ondansetron has been researched along with Allodynia in 22 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to examine whether the intensity of dynamic mechanical allodynia and spontaneous ongoing pain in patients with neuropathic pain associated with peripheral neuropathy was influenced by an intravenous infusion of the 5HT3-antagonist, ondansetron." | 9.15 | Ondansetron, a 5HT3-antagonist, does not alter dynamic mechanical allodynia or spontaneous ongoing pain in peripheral neuropathy. ( Hansson, P; Leffler, AS; Tuveson, B, 2011) |
| "The aim of this study was to examine whether the intensity of dynamic mechanical allodynia and spontaneous ongoing pain in patients with neuropathic pain associated with peripheral neuropathy was influenced by an intravenous infusion of the 5HT3-antagonist, ondansetron." | 5.15 | Ondansetron, a 5HT3-antagonist, does not alter dynamic mechanical allodynia or spontaneous ongoing pain in peripheral neuropathy. ( Hansson, P; Leffler, AS; Tuveson, B, 2011) |
| " Facilitation of pain behaviour induced by GAL in the DMH was reversed by lidocaine in the DRt and by ondansetron, a 5HT3R antagonist, in the spinal cord." | 3.81 | Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. ( Almeida, A; Amorim, D; Pertovaara, A; Pinto-Ribeiro, F; Viisanen, H; Wei, H, 2015) |
| "We found that paracetamol 100 mg kg⁻¹ blocked the development of hyperalgesia and allodynia after fracture pain and ondansetron did not modify the antinociceptive effect of paracetamol in this model." | 3.77 | Ondansetron does not block paracetamol-induced analgesia in a mouse model of fracture pain. ( Fourcade, O; Girolami, JP; Mazoit, JX; Minville, V; Tack, I, 2011) |
| " We investigated pregabalin, indicated for neuropathic pain, and ondansetron, a drug that disrupts descending serotonergic processing in the central nervous system, on spinal neuronal hyperexcitability and visceral hypersensitivity in a rat model of opioid-induced hyperalgesia." | 3.77 | Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Porreca, F; Sikandar, S, 2011) |
| " In uninjured rats, RVM microinjection of morphine produced dose-dependent antinociception in the noxious thermal paw flick test while RVM microinjection of CCK produced thermal hyperalgesia and tactile allodynia." | 3.75 | Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. ( Dogrul, A; Ossipov, MH; Porreca, F, 2009) |
| "The involvement of opioid receptor activation in the antinociceptive effect of either fluvoxamine, a selective serotonin reuptake inhibitor, or serotonin (5-HT) on thermal hyperalgesia and mechanical allodynia in a model of neuropathic pain in mice induced by sciatic nerve ligation was examined." | 3.73 | Possible involvement of opioidergic systems in the antinociceptive effect of the selective serotonin reuptake inhibitors in sciatic nerve-injured mice. ( Kamei, J; Nozaki, C, 2006) |
| "We hypothesized that hyperalgesia of 6-OHDA rats may be related to increased excitability of SDH neurons, and functional change of 5-HT3 receptor may reverse the hyperalgesia of 6-OHDA lesioned rats and decrease cell excitability of SDH neurons." | 1.72 | Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. ( An, MQ; Dai, YP; Dong, LG; Gu, HY; Li, CJ; Liu, CF; Liu, LB; Mao, CJ; Wang, F; Zhang, LG, 2022) |
| "We observed significant hindpaw allodynia in TBI rats that was reduced after DHT but not vehicle treatment." | 1.51 | Enhanced descending pain facilitation in acute traumatic brain injury. ( Clark, JD; Ferguson, AR; Irvine, KA; Sahbaie, P, 2019) |
| "After confirming hyperalgesia, male mice were treated with αTPN-βCD (25, 50 or 100 mg/kg; p." | 1.43 | α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study. ( Almeida, JR; Araújo, AA; Araújo-Filho, HG; Brito, RG; Carvalho, YM; Menezes, PP; Oliveira, MG; Quintans, JS; Quintans-Júnior, LJ; Santos, PL; Scotti, L; Scotti, MT; Serafini, MR; Shanmugam, S; Silva, JC; Thangaraj, P, 2016) |
