hydrochloric acid has been researched along with Allodynia in 14 studies
Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
hydrogen chloride : A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesized that chemically-induced hyperalgesia in the oesophagus could provoke widespread visceral hypersensitivity and also influence descending modulatory pain pathways." | 5.36 | Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus. ( Andresen, T; Arendt-Nielsen, L; Brock, C; Drewes, AM; Frøkjaer, JB; Gale, J; Olesen, AE, 2010) |
| "In 16 acid-sensitizers, the degree of hyperalgesia correlated with increasing heart rate (r = -0." | 2.77 | The autonomic response to human esophageal acidification and the development of hyperalgesia. ( Aziz, Q; Chua, YC; Paine, P; Rhodes, S; Sharma, A; Warburton, F, 2012) |
| "We hypothesized that chemically-induced hyperalgesia in the oesophagus could provoke widespread visceral hypersensitivity and also influence descending modulatory pain pathways." | 1.36 | Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus. ( Andresen, T; Arendt-Nielsen, L; Brock, C; Drewes, AM; Frøkjaer, JB; Gale, J; Olesen, AE, 2010) |
| "Distal esophageal acidification induces hyperalgesia in the non-acid exposed proximal esophagus, due to the sensitization of spinal dorsal horn neurones." | 1.36 | Anxiety increases acid-induced esophageal hyperalgesia. ( Aziz, Q; Gregory, L; Paine, P; Sharma, A; Van Oudenhove, L, 2010) |
| "The sensitization resulted in allodynia and hyperalgesia to the distension volumes, and the degree of sensitization was related to the infused volume of acid." | 1.33 | Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid. ( Arendt-Nielsen, L; Drewes, AM; Funch-Jensen, P; Gregersen, H; Pedersen, J; Reddy, H; Staahl, C, 2005) |
| "Mechanical hyperalgesia was assessed by measuring the withdrawal thresholds to mechanical stimuli (von Frey filaments) before the first and second intramuscular injection, 24 h after the second intramuscular injection, and for 1 h after administration of the opioid agonist or vehicle." | 1.31 | Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists. ( Bussey, RA; Eikenberry, SA; Rohlwing, JJ; Sluka, KA; Wilken, JM, 2002) |
| "To quantify hyperalgesia, paw withdrawal latency to radiant heat (heat hyperalgesia) and withdrawal threshold to mechanical stimuli (mechanical hyperalgesia) were measured." | 1.31 | Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia. ( Kalra, A; Moore, SA; Sluka, KA, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (64.29) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brock, C | 1 |
| Andresen, T | 1 |
| Frøkjaer, JB | 1 |
| Gale, J | 1 |
| Olesen, AE | 1 |
| Arendt-Nielsen, L | 2 |
| Drewes, AM | 3 |
| Krarup, AL | 1 |
| Villadsen, GE | 1 |
| Mejlgaard, E | 1 |
| Olesen, SS | 1 |
| Funch-Jensen, P | 2 |
| Yang, M | 2 |
| Li, ZS | 2 |
| Chen, DF | 1 |
| Zou, DW | 2 |
| Xu, XR | 2 |
| Fang, DC | 2 |
| Xu, GM | 2 |
| Stephens, RL | 1 |
| Wang, ZG | 1 |
| Sharma, A | 2 |
| Van Oudenhove, L | 1 |
| Paine, P | 2 |
| Gregory, L | 1 |
| Aziz, Q | 5 |
| Rhodes, S | 1 |
| Warburton, F | 1 |
| Chua, YC | 2 |
| Sluka, KA | 2 |
| Rohlwing, JJ | 1 |
| Bussey, RA | 1 |
| Eikenberry, SA | 1 |
| Wilken, JM | 1 |
| Willert, RP | 1 |
| Woolf, CJ | 2 |
| Hobson, AR | 3 |
| Delaney, C | 2 |
| Thompson, DG | 2 |
| Jones, NG | 1 |
| Slater, R | 1 |
| Cadiou, H | 1 |
| McNaughton, P | 1 |
| McMahon, SB | 1 |
| Reddy, H | 1 |
| Staahl, C | 1 |
| Pedersen, J | 1 |
| Gregersen, H | 1 |
| Sun, ZX | 1 |
| Tu, ZX | 1 |
| Rong, W | 1 |
| Winchester, WJ | 1 |
| Grundy, D | 1 |
| Matthews, PJ | 1 |
| Knowles, CH | 1 |
| Sarkar, S | 1 |
| Kalra, A | 1 |
| Moore, SA | 1 |
4 trials available for hydrochloric acid and Allodynia
| Article | Year |
|---|---|
The autonomic response to human esophageal acidification and the development of hyperalgesia.
Topics: Adult; Autonomic Nervous System; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Esop | 2012 |
The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor.
Topics: Adult; Area Under Curve; Attention; Cross-Over Studies; Double-Blind Method; Electric Stimulation; E | 2004 |
Effects of the concentration and frequency of acid infusion on the development and maintenance of esophageal hyperalgesia in a human volunteer model.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electric | 2008 |
Contribution of central sensitisation to the development of non-cardiac chest pain.
Topics: Adult; Chest Pain; Electric Stimulation; Esophagus; Female; Humans; Hydrochloric Acid; Hyperalgesia; | 2000 |
10 other studies available for hydrochloric acid and Allodynia
| Article | Year |
|---|---|
Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus.
Topics: Adult; Analysis of Variance; Body Temperature; Capsaicin; Cerebral Cortex; Electric Stimulation; Ele | 2010 |
Acid hypersensitivity in patients with eosinophilic oesophagitis.
Topics: Adult; Aged; Case-Control Studies; Esophagitis; Female; Humans; Hydrochloric Acid; Hyperalgesia; Mal | 2010 |
Quantitative assessment and characterization of visceral hyperalgesia evoked by esophageal balloon distention and acid perfusion in patients with functional heartburn, nonerosive reflux disease, and erosive esophagitis.
Topics: Acids; Adult; Analysis of Variance; Catheterization; Esophageal pH Monitoring; Esophagitis, Peptic; | 2010 |
Anxiety increases acid-induced esophageal hyperalgesia.
Topics: Adult; Affect; Anxiety; Autonomic Nervous System; Baroreflex; Cross-Over Studies; Esophageal Disease | 2010 |
Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2002 |
Acid-induced pain and its modulation in humans.
Topics: Acid Sensing Ion Channels; Administration, Cutaneous; Adult; Amiloride; Analgesics; Anti-Inflammator | 2004 |
Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid.
Topics: Adult; Catheterization; Esophagus; Female; Humans; Hydrochloric Acid; Hyperalgesia; Male; Middle Age | 2005 |
Characterization of cortical potentials evoked by oesophageal balloon distention and acid perfusion in patients with functional heartburn.
Topics: Adult; Aged; Cerebral Cortex; Dilatation; Electroencephalography; Esophagus; Evoked Potentials, Soma | 2006 |
Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor.
Topics: Afferent Pathways; Animals; Bradykinin; Dilatation; Hydrochloric Acid; Hyperalgesia; In Vitro Techni | 2007 |
Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia.
Topics: Animals; Behavior, Animal; Body Weight; Coloring Agents; Disease Models, Animal; Drug Combinations; | 2001 |