Page last updated: 2024-10-20

uric acid and Allodynia

uric acid has been researched along with Allodynia in 20 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Research Excerpts

ExcerptRelevanceReference
"To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis."7.96Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020)
"To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis."3.96Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020)
"The underlying mechanism of muscle hyperalgesia associated with locally recruited neutrophils forming NETs due to increased tissue UA levels potentially plays a significant role in creating a vicious circle of muscle pain."1.72Tissue accumulation of neutrophil extracellular traps mediates muscle hyperalgesia in a mouse model. ( Aizawa, T; Chen, W; Fujita, R; Hagiwara, Y; Kanzaki, M; Li, Y; Ogawa, K; Suzuki, K; Takahashi, T; Tsuchiya, M; Yabe, Y; Yoshida, S, 2022)
"Acute gouty arthritis was induced by injection of monosodium urate (MSU) crystals into the ankle joint of mice."1.72Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice. ( Li, G; Xu, X; Yuan, Z; Zhang, G; Zhang, S, 2022)
"Resolvin D1 (RvD1) is a specialized pro-resolving lipid mediator with anti-inflammatory and analgesic proprieties."1.72RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice. ( Amaral, FA; Andrade, KC; Artero, NA; Badaro-Garcia, S; Bertozzi, MM; Borghi, SM; Casagrande, R; Fattori, V; Ferraz, CR; Manchope, MF; Rasquel-Oliveira, F; Rogers, MS; Saraiva-Santos, T; Staurengo-Ferrari, L; Teixeira, MM; Verri, WA; Zaninelli, TH, 2022)
"Mechanical allodynia and grip force tests were performed before and 1, 3, 6, 9, 12, 24, 48 and 72h after the downhill running."1.43Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats. ( Braga, AC; Bresciani, G; Busanello, GL; Chagas, PM; Fighera, MR; Furian, AF; Lima, FD; Nogueira, CW; Oliveira, MS; Retamoso, LT; Ribeiro, LR; Royes, LF; Silveira, ME, 2016)
"Gout was induced by the injection of MSU crystals into the knee joints of mice."1.42A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. ( Amaral, FA; Canesso, MC; De Leon, E; Galvão, I; Garcia, CC; Harper, JL; Macia, L; Mackay, CR; Martins, FS; Maslowski, KM; Nicoli, JR; Shim, D; Teixeira, MM; Vieira, AT, 2015)
"Gout was induced by injecting MSU crystals into the joints of mice."1.38NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. ( Amaral, FA; Coelho, FM; Costa, VV; Cunha, FQ; Cunha, LD; Cunha, TM; Fagundes, CT; Peres, RS; Quesniaux, V; Ryffel, B; Sachs, D; Silveira, TN; Soriani, FM; Souza, DG; Tavares, LD; Teixeira, MM; Zamboni, DS, 2012)
"The significant inhibition of joint hyperalgesia in neutropenic animals was associated to significantly decreased cell influx, myeloperoxidase activity, nitric oxide, and nitrotyrosine levels in the joint exudates, as compared to naive rats."1.34Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis. ( Bezerra, MM; Brain, SD; Girão, VC; Greenacre, S; Keeble, J; Rocha, FA, 2007)
"Hyperalgesia was evaluated by the reduction in the threshold of the head-withdrawal response to pressure stimulation, and inflammatory change was determined by the quantitative Evans-blue test and light-microscopic examination of histological sections."1.29Hyperalgesic change over the craniofacial area following urate crystal injection into the rabbit's temporomandibular joint. ( Okuda-Akabane, K, 1994)
"We present here two models of prolonged hyperalgesia in the rat induced by intra-articular injection of uric acid or Freund's complete adjuvant into the knee."1.29The effect of capsaicin and conventional analgesics in two models of monoarthritis in the rat. ( Davis, A; Perkins, MN, 1993)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's3 (15.00)18.2507
2000's4 (20.00)29.6817
2010's6 (30.00)24.3611
2020's6 (30.00)2.80

Authors

AuthorsStudies
Suzuki, K1
Tsuchiya, M1
Yoshida, S1
Ogawa, K1
Chen, W1
Kanzaki, M1
Takahashi, T1
Fujita, R1
Li, Y1
Yabe, Y1
Aizawa, T1
Hagiwara, Y1
Xu, X2
Yuan, Z1
Zhang, S2
Li, G2
Zhang, G2
Zaninelli, TH1
Fattori, V1
Saraiva-Santos, T1
Badaro-Garcia, S1
Staurengo-Ferrari, L1
Andrade, KC1
Artero, NA1
Ferraz, CR1
Bertozzi, MM1
Rasquel-Oliveira, F1
Manchope, MF1
Amaral, FA4
Teixeira, MM4
Borghi, SM1
Rogers, MS1
Casagrande, R1
Verri, WA1
Zhang, F1
Liu, S1
Jin, L1
Tang, L1
Zhao, X1
Yang, T1
Wang, Y1
Huo, B1
Liu, R1
Li, H1
Qiu, J1
Xu, HL1
Li, SK1
Xue, XA1
Chen, ZY1
Hua, YH1
Chen, L1
Mola, M1
Deng, X1
Mei, Z1
Huang, X1
Shu, G1
Wei, L1
Hou, X1
Lan, Z1
Lin, Q1
Vieira, AT1
Macia, L1
Galvão, I2
Martins, FS1
Canesso, MC1
Garcia, CC1
Maslowski, KM1
De Leon, E1
Shim, D1
Nicoli, JR1
Harper, JL1
Mackay, CR1
Bastos, LF1
Oliveira, TH1
Dias, AC1
Oliveira, VL1
Tavares, LD2
Costa, VV2
Soriani, FM2
Szymkowski, DE1
Ryffel, B2
Souza, DG2
Retamoso, LT1
Silveira, ME1
Lima, FD1
Busanello, GL1
Bresciani, G1
Ribeiro, LR1
Chagas, PM1
Nogueira, CW1
Braga, AC1
Furian, AF1
Oliveira, MS1
Fighera, MR1
Royes, LF1
Torres, R1
Macdonald, L1
Croll, SD1
Reinhardt, J1
Dore, A1
Stevens, S1
Hylton, DM1
Rudge, JS1
Liu-Bryan, R1
Terkeltaub, RA1
Yancopoulos, GD1
Murphy, AJ1
Sachs, D1
Coelho, FM1
Fagundes, CT1
Silveira, TN1
Cunha, LD1
Zamboni, DS1
Quesniaux, V1
Peres, RS1
Cunha, TM1
Cunha, FQ1
Silva, CR1
Fröhlich, JK1
Oliveira, SM1
Cabreira, TN1
Rossato, MF1
Trevisan, G1
Froeder, AL1
Bochi, GV1
Moresco, RN1
Athayde, ML1
Ferreira, J1
Déciga-Campos, M1
Díaz-Reval, MI1
Ventura-Martínez, R1
López-Muñoz, FJ1
Bezerra, MM1
Brain, SD1
Girão, VC1
Greenacre, S1
Keeble, J1
Rocha, FA1
Okuda-Akabane, K1
Davis, A1
Perkins, MN2
Liu, T1
Knight, KR1
Tracey, DJ1
Campbell, EA1
Dubinsky, B1
Gebre-Mariam, S1
Capetola, RJ1
Rosenthale, ME1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessing the Role of the NLRP3 Inflammasome in Driving Inflammation in Affected Joints of Patients With Intercritical Gout[NCT04125459]8 participants (Anticipated)Observational2020-01-22Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for uric acid and Allodynia

ArticleYear
The antialgesic drugs: human therapeutic correlates of their potency in laboratory animal models of hyperalgesia.
    Agents and actions, 1987, Volume: 20, Issue:1-2

    Topics: Acetylcholine; Administration, Oral; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ar

1987

Other Studies

19 other studies available for uric acid and Allodynia

ArticleYear
Tissue accumulation of neutrophil extracellular traps mediates muscle hyperalgesia in a mouse model.
    Scientific reports, 2022, 03-09, Volume: 12, Issue:1

    Topics: Animals; Disease Models, Animal; DNA; Extracellular Traps; Febuxostat; Histones; Hyperalgesia; Mice;

2022
Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2022, Volume: 71, Issue:4

    Topics: Animals; Arthritis, Gouty; Calcium; Edema; Hyperalgesia; Mice; Pain; Transient Receptor Potential Ch

2022
RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice.
    British journal of pharmacology, 2022, Volume: 179, Issue:18

    Topics: Animals; Arthritis, Gouty; Calcitonin Gene-Related Peptide; Docosahexaenoic Acids; Hyperalgesia; Inf

2022
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
    Pharmacology, 2020, Volume: 105, Issue:7-8

    Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Ca

2020
Modulations of Na
    Inflammation, 2021, Volume: 44, Issue:4

    Topics: Animals; Arthritis, Gouty; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; NAV1.8 Volta

2021
Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model.
    BioMed research international, 2021, Volume: 2021

    Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Hyperalgesia; Inflammation; Injections, Intra-Art

2021
Dolichos falcata Klein attenuated the inflammation induced by monosodium urate crystals in vivo and in vitro.
    Journal of ethnopharmacology, 2013, Nov-25, Volume: 150, Issue:2

    Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Gouty; Cell Line; Cytokines; Dolichos; Fe

2013
A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:6

    Topics: Animals; Cell Movement; Chemokine CXCL1; Disease Models, Animal; Fatty Acids, Volatile; Gout; Hypera

2015
Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout.
    European journal of immunology, 2016, Volume: 46, Issue:1

    Topics: Animals; Disease Models, Animal; Gout; Hyperalgesia; Inflammation; Interleukin-1beta; Knee Joint; Ma

2016
Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats.
    Life sciences, 2016, May-01, Volume: 152

    Topics: Animals; Antioxidants; Calcium-Transporting ATPases; Hand Strength; Hyperalgesia; Male; Muscle, Skel

2016
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.
    Annals of the rheumatic diseases, 2009, Volume: 68, Issue:10

    Topics: Animals; Arthritis, Experimental; Arthritis, Gouty; Biomarkers; Colchicine; Cytokines; Disease Model

2009
NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
    Arthritis and rheumatism, 2012, Volume: 64, Issue:2

    Topics: Animals; Carrier Proteins; Caspase 1; Cytokines; Gout; Hyperalgesia; Inflammasomes; Inflammation; In

2012
The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model.
    Journal of ethnopharmacology, 2013, Jan-09, Volume: 145, Issue:1

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Biomarkers, Pharmacological; Disease

2013
Participation of the serotonin system in rofecoxib-induced antinociception.
    Proceedings of the Western Pharmacology Society, 2004, Volume: 47

    Topics: Analgesics; Animals; Cyclooxygenase Inhibitors; Female; Hyperalgesia; Indoles; Injections, Intravent

2004
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 374, Issue:4

    Topics: Acute Disease; Animals; Arthritis, Experimental; Hindlimb; Hyperalgesia; Injections, Intra-Articular

2007
Hyperalgesic change over the craniofacial area following urate crystal injection into the rabbit's temporomandibular joint.
    Journal of oral rehabilitation, 1994, Volume: 21, Issue:3

    Topics: Analysis of Variance; Animals; Arthritis; Facial Pain; Female; Hyperalgesia; Male; Masticatory Muscl

1994
The effect of capsaicin and conventional analgesics in two models of monoarthritis in the rat.
    Agents and actions, 1993, Volume: 38 Spec No

    Topics: Animals; Arthritis, Experimental; Capsaicin; Disease Models, Animal; Enflurane; Female; Freund's Adj

1993
Hyperalgesia due to nerve injury-role of peroxynitrite.
    Neuroscience, 2000, Volume: 97, Issue:1

    Topics: Animals; Hyperalgesia; Hyperthermia, Induced; Immunohistochemistry; Male; Nerve Compression Syndrome

2000
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
    British journal of pharmacology, 1992, Volume: 107, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Female; F

1992