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ifenprodil and Allodynia

ifenprodil has been researched along with Allodynia in 13 studies

ifenprodil: NMDA receptor antagonist

Research Excerpts

ExcerptRelevanceReference
", twice a week) caused mechanical allodynia in the fourth week, which was reversed by intrathecal injection of MK-801 (10 nmol) and memantine (1 μmol), NMDA receptor antagonists."3.77Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. ( Egashira, N; Ikesue, H; Kawashiri, T; Mihara, Y; Oishi, R; Sada, H; Ushio, S; Yano, T, 2011)
" Intrathecal administration of 5 and 10 microg of NR2B subunit-specific NMDA receptor antagonist ifenprodil attenuated cancer-evoked spontaneous pain, thermal hyperalgesia and mechanical allodynia."3.76The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain. ( Gao, Q; Gu, X; Jin, Y; Ma, Z; Mei, F; Wang, J; Xia, X; Zhang, J; Zhou, X, 2010)
"Ifenprodil treatment for both doses showed anti-allodynic and anti-nociceptive effects with lower expression of phosphorylated and total spinal NR2B."1.51Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of ( Abd Aziz, CB; Haris, K; Ismail, CAN; Long, I; Suppian, R, 2019)
"Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor."1.36The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. ( Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS, 2010)
"In contrast, hyperalgesia persisted for 2 weeks in the group that received vibration stimulation."1.34Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. ( Baron, R; Chung, JM; Chung, K; Kim, HK; Lee, I; Schattschneider, J, 2007)
"Mechanical hyperalgesia was clearly observed during ethanol consumption and even after ethanol withdrawal, and lasted for 14 weeks."1.34Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption. ( Miyoshi, K; Narita, M; Suzuki, T, 2007)
"Pretreatment with naloxone, an opioid receptor antagonist (1."1.31Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. ( Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C, 2002)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's3 (23.08)29.6817
2010's9 (69.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ismail, CAN1
Suppian, R1
Abd Aziz, CB1
Haris, K1
Long, I1
Ferrier, J1
Bayet-Robert, M1
Pereira, B1
Daulhac, L1
Eschalier, A1
Pezet, D1
Moulinoux, JP1
Balayssac, D1
Wang, EM1
Li, WT1
Yan, XJ1
Chen, X1
Liu, Q1
Feng, CC1
Cao, ZJ1
Fang, JY1
Chen, SL1
Gu, X1
Zhang, J1
Ma, Z1
Wang, J1
Zhou, X1
Jin, Y1
Xia, X1
Gao, Q1
Mei, F1
Ivanusic, JJ1
Beaini, D1
Hatch, RJ1
Staikopoulos, V1
Sessle, BJ1
Jennings, EA1
Rondon, ES1
Vieira, AS1
Valadão, CA1
Parada, CA1
Mihara, Y1
Egashira, N1
Sada, H1
Kawashiri, T1
Ushio, S1
Yano, T1
Ikesue, H1
Oishi, R1
Wang, W2
Mei, XP1
Wei, YY1
Zhang, MM1
Zhang, T1
Xu, LX1
Wu, SX1
Li, YQ1
Li, S1
Cao, J1
Yang, X1
Suo, ZW1
Shi, L1
Liu, YN1
Yang, HB1
Hu, XD1
Kim, HK1
Schattschneider, J1
Lee, I1
Chung, K1
Baron, R1
Chung, JM1
Narita, M2
Miyoshi, K1
Suzuki, T1
Boyce, S1
Wyatt, A1
Webb, JK1
O'Donnell, R1
Mason, G1
Rigby, M1
Sirinathsinghji, D1
Hill, RG1
Rupniak, NM1
Sakurada, T1
Watanabe, C1
Okuda, K1
Sugiyama, A1
Moriyama, T1
Sakurada, C1
Tan-No, K1
Sakurada, S1

Other Studies

13 other studies available for ifenprodil and Allodynia

ArticleYear
Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of
    Diabetes & metabolism journal, 2019, Volume: 43, Issue:2

    Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disea

2019
A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Acute Disease; Animals; Antineoplastic Agents; Behavior, Animal; Cold Temperature; Diet; Glutamic Ac

2013
Vagal afferent-dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA-NR2B receptors in rats.
    Neurogastroenterology and motility, 2015, Volume: 27, Issue:9

    Topics: Abdominal Muscles; Afferent Pathways; Animals; Central Amygdaloid Nucleus; Hyperalgesia; Male; Nocic

2015
The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain.
    European journal of pain (London, England), 2010, Volume: 14, Issue:5

    Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Cells, Cultured;

2010
Peripheral N-methyl-d-aspartate receptors contribute to mechanical hypersensitivity in a rat model of inflammatory temporomandibular joint pain.
    European journal of pain (London, England), 2011, Volume: 15, Issue:2

    Topics: Analysis of Variance; Animals; Blotting, Western; Excitatory Amino Acid Antagonists; Hyperalgesia; I

2011
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
    European journal of pharmacology, 2010, Nov-25, Volume: 647, Issue:1-3

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glut

2010
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
    Molecular pain, 2011, Jan-20, Volume: 7

    Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles

2011
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain.
    Brain, behavior, and immunity, 2011, Volume: 25, Issue:7

    Topics: Animals; Astrocytes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hype

2011
NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice.
    Journal of neuroscience research, 2011, Volume: 89, Issue:11

    Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Mice; N-Methylaspartate; Pain Measur

2011
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli.
    Pain, 2007, Volume: 129, Issue:1-2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Dr

2007
Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption.
    Life sciences, 2007, Feb-06, Volume: 80, Issue:9

    Topics: Alcohol Drinking; Animals; Chronic Disease; Disease Models, Animal; Ethanol; Hyperalgesia; Immunoblo

2007
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
    Neuropharmacology, 1999, Volume: 38, Issue:5

    Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excita

1999
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
    Brain research. Molecular brain research, 2002, Jan-31, Volume: 98, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Di

2002