bicuculline has been researched along with Allodynia in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (12.24) | 18.2507 |
| 2000's | 13 (26.53) | 29.6817 |
| 2010's | 29 (59.18) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Candiotti, KA; Gitlin, M; Rodriguez-Blanco, YF; Sevilla, A; Su, C; Weller, R; Wu, J; Yang, J; Zhang, Y; Zheng, C | 1 |
| Li, J; Li, JX; Ling, Y; Ou, Y; Pan, F; Su, M; Wei, Q; Zhu, Q | 1 |
| Chen, Y; Shi, Y; Wang, Y | 1 |
| Antunes, GF; Assis, DV; Auada, AVV; de Andrade, EM; Fonoff, ET; Gouveia, FV; Lebrun, I; Lopes, PSS; Martinez, RCR; Pagano, RL | 1 |
| Coimbra, NC; Crippa, JA; Freitas, RL; Hallak, JE; Salgado-Rohner, CJ | 1 |
| Barry, DM; Du, JQ; Huo, FQ; Qu, CL; Tang, JS; Xu, FY; Xu, WJ; Zhao, Y; Zhu, JX | 1 |
| Fan, QQ; Hu, XD; Suo, ZW; Yang, X | 1 |
| Aissouni, Y; Chalus, M; Courteix, C; Dupuis, A; Eschalier, A; Hernández, A; Marin, P; Pelissier, T; Pichon, X; Privat, AM; Wattiez, AS | 1 |
| Almeida, A; Amorim, D; Costa, P; David-Pereira, A; Monteiro, AM; Pertovaara, A; Pinto-Ribeiro, F | 1 |
| Bach-Rojecky, L; Drinovac, V; Lacković, Z | 1 |
| Bao, W; Cui, S; Jiang, H; Liu, Q; Ma, X; Wang, X; Wang, Z; Yao, Z; Zhang, D | 1 |
| Cai, J; Fang, D; Jiang, H; Jin, ZR; Kang, XJ; Kong, LY; Wan, Y; Xing, GG | 1 |
| Jin, CY; Pertovaara, A; Viisanen, H; Wei, H; You, HJ | 1 |
| Gwak, YS; Jung, SJ; Lee, MC; Leem, JW; Nam, TS | 1 |
| Hu, ZY; Li, XL; Liu, X; Ma, Q; Wang, C; Zhao, X; Zhou, DS; Zhou, WH | 1 |
| Artola, A; Bourgois, N; Dallel, R; Peirs, C | 1 |
| Dias, QM; Prado, WA | 1 |
| Hou, Y; Li, YF; Liu, FY; Liu, J; Wan, Y; Wu, H; Yi, M; Yin, Y; Zhang, M; Zheng, L; Zhou, MM | 1 |
| Bach-Rojecky, L; Drinovac Vlah, V; Lacković, Z | 1 |
| Donahue, R; Jamal, AB; Kaushal, R; Ma, F; Taylor, BK; Westlund, KN; Zhang, L | 1 |
| Furue, H; Ishida, T; Kawamata, M; Kozuka, Y; Namiki, A; Tanaka, S; Yamakage, M | 1 |
| Chen, J; Geng, KW; Guan, SM; He, T; Li, CL; Li, Z; Lu, YF; Luo, WJ; Wang, RR; Wang, Y; Wu, FF | 1 |
| Garraway, SM; Grau, JW; Huang, YJ; Lee, KH; Murphy, L | 1 |
| Charlet, A; Darbon, P; Lasbennes, F; Poisbeau, P | 1 |
| Asouchidou, I; Asprodini, EK; Kilindris, T; Kostopoulos, G; Koukoutianou, I; Kouvaras, E; Michaloudis, D; Papatheodoropoulos, C; Vasilaki, A | 1 |
| Dallel, R; Miraucourt, LS; Moisset, X; Voisin, DL | 1 |
| Lee, IO; Lim, ES | 1 |
| Cao, J; Hu, XD; Li, S; Liu, YN; Shi, L; Suo, ZW; Yang, HB; Yang, X; Zheng, CR | 1 |
| Chung, JM; Chung, K; Kim, HK; Kim, HY; Lee, KY; Wang, J; Yowtak, J | 1 |
| Chen, Q; Su, SF; Wang, HH; Wang, NB; Yang, AM; Yang, SB | 1 |
| Micov, AM; Paranos, SLj; Stepanović-Petrović, RM; Tomić, MA | 1 |
| Barchini, J; Jabbur, SJ; Linderoth, B; Meyerson, BA; Saadé, NE; Shamaa, F; Song, Z; Tchachaghian, S | 1 |
| Malmierca, E; Martin, YB; Nuñez, A | 1 |
| Bloms-Funke, P; Chizh, B; Mascias, P; Scheede, M | 1 |
| Radhakrishnan, R; Rohlwing, JJ; Skyba, DA; Sluka, KA; Wright, A | 1 |
| Drew, GM; Duggan, AW; Siddall, PJ | 1 |
| Fink, DJ; Glorioso, JC; Hao, S; Huang, S; Liu, J; Mata, M; Wolfe, D | 1 |
| Cao, JL; Dai, TJ; Wang, QY; Zeng, YM | 1 |
| Collins, JG; Kawamata, M; Koshizaki, M; Kozuka, Y; Namiki, A; Narimatsu, E; Shimada, SG; Takahashi, T | 1 |
| Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD | 1 |
| Covey, DF; Jevtovic-Todorovic, V; Pathirathna, S; Todorovic, SM | 1 |
| Bosković, B; Kocev, N; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM | 1 |
| Bowery, NG; Malcangio, M | 1 |
| Hayaishi, O; Horiguchi, S; Hyodo, M; Ito, S; Minami, T; Uda, R | 1 |
| Sluka, KA; Westlund, KN; Willis, WD | 2 |
| Hwang, JH; Yaksh, TL | 1 |
| Eguchi, N; Hayaishi, O; Ito, S; Kanaoka, Y; Minami, T; Nagata, A; Shirafuji, N; Tanaka, T; Urade, Y; Yoshida, N | 1 |
| Francischi, JN; Pesquero, SM; Tatsuo, MA; Turchetti-Maia, RM; Yokoro, CM | 1 |
49 other study(ies) available for bicuculline and Allodynia
| Article | Year |
|---|---|
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Male; Naloxone; Nicotine; Pain Perception; Pain Threshold; Rats; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome; Time Factors; Up-Regulation | 2020 |
Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain.
Topics: Analgesics; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Morphinans; Pain, Postoperative; Receptors, GABA-A | 2018 |
Kir2.1 Channel Regulation of Glycinergic Transmission Selectively Contributes to Dynamic Mechanical Allodynia in a Mouse Model of Spared Nerve Injury.
Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hyperalgesia; Imidazoles; Inhibitory Postsynaptic Potentials; Male; Mice, Inbred C57BL; Neurons; Neurotransmitter Agents; Peripheral Nerve Injuries; Phenanthrolines; Potassium Channels, Inwardly Rectifying; Receptors, GABA-A; Receptors, Glycine; Strychnine; Synaptic Transmission; Tissue Culture Techniques; Touch | 2019 |
Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain.
Topics: Analgesia; Animals; Bicuculline; Deep Brain Stimulation; Efferent Pathways; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hyperalgesia; Male; Microdialysis; Microinjections; Motor Cortex; Neuralgia; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Sciatic Nerve; Sciatica; Strychnine | 2019 |
Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid
Topics: Analysis of Variance; Animals; Bicuculline; Defense Mechanisms; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; Hyperalgesia; Hypothalamus; Instinct; Male; Microinjections; Pain Measurement; Pain Threshold; Panic; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-A | 2013 |
The role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex on allodynia following spared nerve injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Bicuculline; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; GABA Antagonists; Hyperalgesia; Male; Norepinephrine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sciatic Nerve; Sciatic Neuropathy; Yohimbine | 2013 |
Ca2+ /calmodulin-dependent protein kinase II in spinal dorsal horn contributes to the pain hypersensitivity induced by γ-aminobutyric acid type a receptor inhibition.
Topics: Animals; Bicuculline; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Sensitization; GABA-A Receptor Antagonists; Hyperalgesia; Immunoprecipitation; Male; Mice; Mice, Inbred C57BL; Posterior Horn Cells; Receptors, GABA-A; Signal Transduction; Spinal Cord; Synaptic Transmission | 2013 |
Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats.
Topics: Animals; Bicuculline; Carrageenan; Disks Large Homolog 4 Protein; Fluorobenzenes; Fluoxetine; Hyperalgesia; Inflammation; Injections; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Pain; Peptides; Piperidines; Posterior Horn Cells; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists | 2013 |
Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals.
Topics: Animals; Arthritis; Bicuculline; Carrageenan; Disease Models, Animal; Dorsomedial Hypothalamic Nucleus; Drug Interactions; GABA-A Receptor Antagonists; Hyperalgesia; Male; Medulla Oblongata; Neural Pathways; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Reaction Time | 2013 |
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
Topics: Animals; Bicuculline; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Routes; Formaldehyde; Hyperalgesia; Neurotoxins; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, GABA-A; Sciatica | 2014 |
Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia.
Topics: Analysis of Variance; Animals; Bicuculline; Disease Models, Animal; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Gene Expression Regulation; Hyperalgesia; Male; Muscimol; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Spinal Cord; Stress, Psychological; Time Factors | 2014 |
Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats.
Topics: Action Potentials; Animals; Anxiety; Apoptosis; Behavior, Animal; Bicuculline; Blotting, Western; Caspase 3; Cell Membrane; Central Amygdaloid Nucleus; GABAergic Neurons; Hyperalgesia; In Situ Nick-End Labeling; Ligation; Male; Muscimol; Neural Inhibition; Neuralgia; Rats, Sprague-Dawley; Spinal Nerves | 2014 |
Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; Animals; Benzothiazoles; Bicuculline; GABA-A Receptor Antagonists; Histamine; Histamine H2 Antagonists; Hot Temperature; Hyperalgesia; Imidazoles; Indans; Locus Coeruleus; Male; Neuralgia; Phenoxypropanolamines; Physical Stimulation; Piperidines; Prazosin; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Histamine; Spinal Nerves | 2014 |
Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
Topics: Animals; Behavior, Animal; Benzylamines; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Hindlimb; Hyperalgesia; Male; Pain Measurement; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Compression | 2015 |
Antinociceptive effects of fisetin against diabetic neuropathic pain in mice: Engagement of antioxidant mechanisms and spinal GABAA receptors.
Topics: Analgesics; Animals; Antioxidants; Bicuculline; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Flavonoids; Flavonols; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Oxidative Stress; Reactive Oxygen Species; Receptors, GABA-A; Spinal Cord; Streptozocin | 2015 |
Protein Kinase C γ Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior.
Topics: Animals; Bicuculline; Capsaicin; Excitatory Amino Acid Antagonists; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Nerve Fibers, Unmyelinated; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, GABA-B | 2016 |
The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats.
Topics: Animals; Baclofen; Bicuculline; Functional Laterality; GABA Agents; Hyperalgesia; Injections, Spinal; Ligation; Male; Muscimol; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord Dorsal Horn; Spinal Nerves; Statistics, Nonparametric | 2016 |
Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury.
Topics: Animals; Antineoplastic Agents; Bicuculline; Calcium-Binding Proteins; Carrier Proteins; Disease Models, Animal; GABA Antagonists; Glial Fibrillary Acidic Protein; Hyperalgesia; Isoquinolines; Mice; Microfilament Proteins; Neurotransmitter Agents; Pain Measurement; Phosphopyruvate Hydratase; Purines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sciatica; Thalamus; Up-Regulation | 2016 |
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.
Topics: Analgesics; Animals; Bicuculline; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Functional Laterality; Hyperalgesia; Male; Naloxone; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord; Synaptosomal-Associated Protein 25 | 2016 |
GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex.
