 2 |
| Tassorelli, C | 20 |
| Wu, S | 1 |
| Ren, X | 1 |
| Zhu, C | 1 |
| Wang, W | 1 |
| Zhang, K | 1 |
| Li, Z | 3 |
| Liu, X | 1 |
| Magni, G | 3 |
| Riboldi, B | 3 |
| Nativi, C | 4 |
| Ceruti, S | 3 |
| Foudah, AI | 3 |
| Devi, S | 3 |
| Alqarni, MH | 3 |
| Alam, A | 3 |
| Salkini, MA | 3 |
| Kumar, M | 3 |
| Almalki, HS | 3 |
| Chou, TM | 2 |
| Lee, ZF | 2 |
| Wang, SJ | 2 |
| Lien, CC | 2 |
| Chen, SP | 2 |
| Wang, Z | 1 |
| Lin, Q | 1 |
| Peng, YB | 1 |
| Sodergren, MH | 1 |
| Facchetti, S | 2 |
| Pacchetti, B | 1 |
| Palmisani, M | 2 |
| Franco, V | 2 |
| He, W | 4 |
| Luo, Y | 1 |
| Qiu, Y | 1 |
| Zhou, R | 1 |
| Ji, X | 1 |
| Liu, Z | 1 |
| Li, R | 1 |
| Yang, F | 1 |
| Hou, J | 1 |
| Zhang, S | 4 |
| Wang, T | 1 |
| Song, H | 1 |
| Tao, X | 1 |
| Jing, F | 1 |
| Zou, Q | 1 |
| Pu, Y | 1 |
| Long, T | 3 |
| Lin, J | 1 |
| Zhang, X | 1 |
| Li, C | 1 |
| Lu, H | 1 |
| Chen, J | 1 |
| Yang, X | 1 |
| Wu, Z | 1 |
| Tian, K | 1 |
| Fan, X | 1 |
| Kooshki, R | 1 |
| Abbasnejad, M | 1 |
| Shamsizadeh, A | 1 |
| Raoof, M | 1 |
| Askari-Zahabi, K | 1 |
| Esmaeili-Mahani, S | 1 |
| Dripps, IJ | 1 |
| Bertels, Z | 3 |
| Moye, LS | 4 |
| Tipton, AF | 3 |
| Siegersma, K | 2 |
| Baca, SM | 1 |
| Kieffer, BL | 1 |
| Pradhan, AA | 6 |
| Akerman, S | 2 |
| Romero-Reyes, M | 2 |
| Karsan, N | 2 |
| Bose, P | 2 |
| Hoffmann, JR | 2 |
| Holland, PR | 2 |
| Goadsby, PJ | 2 |
| Witkowski, WD | 1 |
| Asif, S | 1 |
| van Rijn, RM | 1 |
| He, Y | 1 |
| Shi, Z | 1 |
| Kashyap, Y | 1 |
| Messing, RO | 1 |
| Wang, ZJ | 1 |
| Gölöncsér, F | 1 |
| Baranyi, M | 1 |
| Iring, A | 1 |
| Hricisák, L | 1 |
| Otrokocsi, L | 1 |
| Benyó, Z | 1 |
| Sperlágh, B | 1 |
| Yazğan, Y | 1 |
| Nazıroğlu, M | 1 |
| Zhang, XF | 1 |
| Zhang, WJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage[NCT04126408] | 40 participants (Actual) | Interventional | 2020-01-13 | Completed | |||
| The Effect Of Transcutaneous Auricular Vagus Nerve Stimulation On Sports Performance And Physiological Parameters In Healthy Young Individuals: Randomized, Double-Blind Study[NCT04768738] | 46 participants (Actual) | Interventional | 2020-02-01 | Completed | |||
| Peripheral Gene Expression of Endocannabinoid System Components in Episodic and Chronic Migraine Patients: a Pilot Study[NCT04324710] | 75 participants (Actual) | Observational | 2017-12-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for nitroglycerin and Allodynia
| Article | Year |
|---|---|
Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity.
Topics: Adolescent; Adult; Aspirin; Double-Blind Method; Humans; Hyperalgesia; Middle Aged; Migraine Disorde | 2019 |
Effects of nimesulide on nitric oxide-induced hyperalgesia in humans--a neurophysiological study.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycl | 2002 |
Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia.
Topics: Analgesia; Animals; Brain; Disease Models, Animal; Gene Expression; Genes, fos; Hyperalgesia; Male; | 2003 |
68 other studies available for nitroglycerin and Allodynia
| Article | Year |
|---|---|
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.
Topics: Acetates; Animals; Cell Line; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Edema; Esters; | 2011 |
The gut microbiome modulates nitroglycerin-induced migraine-related hyperalgesia in mice.