| "Mechanisms underlying the chronicity of neuropathic pain are not well understood." | 1.39 | Descending facilitation maintains long-term spontaneous neuropathic pain. ( De Felice, M; Guo, W; King, T; Ossipov, MH; Porreca, F; Wang, R, 2013) |
| "Interestingly, tactile allodynia and thermal hyperalgesia in both models can be blocked similarly by intrathecal, but not systemic, injection of ondansetron." | 1.39 | Spinal 5-HT3 receptors facilitate behavioural hypersensitivity induced by elevated calcium channel alpha-2-delta-1 protein. ( Chang, EY; Chen, X; Li, CY; Luo, ZD; Sandhu, A, 2013) |
| "The SP-induced hyperalgesia was both GABA(A) and NMDA receptor-dependent after pre- and post-treatment with selective antagonists at the spinal level." | 1.36 | Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. ( Dubner, R; Guo, W; Lagraize, SC; Ren, K; Wei, F; Yang, K, 2010) |
| " Ablation of NK-1 receptor expressing cells prevented (a) morphine-induced thermal and mechanical hypersensitivity, (b) increased touch-evoked spinal FOS expression, (c) upregulation of spinal dynorphin content and (d) the rightward displacement of the spinal morphine antinociceptive dose-response curve (i." | 1.34 | Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. ( King, T; Lai, J; Ossipov, MH; Porreca, F; Vanderah, TW; Vera-Portocarrero, LP; Zhang, ET, 2007) |
| "Diabetic mice exhibited significant hyperalgesia compared with control mice." | 1.32 | Fluoxetine attenuates thermal hyperalgesia through 5-HT1/2 receptors in streptozotocin-induced diabetic mice. ( Anjaneyulu, M; Chopra, K, 2004) |
| "However, the hyperalgesia was not modified by RP 67580 (1." | 1.30 | Involvement of 5-hydroxytryptamine and bradykinin in the hyperalgesia induced in rats by collagenase from Clostridium histolyticum. ( Bourdon, V; Damas, J; Liégeois, JF, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Li, CJ | 1 |
| Zhang, LG | 1 |
| Liu, LB | 1 |
| An, MQ | 1 |
| Dong, LG | 1 |
| Gu, HY | 1 |
| Dai, YP | 1 |
| Wang, F | 1 |
| Mao, CJ | 1 |
| Liu, CF | 1 |
| Nascimento, EB | 1 |
| Romero, TRL | 1 |
| Dutra, MMGB | 1 |
| Fiebich, BL | 1 |
| Duarte, IDG | 1 |
| Coelho, MM | 1 |
| Sasaki, M | 1 |
| Kamiya, Y | 1 |
| Bamba, K | 1 |
| Onishi, T | 1 |
| Matsuda, K | 1 |
| Kohno, T | 1 |
| Kurabe, M | 1 |
| Furutani, K | 1 |
| Yanagimura, H | 1 |
| Giorno, TBS | 1 |
| Moreira, IGDS | 1 |
| Rezende, CM | 1 |
| Fernandes, PD | 1 |
| Irvine, KA | 1 |
| Sahbaie, P | 1 |
| Ferguson, AR | 1 |
| Clark, JD | 2 |
| Wang, R | 1 |
| King, T | 2 |
| De Felice, M | 1 |
| Guo, W | 2 |
| Ossipov, MH | 3 |
| Porreca, F | 4 |
| Bektas, N | 1 |
| Arslan, R | 1 |
| Ozturk, Y | 1 |
| Diniz, DA | 1 |
| Petrocchi, JA | 1 |
| Navarro, LC | 1 |
| Souza, TC | 1 |
| Castor, MG | 1 |
| Perez, AC | 1 |
| Duarte, ID | 1 |
| Romero, TR | 1 |
| Amorim, D | 1 |
| Viisanen, H | 1 |
| Wei, H | 1 |
| Almeida, A | 1 |
| Pertovaara, A | 1 |
| Pinto-Ribeiro, F | 1 |
| Oliveira, MG | 1 |
| Brito, RG | 1 |
| Santos, PL | 1 |
| Araújo-Filho, HG | 1 |
| Quintans, JS | 1 |
| Menezes, PP | 1 |
| Serafini, MR | 1 |
| Carvalho, YM | 1 |
| Silva, JC | 1 |
| Almeida, JR | 1 |
| Scotti, L | 1 |
| Scotti, MT | 1 |
| Shanmugam, S | 1 |
| Thangaraj, P | 1 |
| Araújo, AA | 1 |
| Quintans-Júnior, LJ | 1 |
| Dogrul, A | 1 |
| Lagraize, SC | 1 |
| Yang, K | 1 |
| Wei, F | 1 |
| Ren, K | 1 |
| Dubner, R | 1 |
| Minville, V | 1 |
| Fourcade, O | 1 |
| Mazoit, JX | 1 |
| Girolami, JP | 1 |
| Tack, I | 1 |
| Tuveson, B | 1 |
| Leffler, AS | 1 |
| Hansson, P | 1 |
| Liang, DY | 1 |
| Li, X | 1 |
| Bannister, K | 1 |
| Sikandar, S | 1 |
| Bauer, CS | 1 |
| Dolphin, AC | 1 |
| Dickenson, AH | 1 |
| Heinl, C | 1 |
| Drdla-Schutting, R | 1 |
| Xanthos, DN | 1 |
| Sandkühler, J | 1 |
| Chang, EY | 1 |
| Chen, X | 1 |
| Sandhu, A | 1 |
| Li, CY | 1 |
| Luo, ZD | 1 |
| Anjaneyulu, M | 1 |
| Chopra, K | 1 |
| Nozaki, C | 1 |
| Kamei, J | 1 |
| Vera-Portocarrero, LP | 1 |
| Zhang, ET | 1 |
| Vanderah, TW | 1 |
| Lai, J | 1 |
| Damas, J | 1 |
| Liégeois, JF | 1 |
