glutamic acid has been researched along with Allodynia in 173 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (9.83) | 18.2507 |
| 2000's | 63 (36.42) | 29.6817 |
| 2010's | 79 (45.66) | 24.3611 |
| 2020's | 14 (8.09) | 2.80 |
| Authors | Studies |
|---|---|
| Bang, SK; Cho, SJ; Choi, KH; Kang, SY; Ryu, Y; Seo, SY | 1 |
| Cervetto, C; Di Cesare Mannelli, L; Ghelardini, C; Lucarini, E; Marcoli, M; Micheli, L; Parisio, C; Toti, A | 1 |
| Cirillo, G; Cirillo, R; De Luca, C; Gargano, F; Korai, SA; Papa, M; Virtuoso, A | 1 |
| Abdallah, DM; Mohammed, RA; Nassar, NN; Safar, MM; Zaki, OS | 1 |
| Bai, Y; Chen, T; Chen, YB; Fan, BY; Li, H; Li, YQ; Ma, LT; Qiu, XT; Ren, D; Sun, HK; Yi, XN; Zhang, MM; Zhang, T | 1 |
| Deng, M; Ding, Z; Guo, Q; Huang, J; Kong, Y; Wang, J; Xu, W; Zou, W | 1 |
| Gong, ZH; Li, YL; Liang, XN; Peng, J; Su, RB; Wang, HB; Yu, G; Zhang, ZL | 1 |
| Chen, C; Jin, Y; Li, J; Li, X; Mao, Y; Pan, ZZ; Tang, ZQ; Tao, W; Wang, H; Wang, L; Wang, Y; Xie, W; Zhang, X; Zhang, Z; Zhou, C; Zhou, W | 1 |
| Chen, T; Chu, YX; Cui, WQ; Li, Q; Mao-Ying, QL; Mi, WL; Wang, YQ; Xu, F; Zhang, WW | 1 |
| Antunes, FTT; Caminski, ES; Dallegrave, E; de Freitas, LM; de Souza, AH; Gomez, MV; Junior, CADS; Pereira, EMR | 1 |
| Fei, SJ; Miao, B; Su, Z; Xu, MQ; Yang, MJ; Zhang, JF | 1 |
| Huang, S; Li, L; Liang, S; Liu, W; Tao, J; Wang, Z; Yang, M; Yu, X | 1 |
| Guo, H; Kang, JJ; Liang, YT; Liu, YK; Liu, YY; Luo, C; Ma, SB; Ma, SY; Wu, SX; Wu, WB; Xian, H; Xie, RG; Zhang, H | 1 |
| Chen, Z; Duan, S; Guo, F; Li, KY; Li, XJ; Li, XY; Li, YY; Liu, R; Ma, XL; Sun, H; Sun, L; Wen, MQ; Wu, MY; Xu, CL; Yu, YQ; Zhu, ZG | 1 |
| Amodeo, P; Belardo, C; Boccella, S; Calignano, A; Cristiano, C; de Novellis, V; Di Marzo, V; Guida, F; Iannotta, M; Iannotti, FA; Infantino, R; Luongo, L; Maione, S; Marabese, I; Paino, S; Palazzo, E; Ricciardi, F; Vitale, RM | 1 |
| Chen, H; Chen, SR; Huang, Y; Jin, D; Pan, HL; Zhang, GF | 1 |
| Iwata, K; Kubota, Y; Shimazu, Y; Takeda, M; Takehana, S; Uotsu, N; Yui, K | 1 |
| Farahmandfar, M; Janzadeh, A; Naghdi, N; Nasirinezhad, F; Saffarpour, S; Shaabani, M | 1 |
| Chen, CH; Chen, NF; Chen, WF; Feng, CW; Huang, SY; Sung, CS; Wen, ZH; Wong, CS | 1 |
| Akasaka, R; Furukawa, A; Honda, K; Iwata, K; Kondo, M; Otsuki, K; Shimizu, K; Shinoda, M; Yonemoto, H | 1 |
| Lin, B; Lu, Y; Zhong, J | 1 |
| Guo, Y; Sun, Z; Wang, H; Wang, J; Wang, Y | 1 |
| Chang, JL; Lian, YN; Lu, Q; Zhang, Y | 1 |
| Li, CB; Ren, CZ; Shi, XY; Tan, X; Wang, W; Wang, WZ; Yao, XY; Zhang, RW; Zou, Z | 1 |
| Boccella, S; de Novellis, V; Farina, A; Guida, F; Iannotta, M; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Serra, N | 1 |
| Gong, ZH; Liang, XN; Su, RB; Yu, G; Zhang, ZL | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Chen, GD; Chou, D; Ho, YC; Hsieh, MC; Lai, CY; Lin, TB; Peng, HY | 1 |
| Kato, D; Obata, H; Saito, S; Suto, T | 1 |
| Antunes, GF; Assis, DV; Auada, AVV; de Andrade, EM; Fonoff, ET; Gouveia, FV; Lebrun, I; Lopes, PSS; Martinez, RCR; Pagano, RL | 1 |
| Clauw, DJ; Harris, RE; Harte, SE; Ichesco, E; Kaplan, CM; Kochlefl, L; Larkin, TE; Mashour, GA; Mawla, I; Schrepf, A; Vatansever, D | 1 |
| Cao, P; Mao, Y; Mei, L; Niu, C; Tao, W; Wang, Y; Yin, W; Zhang, Z | 1 |
| Dawson, A | 1 |
| Akimoto, N; Beppu, K; Honda, K; Imoto, K; Kido, MA; Matsuzaki, Y; Nakashima, S; Noda, M; Takano, Y; Ushijima, Y; Uta, D | 1 |
| Bardhi, E; Dagostino, C; Gliozzi, M; Ilari, S; Lauro, F; Mollace, V; Muscoli, C; Palma, E; Salvemini, D | 1 |
| Dimitrov, EL; Kohno, K; Kuo, J; Usdin, TB | 1 |
| Eisenach, JC; Hayashida, K; Yoshizumi, M | 1 |
| Asgari, AR; Falahatpishe, HR; Ghanbari, A; Jorjani, M; Kaka, GR; Naderi, A | 1 |
| Balayssac, D; Bayet-Robert, M; Daulhac, L; Eschalier, A; Ferrier, J; Moulinoux, JP; Pereira, B; Pezet, D | 1 |
| Cherng, CH; Huang, HY; Lee, SO; Tao, PL; Wong, CS; Wu, CT; Yang, CP | 1 |
| Andersen, HH; Kullander, K; Lagerström, MC; Rogoz, K | 1 |
| Chen, YL; Huang, CY; Li, AH; Lu, JC; Wang, HL | 1 |
| Cooper, M; Hekierski, H; Murphy, AL; Oshinsky, ML; Simon, BJ | 1 |
| Andresen, T; Arendt-Nielsen, L; Drewes, AM; Lassen, D; Nielsen, AK; Nilsson, M | 1 |
| Li, H; Li, W; Wang, P | 1 |
| Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR | 1 |
| Asgari, AR; Ghanbari, A; Jorjani, M; Naderi, A; Samandari, R; Zahed, R | 1 |
| Campos, MM; Klein, CP; Leite, CE; Maciel, IS; Souza, AH; Sperotto, ND | 1 |
| Crosby, ND; Gilliland, TM; Winkelstein, BA | 1 |
| Bianchi, E; Cerretani, D; Ghelardini, C; Menicacci, C | 1 |
| Bae, YC; Cho, YS; Choi, SY; Hong, JH; Jin, MU; Kim, TH; Kim, YS; Yang, ES | 1 |
| Ahn, DK; Bae, YC; Ju, JS; Kim, MJ; Kim, ST; Mun, JH; Park, KD; Yang, KY | 1 |
| Kullander, K; Lagerström, MC; Rogoz, K; Stjärne, L | 1 |
| Balog, A; Majláth, Z; Tajti, J; Vécsei, L | 1 |
| Brüning, CA; Duarte, MM; Gai, BM; Martini, F; Nogueira, CW; Sampaio, TB; Soares, SM | 1 |
| Gong, ZH; Su, RB; Wang, HS; Wang, ZT; Yi, SP; Yu, G | 1 |
| Ding, CP; Wang, J; Wang, JY; Wang, T; Yu, J; Zeng, XY; Zhang, T | 1 |
| Almeida, A; Amorim, D; David-Pereira, A; Gonçalves, S; Pertovaara, A; Pinto-Ribeiro, F; Puga, S; Silva, C | 1 |
| Almeida, A; Amorim, D; Pertovaara, A; Pinto-Ribeiro, F; Viisanen, H; Wei, H | 1 |
| González-Sepúlveda, M; Marcos, J; Pozo, OJ; Valverde, O | 1 |
| Jang, JH; Jun, J; Jung, SJ; Kim, DW; Leem, JW; Nam, TS | 1 |
| Bandegi, P; Coderre, TJ; Cornea, VM; Fung, JST; Jong, YI; Kumar, N; Laferrière, A; Mickeviciute, A; O'Malley, KL; Ribeiro-da-Silva, A; Vincent, K | 1 |
| Chen, L; Mao, J; McCabe, MF; Mi, W; Shen, S; Sun, Y; Wang, S; Yang, J; Yang, L; You, Z; Zhang, S | 1 |
| Hooks, SB; Maixner, DW; Weng, HR; Yan, X | 1 |
| Bingel, U; Harris, RE; Schmidt-Wilcke, T; Schweizer, LM; Witte, V; Zunhammer, M | 1 |
| Batista, PA; Brum, LF; Burgos, L; Oliveira, EC; Pereira, P; Santos, AR; Werner, MF | 1 |
| Choi, HW; Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Nam, JS; Park, SH; Seo, YJ; Suh, HW | 1 |
| Battaglia, A; Cibert-Goton, V; Gavazzi, I; Slack, S | 1 |
| Ally, A; Chaitoff, KA; Patel, D | 1 |
| Arendt-Nielsen, L; Gibson, W; Graven-Nielsen, T; Sessle, BJ | 1 |
| Furuyama, A; Jin, YH; Koike, Y; Takemura, M; Yamaki, F; Yonehara, N | 1 |
| Cristino, L; de Novellis, V; Di Marzo, V; Guida, F; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Starowicz, K | 1 |
| Arendt-Nielsen, L; Ge, HY; Li, LT; Yue, SW | 1 |
| Landry, M; Nagy, F | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA | 1 |
| Bian, ZX; Chen, HL; Li, Z; Sung, JJ; Xu, HX; Zhang, HQ; Zhang, XJ | 1 |
| Böhmer, AE; Elisabetsky, E; Paniz, L; Portela, LV; Schallenberger, C; Schmidt, AP; Souza, DO; Wofchuk, ST | 1 |
| Dong, L; Winkelstein, BA | 1 |
| Chen, HS; He, X; Kang, SM; Liao, D; Lu, SJ; Qu, F | 1 |
| Da Silva, LF; Desantana, JM; Sluka, KA | 1 |
| Larsson, M | 1 |
| Zheng, W | 1 |
| Cai, J; Hu, Y; Li, L; Li, Q; Li, W; Lu, L; Xian, X; Zhang, M | 1 |
| Cui, S; Gu, X; Liu, Y; Ma, Z; Wu, X | 1 |
| Coderre, TJ; Kumar, N; Laferriere, A; Leavitt, A; Yu, JS | 1 |
| Bryant, L; Chen, Z; Cuzzocrea, S; Doyle, T; Masini, E; Mastroianni, R; Mollace, V; Muscoli, C; Salvemini, D | 1 |
| Antonialli, CS; Corrêa, R; da Silva, GF; de Campos-Buzzi, F; Filho, VC; Quintão, NL | 1 |
| Chen, Y; Smith, PA | 1 |
| Ghazi-Khansari, M; Jaberi, E; Mohammadi-Farani, A; Sahebgharani, M; Sepehrizadeh, Z | 1 |
| Bao, L; Gong, LQ; Li, KC; Li, ZY; Lin, LB; Liu, XJ; Lu, YJ; Xiao, HS; Yao, JR; Zhang, FX; Zhang, X; Zhang, XH | 1 |
| Enomoto, T; Furuya, M; Horiuchi, H; Imai, S; Iseki, M; Kinoshita, H; Kobayashi, Y; Kuzumaki, N; Narita, M; Niikura, K; Suzuki, T; Takemura, Y; Tomiyasu, S; Torigoe, K; Yamazaki, M | 1 |
| Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS | 1 |
| Higashi, H; Tadano, T; Tan-No, K; Watanabe, S | 1 |
| Callam, CS; Price, DD; Verne, GN; Woodruff, MA; Zhou, Q | 1 |
| Berger, JV; Deumens, R; Goursaud, S; Hermans, E; Joosten, EA; Lavand'homme, P; Schäfer, S | 1 |
| Cardenas, R; Quintero, L; Suarez-Roca, H | 1 |
| Bakirtzi, K; Bradesi, S; Ennes, HS; Golovatscka, V; Karagiannides, I; Karagiannidis, I; Mayer, EA; McRoberts, JA; Pothoulakis, C | 1 |
| Du, JQ; Han, M; Huo, FQ; Liu, XH; Sun, N; Tang, JS; Zhu, JX | 1 |
| Cao, B; Cao, Z; Chen, S; Li, Y; Liu, H; Liu, J; Zhang, X | 1 |
| Arendt-Nielsen, L; Ge, HY; Ibarra, JM; Madeleine, P; Wang, C; Yue, SW | 1 |
| Malmierca, E; Martin, YB; Nuñez, A | 1 |
| Andó, RD; Sperlágh, B | 1 |
| Castrillon, EE; Ernberg, M; Gerdle, B; Ghafouri, B; Larsson, B; List, T; Svensson, P | 1 |
| Fan, XL; Lei, J; Li, Q; Niu, N; Tjølsen, A; Yang, L; You, HJ | 1 |
| Cechinel Filho, V; de Campos Buzzi, F; Klein-Júnior, LC; Moreira, J | 1 |
| Baggio, CH; Carbonero, ER; Córdova, MM; Iacomini, M; Martins, DF; Ruthes, AC; Santos, AR; Silva, MD | 1 |
| Ebersberger, A; Schaible, HG; Von Banchet, GS | 1 |
| Clark, JD; Li, X | 1 |
| Lim, G; Mao, J; Sung, B | 1 |
| Ito, S; Kitano, T; Kojima, H; Mabuchi, T; Matsumura, S; Minami, T; Nagano, T; Okuda-Ashitaka, E | 1 |
| Ishikawa, T; Kinoshita, H; Lambert, C; Matsui, T; Nakanishi, O; Shinohara, N; Yamamoto, S | 1 |
| Bie, B; Pan, ZZ | 1 |
| Delaney, A; Fleetwood-Walker, SM; Garry, EM; Mitchell, R; Moss, A; Rosie, R | 1 |
| Hua, XY; Koetzner, L; Lai, J; Porreca, F; Yaksh, T | 1 |
| Lähdesmäki, J; Mansikka, H; Pertovaara, A; Scheinin, M | 1 |
| D'Aquila, PS; De Montis, MG; Peana, AT; Pippia, P; Sechi, S; Sircana, G | 1 |
| Fujita, T; Kamisaki, Y; Yonehara, N | 1 |
| Barker, K; Dykhuizen, M; Harrington, JF; Hoffman, L; Messier, AA; Yu, E | 1 |
| Coste, O; Del Turco, D; Deller, T; Ehnert, C; Geisslinger, G; Niederberger, E; Ruth, P; Schmidtko, A; Tegeder, I | 1 |
| Aravindan, N; Cata, JP; Chen, JH; Dougherty, PM; Shaw, AD; Weng, HR | 1 |
| Allchorne, A; Amaya, F; Brenner, GJ; Ito, N; Ji, RR; Kohno, T; Wang, H; Woolf, CJ | 1 |
| Lisi, TL; Skyba, DA; Sluka, KA | 1 |
| Berrino, L; de Novellis, V; Maione, S; Marabese, I; Mariani, L; Oliva, P; Palazzo, E; Rossi, F; Scafuro, M; Siniscalco, D | 1 |
| Cata, JP; Chen, JH; Weng, HR | 1 |
| Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D | 1 |
| Coste, O; Ehnert, C; Geisslinger, G; Marian, C; Niederberger, E; Schmidtko, A | 1 |
| Capra, NF; Ro, JY | 1 |
| Dubner, R; Ren, K; Wang, H; Wei, F | 1 |
| Arendt-Nielsen, L; Cairns, BE; Gazerani, P; Svensson, P; Wang, K | 1 |
| Calcutt, NA; Ceseña, R; Glennon, JC; Malmberg, AB; O'Connor, WT | 1 |
| Ahn, DK; Bae, YC; Choi, HS; Ju, JS; Jung, CY; Kwon, TG; Park, HS | 1 |
| Brennan, TJ; Lee, HJ; Pogatzki-Zahn, EM | 1 |
| Dolan, S; Nolan, AM | 1 |
| Cao, DY; Guo, Y; Tian, YL; Wang, HS; Yao, FR; Zhang, Q; Zhao, Y | 1 |
| Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS | 1 |
| Kang, JX; Lim, G; Lim, JA; Mao, J; Sung, B; Wang, JD; Wang, S; Yang, L; Zeng, Q; Zhou, B | 1 |
| Ally, A; Böhlke, M; Chaitoff, KA; Hossain, S; Karlsson, GA; Maher, TJ | 1 |
| Carqueja, CL; Gadotti, Vde M; Meotti, FC; Santos, AR; Tasca, CI; Walz, R | 1 |
| Pertovaara, A; Viisanen, H | 1 |
| Cristino, L; de Novellis, V; Di Marzo, V; Gatta, L; Guida, F; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Starowicz, K; Vita, D | 1 |
| Erzurumlu, RS; Quintero, GC; Vaccarino, AL | 1 |
| Furuta, K; Ito, S; Mabuchi, T; Maeda, M; Minami, T; Soen, M; Suzuki, M; Tatsumi, S | 1 |
| Jesse, CR; Nogueira, CW; Pinto, LG; Rocha, JB; Savegnago, L | 1 |
| Chefer, V; Mahoney, JL; Schepers, RJ; Shippenberg, TS; Zapata, A | 1 |
| Carroll, FI; Dewey, WL; Gabra, BH; Navarro, HA; Smith, FL | 1 |
| Bouhassira, D; Kern, D; Luce, V; Pelle-Lancien, E | 1 |
| Fan, J; Gao, J; Li, Y; Owyang, C; Wu, X; Yan, J | 1 |
| Arendt-Nielsen, L; Cairns, BE; Svensson, P; Wang, K | 1 |
| Coderre, TJ; Yashpal, K | 1 |
| Kagawa, M; Kuraishi, Y; Minami, M; Onogi, T; Satoh, M | 1 |
| Hayaishi, O; Horiguchi, S; Hyodo, M; Ito, S; Minami, T; Uda, R | 1 |
| Sluka, KA; Westlund, KN; Willis, WD | 1 |
| Graff, CB; Hargreaves, KM; Jackson, DL; Richardson, JD | 1 |
| Deleo, JA; Wagner, R | 1 |
| Ferreira, SH; Lorenzetti, BB | 1 |
| Chapman, V; Dickenson, AH; Green, GM | 1 |
| Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR | 1 |
| Carlton, SM; Coggeshall, RE; Zhou, S | 1 |
| Kuraishi, Y; Sasaki, M; Tohda, C | 1 |
| Gebhart, GF; Urban, MO | 1 |
| Imamura, Y; Ishikawa, T; Nakanishi, O | 1 |
| Funatsu, N; Ishikawa, T; Kameyama, H; Nakanishi, O | 1 |
| Calixto, JB; Ferreira, J; Santos, AR | 2 |
| Calixto, JB; Filho, VC; Malheiros, A; Mendes, GL; Santos, AR; Yunes, RA | 1 |
| Abarca, C; Contreras, E; Oliva, P; Sepúlveda, MJ; Silva, E | 1 |
| Hulsebosch, CE; Johnson, KM; McAdoo, DJ; Mills, CD; Xu, GY | 1 |
| Choi, Y; Hwang, JH; Hwang, SJ; Kim, MK; Leem, JW; Park, H | 1 |
| Mishina, M; Seo, N; Takeuchi, T; Wainai, T | 1 |
| Ito, S; Minami, T; Okuda-Ashitaka, E | 1 |
| Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C | 1 |
| Clemente, FR; Somers, DL | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
8 review(s) available for glutamic acid and Allodynia
| Article | Year |
|---|---|
The role of glutamate and its receptors in central nervous system in stress-induced hyperalgesia.
Topics: Animals; Central Nervous System; Glutamic Acid; Humans; Hyperalgesia; Receptors, Glutamate; Stress, Psychological | 2018 |
Drug targets of migraine and neuropathy: treatment of hyperexcitability.
Topics: Animals; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Hyperalgesia; Kynurenine; Migraine Disorders; Neuralgia | 2015 |
[GABA(B) receptors and sensitization to pain].
Topics: 14-3-3 Proteins; Allosteric Regulation; Animals; Baclofen; Calcium Channels; Calcium-Binding Proteins; Chronic Disease; Dimerization; Extracellular Matrix Proteins; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Mice; Mice, Knockout; Nerve Tissue Proteins; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Receptors, GABA-B | 2009 |
Ionotropic glutamate receptors in spinal nociceptive processing.
Topics: Afferent Pathways; Animals; Glutamic Acid; Humans; Hyperalgesia; Ion Channel Gating; Neuronal Plasticity; Neurons, Afferent; Pain; Receptors, Glutamate; Spinal Cord; Synaptic Transmission | 2009 |
Mechanisms of pain in arthritis.
Topics: Afferent Pathways; Analgesics, Non-Narcotic; Animals; Arthritis; Cyclooxygenase Inhibitors; Dinoprostone; Efferent Pathways; Ganglia, Spinal; Glutamic Acid; Humans; Hyperalgesia; Inflammation Mediators; Ion Channel Gating; Mechanoreceptors; Models, Biological; Neuropeptides; Nociceptors; Pain; Rats; Receptors, Neuropeptide; Receptors, Neurotransmitter; Receptors, Prostaglandin E; Spinal Cord | 2002 |
The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord.
Topics: Animals; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Neural Inhibition; Pain; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1997 |
The glutamate synapse: a target in the pharmacological management of hyperalgesic pain states.
Topics: Animals; Glutamic Acid; Humans; Hyperalgesia; Nociceptors; Pain; Receptors, Amino Acid; Synapses | 1998 |
Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Brain; Cattle; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Synergism; Glutamic Acid; Humans; Hyperalgesia; Inflammation; Isoenzymes; Membrane Proteins; Mice; Mice, Knockout; Models, Animal; Models, Biological; Neuralgia; Neuronal Plasticity; Nitric Oxide; Nociceptin; Nociceptors; Opioid Peptides; Pain; Peripheral Nerves; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Precursors; Rats; Spinal Cord; Thromboxane-A Synthase | 2001 |
6 trial(s) available for glutamic acid and Allodynia
| Article | Year |
|---|---|
Experimental tooth clenching. A model for studying mechanisms of muscle pain.
Topics: Adult; Bruxism; Case-Control Studies; Cross-Over Studies; Female; Follow-Up Studies; Glutamic Acid; Humans; Hyperalgesia; Lactic Acid; Male; Masseter Muscle; Microdialysis; Muscle Contraction; Muscle Fatigue; Pain Measurement; Pain Threshold; Proprioception; Pyruvic Acid; Regional Blood Flow; Reproducibility of Results; Research Design; Serotonin; Single-Blind Method; Temporomandibular Joint Dysfunction Syndrome; Vibration | 2013 |
Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome.
Topics: Adult; Dextromethorphan; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Hyperalgesia; Irritable Bowel Syndrome; Male; Nociceptors; Pain Measurement; Pain Threshold; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2011 |
Experimental myalgia induced by repeated infusion of acidic saline into the human masseter muscle does not cause the release of algesic substances.
Topics: Acids; Adult; Female; Glucose; Glutamic Acid; Humans; Hyperalgesia; Lactic Acid; Male; Masseter Muscle; Microdialysis; Muscular Diseases; Pain Measurement; Physical Stimulation; Pyruvic Acid; Serotonin; Severity of Illness Index; Single-Blind Method | 2013 |
Effects of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women.
Topics: Adult; Female; Forehead; Glutamic Acid; Humans; Hyperalgesia; Injections, Subcutaneous; Male; Pain; Pain Threshold; Regional Blood Flow; Sex Characteristics; Skin; Skin Temperature; Sodium Chloride | 2006 |
Pharmacological dissection of the paradoxical pain induced by a thermal grill.
Topics: Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; Humans; Hyperalgesia; Illusions; Ketamine; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain Measurement; Pain Threshold; Pain, Intractable; Placebos; Receptors, Glutamate; Receptors, Opioid; Thermosensing | 2008 |
Effects of NGF-induced muscle sensitization on proprioception and nociception.
Topics: Adult; Analysis of Variance; Double-Blind Method; Electromyography; Glutamic Acid; Humans; Hyperalgesia; Male; Masseter Muscle; Nerve Growth Factor; Pain Measurement; Pain Threshold; Physical Stimulation; Proprioception; Reaction Time; Reflex, Stretch; Time Factors | 2008 |
159 other study(ies) available for glutamic acid and Allodynia
| Article | Year |
|---|---|
Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred ICR; Pain; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Spinal Cord; TRPV Cation Channels | 2021 |
Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain.
Topics: Alarmins; Animals; Antineoplastic Agents; Astrocytes; Glutamic Acid; Hyperalgesia; Interleukin-1alpha; Neuralgia; Neurons; Oxaliplatin; Rats; Rats, Sprague-Dawley; Spinal Cord | 2022 |
Altered Spinal Homeostasis and Maladaptive Plasticity in GFAP Null Mice Following Peripheral Nerve Injury.
