lactic acid has been researched along with Allodynia in 18 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended." | 7.81 | Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015) |
| "We analyzed the relationship between the frequency of response at each sensation (stinging, burning, and itching) during a lactic acid sting test and the current perception threshold (CPT) value of each frequency." | 3.83 | Itching sensation and neuronal sensitivity of the skin. ( An, SM; Ham, H; Kim, HO; Koh, JS; Lee, E; Lee, EJ, 2016) |
| " In the CPIP acute phase, we observed mechanical and cold allodynia; increased levels of tumor necrosis factor-α (hind paw), ischemia-modified albumin (IMA) (serum), protein carbonyl (hind paw and spinal cord), lactate (serum), and 4-hydroxy-2-nonenal (4-HNE, hind paw and spinal cord); and higher myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAGase) activities (hind paw)." | 3.83 | Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms. ( Bochi, GV; da Silva, MA; de Prá, SD; Ferreira, J; Klafke, JZ; Moresco, RN; Rigo, FK; Rossato, MF; Trevisan, G; Walker, CI, 2016) |
| " Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended." | 3.81 | Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015) |
| "Investigate proprioceptive allodynia after experimental tooth clenching exercises (study II)." | 2.78 | Experimental tooth clenching. A model for studying mechanisms of muscle pain. ( Dawson, A, 2013) |
| "Bupivacaine is a commonly used local anesthetic in postoperative pain management." | 1.48 | Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. ( Dai, F; Hurwitz, O; LaMotte, RH; Ma, C; Shimada, SG; Tian, D; Wang, T; Zhou, J, 2018) |
| "Opioid-induced hyperalgesia (OIH) is one of the major problems associated with prolonged use of opioids for the treatment of chronic pain." | 1.43 | PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα. ( Hu, X; Huang, F; Liu, Y; Szymusiak, M; Tian, X; Wang, ZJ, 2016) |
| "Chronic muscle pain is a significant health problem leading to disability[1]." | 1.42 | Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats. ( Gregory, NS; Sluka, KA; Whitley, PE, 2015) |
| "Daily stavudine administration induced mechanical hyperalgesia within three weeks, which was sustained until week six, but the hyperalgesia was not associated with neuronal apoptosis or necrosis, or elevated IL-6 concentrations in the spinal cord." | 1.35 | Hyperalgesia induced by oral stavudine administration to rats does not depend on spinal neuronal cell death, or on spinal or systemic inflammatory cytokine secretion, or metabolic dysregulation. ( Kamerman, PR; Mitchell, B; Mitchell, D; Veliotes, D; Weber, J, 2009) |
| " The fatigue task altered the dose-response relationship to intramuscular acidic saline injections." | 1.34 | Muscle fatigue increases the probability of developing hyperalgesia in mice. ( Lisi, TL; Moore, SA; Sluka, KA; Yokoyama, T, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 13 (72.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, R | 1 |
| Han, S | 1 |
| Qiu, Y | 1 |
| Zhou, T | 1 |
| Wu, Y | 1 |
| Du, H | 1 |
| Xu, J | 1 |
| Wei, X | 1 |
| Wang, T | 2 |
| Hurwitz, O | 1 |
| Shimada, SG | 1 |
| Tian, D | 1 |
| Dai, F | 1 |
| Zhou, J | 1 |
| Ma, C | 1 |
| LaMotte, RH | 1 |
| Kern, K | 1 |
| Schäfer, SMG | 1 |
| Cohnen, J | 1 |
| Pierre, S | 1 |
| Osthues, T | 1 |
| Tarighi, N | 1 |
| Hohmann, S | 1 |
| Ferreiros, N | 1 |
| Brüne, B | 1 |
| Weigert, A | 1 |
| Geisslinger, G | 1 |
| Sisignano, M | 1 |
| Scholich, K | 1 |
| Miyamoto, K | 1 |
| Ishikura, KI | 1 |
| Kume, K | 1 |
| Ohsawa, M | 1 |
| Dawson, A | 1 |
| Freitas, KC | 1 |
| Hillhouse, TM | 1 |
| Leitl, MD | 1 |
| Negus, SS | 1 |
| Ham, H | 1 |
| An, SM | 1 |
| Lee, EJ | 1 |
| Lee, E | 1 |
| Kim, HO | 1 |
| Koh, JS | 1 |
| Gregory, NS | 1 |
| Whitley, PE | 1 |
| Sluka, KA | 2 |
| Klafke, JZ | 1 |
| da Silva, MA | 1 |
| Rossato, MF | 1 |
| de Prá, SD | 1 |
| Rigo, FK | 1 |
| Walker, CI | 1 |
| Bochi, GV | 1 |
| Moresco, RN | 1 |
| Ferreira, J | 1 |
| Trevisan, G | 1 |
| Jha, MK | 1 |
| Song, GJ | 1 |
| Lee, MG | 1 |
| Jeoung, NH | 1 |
| Go, Y | 1 |
| Harris, RA | 1 |
| Park, DH | 1 |
| Kook, H | 1 |
| Lee, IK | 1 |
| Suk, K | 1 |
| Hu, X | 1 |
| Huang, F | 1 |
| Szymusiak, M | 1 |
| Tian, X | 1 |
| Liu, Y | 1 |
| Wang, ZJ | 1 |
| Sun, L | 1 |
| Wang, X | 1 |
| Zhang, Y | 1 |
| Li, X | 1 |
| Ma, Y | 1 |
| Weber, J | 1 |
| Mitchell, D | 1 |
| Veliotes, D | 1 |
| Mitchell, B | 1 |
| Kamerman, PR | 1 |
| Bao, H | 1 |
| Jin, X | 1 |
| Li, L | 1 |
| Lv, F | 1 |
| Liu, T | 1 |
| Ernberg, M | 1 |
| Castrillon, EE | 1 |
| Ghafouri, B | 1 |
| Larsson, B | 1 |
| Gerdle, B | 1 |
| List, T | 1 |
| Svensson, P | 1 |
| Hasirci, V | 1 |
| Bonney, I | 1 |
| Goudas, LC | 1 |
| Shuster, L | 1 |
| Carr, DB | 1 |
| Wise, DL | 1 |
| Taguchi, T | 1 |
| Sato, J | 1 |
| Mizumura, K | 1 |
| Yokoyama, T | 1 |
| Lisi, TL | 1 |
| Moore, SA | 1 |
2 trials available for lactic acid and Allodynia
| Article | Year |
|---|---|
Experimental tooth clenching. A model for studying mechanisms of muscle pain.