| Bourdon, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Pgp Transporter Inhibition on CNS Biodistribution of Ondansetron in Healthy Volunteers[NCT03809234] | Phase 1 | 14 participants (Actual) | Interventional | 2019-05-20 | Terminated (stopped due to Adverse effects related to study procedure (not study drug)) | ||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ondansetron and Allodynia
| Article | Year |
|---|---|
Ondansetron, a 5HT3-antagonist, does not alter dynamic mechanical allodynia or spontaneous ongoing pain in peripheral neuropathy.
Topics: Adult; Analysis of Variance; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypera | 2011 |
21 other studies available for ondansetron and Allodynia
| Article | Year |
|---|---|
Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Hyperalgesia; Ondansetron; Oxidopamine; P | 2022 |
Role of peripheral 5-HT
Topics: Animals; Carrageenan; Disease Models, Animal; Hyperalgesia; Male; Mice; Nociception; Ondansetron; Pa | 2021 |
Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice.
Topics: Analgesics, Opioid; Animals; Astrocytes; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inb | 2021 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehy | 2018 |
Enhanced descending pain facilitation in acute traumatic brain injury.
Topics: Animals; Brain Injuries, Traumatic; Hyperalgesia; Male; Ondansetron; Pain; Rats; Rats, Sprague-Dawle | 2019 |
Descending facilitation maintains long-term spontaneous neuropathic pain.
Topics: Afferent Pathways; Anesthetics, Local; Animals; Benzodiazepines; Conditioning, Operant; Disease Mode | 2013 |
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Disease Models, Animal; Dose-Respons | 2014 |
Serotonin induces peripheral mechanical antihyperalgesic effects in mice.
Topics: Animals; Biphenyl Compounds; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Ketanseri | 2015 |
Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways.
Topics: Animals; Arthritis; Behavior, Animal; Disease Models, Animal; Electrophysiology; Galanin; Glutamic A | 2015 |
α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study.
Topics: Analgesics; Animals; Behavior, Animal; beta-Cyclodextrins; Binding Sites; Cyclohexane Monoterpenes; | 2016 |
Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Medulla Oblongata | 2009 |
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilp | 2010 |
Ondansetron does not block paracetamol-induced analgesia in a mouse model of fracture pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antiemetics; Disease Models, Animal; Drug Interact | 2011 |
5-hydroxytryptamine type 3 receptor modulates opioid-induced hyperalgesia and tolerance in mice.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred | 2011 |
Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.
Topics: Analgesics; Analgesics, Opioid; Animals; Dilatation; Electrophysiology; gamma-Aminobutyric Acid; Hyp | 2011 |
Distinct mechanisms underlying pronociceptive effects of opioids.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Rela | 2011 |
Spinal 5-HT3 receptors facilitate behavioural hypersensitivity induced by elevated calcium channel alpha-2-delta-1 protein.
Topics: Animals; Calcium Channels; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mice | 2013 |
Fluoxetine attenuates thermal hyperalgesia through 5-HT1/2 receptors in streptozotocin-induced diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fluoxetine; | 2004 |
Possible involvement of opioidergic systems in the antinociceptive effect of the selective serotonin reuptake inhibitors in sciatic nerve-injured mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Fluvoxamine; Hyperalgesia; Injections, Spinal | 2006 |
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.
Topics: Afferent Pathways; Animals; Drug Tolerance; Dynorphins; Hyperalgesia; Male; Morphine; Neurons; Ondan | 2007 |
Involvement of 5-hydroxytryptamine and bradykinin in the hyperalgesia induced in rats by collagenase from Clostridium histolyticum.
Topics: Analgesics; Angiotensin-Converting Enzyme Inhibitors; Animals; Behavior, Animal; Bradykinin; Clostri | 1997 |