Topics: Animals; Gliosis; Glutamic Acid; Homeostasis; Hyperalgesia; Mice; Mice, Knockout; Neuroglia; Peripheral Nerve Injuries; Vimentin | 2022 |
Cilostazol Alleviates NLRP3 Inflammasome-Induced Allodynia/Hyperalgesia in Murine Cerebral Cortex Following Transient Ischemia: Focus on TRPA1/Glutamate and Akt/Dopamine/BDNF/Nrf2 Trajectories.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Carrier Proteins; Cerebral Cortex; Cilostazol; Dopamine; Glutamic Acid; Hyperalgesia; Inflammasomes; Ischemia; Mice; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2022 |
Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats.
Topics: Abdomen; Animals; Anxiety; Behavior, Animal; Cell Membrane; Cerebral Cortex; Glutamic Acid; Hyperalgesia; Hypersensitivity; Long-Term Potentiation; Male; Neurotransmitter Agents; Pancreatitis, Chronic; Phosphorylation; Presynaptic Terminals; Protein Subunits; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Trinitrobenzenesulfonic Acid | 2019 |
SNAP-25 Contributes to Neuropathic Pain by Regulation of VGLuT2 Expression in Rats.
Topics: Animals; Astrocytes; Botulinum Toxins, Type A; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Glutamic Acid; Hyperalgesia; Male; Neuralgia; Protein Kinases; Rats; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Synaptosomal-Associated Protein 25; Up-Regulation; Vesicular Glutamate Transport Protein 2 | 2019 |
Wnt1/β-catenin signaling upregulates spinal VGLUT2 expression to control neuropathic pain in mice.
Topics: Animals; beta Catenin; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Neuralgia; RNA, Small Interfering; Spinal Cord; Synaptosomes; Up-Regulation; Vesicular Glutamate Transport Protein 2; Wnt Signaling Pathway | 2020 |
MeCP2 mediates transgenerational transmission of chronic pain.
Topics: Animals; Behavior, Animal; Chronic Pain; Disease Models, Animal; Down-Regulation; Epigenesis, Genetic; Female; Glutamic Acid; Hyperalgesia; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Somatosensory Cortex; Up-Regulation | 2020 |
Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia.
Topics: Animals; Antipsychotic Agents; Anxiety; Behavior, Animal; Clozapine; Disease Models, Animal; Elevated Plus Maze Test; Glutamic Acid; Habenula; Hyperalgesia; Maxillary Nerve; Mice; Neural Inhibition; Neurons; Open Field Test; Receptors, Neurokinin-3; Transcriptome; Trigeminal Neuralgia | 2020 |
Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats.
Topics: Analgesics; Animals; Calcium Channels, N-Type; Capsaicin; Disease Models, Animal; Facial Pain; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Neuralgia; omega-Conotoxins; Pain Measurement; Rats; Rats, Wistar; TRPA1 Cation Channel | 2020 |
Protective effect of microinjection of glutamate into hypothalamus paraventricular nucleus on chronic visceral hypersensitivity in rats.
Topics: Animals; Arginine Vasopressin; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Kainic Acid; Male; Microinjections; Pain Threshold; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Vagus Nerve; Visceral Pain | 2020 |
Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain.
Topics: Animals; Aspartic Acid; Constriction; Glutamic Acid; Hyperalgesia; Neuralgia; Neurotransmitter Agents; Rats; Thalamus; Wounds and Injuries | 2020 |
CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals.
Topics: Animals; Benzoxazines; Calcitonin Gene-Related Peptide; Calcium Signaling; Chemokine CCL2; Ganglia, Spinal; Glutamic Acid; Hyperalgesia; Inflammation; Injections, Spinal; Mice, Inbred C57BL; Neurons; Nociceptors; Pain; Presynaptic Terminals; Protein Binding; Receptors, CCR2; Spinal Cord; Spinal Cord Dorsal Horn; Spiro Compounds; Synaptic Transmission; Up-Regulation | 2020 |
Parabrachial nucleus circuit governs neuropathic pain-like behavior.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Transgenic; Neural Pathways; Neuralgia; Neurons; Nociception; Optogenetics; Parabrachial Nucleus; Peroneal Nerve; Stereotaxic Techniques | 2020 |
2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.
Topics: Amino Acid Sequence; Animals; Anxiety; Behavior, Animal; Chlorocebus aethiops; Cognition; COS Cells; Dentate Gyrus; Depression; Entorhinal Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Locus Coeruleus; Long-Term Potentiation; Male; Memory Disorders; Mice, Inbred C57BL; Neuralgia; Norepinephrine; Oxazoles; Receptors, Adrenergic, alpha-2; Receptors, Histamine H3; Structural Homology, Protein | 2021 |
α2δ-1 Upregulation in Primary Sensory Neurons Promotes NMDA Receptor-Mediated Glutamatergic Input in Resiniferatoxin-Induced Neuropathy.
Topics: Animals; Calcium Channels, L-Type; Diterpenes; Ganglia, Spinal; Glutamic Acid; Hyperalgesia; Male; Mice; Neuralgia; Neuralgia, Postherpetic; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells; Up-Regulation | 2021 |
The dietary constituent resveratrol suppresses nociceptive neurotransmission via the NMDA receptor.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Hyperalgesia; Iontophoresis; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Resveratrol; Sensory Receptor Cells; Stilbenes; Trigeminal Nucleus, Spinal | 2017 |
In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liquid; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hyperalgesia; Male; Maze Learning; Memory Disorders; Microdialysis; Neuralgia; Pain Threshold; Rats; Reaction Time | 2017 |
Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1β-induced thermal hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hot Temperature; Hyperalgesia; Imidazoles; Interleukin-1beta; Male; Microglia; Minocycline; Neurons; Nitric Oxide; Nociceptive Pain; Phosphorylation; Pyridines; Random Allocation; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2017 |
Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.
Topics: Acetanilides; Animals; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Glutamic Acid; Glycine; Hyperalgesia; Male; Neurons; Pain; Pain Threshold; Phenylacetates; Physical Stimulation; Purines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Signal Transduction; Skin; Thiazoles; Trigeminal Ganglion; TRPA1 Cation Channel; TRPV Cation Channels | 2017 |
The Therapeutic Effect of Dexmedetomidine on Rat Diabetic Neuropathy Pain and the Mechanism.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Cytokines; Dexmedetomidine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glutamic Acid; Hyperalgesia; Inflammation; Interleukin-1beta; Male; Microglia; Pain Threshold; Rats, Sprague-Dawley; Spinal Cord; Tumor Necrosis Factor-alpha; Yohimbine | 2017 |
The role and mechanism of glutamic NMDA receptor in the mechanical hyperalgesia in diabetic rats.
Topics: Analgesics, Non-Narcotic; Animals; Cyclic AMP Response Element-Binding Protein; Diabetes Mellitus, Experimental; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Male; Pain Threshold; Phosphorylation; Posterior Horn Cells; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Touch | 2017 |
Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure.
Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutaminase; Hyperalgesia; Hypertension; Male; Medulla Oblongata; Neuralgia; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Rats, Sprague-Dawley; Receptors, Glutamate; Sympathetic Nervous System; Vesicular Glutamate Transport Protein 2 | 2017 |
Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats.
Topics: Animals; Benzhydryl Compounds; Benzoxazoles; Corpus Striatum; Glutamic Acid; Hyperalgesia; Lidocaine; Male; Medulla Oblongata; Microinjections; Neuralgia; Neurons; Neuroprotective Agents; Pain; Rats; Receptors, Metabotropic Glutamate; Reticular Formation; Sciatic Nerve; Subthalamic Nucleus | 2018 |
Selective downregulation of vesicular glutamate transporter2 in ventral posterolateral nucleus of thalamus attenuates neuropathic mechanical allodynia in mice.
Topics: Animals; Down-Regulation; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Neurons; RNA, Small Interfering; Ventral Thalamic Nuclei; Vesicular Glutamate Transport Protein 2 | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats.
Topics: Animals; Antibodies, Neutralizing; Excitatory Postsynaptic Potentials; F-Box Proteins; Glutamic Acid; Hyperalgesia; Male; Nerve Tissue Proteins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Spinal Cord Dorsal Horn; Spinal Nerves; Tumor Necrosis Factor-alpha; Ubiquitination | 2018 |
Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats.
Topics: Analgesics; Animals; Disease Models, Animal; Flavones; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Locus Coeruleus; Male; Neuralgia; Pregabalin; Random Allocation; Rats, Sprague-Dawley; Receptor, trkB; Spinal Nerves | 2019 |
Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain.
Topics: Analgesia; Animals; Bicuculline; Deep Brain Stimulation; Efferent Pathways; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hyperalgesia; Male; Microdialysis; Microinjections; Motor Cortex; Neuralgia; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Sciatic Nerve; Sciatica; Strychnine | 2019 |
Functional and neurochemical disruptions of brain hub topology in chronic pain.
