Page last updated: 2024-11-04

rolipram and Allodynia

rolipram has been researched along with Allodynia in 10 studies

Research Excerpts

ExcerptRelevanceReference
" The objective of the present paper was to evaluate the relevance of neuronal balance of cyclic AMP and cyclic GMP concentration for functional regulation of nociceptor sensitivity during inflammation."3.70Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia. ( Cunha, FQ; Ferreira, SH; Teixeira, MM, 1999)
"Pharmac."1.29Delayed sympathectomy after a prolonged hyperalgesia results in a subsequent enhanced acute hyperalgesic response. ( Aley, KO; Kinnman, E; Levine, JD, 1996)
"The duration of this hyperalgesia was prolonged by the phosphodiesterase inhibitors, isobutylmethylxanthine and rolipram."1.28Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. ( Levine, JD; Taiwo, YO, 1991)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (60.00)18.2507
2000's0 (0.00)29.6817
2010's3 (30.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Chłoń-Rzepa, G1
Ślusarczyk, M1
Jankowska, A1
Gawalska, A1
Bucki, A1
Kołaczkowski, M1
Świerczek, A1
Pociecha, K1
Wyska, E1
Zygmunt, M1
Kazek, G1
Sałat, K1
Pawłowski, M1
Megat, S1
Hugel, S1
Journée, SH1
Bohren, Y1
Lacaud, A1
Lelièvre, V1
Doridot, S1
Villa, P1
Bourguignon, JJ1
Salvat, E1
Schlichter, R1
Freund-Mercier, MJ1
Yalcin, I1
Barrot, M1
Guo, CH1
Bai, L1
Wu, HH1
Yang, J1
Cai, GH1
Wang, X1
Wu, SX1
Ma, W1
Bretzner, F1
Plemel, JR1
Liu, J1
Richter, M1
Roskams, AJ1
Tetzlaff, W1
Ouseph, AK2
Khasar, SG1
Levine, JD5
Aley, KO1
Kinnman, E1
Cunha, FQ1
Teixeira, MM1
Ferreira, SH1
Taiwo, YO2
Heller, PH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Regeneration in Cervical Degenerative Myelopathy - a Multi-centre, Double-blind, Randomised, Placebo Controlled Trial Assessing the Efficacy of Ibudilast as an Adjuvant Treatment to Decompressive Surgery for Degenerative Cervical Myelopathy[NCT04631471]Phase 3400 participants (Anticipated)Interventional2021-12-22Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

10 other studies available for rolipram and Allodynia

ArticleYear
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
    European journal of medicinal chemistry, 2018, Oct-05, Volume: 158

    Topics: Amides; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phospho

2018
Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury.
    Neuropharmacology, 2022, 03-01, Volume: 205

    Topics: Animals; Disease Models, Animal; Hyperalgesia; Mice; Neuralgia; Peripheral Nerve Injuries; Phosphodi

2022
The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain.
    International journal of molecular medicine, 2016, Volume: 38, Issue:5

    Topics: Analgesics; Animals; Anthracenes; Astrocytes; Bone Neoplasms; Cancer Pain; Chemokine CCL2; Cyclic Nu

2016
Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury.
    Journal of neuroscience research, 2010, Volume: 88, Issue:13

    Topics: Animals; Axons; Cell Transplantation; Cyclic AMP; Disease Models, Animal; Glial Fibrillary Acidic Pr

2010
Multiple second messenger systems act sequentially to mediate rolipram-induced prolongation of prostaglandin E2-induced mechanical hyperalgesia in the rat.
    Neuroscience, 1995, Volume: 64, Issue:3

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminoquinolines; Animals; Calcium; Carrier Proteins; Cyclic

1995
Alpha 1-adrenoceptor-mediated sympathetically dependent mechanical hyperalgesia in the rat.
    European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2

    Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, P

1995
Delayed sympathectomy after a prolonged hyperalgesia results in a subsequent enhanced acute hyperalgesic response.
    Neuroscience, 1996, Volume: 71, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Drug Combinations; Hyperalgesia; Mal

1996
Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia.
    British journal of pharmacology, 1999, Volume: 127, Issue:3

    Topics: Animals; Bradykinin; Carrageenan; Cyclic AMP; Cyclic GMP; Dinoprostone; Dopamine; Hyperalgesia; Infl

1999
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
    Neuroscience, 1992, Volume: 48, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-

1992
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
    Neuroscience, 1991, Volume: 44, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dinoprost

1991