uric acid has been researched along with Allodynia in 20 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis." | 7.96 | Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020) |
| "To determine the effects of retigabine and flupirtine on pain behavior associated with monosodium urate (MSU)-induced gout arthritis." | 3.96 | Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. ( Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X, 2020) |
| "The underlying mechanism of muscle hyperalgesia associated with locally recruited neutrophils forming NETs due to increased tissue UA levels potentially plays a significant role in creating a vicious circle of muscle pain." | 1.72 | Tissue accumulation of neutrophil extracellular traps mediates muscle hyperalgesia in a mouse model. ( Aizawa, T; Chen, W; Fujita, R; Hagiwara, Y; Kanzaki, M; Li, Y; Ogawa, K; Suzuki, K; Takahashi, T; Tsuchiya, M; Yabe, Y; Yoshida, S, 2022) |
| "Acute gouty arthritis was induced by injection of monosodium urate (MSU) crystals into the ankle joint of mice." | 1.72 | Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice. ( Li, G; Xu, X; Yuan, Z; Zhang, G; Zhang, S, 2022) |
| "Resolvin D1 (RvD1) is a specialized pro-resolving lipid mediator with anti-inflammatory and analgesic proprieties." | 1.72 | RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice. ( Amaral, FA; Andrade, KC; Artero, NA; Badaro-Garcia, S; Bertozzi, MM; Borghi, SM; Casagrande, R; Fattori, V; Ferraz, CR; Manchope, MF; Rasquel-Oliveira, F; Rogers, MS; Saraiva-Santos, T; Staurengo-Ferrari, L; Teixeira, MM; Verri, WA; Zaninelli, TH, 2022) |
| "Mechanical allodynia and grip force tests were performed before and 1, 3, 6, 9, 12, 24, 48 and 72h after the downhill running." | 1.43 | Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats. ( Braga, AC; Bresciani, G; Busanello, GL; Chagas, PM; Fighera, MR; Furian, AF; Lima, FD; Nogueira, CW; Oliveira, MS; Retamoso, LT; Ribeiro, LR; Royes, LF; Silveira, ME, 2016) |
| "Gout was induced by the injection of MSU crystals into the knee joints of mice." | 1.42 | A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. ( Amaral, FA; Canesso, MC; De Leon, E; Galvão, I; Garcia, CC; Harper, JL; Macia, L; Mackay, CR; Martins, FS; Maslowski, KM; Nicoli, JR; Shim, D; Teixeira, MM; Vieira, AT, 2015) |
| "Gout was induced by injecting MSU crystals into the joints of mice." | 1.38 | NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. ( Amaral, FA; Coelho, FM; Costa, VV; Cunha, FQ; Cunha, LD; Cunha, TM; Fagundes, CT; Peres, RS; Quesniaux, V; Ryffel, B; Sachs, D; Silveira, TN; Soriani, FM; Souza, DG; Tavares, LD; Teixeira, MM; Zamboni, DS, 2012) |
| "The significant inhibition of joint hyperalgesia in neutropenic animals was associated to significantly decreased cell influx, myeloperoxidase activity, nitric oxide, and nitrotyrosine levels in the joint exudates, as compared to naive rats." | 1.34 | Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis. ( Bezerra, MM; Brain, SD; Girão, VC; Greenacre, S; Keeble, J; Rocha, FA, 2007) |
| "Hyperalgesia was evaluated by the reduction in the threshold of the head-withdrawal response to pressure stimulation, and inflammatory change was determined by the quantitative Evans-blue test and light-microscopic examination of histological sections." | 1.29 | Hyperalgesic change over the craniofacial area following urate crystal injection into the rabbit's temporomandibular joint. ( Okuda-Akabane, K, 1994) |
| "We present here two models of prolonged hyperalgesia in the rat induced by intra-articular injection of uric acid or Freund's complete adjuvant into the knee." | 1.29 | The effect of capsaicin and conventional analgesics in two models of monoarthritis in the rat. ( Davis, A; Perkins, MN, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 6 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Suzuki, K | 1 |
| Tsuchiya, M | 1 |
| Yoshida, S | 1 |
| Ogawa, K | 1 |
| Chen, W | 1 |
| Kanzaki, M | 1 |
| Takahashi, T | 1 |
| Fujita, R | 1 |
| Li, Y | 1 |
| Yabe, Y | 1 |
| Aizawa, T | 1 |
| Hagiwara, Y | 1 |
| Xu, X | 2 |
| Yuan, Z | 1 |
| Zhang, S | 2 |
| Li, G | 2 |
| Zhang, G | 2 |
| Zaninelli, TH | 1 |
| Fattori, V | 1 |
| Saraiva-Santos, T | 1 |
| Badaro-Garcia, S | 1 |
| Staurengo-Ferrari, L | 1 |
| Andrade, KC | 1 |
| Artero, NA | 1 |
| Ferraz, CR | 1 |
| Bertozzi, MM | 1 |
| Rasquel-Oliveira, F | 1 |
| Manchope, MF | 1 |
| Amaral, FA | 4 |
| Teixeira, MM | 4 |
| Borghi, SM | 1 |
| Rogers, MS | 1 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Zhang, F | 1 |
| Liu, S | 1 |
| Jin, L | 1 |
| Tang, L | 1 |
| Zhao, X | 1 |
| Yang, T | 1 |
| Wang, Y | 1 |
| Huo, B | 1 |
| Liu, R | 1 |
| Li, H | 1 |
| Qiu, J | 1 |
| Xu, HL | 1 |
| Li, SK | 1 |
| Xue, XA | 1 |
| Chen, ZY | 1 |
| Hua, YH | 1 |
| Chen, L | 1 |
| Mola, M | 1 |
| Deng, X | 1 |
| Mei, Z | 1 |
| Huang, X | 1 |
| Shu, G | 1 |
| Wei, L | 1 |
| Hou, X | 1 |
| Lan, Z | 1 |
| Lin, Q | 1 |
| Vieira, AT | 1 |
| Macia, L | 1 |
| Galvão, I | 2 |
| Martins, FS | 1 |
| Canesso, MC | 1 |
| Garcia, CC | 1 |
| Maslowski, KM | 1 |
| De Leon, E | 1 |
| Shim, D | 1 |
| Nicoli, JR | 1 |
| Harper, JL | 1 |
| Mackay, CR | 1 |
| Bastos, LF | 1 |
| Oliveira, TH | 1 |
| Dias, AC | 1 |
| Oliveira, VL | 1 |
| Tavares, LD | 2 |
| Costa, VV | 2 |
| Soriani, FM | 2 |
| Szymkowski, DE | 1 |
| Ryffel, B | 2 |
| Souza, DG | 2 |
| Retamoso, LT | 1 |
| Silveira, ME | 1 |
| Lima, FD | 1 |
| Busanello, GL | 1 |
| Bresciani, G | 1 |
| Ribeiro, LR | 1 |
| Chagas, PM | 1 |
| Nogueira, CW | 1 |
| Braga, AC | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Fighera, MR | 1 |
| Royes, LF | 1 |
| Torres, R | 1 |
| Macdonald, L | 1 |
| Croll, SD | 1 |
| Reinhardt, J | 1 |
| Dore, A | 1 |
| Stevens, S | 1 |
| Hylton, DM | 1 |
| Rudge, JS | 1 |
| Liu-Bryan, R | 1 |
| Terkeltaub, RA | 1 |
| Yancopoulos, GD | 1 |
| Murphy, AJ | 1 |
| Sachs, D | 1 |
| Coelho, FM | 1 |
| Fagundes, CT | 1 |
| Silveira, TN | 1 |
| Cunha, LD | 1 |
| Zamboni, DS | 1 |
| Quesniaux, V | 1 |
| Peres, RS | 1 |
| Cunha, TM | 1 |
| Cunha, FQ | 1 |
| Silva, CR | 1 |
| Fröhlich, JK | 1 |
| Oliveira, SM | 1 |
| Cabreira, TN | 1 |
| Rossato, MF | 1 |
| Trevisan, G | 1 |
| Froeder, AL | 1 |
| Bochi, GV | 1 |
| Moresco, RN | 1 |
| Athayde, ML | 1 |
| Ferreira, J | 1 |
| Déciga-Campos, M | 1 |
| Díaz-Reval, MI | 1 |
| Ventura-Martínez, R | 1 |
| López-Muñoz, FJ | 1 |
| Bezerra, MM | 1 |
| Brain, SD | 1 |
| Girão, VC | 1 |
| Greenacre, S | 1 |
| Keeble, J | 1 |
| Rocha, FA | 1 |
| Okuda-Akabane, K | 1 |
| Davis, A | 1 |
| Perkins, MN | 2 |
| Liu, T | 1 |
| Knight, KR | 1 |
| Tracey, DJ | 1 |
| Campbell, EA | 1 |
| Dubinsky, B | 1 |
| Gebre-Mariam, S | 1 |
| Capetola, RJ | 1 |
| Rosenthale, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessing the Role of the NLRP3 Inflammasome in Driving Inflammation in Affected Joints of Patients With Intercritical Gout[NCT04125459] | 8 participants (Anticipated) | Observational | 2020-01-22 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for uric acid and Allodynia
| Article | Year |
|---|---|
The antialgesic drugs: human therapeutic correlates of their potency in laboratory animal models of hyperalgesia.
