Page last updated: 2024-08-23

ng-nitroarginine methyl ester and Allodynia

ng-nitroarginine methyl ester has been researched along with Allodynia in 91 studies

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's33 (36.26)18.2507
2000's32 (35.16)29.6817
2010's23 (25.27)24.3611
2020's3 (3.30)2.80

Authors

AuthorsStudies
Ahmadi-Zeidabadi, M; Jeddi, S; Kohlmeier, KA; Mohammadi, F; Shabani, M1
Ishioh, M; Miyagishi, S; Nozu, T; Okumura, T; Takakusaki, K1
Ayaz, B; Aydın, Ş; Çengelli Ünel, Ç; Erol, K; Kaygısız, B; Özatik, O; Ulupınar, E; Yıldırım, E1
Honda, K; Iwata, K; Kamio, N; Nagashima, H; Sato, S; Shinoda, M; Sugano, N; Suzuki, T; Watanabe, M1
Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K2
Aydin, S; Cengelli Unel, C; Donertas, B; Erol, K; Kaygisiz, B; Ozatik, O; Ulupinar, E; Yildirim, E1
Harada, S; Liu, K; Matsuura, W; Nishibori, M; Tokuyama, S1
Delphi, L; Rezayof, A; Tolou-Dabbaghian, B1
Cervantes-Durán, C; Granados-Soto, V; Murbartián, J; Quiñonez-Bastidas, GN; Rocha-González, HI1
Antunes, E; Camargo, EA; Costa, SK; Cotrim, C; Landucci, EC; Muscara, MN; Santana, DG; Silva, CI; Teixeira, SA; Toyama, MH1
Abareghi, F; Nazeri, M; Razavinasab, M; Shabani, M1
Bhattacharya, SK; Gupta, LK; Gupta, R1
Prostran, MS; Savic Vujovic, KR; Srebro, DP; Vucković, SM1
Benard, M; Bridoux, V; Caremel, R; Dechelotte, P; Ducrotte, P; Gourcerol, G; Grise, P; Langlois, L; Leroi, AM; Meleine, M; Ouelaa, W1
Otari, KV; Upasani, CD1
Ardalan, FA; Bahadori, M; Behfar, B; Dehpour, AR; Moezi, L; Paragomi, P; Paydar, MJ; Shamshiri, H1
Bosch, F; Delgado, R; Garrido, G; Garrido-Suárez, BB; Hernández, I; Luque, Y; Márquez, L; Martínez, I; Merino, N1
Chung, JM; Chung, K; Kim, HY; Lu, Y; Wang, J1
Andrade, EL; Calixto, JB; Dutra, RC; Nguelefack, TB; Paszcuk, AF; Tapondjou, LA1
Boettger, MK; Chen, Y; Reif, A; Schmitt, A; Sommer, C; Uçeyler, N1
Chen, Z; Doyle, T; Finley, A; Salvemini, D1
Egashira, N; Ikesue, H; Kawashiri, T; Mihara, Y; Oishi, R; Sada, H; Ushio, S; Yano, T1
Curcio, A; De Chiaro, M; de Novellis, V; Giordano, C; Luongo, L; Maione, S; Marabese, I; Melisi, D; Palazzo, E; Rimoli, MG; Rossi, F; Siniscalco, D; Soukupova, M1
Beitz, AJ; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY1
Berman, B; Che, CT; Fong, HH; Ip, SP; Lao, L; Sung, JJ; Tjong, YW; Wu, J1
Gupta, A; Kalonia, H; Kumar, A; Kumar, P; Meena, S1
Cheng, HT; Dauch, JR; Hsieh, W; Oh, SS; Yanik, BM1
Cheng, JT; Chuang, YC; Lin, CR; Wang, CJ; Yang, LC1
Jain, NK; Kulkarni, SK; Patil, CS; Singh, A2
Ito, S; Kitano, T; Kojima, H; Mabuchi, T; Matsumura, S; Minami, T; Nagano, T; Okuda-Ashitaka, E1
Johns, RA; Li, D; Liaw, WJ; Mao, P; Raja, SN; Tao, F; Tao, YX; Zhao, C1
Jain, NK; Kulkarni, SK; Patil, CS; Singh, VP1
Barrientos, RM; Chacur, M; Cury, Y; Gutiérrez, JM; Lomonte, B; Maier, SF; Martin, D; Milligan, ED; Poole, S; Sloan, EM; Watkins, LR; Wieseler-Frank, J1
Li, F; Sima, AA; Stevens, MJ; Zhang, W1