Topics: Animals; Gastrointestinal Microbiome; Humans; Hyperalgesia; Mice; Migraine Disorders; Nitroglycerin; | 2022 |
SCFA Treatment Alleviates Pathological Signs of Migraine and Related Intestinal Alterations in a Mouse Model of NTG-Induced Migraine.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Down-Regulation; Fatty Acids, | 2021 |
Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model.
Topics: Animals; Central Nervous System Sensitization; Disease Models, Animal; Hyperalgesia; Mice; Migraine | 2022 |
Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine.
Topics: Animals; Butyric Acid; Dietary Supplements; Disease Models, Animal; Fatty Acids, Volatile; Gastroint | 2022 |
Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats.
Topics: Animals; Anxiety; Cortical Excitability; Female; Homocysteine; Hyperalgesia; Hyperhomocysteinemia; M | 2022 |
Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine.
Topics: Amides; Amidohydrolases; Animals; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Inflammati | 2022 |
Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin | 2022 |
A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Crom | 2022 |
Antagonism of CGRP Receptor: Central and Peripheral Mechanisms and Mediators in an Animal Model of Chronic Migraine.
Topics: Animals; Ankyrins; Calcitonin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Rece | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Amygdaloid Nucleus; Hyperalgesia; Mice; Migraine D | 2022 |
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Amygdaloid Nucleus; Hyperalgesia; Mice; Migraine D | 2022 |
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Amygdaloid Nucleus; Hyperalgesia; Mice; Migraine D | 2022 |
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Amygdaloid Nucleus; Hyperalgesia; Mice; Migraine D | 2022 |
Multi-region local field potential signatures and brain coherence alternations in response to nitroglycerin-induced migraine attacks.
Topics: Animals; Brain; Disease Models, Animal; Hyperalgesia; Migraine Disorders; Nitroglycerin; Rats | 2023 |
Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabidiol; Disease Models, Animal; Hyperalgesia; Male; M | 2023 |
The status of knowledge on migraines: The role of microglia.
Topics: Animals; Hyperalgesia; Microglia; Migraine Disorders; Nitroglycerin; Signal Transduction | 2023 |
Shaoyao Gancao decoction alleviates the central hyperalgesia of recurrent NTG-induced migraine in rats by regulating the NGF/TRPV1/COX-2 signal pathway.
Topics: Animals; Calcitonin Gene-Related Peptide; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinas | 2023 |
Activity of FAAH-Inhibitor JZP327A in an Experimental Rat Model of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Ma | 2023 |
GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model.
Topics: Animals; Disease Models, Animal; Glucagon-Like Peptide-1 Receptor; Hyperalgesia; Interleukin-10; Lir | 2023 |
Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model.
Topics: Adenosine Triphosphate; Animals; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; | 2020 |
Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response.
Topics: Analgesics; Animals; Hyperalgesia; Male; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase Typ | 2020 |
Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin; Pro | 2020 |
Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Hyperalgesia; | 2020 |
Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Benzamides; Cortical Spreading Depression; Disease Models, Animal; GABA | 2020 |
Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives.
Topics: Animals; Headache; Hyperalgesia; Migraine Disorders; Neurons; Nitroglycerin; Rats | 2021 |
A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia.
Topics: Analgesics, Opioid; Animals; Cortical Spreading Depression; Disease Models, Animal; Female; Hyperalg | 2021 |
Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice.
Topics: Animals; Disease Models, Animal; Headache; Hyperalgesia; Mice; Migraine Disorders; Nitroglycerin; Pr | 2021 |
Involvement of P2Y
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Migraine Disorders; N | 2021 |
Involvement of TRPM2 in the Neurobiology of Experimental Migraine: Focus on Oxidative Stress and Apoptosis.
Topics: Adenosine Diphosphate Ribose; Animals; Apoptosis; Boron Compounds; Calcium Signaling; Caspases; Cinn | 2021 |
Analgesia effect of baicalein against NTG-induced migraine in rats.
Topics: Analgesia; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Endothelins; Flavanones | 2017 |
The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Endpoint Determination; Hyperalgesia; | 2017 |
Animal Model of Chronic Migraine-Associated Pain.
Topics: Animals; Association Learning; Chronic Pain; Disease Models, Animal; Female; Hyperalgesia; Mice; Mic | 2017 |
The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Migraine Disor | 2017 |
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
Topics: Adrenergic beta-Antagonists; Allosteric Regulation; Animals; Anticonvulsants; Calcitonin Gene-Relate | 2018 |
Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents.
Topics: Animals; Capsaicin; Cold Temperature; Diterpenes; Drug Resistance; Facial Nerve Diseases; Hindlimb; | 2018 |
Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management.
Topics: Animals; Calcitonin Gene-Related Peptide; Ghrelin; Hyperalgesia; Male; Nitroglycerin; Rats; Rats, Wi | 2018 |
AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain.
Topics: Animals; Avoidance Learning; Calcium; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Locomot | 2018 |
Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats.
Topics: Amino Acids; Animals; Central Nervous System Agents; Disease Models, Animal; Grooming; Hyperalgesia; | 2018 |
TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Cell Body; Headache; Hyperalgesia; Male; Mice; Mice, | 2018 |
Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation.
Topics: Animals; Benzodiazepinones; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Disease Model | 2018 |
Delta opioid receptor agonists are effective for multiple types of headache disorders.
Topics: Animals; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Headache Diso | 2019 |
Dissecting out migraine complexity through comprehensive analysis of allodynia.
Topics: Humans; Hyperalgesia; Migraine Disorders; Nitroglycerin; Tryptamines | 2019 |
Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Central Nervous System Sensitiza | 2019 |
Effect of Paeonia lactiflora, a traditional Chinese herb, on migraines based on clinical application and animal behavior analyses.
Topics: Animals; Anxiety; Behavior, Animal; Calcitonin Gene-Related Peptide; Depression; Drugs, Chinese Herb | 2019 |
Casein kinase iδ mutations in familial migraine and advanced sleep phase.
Topics: Animals; Astrocytes; Calcium Signaling; Casein Kinase Idelta; Cortical Spreading Depression; Female; | 2013 |
Characterization of a novel model of chronic migraine.
Topics: Animals; Chronic Disease; Disease Models, Animal; Female; Freund's Adjuvant; Hyperalgesia; Male; Mic | 2014 |
Effects of CGRP receptor antagonism in nitroglycerin-induced hyperalgesia.
Topics: Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Hyperalgesia; | 2014 |
δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.
Topics: Animals; Avoidance Learning; Benzamides; Cortical Spreading Depression; Female; Hyperalgesia; Male; | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Pregabalin alleviates the nitroglycerin-induced hyperalgesia in rats.
Topics: Analgesics; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; | 2015 |
Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine.
Topics: Amidohydrolases; Analgesics; Animals; Cannabinoids; Disease Models, Animal; Dose-Response Relationsh | 2015 |
Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica (L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors.
Topics: Administration, Intranasal; Administration, Oral; Animals; Bradykinin; Centella; Female; Hyperalgesi | 2015 |
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonist | 2015 |
Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Female; Hyperalgesia; Male; Mast Cells; Neutroph | 2016 |
Ghrelin attenuates hyperalgesia and light aversion-induced by nitroglycerin in male rats.
Topics: Animals; Anxiety; Disease Models, Animal; Ghrelin; Hyperalgesia; Male; Migraine Disorders; Nitroglyc | 2016 |
Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidant Response Elements; Heme Oxygenase (Decyclizing); Hyper | 2016 |
Effects of kynurenic acid analogue 1 (KYNA-A1) in nitroglycerin-induced hyperalgesia: Targets and anti-migraine mechanisms.
Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Kynurenic Acid; Male; Migraine Disorders; | 2017 |
Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia.
Topics: Adrenergic Agents; Animals; Basal Ganglia; Denervation; Dopamine; Formaldehyde; Hyperalgesia; Image | 2008 |
Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice.
Topics: Animals; Brain; Cortical Spreading Depression; Gene Expression; Hot Temperature; Hyperalgesia; Immun | 2010 |
Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat.
Topics: Amidohydrolases; Animals; Brain; Cannabinoid Receptor Modulators; Disease Models, Animal; Endocannab | 2010 |
Sildenafil and glyceryl trinitrate reduce tactile allodynia in streptozotocin-injected rats.
Topics: Administration, Cutaneous; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Diabet | 2010 |
St. John's wort relieves pain in an animal model of migraine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Blotting, Western; Cold Temperat | 2013 |
Nitroglycerin induces hyperalgesia in rats--a time-course study.
Topics: Animals; Behavior, Animal; Formaldehyde; Hyperalgesia; Male; Nitroglycerin; Pain; Pain Measurement; | 2003 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid An | 2006 |
Role of calcitonin gene-related peptide and substance P in different models of pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Formaldehyde; Hyperalgesia; Immuno | 2008 |
[Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord].
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Male; NG-Nitroarginine | 1997 |
Spinal antinociceptive effect of epidural nonsteroidal antiinflammatory drugs on nitric oxide-induced hyperalgesia in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Epidural Space; Hyperalgesia; Male; NG-N | 1999 |
Blockade of hyperalgesia and neurogenic oedema by topical application of nitroglycerin.
Topics: Administration, Topical; Animals; Dinoprostone; Edema; Electric Stimulation; Hyperalgesia; Male; Nit | 1992 |