Topics: Adult; Bruxism; Case-Control Studies; Cross-Over Studies; Female; Follow-Up Studies; Glutamic Acid; | 2013 |
Experimental myalgia induced by repeated infusion of acidic saline into the human masseter muscle does not cause the release of algesic substances.
Topics: Acids; Adult; Female; Glucose; Glutamic Acid; Humans; Hyperalgesia; Lactic Acid; Male; Masseter Musc | 2013 |
16 other studies available for lactic acid and Allodynia
| Article | Year |
|---|---|
Glucocorticoid regulation of lactate release from spinal astrocytes contributes to the induction of spinal LTP of C-fiber-evoked field potentials and the development of mechanical allodynia.
Topics: Animals; Astrocytes; Glucocorticoids; Hyperalgesia; Lactic Acid; Long-Term Potentiation; Mice; Pain; | 2022 |
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Lac | 2018 |
The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.
Topics: Analysis of Variance; Animals; Apoptosis; Cell Cycle Proteins; Cell Polarity; Chemotaxis; Cytokines; | 2018 |
Astrocyte-neuron lactate shuttle sensitizes nociceptive transmission in the spinal cord.
Topics: Animals; Astrocytes; Hyperalgesia; Injections, Spinal; Lactic Acid; Male; Mice; Neurons; Nociception | 2019 |
Effects of acute and sustained pain manipulations on performance in a visual-signal detection task of attention in rats.
Topics: Animals; Attention; Behavior, Animal; Edema; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Lactic A | 2015 |
Itching sensation and neuronal sensitivity of the skin.
Topics: Adult; Differential Threshold; Electric Stimulation; Electrodiagnosis; Female; Humans; Hyperalgesia; | 2016 |
Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats.
Topics: Acid Sensing Ion Channels; Adenosine Triphosphate; Animals; Hydrogen-Ion Concentration; Hyperalgesia | 2015 |
Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms.
Topics: Acetylglucosaminidase; Acute Pain; Aldehydes; Animals; Chronic Pain; Cold Temperature; Hindlimb; Hyp | 2016 |
Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Edema; Gene Expression Regulation; Hyperalgesia; I | 2015 |
PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα.
Topics: Analgesics, Opioid; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chronic Pain; Curcu | 2016 |
The evaluation of neural and vascular hyper-reactivity for sensitive skin.
Topics: Adolescent; Adult; Capsaicin; Female; Genetic Predisposition to Disease; Humans; Hyperalgesia; Lacti | 2016 |
Hyperalgesia induced by oral stavudine administration to rats does not depend on spinal neuronal cell death, or on spinal or systemic inflammatory cytokine secretion, or metabolic dysregulation.
Topics: Adiponectin; Administration, Oral; Animals; Apoptosis; Cytokines; Female; Hyperalgesia; Inflammation | 2009 |
OX26 modified hyperbranched polyglycerol-conjugated poly(lactic-co-glycolic acid) nanoparticles: synthesis, characterization and evaluation of its brain delivery ability.
Topics: Analgesics; Animals; Antibodies, Monoclonal; Brain; Glycerol; Hyperalgesia; Lactic Acid; Male; Nanoc | 2012 |
Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model.
Topics: Analgesics, Opioid; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
Augmented mechanical response of muscle thin-fiber sensory receptors recorded from rat muscle-nerve preparations in vitro after eccentric contraction.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Bradykinin; Dose-Response Relationship, Drug; El | 2005 |
Muscle fatigue increases the probability of developing hyperalgesia in mice.
Topics: Animals; Carbon Dioxide; Cumulative Trauma Disorders; Disease Models, Animal; Dose-Response Relation | 2007 |