Page last updated: 2024-08-21

bicuculline and Allodynia

bicuculline has been researched along with Allodynia in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (12.24)18.2507
2000's13 (26.53)29.6817
2010's29 (59.18)24.3611
2020's1 (2.04)2.80

Authors

AuthorsStudies
Candiotti, KA; Gitlin, M; Rodriguez-Blanco, YF; Sevilla, A; Su, C; Weller, R; Wu, J; Yang, J; Zhang, Y; Zheng, C1
Li, J; Li, JX; Ling, Y; Ou, Y; Pan, F; Su, M; Wei, Q; Zhu, Q1
Chen, Y; Shi, Y; Wang, Y1
Antunes, GF; Assis, DV; Auada, AVV; de Andrade, EM; Fonoff, ET; Gouveia, FV; Lebrun, I; Lopes, PSS; Martinez, RCR; Pagano, RL1
Coimbra, NC; Crippa, JA; Freitas, RL; Hallak, JE; Salgado-Rohner, CJ1
Barry, DM; Du, JQ; Huo, FQ; Qu, CL; Tang, JS; Xu, FY; Xu, WJ; Zhao, Y; Zhu, JX1
Fan, QQ; Hu, XD; Suo, ZW; Yang, X1
Aissouni, Y; Chalus, M; Courteix, C; Dupuis, A; Eschalier, A; Hernández, A; Marin, P; Pelissier, T; Pichon, X; Privat, AM; Wattiez, AS1
Almeida, A; Amorim, D; Costa, P; David-Pereira, A; Monteiro, AM; Pertovaara, A; Pinto-Ribeiro, F1
Bach-Rojecky, L; Drinovac, V; Lacković, Z1
Bao, W; Cui, S; Jiang, H; Liu, Q; Ma, X; Wang, X; Wang, Z; Yao, Z; Zhang, D1
Cai, J; Fang, D; Jiang, H; Jin, ZR; Kang, XJ; Kong, LY; Wan, Y; Xing, GG1
Jin, CY; Pertovaara, A; Viisanen, H; Wei, H; You, HJ1
Gwak, YS; Jung, SJ; Lee, MC; Leem, JW; Nam, TS1
Hu, ZY; Li, XL; Liu, X; Ma, Q; Wang, C; Zhao, X; Zhou, DS; Zhou, WH1
Artola, A; Bourgois, N; Dallel, R; Peirs, C1
Dias, QM; Prado, WA1
Hou, Y; Li, YF; Liu, FY; Liu, J; Wan, Y; Wu, H; Yi, M; Yin, Y; Zhang, M; Zheng, L; Zhou, MM1
Bach-Rojecky, L; Drinovac Vlah, V; Lacković, Z1
Donahue, R; Jamal, AB; Kaushal, R; Ma, F; Taylor, BK; Westlund, KN; Zhang, L1
Furue, H; Ishida, T; Kawamata, M; Kozuka, Y; Namiki, A; Tanaka, S; Yamakage, M1
Chen, J; Geng, KW; Guan, SM; He, T; Li, CL; Li, Z; Lu, YF; Luo, WJ; Wang, RR; Wang, Y; Wu, FF1
Garraway, SM; Grau, JW; Huang, YJ; Lee, KH; Murphy, L1
Charlet, A; Darbon, P; Lasbennes, F; Poisbeau, P1
Asouchidou, I; Asprodini, EK; Kilindris, T; Kostopoulos, G; Koukoutianou, I; Kouvaras, E; Michaloudis, D; Papatheodoropoulos, C; Vasilaki, A1
Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL1
Lee, IO; Lim, ES1
Cao, J; Hu, XD; Li, S; Liu, YN; Shi, L; Suo, ZW; Yang, HB; Yang, X; Zheng, CR1
Chung, JM; Chung, K; Kim, HK; Kim, HY; Lee, KY; Wang, J; Yowtak, J1
Chen, Q; Su, SF; Wang, HH; Wang, NB; Yang, AM; Yang, SB1
Micov, AM; Paranos, SLj; Stepanović-Petrović, RM; Tomić, MA1
Barchini, J; Jabbur, SJ; Linderoth, B; Meyerson, BA; Saadé, NE; Shamaa, F; Song, Z; Tchachaghian, S1
Malmierca, E; Martin, YB; Nuñez, A1
Bloms-Funke, P; Chizh, B; Mascias, P; Scheede, M1
Radhakrishnan, R; Rohlwing, JJ; Skyba, DA; Sluka, KA; Wright, A1
Drew, GM; Duggan, AW; Siddall, PJ1
Fink, DJ; Glorioso, JC; Hao, S; Huang, S; Liu, J; Mata, M; Wolfe, D1
Cao, JL; Dai, TJ; Wang, QY; Zeng, YM1
Collins, JG; Kawamata, M; Koshizaki, M; Kozuka, Y; Namiki, A; Narimatsu, E; Shimada, SG; Takahashi, T1
Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD1
Covey, DF; Jevtovic-Todorovic, V; Pathirathna, S; Todorovic, SM1
Bosković, B; Kocev, N; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM1
Bowery, NG; Malcangio, M1
Hayaishi, O; Horiguchi, S; Hyodo, M; Ito, S; Minami, T; Uda, R1
Sluka, KA; Westlund, KN; Willis, WD2
Hwang, JH; Yaksh, TL1
Eguchi, N; Hayaishi, O; Ito, S; Kanaoka, Y; Minami, T; Nagata, A; Shirafuji, N; Tanaka, T; Urade, Y; Yoshida, N1
Francischi, JN; Pesquero, SM; Tatsuo, MA; Turchetti-Maia, RM; Yokoro, CM1

