ng-nitroarginine methyl ester has been researched along with Allodynia in 91 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 33 (36.26) | 18.2507 |
2000's | 32 (35.16) | 29.6817 |
2010's | 23 (25.27) | 24.3611 |
2020's | 3 (3.30) | 2.80 |
Authors | Studies |
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Ahmadi-Zeidabadi, M; Jeddi, S; Kohlmeier, KA; Mohammadi, F; Shabani, M | 1 |
Ishioh, M; Miyagishi, S; Nozu, T; Okumura, T; Takakusaki, K | 1 |
Ayaz, B; Aydın, Ş; Çengelli Ünel, Ç; Erol, K; Kaygısız, B; Özatik, O; Ulupınar, E; Yıldırım, E | 1 |
Honda, K; Iwata, K; Kamio, N; Nagashima, H; Sato, S; Shinoda, M; Sugano, N; Suzuki, T; Watanabe, M | 1 |
Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K | 2 |
Aydin, S; Cengelli Unel, C; Donertas, B; Erol, K; Kaygisiz, B; Ozatik, O; Ulupinar, E; Yildirim, E | 1 |
Harada, S; Liu, K; Matsuura, W; Nishibori, M; Tokuyama, S | 1 |
Delphi, L; Rezayof, A; Tolou-Dabbaghian, B | 1 |
Cervantes-Durán, C; Granados-Soto, V; Murbartián, J; Quiñonez-Bastidas, GN; Rocha-González, HI | 1 |
Antunes, E; Camargo, EA; Costa, SK; Cotrim, C; Landucci, EC; Muscara, MN; Santana, DG; Silva, CI; Teixeira, SA; Toyama, MH | 1 |
Abareghi, F; Nazeri, M; Razavinasab, M; Shabani, M | 1 |
Bhattacharya, SK; Gupta, LK; Gupta, R | 1 |
Prostran, MS; Savic Vujovic, KR; Srebro, DP; Vucković, SM | 1 |
Benard, M; Bridoux, V; Caremel, R; Dechelotte, P; Ducrotte, P; Gourcerol, G; Grise, P; Langlois, L; Leroi, AM; Meleine, M; Ouelaa, W | 1 |
Otari, KV; Upasani, CD | 1 |
Ardalan, FA; Bahadori, M; Behfar, B; Dehpour, AR; Moezi, L; Paragomi, P; Paydar, MJ; Shamshiri, H | 1 |
Bosch, F; Delgado, R; Garrido, G; Garrido-Suárez, BB; Hernández, I; Luque, Y; Márquez, L; Martínez, I; Merino, N | 1 |
Chung, JM; Chung, K; Kim, HY; Lu, Y; Wang, J | 1 |
Andrade, EL; Calixto, JB; Dutra, RC; Nguelefack, TB; Paszcuk, AF; Tapondjou, LA | 1 |
Boettger, MK; Chen, Y; Reif, A; Schmitt, A; Sommer, C; Uçeyler, N | 1 |
Chen, Z; Doyle, T; Finley, A; Salvemini, D | 1 |
Egashira, N; Ikesue, H; Kawashiri, T; Mihara, Y; Oishi, R; Sada, H; Ushio, S; Yano, T | 1 |
Curcio, A; De Chiaro, M; de Novellis, V; Giordano, C; Luongo, L; Maione, S; Marabese, I; Melisi, D; Palazzo, E; Rimoli, MG; Rossi, F; Siniscalco, D; Soukupova, M | 1 |
Beitz, AJ; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 1 |
Berman, B; Che, CT; Fong, HH; Ip, SP; Lao, L; Sung, JJ; Tjong, YW; Wu, J | 1 |
Gupta, A; Kalonia, H; Kumar, A; Kumar, P; Meena, S | 1 |
Cheng, HT; Dauch, JR; Hsieh, W; Oh, SS; Yanik, BM | 1 |
Cheng, JT; Chuang, YC; Lin, CR; Wang, CJ; Yang, LC | 1 |
Jain, NK; Kulkarni, SK; Patil, CS; Singh, A | 2 |
Ito, S; Kitano, T; Kojima, H; Mabuchi, T; Matsumura, S; Minami, T; Nagano, T; Okuda-Ashitaka, E | 1 |
Johns, RA; Li, D; Liaw, WJ; Mao, P; Raja, SN; Tao, F; Tao, YX; Zhao, C | 1 |
Jain, NK; Kulkarni, SK; Patil, CS; Singh, VP | 1 |
Barrientos, RM; Chacur, M; Cury, Y; Gutiérrez, JM; Lomonte, B; Maier, SF; Martin, D; Milligan, ED; Poole, S; Sloan, EM; Watkins, LR; Wieseler-Frank, J | 1 |
Li, F; Sima, AA; Stevens, MJ; Zhang, W | 1 |
Flores-Murrieta, FJ; Granados-Soto, V; Medina-Santillán, R; Reyes-García, G; Rocha-González, HI; Rodríguez-Silverio, J; Terán-Rosales, F | 1 |
Kamanaka, Y; Kawabata, A; Kawao, N; Matsuya, H; Mita, Y; Sekiguchi, F; Taga, C | 1 |
Lee, CH; Lui, PW | 1 |
Kulkarni, SK; Patil, CS; Singh, S; Singh, VP | 1 |
Zhang, XC; Zhang, YQ; Zhao, ZQ | 1 |
Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M | 1 |
Chu, YC; Guan, Y; Johns, RA; Raja, SN; Skinner, J; Tao, YX | 1 |
Chacur, M; Green, P; Maier, SF; Martin, D; Milligan, E; Poole, S; Schoeniger, D; Watkins, LR; Zapata, V | 1 |
Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D | 1 |
Kamei, J; Nozaki, C; Saitoh, A | 1 |
Honda, M; Ono, H; Takasu, K; Tanabe, M | 1 |
Kulkarni, SK; Padi, SV; Patil, CS; Singh, VP | 1 |
Baamonde, A; García, V; Hidalgo, A; Juárez, L; Menéndez, L | 1 |
Li, CW; Li, P; Liu, KP; Liu, Y; Xu, YC; Xue, FS; Yang, QY | 1 |
Guan, Y; Raja, SN; Tao, YX; Yaster, M | 1 |
Chang, HM; Chen, GD; Chen, MJ; Lai, CY; Lee, SD; Lin, TB; Pan, SF; Peng, ML; Tung, KC; Wang, PY | 1 |
Doom, CM; Maruyama, KP; Nanigian, DB; Sorkin, LS | 1 |
Eneroth, A; Kristensson, K; Olsson, T; Wiesenfeld-Hallin, Z | 1 |
Gebhart, GF; Meller, ST | 1 |
Coderre, TJ; Yashpal, K | 1 |
Mashimoto, T; Ohara, A; Shibuta, S; Yoshiya, I; Zhang, P | 1 |
Babbedge, R; Dray, A; Levers, T; Thompson, SW; Urban, L | 1 |
Furness, LE; Maier, SF; Watkins, LR; Wiertelak, EP | 1 |
Furness, LE; Horan, R; Maier, SF; Martinez, J; Watkins, LR; Wiertelak, EP | 1 |
Cummings, CP; Gebhart, GF; Meller, ST; Traub, RJ | 1 |
Henry, JL; Hui-Chan, CW; Radhakrishnan, V; Yashpal, K | 1 |
Besse, D; Dubner, R; Ren, K; Ruda, MA; Thomas, DA | 1 |
Fujita, M; Nakamura, A; Shiomi, H | 1 |
Cook, M; Kajander, KC; Roche, AK; Wilcox, GL | 1 |
Berde, CB; Sholas, MG; Wilder, RT | 1 |
Goettl, VM; Larson, AA | 1 |
Aley, KO; Levine, JD | 1 |
Lawand, NB; Westlund, KN; Willis, WD | 1 |
Hara, N; Imanishi, T; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E; Onaka, M; Sakai, M; Shingu, K; Sugimoto, T | 1 |
Kuno, Y; Sato, E; Sato, I; Takano, M; Takano, Y | 1 |
Brennan, TJ; Zahn, PK | 1 |
Inoue, T; Mashimo, T; Shibuta, S; Yoshiya, I | 1 |
Iwase, K; Seo, HG; Shigenaga, Y; Takemura, M; Taniguchi, N; Yonehara, N; Yoshimura, M | 1 |
Kikkawa, R; Maeda, K; Sasaki, T; Yasuda, H | 1 |
Lin, Q; McAdoo, DJ; Willis, WD; Wu, J | 1 |
Inoue, T; Mashimo, T; Shibata, M; Shibuta, S; Yoshiya, I | 1 |
Coutinho, VS; Gebhart, FG; Urban, OM | 1 |
Linden, DR; Seybold, VS | 1 |
Dolan, S; Nolan, AM | 1 |
Coutinho, SV; Gebhart, GF; Urban, MO | 1 |
Coderre, TJ; Osborne, MG | 1 |
Asano, T; Dohi, S; Masue, T; Shimonaka, H | 1 |
Calixto, JB; Ferreira, J; Santos, AR | 1 |
Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD | 1 |
Duarte, ID; Ferreira, SH | 1 |
Höke, A; Levy, D; Tal, M; Zochodne, DW | 1 |
Fuseler, J; Grisham, M; Roerig, SC; Tedesco, LS; Wolf, R | 1 |
Haley, JE; Kitto, KF; Wilcox, GL | 1 |
Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS | 1 |
Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D | 1 |
91 other study(ies) available for ng-nitroarginine methyl ester and Allodynia
Article | Year |
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Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.
