fluoxetine has been researched along with Allodynia in 24 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study assessed whether antidepressant and/or antinociceptive drugs, duloxetine, fluoxetine as well as (±)-8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT), are able to reverse depression-like behaviour in animals with chronic neuropathic pain." | 7.83 | Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain. ( Ceci, A; Doods, H; Hu, B; Treede, RD, 2016) |
| " In the present study, pain sensitivity was assessed in a mouse model of anxiety/depression on the basis of chronic corticosterone (CORT) administration through the drinking water (CORT model)." | 7.78 | Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. ( Coudoré, F; David, DJ; Gardier, AM; Guiard, BP; Hache, G; Le Dantec, Y; Orvoën, S, 2012) |
| "Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor antidepressant." | 5.46 | Effects of fluoxetine on changes of pain sensitivity in chronic stress model rats. ( Chang, JL; Lian, YN; Lu, Q; Wang, Y; Zhang, FM; Zhang, Y, 2017) |
| "Using a depression comorbidity of chronic pain rat model induced by spinal nerve ligation (SNL), we investigated the potency of T10 for the treatment of comorbid depression in comparison with a widely used antidepressant, fluoxetine (FLX)." | 5.46 | The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain. ( Dong, Y; Hu, X; Jin, X; Li, J; Shi, J; Zhang, C; Zhang, T; Zhao, J, 2017) |
| "The response frequency to mechanical allodynia in mice was measured with von Frey hairs." | 5.36 | Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. ( Jesse, CR; Nogueira, CW; Wilhelm, EA, 2010) |
| " However, MS mice treated with fluoxetine for 4 weeks after MS did not exhibit augmentation of allodynia, and their emotional response was attenuated." | 3.91 | Maternal separation as a risk factor for aggravation of neuropathic pain in later life in mice. ( Fukumoto, K; Jin, S; Mizoguchi, H; Sakamoto, G; Sato, J; Suzumura, A; Toyama, A; Wang, T, 2019) |
| "The current study assessed whether antidepressant and/or antinociceptive drugs, duloxetine, fluoxetine as well as (±)-8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT), are able to reverse depression-like behaviour in animals with chronic neuropathic pain." | 3.83 | Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain. ( Ceci, A; Doods, H; Hu, B; Treede, RD, 2016) |
| "Co-administration of pioglitazone or metformin with low-dose fluoxetine improved mechanical allodynia, thermal hyperalgesia, and neurohistopathological changes while co-administration of pioglitazone, but not metformin, improved the depressive-like behavior in the peripheral nerve injury model of neuropathic pain in rats." | 3.81 | Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats. ( Ayuob, N; Murad, H, 2015) |
| "Fluoxetine is an antidepressant that has been largely used for treatment of depression in pregnancy." | 3.80 | Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: modulation by folic acid supplementation. ( Gomes, MV; Moreira, EG; Oliveira, JF; Pelosi, GG; Rodrigues, GM; Silva, AS; Toffoli, LV, 2014) |
| " In the present study, pain sensitivity was assessed in a mouse model of anxiety/depression on the basis of chronic corticosterone (CORT) administration through the drinking water (CORT model)." | 3.78 | Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. ( Coudoré, F; David, DJ; Gardier, AM; Guiard, BP; Hache, G; Le Dantec, Y; Orvoën, S, 2012) |
| "Drugs that are clinically effective (mexiletine and desipramine) or ineffective (fluoxetine) in the treatment of human neuropathic pain were evaluated for efficacy in rat models involving central sensitization (i." | 3.69 | The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization. ( Hunter, JC; Jett, MF; McGuirk, J; Waligora, D, 1997) |
| "Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor antidepressant." | 1.46 | Effects of fluoxetine on changes of pain sensitivity in chronic stress model rats. ( Chang, JL; Lian, YN; Lu, Q; Wang, Y; Zhang, FM; Zhang, Y, 2017) |
| "Using a depression comorbidity of chronic pain rat model induced by spinal nerve ligation (SNL), we investigated the potency of T10 for the treatment of comorbid depression in comparison with a widely used antidepressant, fluoxetine (FLX)." | 1.46 | The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain. ( Dong, Y; Hu, X; Jin, X; Li, J; Shi, J; Zhang, C; Zhang, T; Zhao, J, 2017) |
| "Our studies examined the neuropathic pain-relieving properties after intraperitoneal injection of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine 7 days after sciatic nerve injury (CCI) in rats and its influence on microglia/macrophages (IBA-1) and astroglia (GFAP) activation in the spinal cord and dorsal root ganglia (DRG) using Western blot." | 1.42 | The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain. ( Makuch, W; Mika, J; Przewlocka, B; Rojewska, E; Zychowska, M, 2015) |
| "Withdrawal from long-term dosing with exogenous progesterone precipitates increased anxiety-linked changes in behavior in animal models due to the abrupt decrease in brain concentration of allopregnanolone (ALLO), a neuroactive metabolite of progesterone." | 1.42 | Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats. ( Brandão, ML; Devall, AJ; Fry, JP; Honour, JW; Lovick, TA; Santos, JM, 2015) |
| "Mechanical hyperalgesia was assessed after acute treatment with TAT-2ASCV or/and fluoxetine (SSRI) 2." | 1.39 | Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats. ( Aissouni, Y; Chalus, M; Courteix, C; Dupuis, A; Eschalier, A; Hernández, A; Marin, P; Pelissier, T; Pichon, X; Privat, AM; Wattiez, AS, 2013) |
| "Fluoxetine treatment significantly reduced the immunoreactivity in these areas." | 1.37 | Evidence for the participation of cocaine- and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats. ( Dandekar, MP; Kokare, DM; Singru, PS; Subhedar, NK; Upadhya, MA, 2011) |
| "The peptide also enhanced antihyperalgesia induced by the SSRI fluoxetine." | 1.36 | Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. ( Becamel, C; Bockaert, J; Courteix, C; Ehrlich, I; Eschalier, A; Marin, P; Pichon, X; Wattiez, AS, 2010) |
| "The response frequency to mechanical allodynia in mice was measured with von Frey hairs." | 1.36 | Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. ( Jesse, CR; Nogueira, CW; Wilhelm, EA, 2010) |
| "Diabetic mice exhibited significant hyperalgesia compared with control mice." | 1.32 | Fluoxetine attenuates thermal hyperalgesia through 5-HT1/2 receptors in streptozotocin-induced diabetic mice. ( Anjaneyulu, M; Chopra, K, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 17 (70.83) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, P | 1 |
| Terefenko, EA | 1 |
| Bray, J | 1 |
| Deecher, D | 1 |
| Fensome, A | 1 |
| Harrison, J | 1 |
| Kim, C | 1 |
| Koury, E | 1 |
| Mark, L | 1 |
| McComas, CC | 1 |
| Mugford, CA | 1 |
| Trybulski, EJ | 1 |
| Vu, AT | 1 |
| Whiteside, GT | 1 |
| Mahaney, PE | 1 |
| Qi, M | 1 |
| Li, C | 1 |
| Li, J | 2 |
| Zhu, XN | 1 |
| Lu, C | 1 |
| Luo, H | 1 |
| Feng, Y | 1 |
| Cai, F | 1 |
| Sun, X | 1 |
| Li, ST | 1 |
| Hu, J | 1 |
| Luo, Y | 1 |
| Nemoto, W | 3 |
| Kozak, D | 3 |
| Sotocinal, SG | 3 |
| Tansley, S | 3 |
| Bannister, K | 3 |
| Mogil, JS | 3 |
| Chen, M | 1 |
| Hoshino, H | 1 |
| Saito, S | 1 |
| Yang, Y | 1 |
| Obata, H | 1 |
| Lian, YN | 1 |
| Chang, JL | 1 |
| Lu, Q | 1 |
| Wang, Y | 1 |
| Zhang, Y | 1 |
| Zhang, FM | 1 |
| Hernandez-Leon, A | 1 |
| Fernández-Guasti, A | 1 |
| Martínez, A | 1 |
| Pellicer, F | 1 |
| González-Trujano, ME | 1 |
| Mizoguchi, H | 1 |
| Fukumoto, K | 1 |
| Sakamoto, G | 1 |
| Jin, S | 1 |
| Toyama, A | 1 |
| Wang, T | 1 |
| Suzumura, A | 1 |
| Sato, J | 1 |
| Wattiez, AS | 2 |
| Pichon, X | 2 |
| Dupuis, A | 1 |
| Hernández, A | 1 |
| Privat, AM | 1 |
| Aissouni, Y | 1 |
| Chalus, M | 1 |
| Pelissier, T | 1 |
| Eschalier, A | 2 |
| Marin, P | 2 |
| Courteix, C | 2 |
| Toffoli, LV | 1 |
| Rodrigues, GM | 1 |
| Oliveira, JF | 1 |
| Silva, AS | 1 |
| Moreira, EG | 1 |
| Pelosi, GG | 1 |
| Gomes, MV | 1 |
| Zychowska, M | 1 |
| Rojewska, E | 1 |
| Makuch, W | 1 |
| Przewlocka, B | 1 |
| Mika, J | 1 |
| Devall, AJ | 1 |
| Santos, JM | 1 |
| Fry, JP | 1 |
| Honour, JW | 1 |
| Brandão, ML | 1 |
| Lovick, TA | 1 |
| Murad, H | 1 |
| Ayuob, N | 1 |
| Hu, B | 1 |
| Doods, H | 1 |
| Treede, RD | 1 |
| Ceci, A | 1 |
| Hu, X | 1 |
| Dong, Y | 1 |
| Jin, X | 1 |
| Zhang, C | 1 |
| Zhang, T | 1 |
| Zhao, J | 1 |
| Shi, J | 1 |
| Shi, M | 1 |
| Wang, JY | 1 |
| Luo, F | 1 |
| Becamel, C | 1 |
| Ehrlich, I | 1 |
| Bockaert, J | 1 |
| Jesse, CR | 1 |
| Wilhelm, EA | 1 |
| Nogueira, CW | 1 |
| Upadhya, MA | 1 |
| Dandekar, MP | 1 |
| Kokare, DM | 1 |
| Singru, PS | 1 |
| Subhedar, NK | 1 |
| Hache, G | 1 |
| Guiard, BP | 1 |
| Le Dantec, Y | 1 |
| Orvoën, S | 1 |
| David, DJ | 1 |
| Gardier, AM | 1 |
| Coudoré, F | 1 |
| Cervantes-Durán, C | 1 |
| Pineda-Farias, JB | 1 |
| Bravo-Hernández, M | 1 |
| Quiñonez-Bastidas, GN | 1 |
| Vidal-Cantú, GC | 1 |
| Barragán-Iglesias, P | 1 |
| Granados-Soto, V | 1 |
| Anjaneyulu, M | 1 |
| Chopra, K | 1 |
| Jones, CK | 1 |
| Eastwood, BJ | 1 |
| Need, AB | 1 |
| Shannon, HE | 1 |
| Jett, MF | 1 |
| McGuirk, J | 1 |
| Waligora, D | 1 |
| Hunter, JC | 1 |
| Kudriashova, MF | 1 |
| Andreev, BV | 1 |
24 other studies available for fluoxetine and Allodynia
| Article | Year |
|---|---|
1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
Topics: Administration, Oral; Animals; Behavior, Animal; Benzimidazoles; Biological Transport; Dopamine Plas | 2009 |
Fluoxetine reverses hyperactivity of anterior cingulate cortex and attenuates chronic stress-induced hyperalgesia.
Topics: Animals; Fluoxetine; Gyrus Cinguli; Hyperalgesia; Mice; Pain; Serotonin | 2022 |
Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice.
Topics: Analgesics; Animals; Chronic Pain; Fluoxetine; Hyperalgesia; Mice; Nociception; Norepinephrine; Rats | 2023 |
Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice.
Topics: Analgesics; Animals; Chronic Pain; Fluoxetine; Hyperalgesia; Mice; Nociception; Norepinephrine; Rats | 2023 |
Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice.
Topics: Analgesics; Animals; Chronic Pain; Fluoxetine; Hyperalgesia; Mice; Nociception; Norepinephrine; Rats | 2023 |
Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice.
Topics: Analgesics; Animals; Chronic Pain; Fluoxetine; Hyperalgesia; Mice; Nociception; Norepinephrine; Rats | 2023 |
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Disease Models, Animal; Do | 2017 |
Effects of fluoxetine on changes of pain sensitivity in chronic stress model rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Disease Models, Animal; Fluoxetine; Hyperalgesia; | 2017 |
Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Fluoxetine; Hyperalgesia; Ovariectomy; Pain; | 2019 |
Maternal separation as a risk factor for aggravation of neuropathic pain in later life in mice.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Calcium-Binding Proteins; Disea | 2019 |
Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats.
Topics: Animals; Bicuculline; Carrageenan; Disks Large Homolog 4 Protein; Fluorobenzenes; Fluoxetine; Hypera | 2013 |
Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: modulation by folic acid supplementation.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Brain; DNA Methylation; Exp | 2014 |
The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cyclohexanols; Cyclopropane | 2015 |
Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Arabidopsis Proteins; Brain | 2015 |
Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Chronic Pain; Constriction, Pathologi | 2015 |
Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Neurons; Analgesics; Animals; Antidepressive Agen | 2016 |
The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Chronic Pain; Depression; Disease Mode | 2017 |
Depression shows divergent effects on evoked and spontaneous pain behaviors in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Disease Models, Animal; Fluo | 2010 |
Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain.
Topics: Animals; Blotting, Western; Chromatography, Affinity; Diabetic Nephropathies; Electrophoresis, Gel, | 2010 |
Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Depression; | 2010 |
Evidence for the participation of cocaine- and amphetamine-regulated transcript peptide (CART) in the fluoxetine-induced anti-hyperalgesia in neuropathic rats.
Topics: Animals; Antibodies; Arcuate Nucleus of Hypothalamus; Brain; Dose-Response Relationship, Drug; Drug | 2011 |
Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Chronic Pain; Cold Temperature; Corticos | 2012 |
Evidence for the participation of peripheral 5-HT₂A, 5-HT₂B, and 5-HT₂C receptors in formalin-induced secondary mechanical allodynia and hyperalgesia.
Topics: Amphetamines; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Fluoxetine; Formaldehyd | 2013 |
Fluoxetine attenuates thermal hyperalgesia through 5-HT1/2 receptors in streptozotocin-induced diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fluoxetine; | 2004 |
Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition.
Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Stero | 2006 |
The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization.
Topics: Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tr | 1997 |
[Neuropharmacological analysis of participation of the serotoninergic system in hyperalgesia in neurotized rats].
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Buspirone; Fluoxetine; Hyperalgesia; Male; Mian | 2000 |