Other Studies

49 other study(ies) available for bicuculline and Allodynia

ArticleYear
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
    Neuroscience letters, 2020, 01-10, Volume: 715

    Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Male; Naloxone; Nicotine; Pain Perception; Pain Threshold; Rats; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome; Time Factors; Up-Regulation

2020
Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain.
    European journal of pharmacology, 2018, Mar-15, Volume: 823

    Topics: Analgesics; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Morphinans; Pain, Postoperative; Receptors, GABA-A

2018
Kir2.1 Channel Regulation of Glycinergic Transmission Selectively Contributes to Dynamic Mechanical Allodynia in a Mouse Model of Spared Nerve Injury.
    Neuroscience bulletin, 2019, Volume: 35, Issue:2

    Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hyperalgesia; Imidazoles; Inhibitory Postsynaptic Potentials; Male; Mice, Inbred C57BL; Neurons; Neurotransmitter Agents; Peripheral Nerve Injuries; Phenanthrolines; Potassium Channels, Inwardly Rectifying; Receptors, GABA-A; Receptors, Glycine; Strychnine; Synaptic Transmission; Tissue Culture Techniques; Touch

2019
Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain.
    Journal of neurosurgery, 2019, 01-04, Volume: 132, Issue:1

    Topics: Analgesia; Animals; Bicuculline; Deep Brain Stimulation; Efferent Pathways; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hyperalgesia; Male; Microdialysis; Microinjections; Motor Cortex; Neuralgia; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Sciatic Nerve; Sciatica; Strychnine

2019
Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:8

    Topics: Analysis of Variance; Animals; Bicuculline; Defense Mechanisms; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; Hyperalgesia; Hypothalamus; Instinct; Male; Microinjections; Pain Measurement; Pain Threshold; Panic; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-A

2013
The role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex on allodynia following spared nerve injury.
    Experimental neurology, 2013, Volume: 248

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Bicuculline; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; GABA Antagonists; Hyperalgesia; Male; Norepinephrine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sciatic Nerve; Sciatic Neuropathy; Yohimbine

2013
Ca2+ /calmodulin-dependent protein kinase II in spinal dorsal horn contributes to the pain hypersensitivity induced by γ-aminobutyric acid type a receptor inhibition.
    Journal of neuroscience research, 2013, Volume: 91, Issue:11

    Topics: Animals; Bicuculline; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Sensitization; GABA-A Receptor Antagonists; Hyperalgesia; Immunoprecipitation; Male; Mice; Mice, Inbred C57BL; Posterior Horn Cells; Receptors, GABA-A; Signal Transduction; Spinal Cord; Synaptic Transmission

2013
Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Animals; Bicuculline; Carrageenan; Disks Large Homolog 4 Protein; Fluorobenzenes; Fluoxetine; Hyperalgesia; Inflammation; Injections; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Pain; Peptides; Piperidines; Posterior Horn Cells; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists

2013
Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals.
    Brain research bulletin, 2013, Volume: 99

    Topics: Animals; Arthritis; Bicuculline; Carrageenan; Disease Models, Animal; Dorsomedial Hypothalamic Nucleus; Drug Interactions; GABA-A Receptor Antagonists; Hyperalgesia; Male; Medulla Oblongata; Neural Pathways; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Reaction Time

2013
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
    Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:6

    Topics: Animals; Bicuculline; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Routes; Formaldehyde; Hyperalgesia; Neurotoxins; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, GABA-A; Sciatica

2014
Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia.
    Experimental brain research, 2014, Volume: 232, Issue:11

    Topics: Analysis of Variance; Animals; Bicuculline; Disease Models, Animal; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Gene Expression Regulation; Hyperalgesia; Male; Muscimol; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Spinal Cord; Stress, Psychological; Time Factors

2014
Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats.
    Molecular brain, 2014, Oct-04, Volume: 7

    Topics: Action Potentials; Animals; Anxiety; Apoptosis; Behavior, Animal; Bicuculline; Blotting, Western; Caspase 3; Cell Membrane; Central Amygdaloid Nucleus; GABAergic Neurons; Hyperalgesia; In Situ Nick-End Labeling; Ligation; Male; Muscimol; Neural Inhibition; Neuralgia; Rats, Sprague-Dawley; Spinal Nerves

2014
Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity.
    Pharmacological research, 2014, Volume: 90

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; Animals; Benzothiazoles; Bicuculline; GABA-A Receptor Antagonists; Histamine; Histamine H2 Antagonists; Hot Temperature; Hyperalgesia; Imidazoles; Indans; Locus Coeruleus; Male; Neuralgia; Phenoxypropanolamines; Physical Stimulation; Piperidines; Prazosin; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Histamine; Spinal Nerves

2014
Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
    Neural plasticity, 2015, Volume: 2015

    Topics: Animals; Behavior, Animal; Benzylamines; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Hindlimb; Hyperalgesia; Male; Pain Measurement; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Compression

2015
Antinociceptive effects of fisetin against diabetic neuropathic pain in mice: Engagement of antioxidant mechanisms and spinal GABAA receptors.
    Pharmacological research, 2015, Volume: 102

    Topics: Analgesics; Animals; Antioxidants; Bicuculline; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Flavonoids; Flavonols; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Oxidative Stress; Reactive Oxygen Species; Receptors, GABA-A; Spinal Cord; Streptozocin

2015
Protein Kinase C γ Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior.
    Anesthesiology, 2016, Volume: 124, Issue:5

    Topics: Animals; Bicuculline; Capsaicin; Excitatory Amino Acid Antagonists; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Nerve Fibers, Unmyelinated; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, GABA-B

2016
The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats.
    Brain research bulletin, 2016, Volume: 124

    Topics: Animals; Baclofen; Bicuculline; Functional Laterality; GABA Agents; Hyperalgesia; Injections, Spinal; Ligation; Male; Muscimol; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord Dorsal Horn; Spinal Nerves; Statistics, Nonparametric

2016
Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury.
    Neuroscience bulletin, 2016, Volume: 32, Issue:4

    Topics: Animals; Antineoplastic Agents; Bicuculline; Calcium-Binding Proteins; Carrier Proteins; Disease Models, Animal; GABA Antagonists; Glial Fibrillary Acidic Protein; Hyperalgesia; Isoquinolines; Mice; Microfilament Proteins; Neurotransmitter Agents; Pain Measurement; Phosphopyruvate Hydratase; Purines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sciatica; Thalamus; Up-Regulation

2016
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.
    Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:12

    Topics: Analgesics; Animals; Bicuculline; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Functional Laterality; Hyperalgesia; Male; Naloxone; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord; Synaptosomal-Associated Protein 25

2016
GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex.
    Neuroscience, 2016, Oct-15, Volume: 334

    Topics: Activating Transcription Factor 3; Adrenergic alpha-Antagonists; Adrenergic Neurons; Animals; Bicuculline; Chronic Pain; Disease Models, Animal; Facial Pain; GABA-A Receptor Antagonists; Hyperalgesia; Idazoxan; Locus Coeruleus; Male; Neuralgia; Oxathiins; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Trigeminal Nerve Injuries

2016
Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording.
    Molecular pain, 2016, Volume: 12

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Functional Laterality; Hyperalgesia; Male; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Strychnine; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin; Urethane

2016
Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABAA Receptors in Medial Prefrontal Cortex.
    Neuroscience bulletin, 2016, Volume: 32, Issue:5

    Topics: Animals; Bicuculline; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Depressants; Disease Models, Animal; Ethanol; GABA Antagonists; GABA-A Receptor Agonists; Hyperalgesia; Male; Microinjections; Muscimol; Pain Measurement; Pain Threshold; Phosphopyruvate Hydratase; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, GABA; Statistics, Nonparametric

2016
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
    Experimental neurology, 2016, Volume: 285, Issue:Pt A

    Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Hyperalgesia; Indenes; K Cl- Cotransporters; Lipopolysaccharides; Male; MAP Kinase Signaling System; Muscimol; Nociception; Pain Measurement; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Potassium Chloride Symporter Inhibitors; Spinal Cord Injuries; Symporters; Time Factors

2016
Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms.
    Pain, 2008, Oct-31, Volume: 139, Issue:3

    Topics: Allosteric Regulation; Analgesics, Non-Narcotic; Animals; Bicuculline; Carrageenan; Drug Evaluation, Preclinical; Hot Temperature; Hyperalgesia; Inflammation; Male; Molecular Conformation; Pain Threshold; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Strychnine; Touch

2008
Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24 h after acute exposure to the drug.
    Neuropharmacology, 2008, Volume: 55, Issue:7

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Bicuculline; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fentanyl; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Hyperalgesia; Immunohistochemistry; Male; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B

2008
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Feb-25, Volume: 29, Issue:8

    Topics: Analgesics, Opioid; Animals; Bicuculline; Blood Pressure; Capsaicin; Disease Models, Animal; Drug Resistance; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Glycine; Hyperalgesia; Male; Morphine; Nonlinear Dynamics; Oncogene Proteins v-fos; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Strychnine

2009
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:8

    Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Muscimol; Pain; Pain Threshold; Receptors, GABA; Receptors, Glycine; Taurine

2010
GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn.
    Neuropharmacology, 2011, Volume: 60, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Diazepam; Drug Interactions; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Phosphorylation; Posterior Horn Cells; Protein Kinase Inhibitors; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sulfonamides

2011
Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release.
    Pain, 2011, Volume: 152, Issue:4

    Topics: Analysis of Variance; Animals; Bicuculline; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Free Radical Scavengers; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Mice; Neuralgia; Neurons; Reactive Oxygen Species; Spinal Cord; Spinal Nerves; tert-Butylhydroperoxide; Time Factors

2011
Neuronostatin induces hyperalgesia in formalin test in mice.
    Neuroscience letters, 2012, Jan-06, Volume: 506, Issue:1

    Topics: Analysis of Variance; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; GABA-A Receptor Antagonists; Hyperalgesia; Injections, Intraventricular; Male; Melanocyte-Stimulating Hormones; Mice; Mice, Inbred Strains; Pain Measurement; Pain Threshold; Peptide Fragments; Somatostatin; Time Factors

2012
The mechanisms of antihyperalgesic effect of topiramate in a rat model of inflammatory hyperalgesia.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:3

    Topics: Analgesics; Animals; Bicuculline; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Fructose; Hyperalgesia; Inflammation; Male; Naloxone; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Receptors, Opioid; Topiramate; Yohimbine

2013
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
    Neuroscience, 2012, Jul-26, Volume: 215

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; Bicuculline; Disease Models, Animal; Dopamine Antagonists; Electrodes; Female; GABA Antagonists; Hyperalgesia; Ketanserin; Methysergide; Neuralgia; Pain Measurement; Pain Threshold; Phentolamine; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Spinal Cord; Sulpiride; Time Factors; Transcutaneous Electric Nerve Stimulation

2012
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
    Neuroscience, 2012, Sep-27, Volume: 221

    Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal

2012
Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms.
    Neuropharmacology, 2002, Volume: 43, Issue:3

    Topics: Anesthesia; Animals; Behavior, Animal; Bicuculline; Electric Stimulation; Electrophysiology; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Hyperalgesia; Interneurons; Ligands; Male; Motor Neurons; Muscle, Skeletal; Nociceptors; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Spinal Cord

