| Assay ID | Title | Year | Journal | Article |
|---|
| AID302678 | Agonist activity at guinea pig mu-opioid receptor by GPI assay | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| AID302674 | Agonist activity at rat mu-opioid receptor expressed in CHO cells after 90 mins by [35S]GTP-gamma-S assay | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| AID302673 | Agonist activity at human delta-opioid receptor expressed in CHO cells after 90 mins by [35S]GTP-gamma-S assay | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| AID1456637 | Half life in Kunming mouse plasma at 500 uM by RP-HPLC method | | | |
| AID554165 | Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cells | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Development of potent μ and δ opioid agonists with high lipophilicity. |
| AID1562937 | Agonist activity at MOR in Wistar rat brain membranes after 60 mins by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID489384 | Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN9.10 cells | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
| Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. |
| AID302676 | Agonist activity at rat mu-opioid receptor expressed in CHO cells by [35S]GTP-gamma-S assay relative to control | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| AID1831031 | Displacement of [3H]-DPDPE from human delta opioid receptor expressed in mouse HN9.10 cells by radioligand binding assay | 2021 | Bioorganic & medicinal chemistry, 12-01, Volume: 51 | C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. |
| AID302671 | Displacement of [3H]DPDPE from human delta-opioid receptor transfected in HN9.10 cells after 3 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| AID1456634 | Displacement of [3H]DAMGO from mu-opioid receptor in Wistar rat brain membrane after 1 hr by microbeta scintillation counting method | | | |
| AID1562912 | Agonist activity at MOR/CB1R/CB2R receptor in Wistar rat brain membranes after 60 mins by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID1831030 | Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cells assessed as inhibition constant by radioligand binding assay | 2021 | Bioorganic & medicinal chemistry, 12-01, Volume: 51 | C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. |
| AID1831029 | Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cells by radioligand binding assay | 2021 | Bioorganic & medicinal chemistry, 12-01, Volume: 51 | C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. |
| AID1562910 | Selectivity ratio of Ki for displacement of [3H]HS-665 from KOR in guinea pig brain membranes to Ki for displacement of [3H]DAMGO from MOR in Wistar rat brain membranes | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID1456642 | Antinociceptive activity in mouse model of thermal-induced nociception assessed as increase in latency to tail withdrawal at 5 mg/kg, sc measured up to 50 mins by tail flick test | | | |
| AID1562931 | Agonist activity at MOR/CB1R/CB2R receptor in Wistar rat brain membranes at 10 uM after 60 mins by [35S]-GTPgammaS binding assay relative to control | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID1831033 | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in mouse HN9.10 cells by radioligand binding assay | 2021 | Bioorganic & medicinal chemistry, 12-01, Volume: 51 | C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. |
| AID1562925 | Effect on nociception of the contralateral paw in rat model of sodium iodoacetate-induced osteoarthritis assessed as paw withdrawal threshold in early phase at 7 ug administered as intrathecal injection measured up to 45 mins by Von Frey test (Rvb = 44 +/ | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID1562939 | Agonist activity at MOR in Wistar rat brain membranes after 60 mins by [35S]-GTPgammaS binding assay relative to control | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID1831032 | Displacement of [3H]-DPDPE from human delta opioid receptor expressed in mouse HN9.10 cells assessed as inhibition constant by radioligand binding assay | 2021 | Bioorganic & medicinal chemistry, 12-01, Volume: 51 | C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. |
| AID489382 | Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
| Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. |
| AID1562911 | Displacement of [3H]WIN-55,212-2 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysis | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID554164 | Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN9.10 cells | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Development of potent μ and δ opioid agonists with high lipophilicity. |
| AID302672 | Displacement of [3H]DAMGO from rat mu-opioid receptor transfected in HN9.10 cells after 3 hrs | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| AID554170 | Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Development of potent μ and δ opioid agonists with high lipophilicity. |
| AID1562907 | Displacement of [3H]Ile5,6-deltorphin-2 from DOR in Wistar rat brain membranes after 60 mins by liquid scintillation analysis | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID554167 | Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding relative to control | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Development of potent μ and δ opioid agonists with high lipophilicity. |
| AID1562903 | Displacement of [3H]JWH-018 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysis | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID302675 | Agonist activity at human delta-opioid receptor expressed in CHO cells by [35S]GTP-gamma-S assay relative to control | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| AID1562926 | Effect on nociception of the contralateral paw in rat model of sodium iodoacetate-induced osteoarthritis assessed as paw withdrawal threshold in late phase at 7 ug administered as intrathecal injection measured after 60 to 90 mins by Von Frey test (Rvb = | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID1456633 | Selectivity ratio of Ki for displacement of [3H]DPDPE from delta-opioid receptor in Wistar rat membrane to Ki for displacement of [3H]DAMGO from mu-opioid receptor in Wistar rat brain membrane | | | |
| AID489392 | Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
| Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. |
| AID554166 | Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Development of potent μ and δ opioid agonists with high lipophilicity. |
| AID489385 | Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cells | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
| Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. |
| AID1562908 | Displacement of [3H]HS-665 from KOR in guinea pig brain membranes after 60 mins by liquid scintillation analysis | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID554168 | Agonist activity at rat mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Development of potent μ and δ opioid agonists with high lipophilicity. |
| AID554171 | Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Development of potent μ and δ opioid agonists with high lipophilicity. |
| AID1562906 | Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes after 60 mins by liquid scintillation analysis | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID1456636 | Half life in Kunming mouse brain homogenate at 500 uM by RP-HPLC method | | | |
| AID554169 | Agonist activity at rat mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding relative to control | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Development of potent μ and δ opioid agonists with high lipophilicity. |
| AID1562909 | Selectivity ratio, ratio of Ki for displacement of [3H]Ile5,6-deltorphin-2 from DOR in Wistar rat brain membranes to Ki for displacement of [3H]DAMGO from MOR in Wistar rat brain membranes | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID1456635 | Displacement of [3H]DPDPE from delta-opioid receptor in Wistar rat brain membrane after 3 hrs by microbeta scintillation counting method | | | |
| AID1562928 | Antiallodynic activity in sodium iodoacetate-induced rat model of osteoarthritis assessed as increase in maximum effect in early phase at 7 ug administered as intrathecal injection measured up to 45 mins by Von Frey test | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors. |
| AID302677 | Agonist activity at mouse delta-opioid receptor by MVD assay | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| AID1456638 | Antinociceptive activity in mouse model of thermal-induced nociception assessed as increase in latency to tail withdrawal at 10 nmol/kg, icv measured up to 50 mins by tail flick test | | | |
| AID1798042 | Radioligand Labeled Binding Assay and [35S]GTP-gamma-S Binding Assay from Article 10.1021/jm061465o: \\Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.\\ | 2007 | Journal of medicinal chemistry, Nov-01, Volume: 50, Issue:22
| Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |