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agmatine and Allodynia

agmatine has been researched along with Allodynia in 8 studies

Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.

Research Excerpts

ExcerptRelevanceReference
"L-Arginine supplementation prevented the development of mechanical hyperalgesia, tactile, and thermal allodynia in painful diabetic neuropathy with concomitant reduction of NO and increased agmatine production, offering new therapeutic opportunities for the management of diabetic neuropathic pain."7.88L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration. ( Courteix, C; Davin, N; Eschalier, A; Farges, MC; Privat, AM; Rondón, LJ; Sion, B; Vasson, MP, 2018)
"Agmatine is an endogenous neuromodulator that has been previously implicated in the regulation of reward and pain processing."5.91Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder. ( Becker, HC; Cucinello-Ragland, JA; Davis, EC; Edwards, S; Lopez, MF; Regunathan, S, 2023)
"Agmatine is an endogenous neuromodulator that has been shown to exert antiallodynic effects in various animal studies."5.48Agmatine co-treatment attenuates allodynia and structural abnormalities in cisplatin-induced neuropathy in rats. ( Aydin, S; Cengelli Unel, C; Donertas, B; Erol, K; Kaygisiz, B; Ozatik, O; Ulupinar, E; Yildirim, E, 2018)
"Agmatine pretreatment was found to dose-dependently attenuate the thermal hyperalgesia induced by intraplantar carrageenan."5.30Effect of intrathecal agmatine on inflammation-induced thermal hyperalgesia in rats. ( Benedek, G; Dobos, I; Horváth, G; Kékesi, G; Klimscha, W; Szikszay, M, 1999)
"L-Arginine supplementation prevented the development of mechanical hyperalgesia, tactile, and thermal allodynia in painful diabetic neuropathy with concomitant reduction of NO and increased agmatine production, offering new therapeutic opportunities for the management of diabetic neuropathic pain."3.88L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration. ( Courteix, C; Davin, N; Eschalier, A; Farges, MC; Privat, AM; Rondón, LJ; Sion, B; Vasson, MP, 2018)
"Agmatine, an endogenous cationic amine resulting from the decarboxylation of L-arginine, produces antihyperalgesic and antiallodynic effects in animal models of chronic neuropathic and inflammatory pain."3.74Agmatine induces antihyperalgesic effects in diabetic rats and a superadditive interaction with R(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid, a N-methyl-D-aspartate-receptor antagonist. ( Courteix, C; Eschalier, A; Fialip, J; Hernandez, A; Pélissier, T; Privat, AM, 2007)
"Agmatine is an endogenous neuromodulator that has been previously implicated in the regulation of reward and pain processing."1.91Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder. ( Becker, HC; Cucinello-Ragland, JA; Davis, EC; Edwards, S; Lopez, MF; Regunathan, S, 2023)
"Agmatine is an endogenous neuromodulator that has been shown to exert antiallodynic effects in various animal studies."1.48Agmatine co-treatment attenuates allodynia and structural abnormalities in cisplatin-induced neuropathy in rats. ( Aydin, S; Cengelli Unel, C; Donertas, B; Erol, K; Kaygisiz, B; Ozatik, O; Ulupinar, E; Yildirim, E, 2018)
"Agmatine is an endogenous decarboxylation product of arginine that has been previously shown to antagonize the N-methyl-d-aspartate (NMDA) receptor and inhibit nitric-oxide synthase."1.33Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse. ( Fairbanks, CA; Grocholski, BM; Kitto, KF; Roberts, JC, 2005)
"Kynurenic acid alone was ineffective, while adenosine and agmatine alone caused a slight increase in pain threshold."1.32Dose-independent antinociceptive interaction of endogenous ligands at the spinal level. ( Benedek, G; Csullog, E; Horvath, G; Joo, G; Kekesi, G; Peter-Szabo, M, 2004)
"Agmatine pretreatment was found to dose-dependently attenuate the thermal hyperalgesia induced by intraplantar carrageenan."1.30Effect of intrathecal agmatine on inflammation-induced thermal hyperalgesia in rats. ( Benedek, G; Dobos, I; Horváth, G; Kékesi, G; Klimscha, W; Szikszay, M, 1999)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Lopez, MF1
Davis, EC1
Cucinello-Ragland, JA1
Regunathan, S1
Edwards, S1
Becker, HC1
Rondón, LJ1
Farges, MC1
Davin, N1
Sion, B1
Privat, AM2
Vasson, MP1
Eschalier, A2
Courteix, C2
Donertas, B1
Cengelli Unel, C1
Aydin, S1
Ulupinar, E1
Ozatik, O1
Kaygisiz, B1
Yildirim, E1
Erol, K1
Kekesi, G2
Joo, G1
Csullog, E1
Peter-Szabo, M1
Benedek, G2
Horvath, G2
Roberts, JC1
Grocholski, BM1
Kitto, KF1
Fairbanks, CA1
Dogrul, A1
Coskun, I1
Uzbay, T1
Pélissier, T1
Hernandez, A1
Fialip, J1
Dobos, I1
Szikszay, M1
Klimscha, W1

Other Studies

8 other studies available for agmatine and Allodynia

ArticleYear
Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder.
    Alcohol (Fayetteville, N.Y.), 2023, Volume: 109

    Topics: Agmatine; Alcohol Drinking; Alcoholism; Analgesics; Animals; Ethanol; Female; Hyperalgesia; Male; Mi

2023
L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration.
    European journal of nutrition, 2018, Volume: 57, Issue:7

    Topics: Administration, Oral; Agmatine; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Neuropa

2018
Agmatine co-treatment attenuates allodynia and structural abnormalities in cisplatin-induced neuropathy in rats.
    Fundamental & clinical pharmacology, 2018, Volume: 32, Issue:3

    Topics: Agmatine; Analgesics; Animals; Animals, Newborn; Behavior, Animal; Cells, Cultured; Cisplatin; Disea

2018
Dose-independent antinociceptive interaction of endogenous ligands at the spinal level.
    Brain research, 2004, Dec-10, Volume: 1029, Issue:1

    Topics: Adenosine; Agmatine; Analgesics; Animals; Carrageenan; Dose-Response Relationship, Drug; Drug Combin

2004
Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:3

    Topics: Agmatine; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Indazoles; I

2005
The contribution of alpha-1 and alpha-2 adrenoceptors in peripheral imidazoline and adrenoceptor agonist-induced nociception.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:2

    Topics: Adrenergic alpha-Agonists; Agmatine; Analgesics; Animals; Clonidine; Dose-Response Relationship, Dru

2006
Agmatine induces antihyperalgesic effects in diabetic rats and a superadditive interaction with R(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid, a N-methyl-D-aspartate-receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:3

    Topics: Agmatine; Animals; Anticonvulsants; Diabetes Mellitus, Experimental; Drug Interactions; Excitatory A

2007
Effect of intrathecal agmatine on inflammation-induced thermal hyperalgesia in rats.
    European journal of pharmacology, 1999, Mar-05, Volume: 368, Issue:2-3

    Topics: Agmatine; Analgesics, Opioid; Animals; Carrageenan; Dose-Response Relationship, Drug; Hindlimb; Hype

1999