2002
Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Animals; Bicuculline; GABA Antagonists; Hyperalgesia; Joints; Male; Methysergide; Naloxone; Narcotic Antagonists; Pain; Pain Management; Physical Stimulation; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, GABA; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord; Yohimbine

2003
Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hyperalgesia; Neural Inhibition; Neural Pathways; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Spinal Cord Injuries; Touch; Wounds, Nonpenetrating

2004
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 10, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Glutamate Decarboxylase; Hyperalgesia; Injections, Subcutaneous; Isoenzymes; Neurons; Pain; Rats; Simplexvirus; Spinal Cord Injuries; Tissue Distribution; Transduction, Genetic

2004
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:12

    Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Propofol; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord

2004
Changes in response properties and receptive fields of spinal dorsal horn neurons in rats after surgical incision in hairy skin.
    Anesthesiology, 2005, Volume: 102, Issue:1

    Topics: Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Electrophysiology; GABA Antagonists; Hair; Hyperalgesia; Male; Mechanoreceptors; Microelectrodes; Pain Threshold; Pain, Postoperative; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Skin Transplantation

2005
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
    Archives of pharmacal research, 2005, Volume: 28, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A

2005
5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain.
    Pain, 2005, Volume: 117, Issue:3

    Topics: Anesthetics; Animals; Behavior, Animal; Bicuculline; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Estranes; Female; GABA Antagonists; Hot Temperature; Hyperalgesia; Neuralgia; Nitriles; Oxidation-Reduction; Pain Measurement; Pain Threshold; Pregnanediones; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Steroids; Time Factors; Touch; Treatment Outcome

2005
GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia.
    Pharmacology, 2008, Volume: 82, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Anticonvulsants; Bicuculline; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Male; Oxcarbazepine; Pain Threshold; Rats; Rats, Wistar

2008
Spinal cord SP release and hyperalgesia in monoarthritic rats: involvement of the GABAB receptor system.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Animals; Arthritis, Experimental; Bicuculline; Electric Stimulation; GABA-B Receptor Antagonists; Hyperalgesia; In Vitro Techniques; Male; Naloxone; Pain Measurement; Pain Threshold; Radioimmunoassay; Rats; Rats, Inbred Lew; Receptors, GABA-B; Spinal Cord; Substance P; Weight Loss

1994
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice.
    Pain, 1994, Volume: 57, Issue:2

    Topics: Animals; Bicuculline; Dinoprostone; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Pain; Prostaglandin D2; Strychnine

1994
Inflammation-induced release of excitatory amino acids is prevented by spinal administration of a GABAA but not by a GABAB receptor antagonist in rats.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1

    Topics: Animals; Arthritis; Aspartic Acid; Bicuculline; Excitatory Amino Acids; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Glutamic Acid; Hyperalgesia; Organophosphorus Compounds; Rats; Receptors, GABA-A; Receptors, GABA-B; Spinal Cord

1994
Joint inflammation and hyperalgesia are reduced by spinal bicuculline.
    Neuroreport, 1993, Nov-18, Volume: 5, Issue:2

    Topics: Animals; Arthritis; Behavior, Animal; Bicuculline; Carrageenan; GABA Antagonists; Hot Temperature; Hyperalgesia; Injections; Kaolin; Microdialysis; Organophosphorus Compounds; Rats; Receptors, GABA; Spinal Cord

1993
The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat.
    Pain, 1997, Volume: 70, Issue:1

    Topics: Animals; Bicuculline; Catheterization; GABA Agonists; GABA Antagonists; Hyperalgesia; Injections, Spinal; Ligation; Male; Motor Activity; Muscimol; Organophosphorus Compounds; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Touch

1997
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Jan-19, Volume: 96, Issue:2

    Topics: Anesthesia; Animals; Bicuculline; Central Nervous System; Dinoprost; Dinoprostone; GABA Antagonists; Gene Targeting; Hydantoins; Hyperalgesia; Immunohistochemistry; Intramolecular Oxidoreductases; Lipocalins; Mice; Mice, Knockout; Molecular Sequence Data; Pain; Prostaglandin D2; Receptors, Prostaglandin

1999
Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2001, Volume: 34, Issue:3

    Topics: Analysis of Variance; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Pain Measurement; Pain Threshold; Phenobarbital; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord

2001