Topics: Activating Transcription Factor 3; Adrenergic alpha-Antagonists; Adrenergic Neurons; Animals; Bicuculline; Chronic Pain; Disease Models, Animal; Facial Pain; GABA-A Receptor Antagonists; Hyperalgesia; Idazoxan; Locus Coeruleus; Male; Neuralgia; Oxathiins; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Trigeminal Nerve Injuries | 2016 |
Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Functional Laterality; Hyperalgesia; Male; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Strychnine; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin; Urethane | 2016 |
Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABAA Receptors in Medial Prefrontal Cortex.
Topics: Animals; Bicuculline; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Depressants; Disease Models, Animal; Ethanol; GABA Antagonists; GABA-A Receptor Agonists; Hyperalgesia; Male; Microinjections; Muscimol; Pain Measurement; Pain Threshold; Phosphopyruvate Hydratase; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, GABA; Statistics, Nonparametric | 2016 |
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Hyperalgesia; Indenes; K Cl- Cotransporters; Lipopolysaccharides; Male; MAP Kinase Signaling System; Muscimol; Nociception; Pain Measurement; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Potassium Chloride Symporter Inhibitors; Spinal Cord Injuries; Symporters; Time Factors | 2016 |
Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms.
Topics: Allosteric Regulation; Analgesics, Non-Narcotic; Animals; Bicuculline; Carrageenan; Drug Evaluation, Preclinical; Hot Temperature; Hyperalgesia; Inflammation; Male; Molecular Conformation; Pain Threshold; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Strychnine; Touch | 2008 |
Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24 h after acute exposure to the drug.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Bicuculline; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fentanyl; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Hyperalgesia; Immunohistochemistry; Male; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B | 2008 |
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia.
Topics: Analgesics, Opioid; Animals; Bicuculline; Blood Pressure; Capsaicin; Disease Models, Animal; Drug Resistance; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Glycine; Hyperalgesia; Male; Morphine; Nonlinear Dynamics; Oncogene Proteins v-fos; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Strychnine | 2009 |
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Muscimol; Pain; Pain Threshold; Receptors, GABA; Receptors, Glycine; Taurine | 2010 |
GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Diazepam; Drug Interactions; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Phosphorylation; Posterior Horn Cells; Protein Kinase Inhibitors; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sulfonamides | 2011 |
Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release.
Topics: Analysis of Variance; Animals; Bicuculline; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Free Radical Scavengers; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Mice; Neuralgia; Neurons; Reactive Oxygen Species; Spinal Cord; Spinal Nerves; tert-Butylhydroperoxide; Time Factors | 2011 |
Neuronostatin induces hyperalgesia in formalin test in mice.
Topics: Analysis of Variance; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; GABA-A Receptor Antagonists; Hyperalgesia; Injections, Intraventricular; Male; Melanocyte-Stimulating Hormones; Mice; Mice, Inbred Strains; Pain Measurement; Pain Threshold; Peptide Fragments; Somatostatin; Time Factors | 2012 |
The mechanisms of antihyperalgesic effect of topiramate in a rat model of inflammatory hyperalgesia.
Topics: Analgesics; Animals; Bicuculline; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Fructose; Hyperalgesia; Inflammation; Male; Naloxone; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Receptors, Opioid; Topiramate; Yohimbine | 2013 |
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; Bicuculline; Disease Models, Animal; Dopamine Antagonists; Electrodes; Female; GABA Antagonists; Hyperalgesia; Ketanserin; Methysergide; Neuralgia; Pain Measurement; Pain Threshold; Phentolamine; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Spinal Cord; Sulpiride; Time Factors; Transcutaneous Electric Nerve Stimulation | 2012 |
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal | 2012 |
Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms.
Topics: Anesthesia; Animals; Behavior, Animal; Bicuculline; Electric Stimulation; Electrophysiology; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Hyperalgesia; Interneurons; Ligands; Male; Motor Neurons; Muscle, Skeletal; Nociceptors; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Spinal Cord | 2002 |
Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord.
Topics: Adrenergic alpha-Antagonists; Animals; Bicuculline; GABA Antagonists; Hyperalgesia; Joints; Male; Methysergide; Naloxone; Narcotic Antagonists; Pain; Pain Management; Physical Stimulation; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, GABA; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord; Yohimbine | 2003 |
Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hyperalgesia; Neural Inhibition; Neural Pathways; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Spinal Cord Injuries; Touch; Wounds, Nonpenetrating | 2004 |
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Topics: Animals; Baclofen; Bicuculline; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Glutamate Decarboxylase; Hyperalgesia; Injections, Subcutaneous; Isoenzymes; Neurons; Pain; Rats; Simplexvirus; Spinal Cord Injuries; Tissue Distribution; Transduction, Genetic | 2004 |
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Propofol; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord | 2004 |
Changes in response properties and receptive fields of spinal dorsal horn neurons in rats after surgical incision in hairy skin.
Topics: Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Electrophysiology; GABA Antagonists; Hair; Hyperalgesia; Male; Mechanoreceptors; Microelectrodes; Pain Threshold; Pain, Postoperative; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Skin Transplantation | 2005 |
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A | 2005 |
5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain.
Topics: Anesthetics; Animals; Behavior, Animal; Bicuculline; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Estranes; Female; GABA Antagonists; Hot Temperature; Hyperalgesia; Neuralgia; Nitriles; Oxidation-Reduction; Pain Measurement; Pain Threshold; Pregnanediones; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Steroids; Time Factors; Touch; Treatment Outcome | 2005 |
GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia.
Topics: Analgesics, Non-Narcotic; Animals; Anticonvulsants; Bicuculline; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Male; Oxcarbazepine; Pain Threshold; Rats; Rats, Wistar | 2008 |
Spinal cord SP release and hyperalgesia in monoarthritic rats: involvement of the GABAB receptor system.
Topics: Animals; Arthritis, Experimental; Bicuculline; Electric Stimulation; GABA-B Receptor Antagonists; Hyperalgesia; In Vitro Techniques; Male; Naloxone; Pain Measurement; Pain Threshold; Radioimmunoassay; Rats; Rats, Inbred Lew; Receptors, GABA-B; Spinal Cord; Substance P; Weight Loss | 1994 |
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice.
Topics: Animals; Bicuculline; Dinoprostone; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Pain; Prostaglandin D2; Strychnine | 1994 |
Inflammation-induced release of excitatory amino acids is prevented by spinal administration of a GABAA but not by a GABAB receptor antagonist in rats.
Topics: Animals; Arthritis; Aspartic Acid; Bicuculline; Excitatory Amino Acids; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Glutamic Acid; Hyperalgesia; Organophosphorus Compounds; Rats; Receptors, GABA-A; Receptors, GABA-B; Spinal Cord | 1994 |
Joint inflammation and hyperalgesia are reduced by spinal bicuculline.
Topics: Animals; Arthritis; Behavior, Animal; Bicuculline; Carrageenan; GABA Antagonists; Hot Temperature; Hyperalgesia; Injections; Kaolin; Microdialysis; Organophosphorus Compounds; Rats; Receptors, GABA; Spinal Cord | 1993 |
The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat.
Topics: Animals; Bicuculline; Catheterization; GABA Agonists; GABA Antagonists; Hyperalgesia; Injections, Spinal; Ligation; Male; Motor Activity; Muscimol; Organophosphorus Compounds; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Touch | 1997 |
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice.
Topics: Anesthesia; Animals; Bicuculline; Central Nervous System; Dinoprost; Dinoprostone; GABA Antagonists; Gene Targeting; Hydantoins; Hyperalgesia; Immunohistochemistry; Intramolecular Oxidoreductases; Lipocalins; Mice; Mice, Knockout; Molecular Sequence Data; Pain; Prostaglandin D2; Receptors, Prostaglandin | 1999 |
Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors.
Topics: Analysis of Variance; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Pain Measurement; Pain Threshold; Phenobarbital; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord | 2001 |