Flores-Murrieta, FJ; Granados-Soto, V; Medina-Santillán, R; Reyes-García, G; Rocha-González, HI; Rodríguez-Silverio, J; Terán-Rosales, F1
Kamanaka, Y; Kawabata, A; Kawao, N; Matsuya, H; Mita, Y; Sekiguchi, F; Taga, C1
Lee, CH; Lui, PW1
Kulkarni, SK; Patil, CS; Singh, S; Singh, VP1
Zhang, XC; Zhang, YQ; Zhao, ZQ1
Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M1
Chu, YC; Guan, Y; Johns, RA; Raja, SN; Skinner, J; Tao, YX1
Chacur, M; Green, P; Maier, SF; Martin, D; Milligan, E; Poole, S; Schoeniger, D; Watkins, LR; Zapata, V1
Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D1
Kamei, J; Nozaki, C; Saitoh, A1
Honda, M; Ono, H; Takasu, K; Tanabe, M1
Kulkarni, SK; Padi, SV; Patil, CS; Singh, VP1
Baamonde, A; García, V; Hidalgo, A; Juárez, L; Menéndez, L1
Li, CW; Li, P; Liu, KP; Liu, Y; Xu, YC; Xue, FS; Yang, QY1
Guan, Y; Raja, SN; Tao, YX; Yaster, M1
Chang, HM; Chen, GD; Chen, MJ; Lai, CY; Lee, SD; Lin, TB; Pan, SF; Peng, ML; Tung, KC; Wang, PY1
Doom, CM; Maruyama, KP; Nanigian, DB; Sorkin, LS1
Eneroth, A; Kristensson, K; Olsson, T; Wiesenfeld-Hallin, Z1
Gebhart, GF; Meller, ST1
Coderre, TJ; Yashpal, K1
Mashimoto, T; Ohara, A; Shibuta, S; Yoshiya, I; Zhang, P1
Babbedge, R; Dray, A; Levers, T; Thompson, SW; Urban, L1
Furness, LE; Maier, SF; Watkins, LR; Wiertelak, EP1
Furness, LE; Horan, R; Maier, SF; Martinez, J; Watkins, LR; Wiertelak, EP1
Cummings, CP; Gebhart, GF; Meller, ST; Traub, RJ1
Henry, JL; Hui-Chan, CW; Radhakrishnan, V; Yashpal, K1
Besse, D; Dubner, R; Ren, K; Ruda, MA; Thomas, DA1
Fujita, M; Nakamura, A; Shiomi, H1
Cook, M; Kajander, KC; Roche, AK; Wilcox, GL1
Berde, CB; Sholas, MG; Wilder, RT1
Goettl, VM; Larson, AA1
Aley, KO; Levine, JD1
Lawand, NB; Westlund, KN; Willis, WD1
Hara, N; Imanishi, T; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E; Onaka, M; Sakai, M; Shingu, K; Sugimoto, T1
Kuno, Y; Sato, E; Sato, I; Takano, M; Takano, Y1
Brennan, TJ; Zahn, PK1
Inoue, T; Mashimo, T; Shibuta, S; Yoshiya, I1
Iwase, K; Seo, HG; Shigenaga, Y; Takemura, M; Taniguchi, N; Yonehara, N; Yoshimura, M1
Kikkawa, R; Maeda, K; Sasaki, T; Yasuda, H1
Lin, Q; McAdoo, DJ; Willis, WD; Wu, J1
Inoue, T; Mashimo, T; Shibata, M; Shibuta, S; Yoshiya, I1
Coutinho, VS; Gebhart, FG; Urban, OM1
Linden, DR; Seybold, VS1
Dolan, S; Nolan, AM1
Coutinho, SV; Gebhart, GF; Urban, MO1
Coderre, TJ; Osborne, MG1
Asano, T; Dohi, S; Masue, T; Shimonaka, H1
Calixto, JB; Ferreira, J; Santos, AR1
Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD1
Duarte, ID; Ferreira, SH1
Höke, A; Levy, D; Tal, M; Zochodne, DW1
Fuseler, J; Grisham, M; Roerig, SC; Tedesco, LS; Wolf, R1
Haley, JE; Kitto, KF; Wilcox, GL1
Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS1
Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D1

Other Studies

91 other study(ies) available for ng-nitroarginine methyl ester and Allodynia

ArticleYear
Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.
    Scientific reports, 2020, 06-23, Volume: 10, Issue:1

    Topics: Animals; Arginine; Brain; Disease Models, Animal; Empathy; Female; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociception; Pain; Rats, Wistar

2020
Phlorizin attenuates visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139

    Topics: Abdominal Muscles; Animals; Colon; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Electromyography; Hyperalgesia; Injections, Subcutaneous; Irritable Bowel Syndrome; Lipopolysaccharides; Male; Naloxone; NG-Nitroarginine Methyl Ester; Permeability; Phlorhizin; Rats; Rats, Sprague-Dawley

2021
Protective effects of anandamide against cisplatin-induced peripheral neuropathy in rats
    Turkish journal of medical sciences, 2021, 12-13, Volume: 51, Issue:6

    Topics: Animals; Arachidonic Acids; Cisplatin; Endocannabinoids; Female; Hyperalgesia; NG-Nitroarginine Methyl Ester; Peripheral Nervous System Diseases; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley

2021
CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis-induced periodontitis in mice.
    Molecular pain, 2017, Volume: 13

    Topics: Animals; Antibodies; Antigens, Differentiation; Bacteroidaceae Infections; Disease Models, Animal; Hyperalgesia; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Pain Measurement; Periodontitis; Porphyromonas gingivalis; Receptors, CXCR4; Signal Transduction; Statistics, Nonparametric

2017
Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats.
    European journal of pharmacology, 2018, Jan-05, Volume: 818

    Topics: Analgesics; Animals; Avoidance Learning; Colon; Hyperalgesia; Lipopolysaccharides; Lovastatin; Male; NG-Nitroarginine Methyl Ester; Permeability; Rats; Rats, Sprague-Dawley; Stress, Psychological; Water

2018
Agmatine co-treatment attenuates allodynia and structural abnormalities in cisplatin-induced neuropathy in rats.
    Fundamental & clinical pharmacology, 2018, Volume: 32, Issue:3

    Topics: Agmatine; Analgesics; Animals; Animals, Newborn; Behavior, Animal; Cells, Cultured; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Ganglia, Spinal; Hyperalgesia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peripheral Nervous System Diseases; Primary Cell Culture; Rats, Sprague-Dawley; Sciatic Nerve

2018
Evidence of a role for spinal HMGB1 in ischemic stress-induced mechanical allodynia in mice.
    Brain research, 2018, 05-15, Volume: 1687

    Topics: Animals; Antibodies, Monoclonal; Brain Ischemia; Calcium-Binding Proteins; Disease Models, Animal; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; HMGB1 Protein; Hyperalgesia; Lipopolysaccharides; Male; Mice; Microfilament Proteins; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphopyruvate Hydratase; Physical Stimulation; Receptor for Advanced Glycation End Products; Spinal Cord; Toll-Like Receptor 4

2018
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
    Journal of gastroenterology and hepatology, 2019, Volume: 34, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Colon; Disease Models, Animal; Domperidone; Dopamine Antagonists; Evans Blue; Hyperalgesia; Hypoglycemic Agents; Intestinal Mucosa; Irritable Bowel Syndrome; Lipopolysaccharides; Male; Metformin; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nociception; Permeability; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Stress, Physiological; Sulpiride

2019
Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway.
    The journal of pain, 2019, Volume: 20, Issue:8

    Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Morphine; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peripheral Nerve Injuries; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2019
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
    Life sciences, 2013, Oct-17, Volume: 93, Issue:17

    Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glyburide; Hyperalgesia; Indazoles; Methiothepin; Naloxone; NG-Nitroarginine Methyl Ester; Oxadiazoles; Pain Measurement; Piperazines; Piperidones; Pyridines; Quinoxalines; Rats; Spiro Compounds

2013
Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2.
    European journal of pain (London, England), 2014, Volume: 18, Issue:5

    Topics: Animals; Enzyme Inhibitors; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pain; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine

2014
Role of nitric oxide in altered nociception and memory following chronic stress.
    Physiology & behavior, 2014, Apr-22, Volume: 129

    Topics: Animals; Anxiety; Arginine; Avoidance Learning; Chronic Disease; Electroshock; Enzyme Inhibitors; Exploratory Behavior; Hot Temperature; Hyperalgesia; Learning Disabilities; Male; Memory; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociception; Rats, Sprague-Dawley; Stress, Psychological; Swimming

2014
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
    European journal of pharmacology, 2014, Aug-05, Volume: 736

    Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Formaldehyde; Hot Temperature; Hyperalgesia; Indazoles; Male; Mice; Modafinil; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain

2014
Nitric oxide synthase modulates the antihyperalgesic effect of the NMDA receptor antagonist MK-801 on Carrageenan-induced inflammatory pain in rats.
    The Tohoku journal of experimental medicine, 2014, Volume: 234, Issue:4

    Topics: Animals; Arginine; Carrageenan; Dizocilpine Maleate; Hyperalgesia; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2014
Acute sacral nerve stimulation reduces visceral mechanosensitivity in Rat through spinal opioid pathway.
    Neurogastroenterology and motility, 2015, Volume: 27, Issue:6

    Topics: Animals; Arterial Pressure; Colon; Dilatation; Electric Stimulation; Enzyme Inhibitors; Hyperalgesia; Lumbosacral Plexus; Naloxone; Narcotic Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Reflex; Sacrococcygeal Region; Sensory Thresholds; Spinal Cord; Visceral Pain

2015
Involvement of NO-cGMP pathway in anti-hyperalgesic effect of PDE5 inhibitor tadalafil in experimental hyperalgesia.
    Inflammopharmacology, 2015, Volume: 23, Issue:4

    Topics: Animals; Carrageenan; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Rats; Rats, Wistar; Tadalafil

2015
Antinociceptive effect of chronic lithium on visceral hypersensitivity in a rat model of diarrhea-predominant irritable bowel syndrome: The role of nitric oxide pathway.
    Journal of gastroenterology and hepatology, 2009, Volume: 24, Issue:4

    Topics: Administration, Oral; Analgesics; Animals; Colon; Defecation; Diarrhea; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Guanidines; Hyperalgesia; Injections, Intraperitoneal; Irritable Bowel Syndrome; Lithium Carbonate; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Wistar; Rectum; Restraint, Physical; Stress, Psychological

2009
Pre-emptive anti-hyperalgesic effect of electroacupuncture in carrageenan-induced inflammation: role of nitric oxide.
    Brain research bulletin, 2009, Aug-14, Volume: 79, Issue:6

    Topics: Animals; Carrageenan; Electroacupuncture; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Inflammation; Ketamine; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Dioxide; Pain Measurement; Rats; Rats, Sprague-Dawley

2009
Superoxide signaling in pain is independent of nitric oxide signaling.
    Neuroreport, 2009, Oct-28, Volume: 20, Issue:16

    Topics: Animals; Antimycin A; Cyclic N-Oxides; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neuralgia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain Measurement; Peroxynitrous Acid; Reactive Oxygen Species; Signal Transduction; Spin Labels; Superoxides; Tyrosine

2009
Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Animals; Cyclic GMP; Female; Freund's Adjuvant; Glyburide; Hyperalgesia; Inflammation; KATP Channels; Male; Methanol; Mice; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Phytotherapy; Plant Extracts; Plant Roots

2010
Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice.
    Molecular pain, 2010, Mar-02, Volume: 6

    Topics: Animals; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nociceptors; RNA, Messenger; Sensory Receptor Cells; Tumor Necrosis Factor-alpha

2010
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats.
    Pain, 2011, Volume: 152, Issue:3

    Topics: Acetophenones; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Hyperalgesia; Lysophospholipids; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Organophosphonates; Oxadiazoles; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Time Factors

2011
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
    Molecular pain, 2011, Jan-20, Volume: 7

    Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles; Male; Memantine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organoplatinum Compounds; Oxaliplatin; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord

2011
The galactosylation of N(ω)-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice.
    European journal of pharmacology, 2011, Apr-10, Volume: 656, Issue:1-3

    Topics: Analgesics; Animals; Astrocytes; Blood Pressure; Caspases; Galactose; Gene Expression Regulation, Enzymologic; Glucose Transporter Type 3; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Microglia; Neuralgia; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitroarginine; Prodrugs; Psychomotor Performance; RNA, Messenger; Sciatic Nerve; Time Factors

2011
Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.
    British journal of pharmacology, 2011, Volume: 163, Issue:8

    Topics: Analgesics, Opioid; Animals; Control Groups; Disks Large Homolog 4 Protein; Enzyme Inhibitors; Guanylate Kinases; Hyperalgesia; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Spinal Cord

2011
Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats.
    Neurogastroenterology and motility, 2011, Volume: 23, Issue:7