Topics: Animals; Arginine; Brain; Disease Models, Animal; Empathy; Female; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociception; Pain; Rats, Wistar | 2020 |
Phlorizin attenuates visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome.
Topics: Abdominal Muscles; Animals; Colon; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Electromyography; Hyperalgesia; Injections, Subcutaneous; Irritable Bowel Syndrome; Lipopolysaccharides; Male; Naloxone; NG-Nitroarginine Methyl Ester; Permeability; Phlorhizin; Rats; Rats, Sprague-Dawley | 2021 |
Protective effects of anandamide against cisplatin-induced peripheral neuropathy in rats
Topics: Animals; Arachidonic Acids; Cisplatin; Endocannabinoids; Female; Hyperalgesia; NG-Nitroarginine Methyl Ester; Peripheral Nervous System Diseases; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 2021 |
CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis-induced periodontitis in mice.
Topics: Animals; Antibodies; Antigens, Differentiation; Bacteroidaceae Infections; Disease Models, Animal; Hyperalgesia; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Pain Measurement; Periodontitis; Porphyromonas gingivalis; Receptors, CXCR4; Signal Transduction; Statistics, Nonparametric | 2017 |
Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats.
Topics: Analgesics; Animals; Avoidance Learning; Colon; Hyperalgesia; Lipopolysaccharides; Lovastatin; Male; NG-Nitroarginine Methyl Ester; Permeability; Rats; Rats, Sprague-Dawley; Stress, Psychological; Water | 2018 |
Agmatine co-treatment attenuates allodynia and structural abnormalities in cisplatin-induced neuropathy in rats.
Topics: Agmatine; Analgesics; Animals; Animals, Newborn; Behavior, Animal; Cells, Cultured; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Ganglia, Spinal; Hyperalgesia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peripheral Nervous System Diseases; Primary Cell Culture; Rats, Sprague-Dawley; Sciatic Nerve | 2018 |
Evidence of a role for spinal HMGB1 in ischemic stress-induced mechanical allodynia in mice.
Topics: Animals; Antibodies, Monoclonal; Brain Ischemia; Calcium-Binding Proteins; Disease Models, Animal; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; HMGB1 Protein; Hyperalgesia; Lipopolysaccharides; Male; Mice; Microfilament Proteins; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphopyruvate Hydratase; Physical Stimulation; Receptor for Advanced Glycation End Products; Spinal Cord; Toll-Like Receptor 4 | 2018 |
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
Topics: AMP-Activated Protein Kinases; Animals; Colon; Disease Models, Animal; Domperidone; Dopamine Antagonists; Evans Blue; Hyperalgesia; Hypoglycemic Agents; Intestinal Mucosa; Irritable Bowel Syndrome; Lipopolysaccharides; Male; Metformin; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nociception; Permeability; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Stress, Physiological; Sulpiride | 2019 |
Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Morphine; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peripheral Nerve Injuries; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2019 |
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glyburide; Hyperalgesia; Indazoles; Methiothepin; Naloxone; NG-Nitroarginine Methyl Ester; Oxadiazoles; Pain Measurement; Piperazines; Piperidones; Pyridines; Quinoxalines; Rats; Spiro Compounds | 2013 |
Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2.
Topics: Animals; Enzyme Inhibitors; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pain; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2014 |
Role of nitric oxide in altered nociception and memory following chronic stress.
Topics: Animals; Anxiety; Arginine; Avoidance Learning; Chronic Disease; Electroshock; Enzyme Inhibitors; Exploratory Behavior; Hot Temperature; Hyperalgesia; Learning Disabilities; Male; Memory; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociception; Rats, Sprague-Dawley; Stress, Psychological; Swimming | 2014 |
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Formaldehyde; Hot Temperature; Hyperalgesia; Indazoles; Male; Mice; Modafinil; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain | 2014 |
Nitric oxide synthase modulates the antihyperalgesic effect of the NMDA receptor antagonist MK-801 on Carrageenan-induced inflammatory pain in rats.
Topics: Animals; Arginine; Carrageenan; Dizocilpine Maleate; Hyperalgesia; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2014 |
Acute sacral nerve stimulation reduces visceral mechanosensitivity in Rat through spinal opioid pathway.
Topics: Animals; Arterial Pressure; Colon; Dilatation; Electric Stimulation; Enzyme Inhibitors; Hyperalgesia; Lumbosacral Plexus; Naloxone; Narcotic Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Reflex; Sacrococcygeal Region; Sensory Thresholds; Spinal Cord; Visceral Pain | 2015 |
Involvement of NO-cGMP pathway in anti-hyperalgesic effect of PDE5 inhibitor tadalafil in experimental hyperalgesia.
Topics: Animals; Carrageenan; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Rats; Rats, Wistar; Tadalafil | 2015 |
Antinociceptive effect of chronic lithium on visceral hypersensitivity in a rat model of diarrhea-predominant irritable bowel syndrome: The role of nitric oxide pathway.
Topics: Administration, Oral; Analgesics; Animals; Colon; Defecation; Diarrhea; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Guanidines; Hyperalgesia; Injections, Intraperitoneal; Irritable Bowel Syndrome; Lithium Carbonate; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Wistar; Rectum; Restraint, Physical; Stress, Psychological | 2009 |
Pre-emptive anti-hyperalgesic effect of electroacupuncture in carrageenan-induced inflammation: role of nitric oxide.
Topics: Animals; Carrageenan; Electroacupuncture; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Inflammation; Ketamine; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Dioxide; Pain Measurement; Rats; Rats, Sprague-Dawley | 2009 |
Superoxide signaling in pain is independent of nitric oxide signaling.
Topics: Animals; Antimycin A; Cyclic N-Oxides; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neuralgia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain Measurement; Peroxynitrous Acid; Reactive Oxygen Species; Signal Transduction; Spin Labels; Superoxides; Tyrosine | 2009 |
Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation.
Topics: Animals; Cyclic GMP; Female; Freund's Adjuvant; Glyburide; Hyperalgesia; Inflammation; KATP Channels; Male; Methanol; Mice; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Phytotherapy; Plant Extracts; Plant Roots | 2010 |
Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice.
Topics: Animals; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nociceptors; RNA, Messenger; Sensory Receptor Cells; Tumor Necrosis Factor-alpha | 2010 |
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats.
Topics: Acetophenones; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Hyperalgesia; Lysophospholipids; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Organophosphonates; Oxadiazoles; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Time Factors | 2011 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles; Male; Memantine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organoplatinum Compounds; Oxaliplatin; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord | 2011 |
The galactosylation of N(ω)-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice.
Topics: Analgesics; Animals; Astrocytes; Blood Pressure; Caspases; Galactose; Gene Expression Regulation, Enzymologic; Glucose Transporter Type 3; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Microglia; Neuralgia; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitroarginine; Prodrugs; Psychomotor Performance; RNA, Messenger; Sciatic Nerve; Time Factors | 2011 |
Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.
Topics: Analgesics, Opioid; Animals; Control Groups; Disks Large Homolog 4 Protein; Enzyme Inhibitors; Guanylate Kinases; Hyperalgesia; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Spinal Cord | 2011 |
Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats.
Topics: Animals; Animals, Newborn; Colon; Colonic Diseases; Disease Models, Animal; Electromyography; Gastrointestinal Motility; Hyperalgesia; Indazoles; Irritable Bowel Syndrome; Male; Maternal Behavior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stress, Psychological | 2011 |
Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats.
Topics: Animals; Antioxidants; Arginine; Catalase; Chronic Disease; Disease Models, Animal; Glutathione; Hyperalgesia; Lipid Peroxidation; Male; Melatonin; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Sciatic Nerve | 2011 |
Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes.
Topics: Animals; Astrocytes; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dizocilpine Maleate; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; MAP Kinase Signaling System; Mice; Nerve Net; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phosphorylation; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Up-Regulation | 2012 |
Intrathecal clonidine decreases spinal nitric oxide release in a rat model of complete Freund's adjuvant induced inflammatory pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Enzyme Inhibitors; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Spinal; Male; Myelitis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Hyperalgesia; Male; Methylene Blue; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones; Time Factors | 2003 |
Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.
Topics: Aminoquinolines; Animals; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescein; Fluorescence; Fluorescent Dyes; Functional Laterality; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Knockout; NADPH Dehydrogenase; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptin; Opioid Peptides; Peptide Fragments; Reaction Time; Spinal Cord; Spinal Cord Injuries; Time Factors | 2003 |
Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase.
Topics: Animals; Behavior, Animal; Blotting, Western; Carrageenan; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Lumbosacral Region; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pain; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Time Factors | 2003 |
Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Acetylcholine; Animals; Carrageenan; Cholinergic Agents; Cholinesterase Inhibitors; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Female; Guanylate Cyclase; Hyperalgesia; Male; Methylene Blue; Mice; Neostigmine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones | 2004 |
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Topics: Animals; Antibodies; Biomarkers; Crotalid Venoms; Cytokines; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Interleukin-10; Interleukin-6; Lumbar Vertebrae; Male; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phospholipases A; Pressure; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Sciatica; Spinal Cord | 2004 |
C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB/Wor rats.
Topics: Animals; Body Weight; C-Peptide; Diabetic Nephropathies; Enzyme Inhibitors; Hindlimb; Hot Temperature; Hyperalgesia; Insulin; Lipid Peroxidation; Male; Motor Neurons; Nerve Tissue; Neural Conduction; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Oxidative Stress; Oxidoreductases; Rats; Rats, Inbred BB; Rats, Zucker; Reaction Time; Regional Blood Flow | 2004 |
Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat.
Topics: Analgesics; Animals; Carrageenan; Enzyme Inhibitors; Female; Glyburide; Hyperalgesia; Inflammation; Motor Activity; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Pain Measurement; Pain Threshold; Potassium Channel Blockers; Rats; Rats, Wistar; Riboflavin | 2004 |
The potent inducible nitric oxide synthase inhibitor ONO-1714 inhibits neuronal NOS and exerts antinociception in rats.
Topics: Amidines; Analgesics; Animals; Carrageenan; Cerebellum; Heating; Heterocyclic Compounds, 2-Ring; Humans; Hyperalgesia; Indazoles; Injections, Intraperitoneal; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Recombinant Proteins | 2004 |
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrobenzenes; Pain; Pain Threshold; Piroxicam; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sulfonamides | 2004 |
Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Pain Threshold; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones | 2004 |
Involvement of nitric oxide in long-term potentiation of spinal nociceptive responses in rats.
Topics: Analysis of Variance; Animals; Arginine; Drug Interactions; Enzyme Inhibitors; Evoked Potentials; Functional Laterality; Hemoglobins; Hyperalgesia; Long-Term Potentiation; Male; Nerve Fibers, Unmyelinated; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Spinal Cord; Time Factors | 2005 |
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide | 2005 |
Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Freund's Adjuvant; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain Threshold; Posterior Horn Cells | 2005 |
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Blocking; Chemokine CX3CL1; Chemokines, CX3C; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Injections, Spinal; Interleukin-6; Male; Membrane Proteins; Microglia; Microinjections; Minocycline; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2005 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hyperalgesia; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Pain; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley | 2006 |
Effect of mexiletine on vincristine-induced painful neuropathy in mice.
Topics: Animals; Arginine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mexiletine; Mice; Mice, Inbred ICR; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Pain Measurement; Pyrethrins; Vincristine | 2006 |
Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury.
Topics: Adrenergic alpha-2 Receptor Antagonists; Amines; Analgesics; Animals; Atropine; Cholinesterases; Cyclohexanecarboxylic Acids; Enzyme Activation; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Intraventricular; Male; Mice; Muscarinic Antagonists; Narcotic Antagonists; Neostigmine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Sciatic Nerve; Spinal Cord; Touch; Yohimbine | 2006 |
Sildenafil induces hyperalgesia via activation of the NO-cGMP pathway in the rat neuropathic pain model.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Chronic Disease; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Threshold; Piperazines; Purines; Rats; Rats, Wistar; Sciatic Neuropathy; Signal Transduction; Sildenafil Citrate; Sulfones | 2006 |
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.
Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indoles; Loperamide; Mice; Mice, Inbred C3H; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Pain Measurement; Receptors, Opioid | 2007 |
Effect of intrathecal NG-nitro-L-arginine methyl ester administration on Fos expression in the spinal dorsal horn in rats following sciatic nerve ligation.
Topics: Animals; Dogs; Hyperalgesia; Immunohistochemistry; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy | 2007 |
Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice.
Topics: Animals; Enzyme Inhibitors; Female; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Physical Stimulation; Spinal Cord; Spinal Nerves | 2007 |
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats.
Topics: Action Potentials; Anesthesia; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic GMP-Dependent Protein Kinases; Electromyography; Enzyme Inhibitors; Hyperalgesia; Neuronal Plasticity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Reflex; Signal Transduction; Spinal Cord | 2008 |
Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase.
Topics: Animals; Behavior, Animal; Burns; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Diltiazem; Enzyme Inhibitors; Hyperalgesia; Ibuprofen; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-Conotoxins; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Verapamil | 2008 |
A new approach for the pathogenesis of human African trypanosomiasis.
Topics: Animals; Arginine; Brain; CD8-Positive T-Lymphocytes; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Sensory; Ganglia, Spinal; Growth Substances; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Interferon-gamma; Mice; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Rats; Trypanosoma brucei brucei; Trypanosomiasis, African | 1994 |
Spinal mediators of hyperalgesia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Arginine; Calcium; Cycloleucine; Disease Models, Animal; Excitatory Amino Acids; Hot Temperature; Hyperalgesia; Male; N-Methylaspartate; Neuronal Plasticity; Neurons, Afferent; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Mechanical | 1994 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P | 1994 |
Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats.
Topics: Animals; Arginine; Body Temperature; Brain; Hyperalgesia; Injections, Intraventricular; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Nociceptors; Rats; Rats, Sprague-Dawley | 1995 |
No evidence for contribution of nitric oxide to spinal reflex activity in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Electric Stimulation; Hyperalgesia; In Vitro Techniques; N-Methylaspartate; Nerve Fibers; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Reflex; Spinal Cord; Spinal Nerve Roots | 1995 |
Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Aspirin; Binding, Competitive; Disease; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Cordotomy; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat.
Topics: Animals; Arginine; Carrageenan; Edema; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Spinal Cord; Stereoisomerism; Time Factors | 1994 |
Implication of a nitric oxide synthase mechanism in the action of substance P: L-NAME blocks thermal hyperalgesia induced by endogenous and exogenous substance P in the rat.
Topics: Animals; Arginine; Enzyme Inhibitors; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1995 |
Application of nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats.
Topics: Animals; Enzyme Inhibitors; Free Radicals; Hot Temperature; Hyperalgesia; Ligation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 1996 |
Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia.
Topics: Animals; Blister; Bradykinin; Carrageenan; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain Threshold; Rats; Rats, Sprague-Dawley | 1996 |
A nitric oxide synthesis inhibitor (L-NAME) reduces licking behavior and Fos-labeling in the spinal cord of rats during formalin-induced inflammation.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Molecular Sequence Data; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 1996 |
NG-nitro-L-arginine methyl ester (L-NAME) prevents tachyphylaxis to local anesthetics in a dose-dependent manner.
Topics: Anesthetics, Local; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Male; Nerve Block; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Procaine; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Second Messenger Systems; Spinal Cord; Tachyphylaxis | 1996 |
Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice.
Topics: Analgesics; Animals; Arginine; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Peptide Fragments; Stereoisomerism; Substance P; Time Factors | 1996 |
Dissociation of tolerance and dependence for opioid peripheral antinociception in rats.
Topics: Analgesics; Animals; Dinoprostone; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Oxytocics; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Second Messenger Systems; Substance-Related Disorders | 1997 |
Blockade of joint inflammation and secondary hyperalgesia by L-NAME, a nitric oxide synthase inhibitor.
Topics: Analgesics; Animals; Arthritis; Carrageenan; Hyperalgesia; Indazoles; Inflammation; Injections, Intra-Articular; Isomerism; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1997 |
Characterization of nociceptin hyperalgesia and allodynia in conscious mice.
Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Receptors, GABA; Receptors, Glycine; Receptors, Opioid | 1997 |
[Hyperalgesia induced by intrathecal administration of nitroglycerin involves NMDA receptor activation in the spinal cord].
