| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1575948 | Agonist activity at human CB2 receptor expressed in CHO cells coexpressing Galpha16 assessed as reduction in forsklin-induced cAMP production incubated for 30 mins by cAMP Hunter assay based fluorometric analysis | | | |
| AID569312 | Displacement of [3H]CP 55940 from human CB1 receptor in cell free system | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2
| Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. |
| AID569313 | Displacement of [3H]CP 55940 from human CB2 receptor in cell free system | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2
| Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. |
| AID617962 | Selectivity ratio of Ki for CB2 receptor to Ki for CB1 receptor | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives. |
| AID1228776 | Drug level in brain of ip dosed rat after 1 hr | 2015 | Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
| Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor. |
| AID1575957 | Antiinflammatory hyperalgesic activity against complete freund's adjuvant-induced mechanical hyperalgesic Sprague-Dawley rat model assessed as decrease in IL-6 production in paw skin at 10 mg/kg, ip pretreated with CFA for 24 hrs followed by compound admi | | | |
| AID1575958 | Antiinflammatory hyperalgesic activity against complete freund's adjuvant-induced mechanical hyperalgesic Sprague-Dawley rat model assessed as decrease in TNF alpha production in paw skin at 10 mg/kg, ip pretreated with CFA for 24 hrs followed by compound | | | |
| AID412570 | Selectivity ratio of Ki for CB1 receptor to Ki for CB2 receptor | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. |
| AID1575952 | Antiinflammatory hyperalgesic activity against complete freund's adjuvant-induced mechanical hyperalgesic Sprague-Dawley rat model assessed as paw withdraw latency at 10 mg/kg, ip pretreated with CFA for 24 hrs followed by compound administration and meas | | | |
| AID1575956 | Antiinflammatory hyperalgesic activity against complete freund's adjuvant-induced mechanical hyperalgesic Sprague-Dawley rat model assessed as decrease in IL-1 beta production in paw skin at 10 mg/kg, ip pretreated with CFA for 24 hrs followed by compound | | | |
| AID591352 | Binding affinity to human CB1 receptor | 2011 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8
| Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy. |
| AID1127506 | Selectivity ratio of Ki for human CB2 receptor to Ki for human CB1 receptor | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. |
| AID569314 | Selectivity ratio of Ki for human CB1 to Ki for human CB2 | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2
| Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. |
| AID1575947 | Agonist activity at human CB1 receptor expressed in CHO cells coexpressing Galpha16 assessed as reduction in forsklin-induced cAMP production incubated for 30 mins by cAMP Hunter assay based fluorometric analysis | | | |
| AID314553 | Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP level relative to CP-55940 | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity. |
| AID1127526 | selectivity ratio of Ki for rat CB2 receptor to Ki for rat CB1 receptor | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. |
| AID1127525 | Agonist activity at human CB1 receptor | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. |
| AID383284 | Activity at CB2 receptor | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3
| Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. |
| AID1575951 | Antiinflammatory hyperalgesic activity against complete freund's adjuvant-induced mechanical hyperalgesic Sprague-Dawley rat model assessed as increase in paw withdraw latency at 10 mg/kg, ip pretreated with CFA for 24 hrs followed by compound administrat | | | |
| AID1127524 | Agonist activity at human CB2 receptor | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. |
| AID412568 | Binding affinity to CB1 receptor | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. |
| AID591332 | Binding affinity to human CB2 receptor | 2011 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8
| Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy. |
| AID383285 | Selectivity for CB2 receptor over CB1 receptor | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3
| Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. |
| AID1575965 | Selectivity ratio of EC50 for human CB1 receptor expressed in CHO cells coexpressing Galpha16 to EC50 for human CB2 receptor expressed in CHO cells coexpressing Galpha16 | | | |
| AID1228774 | Binding affinity to human CB2 receptor | 2015 | Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
| Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor. |
| AID412569 | Binding affinity to CB2 receptor | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. |
| AID314552 | Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP level | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity. |
| AID1228775 | Ratio of drug level in brain to plasma in ip dosed rat | 2015 | Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
| Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor. |
| AID617964 | Binding affinity to CB2 receptor | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |