Page last updated: 2024-08-08 00:07:05
KiSS-1 receptor
A KiSS-1 receptor that is encoded in the genome of rat. [OMA:Q924U1, PRO:DNx]
Synonyms
KiSS-1R;
G-protein coupled receptor 54;
G-protein coupled receptor OT7T175;
rOT7T175;
Kisspeptins receptor;
Metastin receptor
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| kisspeptin-10 protein, human | Rattus norvegicus (Norway rat) | EC50 | 0.0042 | 2 | 2 |
| tak-683 | Rattus norvegicus (Norway rat) | EC50 | 0.0013 | 2 | 2 |
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NHJournal of medicinal chemistry, , 10-13, Volume: 59, Issue:19, 2016
Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.Journal of medicinal chemistry, , Jul-24, Volume: 57, Issue:14, 2014
Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NHJournal of medicinal chemistry, , 10-13, Volume: 59, Issue:19, 2016
Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.Journal of medicinal chemistry, , Jul-24, Volume: 57, Issue:14, 2014