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Vasodilator Agents | 1997 |
Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Motor Activity; NG-Nitroarginine Methyl Ester; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1998 |
Intrathecal administration of a new nitric oxide donor, NOC-18, produces acute thermal hyperalgesia in the rat.
Topics: Animals; Enzyme Inhibitors; Guanylate Cyclase; Hemoglobins; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroso Compounds; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time | 1997 |
Nitric oxide in the rat spinal cord in Freund's adjuvant-induced hyperalgesia.
Topics: Animals; Arginine; Enzyme Inhibitors; Freund's Adjuvant; Hindlimb; Hot Temperature; Hyperalgesia; Immunohistochemistry; Injections, Intravenous; Injections, Subcutaneous; Male; NADPH Dehydrogenase; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Hyperalgesia and decreased neuronal nitric oxide synthase in diabetic rats.
Topics: Animals; Blotting, Western; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Ganglia, Spinal; Histocytochemistry; Hyperalgesia; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain Measurement; Rats; Rats, Sprague-Dawley | 1998 |
Nitric oxide contributes to central sensitization following intradermal injection of capsaicin.
Topics: Analysis of Variance; Animals; Capsaicin; Hindlimb; Hyperalgesia; Injections, Intradermal; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Sprague-Dawley; Spinal Cord | 1998 |
Rapid development of nitric oxide-induced hyperalgesia depends on an alternate to the cGMP-mediated pathway in the rat neuropathic pain model.
Topics: Animals; Antidotes; Cyclic GMP; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hemoglobins; Hot Temperature; Hyperalgesia; Ligation; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 1998 |
Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Colon; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Microinjections; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Viscera; Zymosan | 1998 |
Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide.
Topics: Animals; Animals, Newborn; Body Temperature; Electric Stimulation; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Male; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Physical Stimulation; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Spinal Cord; Substance P | 1999 |
N-methyl D-aspartate induced mechanical allodynia is blocked by nitric oxide synthase and cyclooxygenase-2 inhibitors.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Furans; Hyperalgesia; Injections, Spinal; Isoenzymes; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Sheep; Spinal Cord | 1999 |
Involvement of excitatory amino acid receptors and nitric oxide in the rostral ventromedial medulla in modulating secondary hyperalgesia produced by mustard oil.
Topics: Animals; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Hyperalgesia; Male; Medulla Oblongata; Microinjections; Mustard Plant; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nociceptors; Pain Threshold; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Triazoles | 1999 |
Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Hyperalgesia; Indazoles; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pain Measurement; Rats; Rats, Long-Evans; Spinal Cord | 1999 |
Spinal antinociceptive effect of epidural nonsteroidal antiinflammatory drugs on nitric oxide-induced hyperalgesia in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Epidural Space; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Rats; Rats, Sprague-Dawley; Spinal Cord | 1999 |
The role of systemic, spinal and supraspinal L-arginine-nitric oxide-cGMP pathway in thermal hyperalgesia caused by intrathecal injection of glutamate in mice.
Topics: Analysis of Variance; Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine | 1999 |
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indomethacin; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
L-NAME causes antinociception by stimulation of the arginine-NO-cGMP pathway.
Topics: Analgesics; Animals; Arginine; Carrageenan; Cyclic GMP; Dinoprostone; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Phthalazines; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2000 |
Transient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury.
Topics: Animals; Axonal Transport; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Mechanoreceptors; Nerve Endings; Nerve Fibers, Myelinated; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nociceptors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sciatic Nerve | 2000 |
Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Analgesia; Animals; Arginine; Carrageenan; Central Nervous System; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Nociceptors; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones | 2001 |
Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis.
Topics: Animals; Arthritis; Body Weight; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Female; Hot Temperature; Hyperalgesia; Indomethacin; Lysine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Physical Stimulation; Rats; Rats, Inbred Lew | 2002 |
Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Cycloleucine; Hemoglobins; Hydroxylamine; Hydroxylamines; Hyperalgesia; Ibotenic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Spinal Cord; Time Factors | 1992 |
Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
Topics: Analysis of Variance; Animals; Arginine; Hot Temperature; Hyperalgesia; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1992 |
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalgesia; Indoles; Ligation; Neuralgia; Nitric Oxide Synthase Type I; Pain; Pyridines; Spinal Nerves; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance; Vasoconstriction | 2011 |