    Topics: Animals; Animals, Newborn; Colon; Colonic Diseases; Disease Models, Animal; Electromyography; Gastrointestinal Motility; Hyperalgesia; Indazoles; Irritable Bowel Syndrome; Male; Maternal Behavior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stress, Psychological

2011
Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats.
    Indian journal of experimental biology, 2011, Volume: 49, Issue:9

    Topics: Animals; Antioxidants; Arginine; Catalase; Chronic Disease; Disease Models, Animal; Glutathione; Hyperalgesia; Lipid Peroxidation; Male; Melatonin; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Sciatic Nerve

2011
Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes.
    Glia, 2012, Volume: 60, Issue:9

    Topics: Animals; Astrocytes; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dizocilpine Maleate; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; MAP Kinase Signaling System; Mice; Nerve Net; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phosphorylation; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Up-Regulation

2012
Intrathecal clonidine decreases spinal nitric oxide release in a rat model of complete Freund's adjuvant induced inflammatory pain.
    Inflammation, 2002, Volume: 26, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Enzyme Inhibitors; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Spinal; Male; Myelitis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord

2002
Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine.
    Pharmacology, 2003, Volume: 67, Issue:3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Hyperalgesia; Male; Methylene Blue; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones; Time Factors

2003
Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.
    The European journal of neuroscience, 2003, Volume: 17, Issue:7

    Topics: Aminoquinolines; Animals; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescein; Fluorescence; Fluorescent Dyes; Functional Laterality; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Knockout; NADPH Dehydrogenase; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptin; Opioid Peptides; Peptide Fragments; Reaction Time; Spinal Cord; Spinal Cord Injuries; Time Factors

2003
Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase.
    Neuroscience, 2003, Volume: 120, Issue:3

    Topics: Animals; Behavior, Animal; Blotting, Western; Carrageenan; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Lumbosacral Region; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pain; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Time Factors

2003
Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception.
    Indian journal of experimental biology, 2004, Volume: 42, Issue:4

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Acetylcholine; Animals; Carrageenan; Cholinergic Agents; Cholinesterase Inhibitors; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Female; Guanylate Cyclase; Hyperalgesia; Male; Methylene Blue; Mice; Neostigmine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones

2004
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
    Pain, 2004, Volume: 108, Issue:1-2

    Topics: Animals; Antibodies; Biomarkers; Crotalid Venoms; Cytokines; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Interleukin-10; Interleukin-6; Lumbar Vertebrae; Male; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phospholipases A; Pressure; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Sciatica; Spinal Cord

2004
C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB/Wor rats.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 287, Issue:3

    Topics: Animals; Body Weight; C-Peptide; Diabetic Nephropathies; Enzyme Inhibitors; Hindlimb; Hot Temperature; Hyperalgesia; Insulin; Lipid Peroxidation; Male; Motor Neurons; Nerve Tissue; Neural Conduction; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Oxidative Stress; Oxidoreductases; Rats; Rats, Inbred BB; Rats, Zucker; Reaction Time; Regional Blood Flow

2004
Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat.
    European journal of pharmacology, 2004, May-10, Volume: 492, Issue:1

    Topics: Analgesics; Animals; Carrageenan; Enzyme Inhibitors; Female; Glyburide; Hyperalgesia; Inflammation; Motor Activity; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Pain Measurement; Pain Threshold; Potassium Channel Blockers; Rats; Rats, Wistar; Riboflavin

2004
The potent inducible nitric oxide synthase inhibitor ONO-1714 inhibits neuronal NOS and exerts antinociception in rats.
    Neuroscience letters, 2004, Jul-22, Volume: 365, Issue:2

    Topics: Amidines; Analgesics; Animals; Carrageenan; Cerebellum; Heating; Heterocyclic Compounds, 2-Ring; Humans; Hyperalgesia; Indazoles; Injections, Intraperitoneal; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Recombinant Proteins

2004
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury.
    Life sciences, 2004, Oct-08, Volume: 75, Issue:21

    Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrobenzenes; Pain; Pain Threshold; Piroxicam; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sulfonamides

2004
Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy.
    Pharmacology, 2004, Volume: 72, Issue:3

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Pain Threshold; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones

2004
Involvement of nitric oxide in long-term potentiation of spinal nociceptive responses in rats.
    Neuroreport, 2005, Aug-01, Volume: 16, Issue:11

    Topics: Analysis of Variance; Animals; Arginine; Drug Interactions; Enzyme Inhibitors; Evoked Potentials; Functional Laterality; Hemoglobins; Hyperalgesia; Long-Term Potentiation; Male; Nerve Fibers, Unmyelinated; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Spinal Cord; Time Factors

2005
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 372, Issue:2

    Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide

2005
Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain.
    Pain, 2005, Dec-15, Volume: 119, Issue:1-3

    Topics: Animals; Behavior, Animal; Chronic Disease; Freund's Adjuvant; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain Threshold; Posterior Horn Cells

2005
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
    The European journal of neuroscience, 2005, Volume: 22, Issue:11

    Topics: Animals; Anti-Bacterial Agents; Antibodies, Blocking; Chemokine CX3CL1; Chemokines, CX3C; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Injections, Spinal; Interleukin-6; Male; Membrane Proteins; Microglia; Microinjections; Minocycline; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord

2005
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
    European journal of pharmacology, 2006, Mar-18, Volume: 534, Issue:1-3

    Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hyperalgesia; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Pain; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley

2006
Effect of mexiletine on vincristine-induced painful neuropathy in mice.
    European journal of pharmacology, 2006, Apr-24, Volume: 536, Issue:1-2

    Topics: Animals; Arginine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mexiletine; Mice; Mice, Inbred ICR; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Pain Measurement; Pyrethrins; Vincristine

2006
Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury.
    British journal of pharmacology, 2006, Volume: 148, Issue:2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Amines; Analgesics; Animals; Atropine; Cholinesterases; Cyclohexanecarboxylic Acids; Enzyme Activation; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Intraventricular; Male; Mice; Muscarinic Antagonists; Narcotic Antagonists; Neostigmine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Sciatic Nerve; Spinal Cord; Touch; Yohimbine

2006
Sildenafil induces hyperalgesia via activation of the NO-cGMP pathway in the rat neuropathic pain model.
    Inflammopharmacology, 2006, Volume: 14, Issue:1-2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Chronic Disease; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Threshold; Piperazines; Purines; Rats; Rats, Wistar; Sciatic Neuropathy; Signal Transduction; Sildenafil Citrate; Sulfones

2006
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indoles; Loperamide; Mice; Mice, Inbred C3H; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Pain Measurement; Receptors, Opioid

2007
Effect of intrathecal NG-nitro-L-arginine methyl ester administration on Fos expression in the spinal dorsal horn in rats following sciatic nerve ligation.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2007, Volume: 45, Issue:2

    Topics: Animals; Dogs; Hyperalgesia; Immunohistochemistry; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy

2007
Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice.
    Molecular pain, 2007, Oct-08, Volume: 3

    Topics: Animals; Enzyme Inhibitors; Female; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Physical Stimulation; Spinal Cord; Spinal Nerves

2007
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:2

    Topics: Action Potentials; Anesthesia; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic GMP-Dependent Protein Kinases; Electromyography; Enzyme Inhibitors; Hyperalgesia; Neuronal Plasticity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Reflex; Signal Transduction; Spinal Cord

2008
Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Animals; Behavior, Animal; Burns; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Diltiazem; Enzyme Inhibitors; Hyperalgesia; Ibuprofen; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-Conotoxins; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Verapamil

2008
A new approach for the pathogenesis of human African trypanosomiasis.
    Bulletin de la Societe de pathologie exotique (1990), 1994, Volume: 87, Issue:5

    Topics: Animals; Arginine; Brain; CD8-Positive T-Lymphocytes; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Sensory; Ganglia, Spinal; Growth Substances; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Interferon-gamma; Mice; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Rats; Trypanosoma brucei brucei; Trypanosomiasis, African

1994
Spinal mediators of hyperalgesia.
    Drugs, 1994, Volume: 47 Suppl 5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Arginine; Calcium; Cycloleucine; Disease Models, Animal; Excitatory Amino Acids; Hot Temperature; Hyperalgesia; Male; N-Methylaspartate; Neuronal Plasticity; Neurons, Afferent; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Mechanical

1994
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
    The European journal of neuroscience, 1994, Aug-01, Volume: 6, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P

1994
Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats.
    Neuroscience letters, 1995, Mar-03, Volume: 187, Issue:2

    Topics: Animals; Arginine; Body Temperature; Brain; Hyperalgesia; Injections, Intraventricular; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Nociceptors; Rats; Rats, Sprague-Dawley

1995
No evidence for contribution of nitric oxide to spinal reflex activity in the rat spinal cord in vitro.
    Neuroscience letters, 1995, Mar-24, Volume: 188, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Electric Stimulation; Hyperalgesia; In Vitro Techniques; N-Methylaspartate; Nerve Fibers; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Reflex; Spinal Cord; Spinal Nerve Roots

1995
Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade.
    Brain research, 1994, Nov-21, Volume: 664, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Aspirin; Binding, Competitive; Disease; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord

1994
Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade.
    Brain research, 1994, Jun-27, Volume: 649, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Cordotomy; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord

1994
The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat.
    Neuroscience, 1994, Volume: 60, Issue:2

    Topics: Animals; Arginine; Carrageenan; Edema; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Spinal Cord; Stereoisomerism; Time Factors

1994
Implication of a nitric oxide synthase mechanism in the action of substance P: L-NAME blocks thermal hyperalgesia induced by endogenous and exogenous substance P in the rat.
    The European journal of neuroscience, 1995, Sep-01, Volume: 7, Issue:9

    Topics: Animals; Arginine; Enzyme Inhibitors; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Stereoisomerism; Substance P

1995
Application of nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats.
    Neuroscience letters, 1996, May-31, Volume: 210, Issue:2

    Topics: Animals; Enzyme Inhibitors; Free Radicals; Hot Temperature; Hyperalgesia; Ligation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve

1996
Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia.
    British journal of pharmacology, 1996, Volume: 117, Issue:3

    Topics: Animals; Blister; Bradykinin; Carrageenan; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain Threshold; Rats; Rats, Sprague-Dawley

1996
A nitric oxide synthesis inhibitor (L-NAME) reduces licking behavior and Fos-labeling in the spinal cord of rats during formalin-induced inflammation.
    Pain, 1996, Volume: 66, Issue:2-3

    Topics: Amino Acid Sequence; Animals; Behavior, Animal; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Molecular Sequence Data; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord

1996
NG-nitro-L-arginine methyl ester (L-NAME) prevents tachyphylaxis to local anesthetics in a dose-dependent manner.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:6

    Topics: Anesthetics, Local; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Male; Nerve Block; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Procaine; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Second Messenger Systems; Spinal Cord; Tachyphylaxis

1996
Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice.
    Pain, 1996, Volume: 67, Issue:2-3

    Topics: Analgesics; Animals; Arginine; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Peptide Fragments; Stereoisomerism; Substance P; Time Factors

1996
Dissociation of tolerance and dependence for opioid peripheral antinociception in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, May-15, Volume: 17, Issue:10

    Topics: Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Oxytocics; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Second Messenger Systems; Substance-Related Disorders

1997
Blockade of joint inflammation and secondary hyperalgesia by L-NAME, a nitric oxide synthase inhibitor.
    Neuroreport, 1997, Mar-03, Volume: 8, Issue:4

    Topics: Analgesics; Animals; Arthritis; Carrageenan; Hyperalgesia; Indazoles; Inflammation; Injections, Intra-Articular; Isomerism; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley

1997
Characterization of nociceptin hyperalgesia and allodynia in conscious mice.
    British journal of pharmacology, 1997, Volume: 121, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Receptors, GABA; Receptors, Glycine; Receptors, Opioid

1997
[Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:10

    Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Vasodilator Agents

1997
Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain.
    Anesthesiology, 1998, Volume: 88, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Motor Activity; NG-Nitroarginine Methyl Ester; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord

1998
Intrathecal administration of a new nitric oxide donor, NOC-18, produces acute thermal hyperalgesia in the rat.
    Journal of the neurological sciences, 1997, Dec-09, Volume: 153, Issue:1

    Topics: Animals; Enzyme Inhibitors; Guanylate Cyclase; Hemoglobins; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroso Compounds; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time

1997
Nitric oxide in the rat spinal cord in Freund's adjuvant-induced hyperalgesia.
    Japanese journal of pharmacology, 1997, Volume: 75, Issue:4

    Topics: Animals; Arginine; Enzyme Inhibitors; Freund's Adjuvant; Hindlimb; Hot Temperature; Hyperalgesia; Immunohistochemistry; Injections, Intravenous; Injections, Subcutaneous; Male; NADPH Dehydrogenase; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Spinal Cord

1997
Hyperalgesia and decreased neuronal nitric oxide synthase in diabetic rats.
    Neuroreport, 1998, Jan-26, Volume: 9, Issue:2

    Topics: Animals; Blotting, Western; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Ganglia, Spinal; Histocytochemistry; Hyperalgesia; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain Measurement; Rats; Rats, Sprague-Dawley