Topics: Adult; Brain; Brain Mapping; Case-Control Studies; Chronic Pain; Cohort Studies; Female; Fibromyalgia; Glutamic Acid; Glutamine; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neurotransmitter Agents; Oxygen; Pain Measurement; Proton Magnetic Resonance Spectroscopy; Visual Analog Scale | 2019 |
Microglia in the Primary Somatosensory Barrel Cortex Mediate Trigeminal Neuropathic Pain.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Mice; Microglia; Neuralgia; Neurons; Somatosensory Cortex | 2019 |
CCL-1 in the spinal cord contributes to neuropathic pain induced by nerve injury.
Topics: Analgesics; Animals; Cells, Cultured; Chemokine CCL1; Dizocilpine Maleate; Ganglia, Spinal; Gene Expression; Gene Knockdown Techniques; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Transgenic; Neuralgia; Neuroglia; Nociception; Peripheral Nerve Injuries; Phosphorylation; Protein Processing, Post-Translational; Receptors, CCR8; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Spinal Cord | 2013 |
Posttranslational nitration of tyrosine residues modulates glutamate transmission and contributes to N-methyl-D-aspartate-mediated thermal hyperalgesia.
Topics: Animals; Cytosol; Glutamic Acid; Glutamine; Hot Temperature; Hyperalgesia; Immunoprecipitation; Lumbar Vertebrae; Male; N-Methylaspartate; Nitrogen; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Tyrosine | 2013 |
Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues.
Topics: Animals; Female; GABAergic Neurons; Glucose Transporter Type 2; Glutamic Acid; Hindlimb; Hyperalgesia; Inflammation; Locus Coeruleus; Male; Mice; Mice, Knockout; Mice, Transgenic; Neuralgia; Neurons; Neuropeptides; Pain Measurement; Receptor, Parathyroid Hormone, Type 2; Receptors, Adrenergic, alpha-2; Signal Transduction | 2013 |
Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Down-Regulation; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hyperalgesia; Male; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Spinal Cord; Valproic Acid | 2013 |
In vivo microdialysis of glutamate in ventroposterolateral nucleus of thalamus following electrolytic lesion of spinothalamic tract in rats.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Electrolysis; Exploratory Behavior; Glutamic Acid; Hyperalgesia; Male; Microdialysis; Motor Activity; Pain Threshold; Physical Stimulation; Posterior Thalamic Nuclei; Rats; Rats, Sprague-Dawley; Spinothalamic Tracts; Time Factors | 2014 |
A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
Topics: Acute Disease; Animals; Antineoplastic Agents; Behavior, Animal; Cold Temperature; Diet; Glutamic Acid; Hyperalgesia; Immunoblotting; Magnetic Resonance Spectroscopy; Male; Metabolomics; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Vasodilator Agents | 2013 |
Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-α and tumor necrosis factor-α receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Behavior, Animal; Disease Models, Animal; Down-Regulation; Drug Synergism; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Posterior Horn Cells; Rats; Rats, Wistar; Reaction Time; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Sciatic Nerve; Sciatica; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Glutamate, substance P, and calcitonin gene-related peptide cooperate in inflammation-induced heat hyperalgesia.
Topics: Androstanes; Animals; Benzimidazoles; Calcitonin Gene-Related Peptide; Female; Glutamic Acid; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Nerve Growth Factor; Neurons, Afferent; Piperazines; Quinazolines; Substance P; TRPV Cation Channels; Vesicular Glutamate Transport Protein 2 | 2014 |
Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons.
Topics: Animals; Chemokine CCL2; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine Agents; Hyperalgesia; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Minocycline; Neurons; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Strychnine; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdialysis; Nitroglycerin; Prostaglandins; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trigeminal Neuralgia; Vagus Nerve Stimulation | 2014 |
Intradermal glutamate and capsaicin injections: intra- and interindividual variability of provoked hyperalgesia and allodynia.
Topics: Adolescent; Adult; Capsaicin; Glutamic Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain Measurement; Physical Stimulation; Reproducibility of Results; Sensory System Agents; Touch; Young Adult | 2014 |
Upregulation of glutamatergic transmission in anterior cingulate cortex in the diabetic rats with neuropathic pain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Diabetes Mellitus, Experimental; Excitatory Postsynaptic Potentials; Glutamic Acid; Gyrus Cinguli; Hot Temperature; Hyperalgesia; Male; Neuralgia; Neurons; Patch-Clamp Techniques; Physical Stimulation; Protein Kinase C; Rats, Sprague-Dawley; Receptors, Glutamate; Streptozocin; Synaptic Transmission; Touch; Up-Regulation | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Estradiol attenuates spinal cord injury-related central pain by decreasing glutamate levels in thalamic VPL nucleus in male rats.
Topics: Analgesics; Animals; Disease Models, Animal; Estradiol; Glutamic Acid; Hyperalgesia; Male; Neuralgia; Pain Threshold; Rats; Rats, Wistar; Spinal Cord Injuries; Ventral Thalamic Nuclei | 2014 |
Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice.
Topics: Analgesics; Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Fibromyalgia; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Nociceptive Pain; Pregabalin; Serotonin; Spinal Cord; Touch | 2014 |
Early afferent activity from the facet joint after painful trauma to its capsule potentiates neuronal excitability and glutamate signaling in the spinal cord.
Topics: Animals; Down-Regulation; Glutamic Acid; Hyperalgesia; Male; Neurons, Afferent; Pain Measurement; Rats; Signal Transduction; Spinal Cord; Up-Regulation; Zygapophyseal Joint | 2014 |
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.
Topics: Analgesics; Animals; Boronic Acids; Bortezomib; Ceftriaxone; Cell Line, Tumor; Cell Survival; Central Nervous System Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hyperalgesia; Injections, Spinal; Male; Neural Conduction; Neuralgia; Peripheral Nervous System Diseases; Pyrazines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5 | 2014 |
Expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in the rat dental pulp and trigeminal ganglion following inflammation.
Topics: Animals; Axons; Dental Pulp; Freund's Adjuvant; Gene Expression Regulation; Glutamic Acid; Hyperalgesia; Inflammation; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Trigeminal Ganglion; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2 | 2014 |
Blockade of spinal glutamate recycling produces paradoxical antinociception in rats with orofacial inflammatory pain.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Botulinum Toxins, Type A; Facial Pain; Freund's Adjuvant; Glutamate-Ammonia Ligase; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Interleukin-1beta; Male; Methionine Sulfoximine; Nociception; Rats; Spinal Cord Dorsal Horn | 2015 |
VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents.
Topics: Animals; Disease Models, Animal; Female; Ganglia, Spinal; Glutamic Acid; Hindlimb; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Transgenic; Neurons, Afferent; Sciatic Nerve; TRPV Cation Channels; Vesicular Glutamate Transport Protein 2 | 2015 |
m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain; Corticosterone; Cytokines; Depression; Disease Models, Animal; Functional Laterality; Glutamic Acid; Hyperalgesia; Male; Mice; Motor Activity; Neuralgia; Organosilicon Compounds; Peripheral Nerve Injuries; Serotonin; Swimming; Synaptosomes; Tritium | 2015 |
Changes in VGLUT2 expression and function in pain-related supraspinal regions correlate with the pathogenesis of neuropathic pain in a mouse spared nerve injury model.
Topics: Animals; Brain; Coloring Agents; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neuralgia; Proto-Oncogene Proteins c-fos; Spinal Cord; Statistics, Nonparametric; Synaptosomes; Tibial Nerve; Trypan Blue; Vesicular Glutamate Transport Protein 2 | 2015 |
Red nucleus glutamate facilitates neuropathic allodynia induced by spared nerve injury through non-NMDA and metabotropic glutamate receptors.
Topics: Analysis of Variance; Animals; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Male; Nerve Tissue Proteins; Neuralgia; Neuroglia; Neurons; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Red Nucleus | 2015 |
Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals.
Topics: Animals; Arthritis; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Male; Nociception; Prefrontal Cortex; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5 | 2016 |
Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways.
Topics: Animals; Arthritis; Behavior, Animal; Disease Models, Animal; Electrophysiology; Galanin; Glutamic Acid; Hyperalgesia; Hypothalamus; Lidocaine; Male; Mediodorsal Thalamic Nucleus; Neurons; Nociception; Ondansetron; Pain; Pressure; Protein Precursors; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Serotonin; Spinal Cord | 2015 |
Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice.