Topics: Acetylcholine; Administration, Oral; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ar | 1987 |
19 other studies available for uric acid and Allodynia
| Article | Year |
|---|---|
Tissue accumulation of neutrophil extracellular traps mediates muscle hyperalgesia in a mouse model.
Topics: Animals; Disease Models, Animal; DNA; Extracellular Traps; Febuxostat; Histones; Hyperalgesia; Mice; | 2022 |
Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice.
Topics: Animals; Arthritis, Gouty; Calcium; Edema; Hyperalgesia; Mice; Pain; Transient Receptor Potential Ch | 2022 |
RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice.
Topics: Animals; Arthritis, Gouty; Calcitonin Gene-Related Peptide; Docosahexaenoic Acids; Hyperalgesia; Inf | 2022 |
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Ca | 2020 |
Modulations of Na
Topics: Animals; Arthritis, Gouty; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; NAV1.8 Volta | 2021 |
Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Hyperalgesia; Inflammation; Injections, Intra-Art | 2021 |
Dolichos falcata Klein attenuated the inflammation induced by monosodium urate crystals in vivo and in vitro.
Topics: Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis, Gouty; Cell Line; Cytokines; Dolichos; Fe | 2013 |
A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout.
Topics: Animals; Cell Movement; Chemokine CXCL1; Disease Models, Animal; Fatty Acids, Volatile; Gout; Hypera | 2015 |
Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout.
Topics: Animals; Disease Models, Animal; Gout; Hyperalgesia; Inflammation; Interleukin-1beta; Knee Joint; Ma | 2016 |
Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats.
Topics: Animals; Antioxidants; Calcium-Transporting ATPases; Hand Strength; Hyperalgesia; Male; Muscle, Skel | 2016 |
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Gouty; Biomarkers; Colchicine; Cytokines; Disease Model | 2009 |
NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
Topics: Animals; Carrier Proteins; Caspase 1; Cytokines; Gout; Hyperalgesia; Inflammasomes; Inflammation; In | 2012 |
The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Biomarkers, Pharmacological; Disease | 2013 |
Participation of the serotonin system in rofecoxib-induced antinociception.
Topics: Analgesics; Animals; Cyclooxygenase Inhibitors; Female; Hyperalgesia; Indoles; Injections, Intravent | 2004 |
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis.
Topics: Acute Disease; Animals; Arthritis, Experimental; Hindlimb; Hyperalgesia; Injections, Intra-Articular | 2007 |
Hyperalgesic change over the craniofacial area following urate crystal injection into the rabbit's temporomandibular joint.
Topics: Analysis of Variance; Animals; Arthritis; Facial Pain; Female; Hyperalgesia; Male; Masticatory Muscl | 1994 |
The effect of capsaicin and conventional analgesics in two models of monoarthritis in the rat.
Topics: Animals; Arthritis, Experimental; Capsaicin; Disease Models, Animal; Enflurane; Female; Freund's Adj | 1993 |
Hyperalgesia due to nerve injury-role of peroxynitrite.
Topics: Animals; Hyperalgesia; Hyperthermia, Induced; Immunohistochemistry; Male; Nerve Compression Syndrome | 2000 |
Capsazepine reversal of the antinociceptive action of capsaicin in vivo.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Female; F | 1992 |