1998
Nitric oxide contributes to central sensitization following intradermal injection of capsaicin.
    Neuroreport, 1998, Mar-09, Volume: 9, Issue:4

    Topics: Analysis of Variance; Animals; Capsaicin; Hindlimb; Hyperalgesia; Injections, Intradermal; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Sprague-Dawley; Spinal Cord

1998
Rapid development of nitric oxide-induced hyperalgesia depends on an alternate to the cGMP-mediated pathway in the rat neuropathic pain model.
    Brain research, 1998, May-11, Volume: 792, Issue:2

    Topics: Animals; Antidotes; Cyclic GMP; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hemoglobins; Hot Temperature; Hyperalgesia; Ligation; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord

1998
Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia.
    Pain, 1998, Volume: 78, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Colon; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Microinjections; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Viscera; Zymosan

1998
Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide.
    Pain, 1999, Volume: 80, Issue:1-2

    Topics: Animals; Animals, Newborn; Body Temperature; Electric Stimulation; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Male; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Physical Stimulation; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Spinal Cord; Substance P

1999
N-methyl D-aspartate induced mechanical allodynia is blocked by nitric oxide synthase and cyclooxygenase-2 inhibitors.
    Neuroreport, 1999, Feb-25, Volume: 10, Issue:3

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Furans; Hyperalgesia; Injections, Spinal; Isoenzymes; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Sheep; Spinal Cord

1999
Involvement of excitatory amino acid receptors and nitric oxide in the rostral ventromedial medulla in modulating secondary hyperalgesia produced by mustard oil.
    Pain, 1999, Volume: 81, Issue:1-2

    Topics: Animals; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Hyperalgesia; Male; Medulla Oblongata; Microinjections; Mustard Plant; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nociceptors; Pain Threshold; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Triazoles

1999
Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia.
    British journal of pharmacology, 1999, Volume: 126, Issue:8

    Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Hyperalgesia; Indazoles; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pain Measurement; Rats; Rats, Long-Evans; Spinal Cord

1999
Spinal antinociceptive effect of epidural nonsteroidal antiinflammatory drugs on nitric oxide-induced hyperalgesia in rats.
    Anesthesiology, 1999, Volume: 91, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Epidural Space; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Rats; Rats, Sprague-Dawley; Spinal Cord

1999
The role of systemic, spinal and supraspinal L-arginine-nitric oxide-cGMP pathway in thermal hyperalgesia caused by intrathecal injection of glutamate in mice.
    Neuropharmacology, 1999, Volume: 38, Issue:6

    Topics: Analysis of Variance; Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine

1999
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
    The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:4

    Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indomethacin; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors

2000
L-NAME causes antinociception by stimulation of the arginine-NO-cGMP pathway.
    Mediators of inflammation, 2000, Volume: 9, Issue:1

    Topics: Analgesics; Animals; Arginine; Carrageenan; Cyclic GMP; Dinoprostone; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Phthalazines; Quinoxalines; Rats; Rats, Wistar; Signal Transduction

2000
Transient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury.
    The European journal of neuroscience, 2000, Volume: 12, Issue:7

    Topics: Animals; Axonal Transport; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Mechanoreceptors; Nerve Endings; Nerve Fibers, Myelinated; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nociceptors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sciatic Nerve

2000
Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.
    Brain research, 2001, Aug-03, Volume: 909, Issue:1-2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Analgesia; Animals; Arginine; Carrageenan; Central Nervous System; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Nociceptors; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones

2001
Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis.
    Pain, 2002, Volume: 95, Issue:3

    Topics: Animals; Arthritis; Body Weight; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Female; Hot Temperature; Hyperalgesia; Indomethacin; Lysine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Physical Stimulation; Rats; Rats, Inbred Lew

2002
Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.
    Neuroscience letters, 1992, Dec-14, Volume: 148, Issue:1-2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Cycloleucine; Hemoglobins; Hydroxylamine; Hydroxylamines; Hyperalgesia; Ibotenic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Spinal Cord; Time Factors

1992
Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
    Neuroscience, 1992, Volume: 50, Issue:1

    Topics: Analysis of Variance; Animals; Arginine; Hot Temperature; Hyperalgesia; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1992
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
    Journal of medicinal chemistry, 2011, Oct-27, Volume: 54, Issue:20

    Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalgesia; Indoles; Ligation; Neuralgia; Nitric Oxide Synthase Type I; Pain; Pyridines; Spinal Nerves; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance; Vasoconstriction

2011