ifenprodil has been researched along with Allodynia in 13 studies
ifenprodil: NMDA receptor antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| ", twice a week) caused mechanical allodynia in the fourth week, which was reversed by intrathecal injection of MK-801 (10 nmol) and memantine (1 μmol), NMDA receptor antagonists." | 3.77 | Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. ( Egashira, N; Ikesue, H; Kawashiri, T; Mihara, Y; Oishi, R; Sada, H; Ushio, S; Yano, T, 2011) |
| " Intrathecal administration of 5 and 10 microg of NR2B subunit-specific NMDA receptor antagonist ifenprodil attenuated cancer-evoked spontaneous pain, thermal hyperalgesia and mechanical allodynia." | 3.76 | The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain. ( Gao, Q; Gu, X; Jin, Y; Ma, Z; Mei, F; Wang, J; Xia, X; Zhang, J; Zhou, X, 2010) |
| "Ifenprodil treatment for both doses showed anti-allodynic and anti-nociceptive effects with lower expression of phosphorylated and total spinal NR2B." | 1.51 | Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of ( Abd Aziz, CB; Haris, K; Ismail, CAN; Long, I; Suppian, R, 2019) |
| "Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor." | 1.36 | The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. ( Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS, 2010) |
| "In contrast, hyperalgesia persisted for 2 weeks in the group that received vibration stimulation." | 1.34 | Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. ( Baron, R; Chung, JM; Chung, K; Kim, HK; Lee, I; Schattschneider, J, 2007) |
| "Mechanical hyperalgesia was clearly observed during ethanol consumption and even after ethanol withdrawal, and lasted for 14 weeks." | 1.34 | Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption. ( Miyoshi, K; Narita, M; Suzuki, T, 2007) |
| "Pretreatment with naloxone, an opioid receptor antagonist (1." | 1.31 | Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. ( Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ismail, CAN | 1 |
| Suppian, R | 1 |
| Abd Aziz, CB | 1 |
| Haris, K | 1 |
| Long, I | 1 |
| Ferrier, J | 1 |
| Bayet-Robert, M | 1 |
| Pereira, B | 1 |
| Daulhac, L | 1 |
| Eschalier, A | 1 |
| Pezet, D | 1 |
| Moulinoux, JP | 1 |
| Balayssac, D | 1 |
| Wang, EM | 1 |
| Li, WT | 1 |
| Yan, XJ | 1 |
| Chen, X | 1 |
| Liu, Q | 1 |
| Feng, CC | 1 |
| Cao, ZJ | 1 |
| Fang, JY | 1 |
| Chen, SL | 1 |
| Gu, X | 1 |
| Zhang, J | 1 |
| Ma, Z | 1 |
| Wang, J | 1 |
| Zhou, X | 1 |
| Jin, Y | 1 |
| Xia, X | 1 |
| Gao, Q | 1 |
| Mei, F | 1 |
| Ivanusic, JJ | 1 |
| Beaini, D | 1 |
| Hatch, RJ | 1 |
| Staikopoulos, V | 1 |
| Sessle, BJ | 1 |
| Jennings, EA | 1 |
| Rondon, ES | 1 |
| Vieira, AS | 1 |
| Valadão, CA | 1 |
| Parada, CA | 1 |
| Mihara, Y | 1 |
| Egashira, N | 1 |
| Sada, H | 1 |
| Kawashiri, T | 1 |
| Ushio, S | 1 |
| Yano, T | 1 |
| Ikesue, H | 1 |
| Oishi, R | 1 |
| Wang, W | 2 |
| Mei, XP | 1 |
| Wei, YY | 1 |
| Zhang, MM | 1 |
| Zhang, T | 1 |
| Xu, LX | 1 |
| Wu, SX | 1 |
| Li, YQ | 1 |
| Li, S | 1 |
| Cao, J | 1 |
| Yang, X | 1 |
| Suo, ZW | 1 |
| Shi, L | 1 |
| Liu, YN | 1 |
| Yang, HB | 1 |
| Hu, XD | 1 |
| Kim, HK | 1 |
| Schattschneider, J | 1 |
| Lee, I | 1 |
| Chung, K | 1 |
| Baron, R | 1 |
| Chung, JM | 1 |
| Narita, M | 2 |
| Miyoshi, K | 1 |
| Suzuki, T | 1 |
| Boyce, S | 1 |
| Wyatt, A | 1 |
| Webb, JK | 1 |
| O'Donnell, R | 1 |
| Mason, G | 1 |
| Rigby, M | 1 |
| Sirinathsinghji, D | 1 |
| Hill, RG | 1 |
| Rupniak, NM | 1 |
| Sakurada, T | 1 |
| Watanabe, C | 1 |
| Okuda, K | 1 |
| Sugiyama, A | 1 |
| Moriyama, T | 1 |
| Sakurada, C | 1 |
| Tan-No, K | 1 |
| Sakurada, S | 1 |
13 other studies available for ifenprodil and Allodynia
| Article | Year |
|---|---|
Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of
Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disea | 2019 |
A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
Topics: Acute Disease; Animals; Antineoplastic Agents; Behavior, Animal; Cold Temperature; Diet; Glutamic Ac | 2013 |
Vagal afferent-dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA-NR2B receptors in rats.
Topics: Abdominal Muscles; Afferent Pathways; Animals; Central Amygdaloid Nucleus; Hyperalgesia; Male; Nocic | 2015 |
The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Cells, Cultured; | 2010 |
Peripheral N-methyl-d-aspartate receptors contribute to mechanical hypersensitivity in a rat model of inflammatory temporomandibular joint pain.
Topics: Analysis of Variance; Animals; Blotting, Western; Excitatory Amino Acid Antagonists; Hyperalgesia; I | 2011 |
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glut | 2010 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles | 2011 |
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain.
Topics: Animals; Astrocytes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hype | 2011 |
NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice.
Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Mice; N-Methylaspartate; Pain Measur | 2011 |
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Dr | 2007 |
Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption.
Topics: Alcohol Drinking; Animals; Chronic Disease; Disease Models, Animal; Ethanol; Hyperalgesia; Immunoblo | 2007 |
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excita | 1999 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Di | 2002 |