Topics: Alcohol Drinking; Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Chronic Pain; Depression; Disease Models, Animal; Ethanol; Glutamic Acid; Hyperalgesia; Interleukin-6; Male; Mice; Prefrontal Cortex; Serotonin; Time Factors | 2016 |
Peripheral NMDA Receptors Mediate Antidromic Nerve Stimulation-Induced Tactile Hypersensitivity in the Rat.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Electric Stimulation; Glutamic Acid; Hyperalgesia; Isoquinolines; Male; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Tibial Nerve | 2015 |
Intracellular mGluR5 plays a critical role in neuropathic pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Calcium; Cells, Cultured; Cytoskeletal Proteins; Excitatory Amino Acid Transporter 3; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Male; Microdialysis; Microscopy, Confocal; Microscopy, Electron; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Nerve Tissue Proteins; Neuralgia; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Long-Evans; Receptor, Metabotropic Glutamate 5; Sciatic Nerve; Sciatic Neuropathy | 2016 |
Neuropeptide S modulates the amygdaloidal HCN activities (Ih) in rats: Implication in chronic pain.
Topics: Amygdala; Animals; Chronic Pain; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Interneurons; Male; MAP Kinase Signaling System; Neuropeptides; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Tachykinins | 2016 |
AMPKα1 knockout enhances nociceptive behaviors and spinal glutamatergic synaptic activities via production of reactive oxygen species in the spinal dorsal horn.
Topics: AMP-Activated Protein Kinases; Animals; Cyclic N-Oxides; Encephalitis; Excitatory Postsynaptic Potentials; Female; Free Radical Scavengers; Glutamic Acid; Heme Oxygenase-1; Hyperalgesia; Interleukin-1beta; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Nociception; Presynaptic Terminals; Reactive Oxygen Species; Spinal Cord Dorsal Horn | 2016 |
Combined glutamate and glutamine levels in pain-processing brain regions are associated with individual pain sensitivity.
Topics: Adult; Brain; Brain Mapping; Cross-Sectional Studies; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Pain; Pain Threshold; Protons; Young Adult | 2016 |
Evidence for the involvement of ionotropic glutamatergic receptors on the antinociceptive effect of (-)-linalool in mice.
Topics: Acyclic Monoterpenes; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Agonists; Glutamic Acid; Hyperalgesia; Male; Mice; Monoterpenes; Pain Measurement; Receptors, Glutamate | 2008 |
The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Pain Measurement; Substance P | 2008 |
EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia.
Topics: Animals; Binding, Competitive; Carrageenan; Ephrin-B2; Glutamic Acid; Hyperalgesia; Inflammation; Inflammation Mediators; Male; Neural Pathways; Neuronal Plasticity; Nociceptors; Pain, Intractable; Phosphorylation; Posterior Horn Cells; Rats; Rats, Wistar; Receptor, EphB1; Receptors, Eph Family; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Synaptic Transmission; Tyrosine | 2008 |
Effects of endothelial NOS antagonism within the periaqueductal gray on cardiovascular responses and neurotransmission during mechanical, heat, and cold nociception.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Dose-Response Relationship, Drug; Electrochemistry; Enzyme Inhibitors; Female; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Hyperalgesia; Neurotransmitter Agents; Ornithine; Pain Threshold; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Sprague-Dawley; Temperature | 2008 |
Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue.
Topics: Adult; Analysis of Variance; Capsaicin; Drug Interactions; Glutamic Acid; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Tendons; Young Adult | 2009 |
Capsaicin-induced glutamate release is implicated in nociceptive processing through activation of ionotropic glutamate receptors and group I metabotropic glutamate receptor in primary afferent fibers.
Topics: Animals; Capsaicin; Glutamic Acid; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sensory System Agents; Time Factors; TRPV Cation Channels | 2009 |
Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
Topics: Action Potentials; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glutamic Acid; Hyperalgesia; Male; Medulla Oblongata; Microinjections; Naloxone; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; TRPV Cation Channels | 2009 |
Nociceptive and non-nociceptive hypersensitivity at latent myofascial trigger points.
Topics: Adult; Chi-Square Distribution; Electromyography; Female; Glutamic Acid; Humans; Hyperalgesia; Injections, Intramuscular; Male; Muscle, Skeletal; Myofascial Pain Syndromes; Pain Measurement; Pain Threshold; Pain, Referred; Saline Solution, Hypertonic; Young Adult | 2009 |
Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice.
Topics: Analgesics; Animals; Bradykinin; Capsaicin; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Hot Temperature; Hyperalgesia; Immersion; Inflammation; Male; Mice; Motor Activity; Organoselenium Compounds; Pain Measurement; Reaction Time; Tetradecanoylphorbol Acetate | 2009 |
Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A(1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway.
Topics: Adenosine A1 Receptor Antagonists; Analgesics; Animals; Animals, Newborn; Benzoates; Brain; Bridged-Ring Compounds; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Glucosides; Glutamic Acid; Hyperalgesia; Male; MAP Kinase Signaling System; Maternal Deprivation; Mitogen-Activated Protein Kinase Kinases; Monoterpenes; Paeonia; Pain Threshold; Phosphorylation; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Reflex, Abdominal; Viscera | 2009 |
Guanosine prevents thermal hyperalgesia in a rat model of peripheral mononeuropathy.
Topics: Analgesics; Animals; Central Nervous System; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Exploratory Behavior; Glutamic Acid; Guanosine; Hyperalgesia; Male; Movement Disorders; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sciatica; Statistics, Nonparametric; Time Factors | 2010 |
Simulated whiplash modulates expression of the glutamatergic system in the spinal cord suggesting spinal plasticity is associated with painful dynamic cervical facet loading.
Topics: Animals; Arthralgia; Cervical Vertebrae; Disease Models, Animal; Excitatory Amino Acid Transporter 3; Glutamic Acid; Hyperalgesia; Male; Neck Pain; Neuronal Plasticity; Nociceptors; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Sensory Receptor Cells; Spinal Cord; Synaptic Transmission; Weight-Bearing; Whiplash Injuries; Zygapophyseal Joint | 2010 |
Differential roles of peripheral metabotropic glutamate receptors in bee venom-induced nociception and inflammation in conscious rats.
Topics: Animals; Bee Venoms; Consciousness; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Foot; Glutamic Acid; Hyperalgesia; Inflammation; Male; Nociceptors; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sensory Receptor Cells; Treatment Outcome | 2010 |
Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Efferent Pathways; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Injections, Intramuscular; Male; Medulla Oblongata; Microinjections; Muscle, Skeletal; Muscular Diseases; Nociceptors; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reticular Formation; Sensory Receptor Cells; Sodium Chloride; Synaptic Transmission | 2010 |
Activation of mu opioid receptor inhibits the excitatory glutamatergic transmission in the anterior cingulate cortex of the rats with peripheral inflammation.
Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Excitatory Postsynaptic Potentials; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Synapses; Synaptic Transmission | 2010 |
An anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats.
Topics: Analgesics; Animals; Ceftriaxone; Chronic Disease; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hyperalgesia; Male; Oligodeoxyribonucleotides, Antisense; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Spinal Cord; Time Factors; Tritium; Up-Regulation | 2010 |
Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Inflammation Mediators; Ketamine; Male; Nociceptors; Pain, Postoperative; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Remifentanil; Spinal Cord; Synaptic Transmission; Tyrosine | 2009 |
Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate.
Topics: Analgesics; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Electrochemistry; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Male; Microdialysis; Pain Measurement; Pain Threshold; Physical Stimulation; Pregabalin; Rats; Rats, Long-Evans; Sciatica; Spinal Cord; Spinal Cord Injuries; Statistics, Nonparametric; Time Factors | 2010 |
NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing.
Topics: Animals; Glutamic Acid; Hyperalgesia; Male; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord | 2010 |
N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system.
Topics: Administration, Oral; Analgesics; Animals; Antipyrine; Behavior, Animal; Carrageenan; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Pain; Pain Measurement; Pain Threshold; Reaction Time; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Signal Transduction; Time Factors | 2010 |
A SIC' and painful story.
Topics: Animals; Astrocytes; Glutamic Acid; Hyperalgesia; Neurons; Posterior Horn Cells; Rats; Signal Transduction | 2010 |
Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray.
Topics: Analgesia; Analgesics; Animals; Benzoxazines; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Down-Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Nociceptors; Periaqueductal Gray; Rats; Receptor, Cannabinoid, CB1; RNA, Messenger; TRPV Cation Channels; Up-Regulation | 2010 |
Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons.
Topics: Analysis of Variance; Animals; Antibodies; Biophysical Phenomena; Calcitonin Gene-Related Peptide; Carbazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Glutamic Acid; Hyperalgesia; Inflammation; Lectins; Male; Membrane Potentials; Natriuretic Peptide, Brain; Pain; Pain Measurement; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Sensory Receptor Cells; Signal Transduction; Time Factors | 2010 |
Enhancement of glutamatergic transmission in the cingulate cortex in response to mild noxious stimuli under a neuropathic pain-like state.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Gyrus Cinguli; Hyperalgesia; Immediate-Early Proteins; Male; Pain Measurement; Pain Threshold; Phosphorylation; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sciatica | 2011 |
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Hyperalgesia; Injections, Spinal; Isomerism; Ketamine; Male; Motor Activity; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2010 |
Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism.
Topics: Animals; Behavior, Animal; Gangliosides; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Sensory Receptor Cells; Signal Transduction | 2011 |
Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1.
Topics: Amino Acid Transport System X-AG; Animals; Behavior, Animal; Calcium-Binding Proteins; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hyperalgesia; Inflammation; Interleukin-1beta; Membrane Glycoproteins; Microfilament Proteins; Microglia; NADPH Oxidase 2; NADPH Oxidases; Neuralgia; Pain Measurement; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Sciatic Nerve; Spinal Cord; Superoxide Dismutase; Toll-Like Receptor 4 | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazenil; Formaldehyde; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Ketamine; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Psychological; Swimming; Time Factors | 2011 |
Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Dizocilpine Maleate; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Hyperalgesia; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Psychological; Synaptic Transmission; Xanthines | 2011 |
Chemical lesioning and glutamate administration reveal a major role for the nucleus tractus solitarius in the cardiac-somatic reflex in rats.
Topics: Animals; Cardiovascular Physiological Phenomena; Denervation; Glutamic Acid; Hyperalgesia; Male; Microinjections; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reflex; Solitary Nucleus | 2012 |
Phosphorylated CaMKII post-synaptic binding to NR2B subunits in the anterior cingulate cortex mediates visceral pain in visceral hypersensitive rats.
Topics: Anaphylaxis; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Catheterization; Colonic Diseases; Electroporation; Genetic Vectors; Glutamic Acid; Gyrus Cinguli; Hyperalgesia; Immunoprecipitation; Male; Peptides; Phosphorylation; Plasmids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Subcellular Fractions; Synapses; Synaptosomes; Visceral Pain | 2012 |
Spatial pain propagation over time following painful glutamate activation of latent myofascial trigger points in humans.
Topics: Area Under Curve; Electromyography; Female; Forearm; Glutamic Acid; Humans; Hyperalgesia; Male; Muscle, Skeletal; Myofascial Pain Syndromes; Pain Measurement; Pain Threshold; Pain, Referred; Trigger Points; Young Adult | 2012 |
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal | 2012 |
The role of glutamate release mediated by extrasynaptic P2X7 receptors in animal models of neuropathic pain.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Disease Models, Animal; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia; Receptors, Purinergic P2X7; Sciatic Nerve; Spinal Cord; Time Factors; Tritium | 2013 |
Specific thalamic nuclei function as novel 'nociceptive discriminators' in the endogenous control of nociception in rats.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Motor Activity; Muscle, Skeletal; Nociception; Pain Threshold; Random Allocation; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Thalamic Nuclei; Touch | 2013 |
Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glucosides; Glutamic Acid; Hot Temperature; Hydrolyzable Tannins; Hyperalgesia; Male; Mice; Motor Activity; Phyllanthus; Phytotherapy | 2013 |
Polysaccharide glucomannan isolated from Heterodermia obscurata attenuates acute and chronic pain in mice.
Topics: Acute Pain; Analgesics; Animals; Ascomycota; Behavior, Animal; Chronic Pain; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Interleukin-1beta; Ligation; Male; Mannans; Mice; Motor Activity; Nociception; Sciatic Nerve; Spinal Cord; Tumor Necrosis Factor-alpha | 2013 |
Hyperalgesia during opioid abstinence: mediation by glutamate and substance p.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Gene Expression; Genes, fos; Glutamic Acid; Histocytochemistry; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Morphine; Neurotransmitter Agents; Pain Measurement; Posterior Horn Cells; Reaction Time; Substance P; Substance Withdrawal Syndrome | 2002 |
Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.
Topics: Amino Acid Transport System X-AG; Animals; Behavior, Animal; Biological Transport; Carbazoles; Constriction; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Flavonoids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hyperalgesia; Indole Alkaloids; Kinetics; Male; Mitogen-Activated Protein Kinases; Neuralgia; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Riluzole; Spinal Cord; Symporters; Up-Regulation | 2003 |
Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.
Topics: Aminoquinolines; Animals; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescein; Fluorescence; Fluorescent Dyes; Functional Laterality; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Knockout; NADPH Dehydrogenase; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptin; Opioid Peptides; Peptide Fragments; Reaction Time; Spinal Cord; Spinal Cord Injuries; Time Factors | 2003 |
Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Cord | 2003 |
Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hyperalgesia; Male; Patch-Clamp Techniques; Pyrrolidines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Presynaptic; Synaptic Transmission | 2003 |
Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carrier Proteins; Cell Membrane; Chronic Disease; Cytoskeletal Proteins; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Hyperalgesia; Male; N-Ethylmaleimide-Sensitive Proteins; Neuralgia; Nuclear Proteins; Pain Threshold; Peptides; Peripheral Nervous System Diseases; Protein Binding; Protein Subunits; Protein Transport; Rats; Rats, Wistar; Receptors, AMPA; Recombinant Fusion Proteins; Reflex; RNA, Messenger; Synaptic Transmission; Vesicular Transport Proteins | 2003 |
Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Antagonism; Dynorphins; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoenzymes; Membrane Proteins; Microdialysis; N-Methylaspartate; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Rats; Spinal Cord | 2004 |
Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia.
Topics: Administration, Rectal; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Capsaicin; Colon; Feedback; Foot; Glutamic Acid; Hyperalgesia; Injections; Mice; Mice, Knockout; Pain Measurement; Receptors, Adrenergic, alpha-2; Spinal Cord; Synaptosomes | 2004 |
Effects of (-)-linalool in the acute hyperalgesia induced by carrageenan, L-glutamate and prostaglandin E2.
Topics: Acute Disease; Acyclic Monoterpenes; Analgesics; Animals; Behavior, Animal; Carrageenan; Dinoprostone; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Monoterpenes; Rats; Rats, Wistar; Touch | 2004 |
Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nerves.
Topics: Animals; Aspartic Acid; Benzoates; Capsaicin; Dental Pulp; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Imidazoles; Injections, Subcutaneous; Ligation; Lip; Male; Mandibular Nerve; Microdialysis; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Trigeminal Nuclei | 2004 |
Physiological and behavioral evidence for focal nociception induced by epidural glutamate infusion in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Glutamic Acid; Hyperalgesia; Infusion Pumps, Implantable; Injections, Epidural; Lumbar Vertebrae; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Single-Blind Method; Spinal Cord | 2005 |
Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord.
Topics: Animals; Female; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Knockout; Neurotransmitter Agents; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord; Synapsins; Synaptic Transmission; Synaptic Vesicles | 2005 |
Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia.
Topics: Amino Acid Transport System X-AG; Animals; Antineoplastic Agents, Phytogenic; Cell Communication; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hyperalgesia; Male; Neuroglia; Nociceptors; Paclitaxel; Peripheral Nervous System Diseases; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Symporters; Synaptic Transmission | 2005 |
Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bradykinin; Drug Synergism; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Mice; Mice, Knockout; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Spinal Cord; Synaptic Transmission | 2005 |
Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injection of acidic saline.
Topics: Adaptation, Physiological; Animals; Aspartic Acid; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Hyperesthesia; Injections, Intramuscular; Male; Myofascial Pain Syndromes; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sodium Chloride; Touch | 2005 |
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
Topics: Acetates; Acrylamides; Animals; Benzyl Compounds; Dimethyl Sulfoxide; Extracellular Fluid; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Male; Mice; Microdialysis; Misoprostol; Naphthalenes; Pain Measurement; Periaqueductal Gray; Prostaglandin Antagonists; Receptors, Prostaglandin E; Thiophenes; Triazoles; Xanthones | 2006 |
Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation.
Topics: Action Potentials; Afferent Pathways; Amino Acid Transport System X-AG; Animals; Dicarboxylic Acids; Excitatory Postsynaptic Potentials; Glutamic Acid; Hyperalgesia; Male; Neurons, Afferent; Neurotransmitter Uptake Inhibitors; Nociceptors; Posterior Horn Cells; Presynaptic Terminals; Pyrrolidines; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Synaptic Transmission | 2006 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hyperalgesia; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Pain; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley | 2006 |
The glutamate transporter GLAST is involved in spinal nociceptive processing.
Topics: Amino Acid Transport System X-AG; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Neurons; Oligonucleotides, Antisense; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission; Zymosan | 2006 |
Assessing mechanical sensitivity of masseter muscle in lightly anesthetized rats: a model for craniofacial muscle hyperalgesia.
Topics: Analgesics, Non-Narcotic; Anesthesia; Animals; Behavior; Bradykinin; Capsaicin; Facial Pain; Glutamic Acid; Humans; Hyperalgesia; Male; Masseter Muscle; Models, Biological; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2006 |
Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone.
Topics: Afferent Pathways; Animals; Cholera Toxin; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Inflammation; Male; Mandibular Nerve; Masticatory Muscles; Neurons, Afferent; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stilbamidines; Synaptic Transmission; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Nucleus, Spinal; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 2006 |
Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats.
Topics: Afferent Pathways; Amino Acids; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Down-Regulation; Extracellular Fluid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Microdialysis; Neurons, Afferent; Nociceptors; Pain Measurement; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Up-Regulation | 2006 |
Central metabotropic glutamate receptors differentially participate in interleukin-1beta-induced mechanical allodynia in the orofacial area of conscious rats.
Topics: Afferent Pathways; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Facial Pain; Glutamic Acid; Hyperalgesia; Interleukin-1beta; Male; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Metabotropic Glutamate; Sensory Receptor Cells; Synaptic Transmission; Vibrissae | 2006 |
The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain.
Topics: Afferent Pathways; Analgesics; Animals; Carboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Isoquinolines; Male; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles; Treatment Outcome | 2006 |
Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery.
Topics: Afferent Pathways; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hyperalgesia; Laparotomy; Neurons, Afferent; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Presynaptic Terminals; Pyridines; Rats; Rats, Wistar; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2007 |
Electrophysiological evidence for the interaction of substance P and glutamate on Adelta and C afferent fibre activity in rat hairy skin.
Topics: Animals; Electric Stimulation; Electrophysiology; Glutamic Acid; Hair; Hyperalgesia; Injections, Subcutaneous; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Conduction; Rats; Rats, Sprague-Dawley; Skin; Substance P | 2006 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Lamotrigine; Male; Microdialysis; Pain; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Long-Evans; Riluzole; Spinal Cord; Touch; Triazines | 2007 |
Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats.
Topics: Adaptation, Physiological; Animals; Arachidonic Acid; Behavior, Animal; Glutamic Acid; Hyperalgesia; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 2007 |
Modulation of cardiovascular responses and neurotransmission during peripheral nociception following nNOS antagonism within the periaqueductal gray.
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Hyperalgesia; Nitric Oxide Synthase Type I; Periaqueductal Gray; Physical Stimulation; Polymethacrylic Acids; Rats; Rats, Sprague-Dawley | 2007 |
Involvement of cellular prion protein in the nociceptive response in mice.
Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Edema; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Knockout; Pain; Pain Measurement; Pain Threshold; PrPC Proteins; Reaction Time; Temperature | 2007 |
Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleospinal antinociception in the rat.
Topics: Action Potentials; Animals; Behavior, Animal; Dose-Response Relationship, Radiation; Efferent Pathways; Electric Stimulation; Functional Laterality; Glutamic Acid; Hyperalgesia; Locus Coeruleus; Male; Neurons; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Reaction Time | 2007 |
Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.
Topics: Action Potentials; Animals; Behavior, Animal; Benzhydryl Compounds; Benzoates; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hyperalgesia; Male; Medulla Oblongata; Neurons; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptors, Metabotropic Glutamate | 2007 |
Decreased pain response in mice following cortex-specific knockout of the N-methyl-D-aspartate NR1 subunit.
Topics: Afferent Pathways; Animals; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Female; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Pain Measurement; Pain Threshold; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Synaptic Transmission | 2007 |
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Inflammation; Kainic Acid; Mice; Mononeuropathies; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Spinal Cord; Time Factors | 2007 |
Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzene Derivatives; Bradykinin; Dinoprostone; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Inflammation Mediators; Male; Mice; N-Methylaspartate; Neuralgia; Neurogenic Inflammation; Nociceptors; Organoselenium Compounds; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Sciatic Neuropathy | 2007 |
The effects of local perfusion of DAMGO on extracellular GABA and glutamate concentrations in the rostral ventromedial medulla.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Behavior, Animal; Dicarboxylic Acids; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Male; Medulla Oblongata; Microdialysis; Narcotic Antagonists; Neurotransmitter Uptake Inhibitors; Peptides; Potassium Chloride; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time | 2008 |
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hyperalgesia; Male; Mice; Morphine; Nociceptors; Pain; Placebo Effect; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission | 2008 |
Role for NMDA receptors in visceral nociceptive transmission in the anterior cingulate cortex of viscerally hypersensitive rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anaphylaxis; Animals; Cerebral Cortex; Colonic Diseases; Disease Models, Animal; Egg Hypersensitivity; Egg Proteins; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hyperalgesia; Male; Microdialysis; Neuronal Plasticity; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2008 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P | 1994 |
Intrathecal neuromedin C enhances mechanical nociception: possible involvement of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Sequence; Animals; Bombesin; Dose-Response Relationship, Drug; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Molecular Sequence Data; Pain Measurement; Pain Threshold; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Bombesin; Receptors, N-Methyl-D-Aspartate | 1994 |
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice.
Topics: Animals; Bicuculline; Dinoprostone; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Pain; Prostaglandin D2; Strychnine | 1994 |
Inflammation-induced release of excitatory amino acids is prevented by spinal administration of a GABAA but not by a GABAB receptor antagonist in rats.
Topics: Animals; Arthritis; Aspartic Acid; Bicuculline; Excitatory Amino Acids; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Glutamic Acid; Hyperalgesia; Organophosphorus Compounds; Rats; Receptors, GABA-A; Receptors, GABA-B; Spinal Cord | 1994 |
Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Body Temperature; Dizocilpine Maleate; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Rats; Rats, Sprague-Dawley | 1995 |
Pre-emptive dynorphin and N-methyl-D-aspartate glutamate receptor antagonism alters spinal immunocytochemistry but not allodynia following complete peripheral nerve injury.
Topics: Animals; Blood-Brain Barrier; Dizocilpine Maleate; Dynorphins; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Male; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Sciatic Nerve; Spinal Cord | 1996 |
Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dinoprostone; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Neurons, Afferent; omega-N-Methylarginine; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Spinal Cord | 1996 |
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord | 1998 |
Evidence for the interaction of glutamate and NK1 receptors in the periphery.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Microscopy, Immunoelectron; Neurons, Afferent; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Skin; Substance P; Tail | 1998 |
Region-specific increase in glutamate release from dorsal horn of rats with adjuvant inflammation.
Topics: Animals; Capsaicin; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Mycobacterium; Myelitis; Nociceptors; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord | 1998 |
Modulation of formalin-evoked hyperalgesia by intrathecal N-type Ca channel and protein kinase C inhibitor in the rat.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels; Carcinogens; Disinfectants; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Morphine; Nociceptors; omega-Conotoxin GVIA; Peptides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Staurosporine; Synapses | 1999 |
Nerve growth factor inducer, 4-methyl catechol, potentiates central sensitization associated with acceleration of spinal glutamate release after mustard oil paw injection in rats.
Topics: Analgesics, Opioid; Animals; Catechols; Glutamic Acid; Hyperalgesia; Male; Morphine; Mustard Plant; Nerve Growth Factors; Neuroprotective Agents; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley; Spinal Cord | 1999 |
The role of systemic, spinal and supraspinal L-arginine-nitric oxide-cGMP pathway in thermal hyperalgesia caused by intrathecal injection of glutamate in mice.
Topics: Analysis of Variance; Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine | 1999 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Postural Balance | 1999 |
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Pain Measurement; Sesquiterpenes | 2000 |
Neurochemical changes after morphine, dizocilpine or riluzole in the ventral posterolateral thalamic nuclei of rats with hyperalgesia.
Topics: Analysis of Variance; Animals; Arginine; Aspartic Acid; Carrageenan; Citrulline; Dialysis Solutions; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Hindlimb; Hyperalgesia; Male; Microdialysis; Morphine; Neuroprotective Agents; Rats; Rats, Wistar; Riluzole; Thalamic Nuclei | 2000 |
AIDA reduces glutamate release and attenuates mechanical allodynia after spinal cord injury.
Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Indans; Male; Mechanoreceptors; Neurons; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord Injuries | 2000 |
The role of peripheral N-methyl-D-aspartate receptors in Freund's complete adjuvant induced mechanical hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Freund's Adjuvant; Glutamic Acid; Hindlimb; Hyperalgesia; Inflammation; Isomerism; Male; Pain Measurement; Pain Threshold; Peripheral Nervous System; Physical Stimulation; Pressure; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2001 |
Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit.
Topics: Acute Disease; Animals; Central Nervous System; Electric Stimulation; Female; Glutamic Acid; Heterozygote; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reflex; Synaptic Transmission | 2001 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve.
Topics: Age Factors; Animals; Aspartic Acid; Causalgia; Down-Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hyperalgesia; Male; Neural Inhibition; Pain Threshold; Peripheral Nervous System Diseases; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Synaptic Transmission; Synaptosomes; Up-Regulation | 2002 |
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hyperalgesia; Ibotenic Acid; Injections, Spinal; N-Methylaspartate; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |