Page last updated: 2024-10-28

glyburide and Allodynia

glyburide has been researched along with Allodynia in 16 studies

Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Research Excerpts

ExcerptRelevanceReference
" The accompanying mechanical allodynia may be reduced by the intrathecal administration of adenosine."3.77Adenosine triphosphate-sensitive potassium channel blockers attenuate the antiallodynic effect of R-PIA in neuropathic rats. ( Hahm, KD; Jeong, SM; Kim, YK; Lee, C; Leem, JG; Park, PH; Shin, JW; Song, JG, 2011)
"The present work evaluated the effects of the methanol extract of the bulbs of Dioscorea bulbifera in inflammatory and neuropathic models of pain and further investigated its possible mechanism of action."3.76Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation. ( Andrade, EL; Calixto, JB; Dutra, RC; Nguelefack, TB; Paszcuk, AF; Tapondjou, LA, 2010)
"Metformin was administered per os (p."1.51Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms. ( Augusto, PSA; Batista, CRA; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF, 2019)
"Even ongoing inflammatory edema and mechanical allodynia were reduced by leflunomide."1.48Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1. ( Augusto, PSA; Brito, AMS; Coelho, MM; Costa, SOAM; Dutra, MGMB; Godin, AM; Goulart, FA; Ísis Morais, M; Machado, RR; Melo, ISF; Menezes, RR; Rodrigues, FF, 2018)
"Bone cancer pain is a major clinical problem and remains difficult to treat."1.40Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain. ( Fan, L; Pan, HL; Ren, J; Tian, Y; Wang, X; Wang, Y; Wu, J; Xia, H; Xu, L; Yang, S; Yao, W; Zhang, C; Zhang, D, 2014)
"This blockade of PGE2 mechanical hyperalgesia induced by diclofenac (100 microg/paw) was antagonized in a dose-dependent manner by intraplantar administration of the sulphonylureas glibenclamide (40, 80 and 160 microg) and tolbutamide (80, 160 and 320 microg), specific blockers of ATP-sensitive K+ channels, and it was observed even when the hyperalgesic agent used was carrageenin, while the antinociceptive action of indomethacin (200 microg/paw), a typical cyclo-oxygenase inhibitor, over carrageenin-induced hyperalgesia was not affected by this treatment."1.32Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation. ( Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA, 2004)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (37.50)29.6817
2010's9 (56.25)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Christensen, SL1
Munro, G1
Petersen, S1
Shabir, A1
Jansen-Olesen, I1
Kristensen, DM1
Olesen, J1
Raafat, K1
El-Lakany, A1
Brito, AMS1
Godin, AM1
Augusto, PSA2
Menezes, RR1
Melo, ISF2
Dutra, MGMB1
Costa, SOAM2
Goulart, FA2
Rodrigues, FF2
Ísis Morais, M1
Machado, RR2
Coelho, MM2
Braga, AV1
Morais, MI1
Dutra, MMGB1
Batista, CRA1
Quiñonez-Bastidas, GN1
Cervantes-Durán, C1
Rocha-González, HI2
Murbartián, J1
Granados-Soto, V2
Redondo-Castro, E1
Hernández, J1
Mahy, N1
Navarro, X1
Xia, H1
Zhang, D1
Yang, S1
Wang, Y1
Xu, L1
Wu, J1
Ren, J1
Yao, W1
Fan, L1
Zhang, C1
Tian, Y1
Pan, HL1
Wang, X1
Nguelefack, TB1
Dutra, RC1
Paszcuk, AF1
Andrade, EL1
Tapondjou, LA1
Calixto, JB2
Song, JG1
Hahm, KD1
Kim, YK1
Leem, JG1
Lee, C1
Jeong, SM1
Park, PH1
Shin, JW1
Romero, TR1
Duarte, ID4
Santos, AR1
Trentin, AP1
Ferreira, J1
Yunes, RA1
Alves, DP2
Tatsuo, MA1
Leite, R1
Terán-Rosales, F1
Reyes-García, G1
Medina-Santillán, R1
Rodríguez-Silverio, J1
Flores-Murrieta, FJ1
Amarante, LH1
Menéndez, L1
Juárez, L1
García, V1
Hidalgo, A1
Baamonde, A1
Soares, AC1

Other Studies

16 other studies available for glyburide and Allodynia

ArticleYear
ATP sensitive potassium (K
    Cephalalgia : an international journal of headache, 2020, Volume: 40, Issue:7

    Topics: Animals; Calcitonin Gene-Related Peptide; Dura Mater; Glyburide; Hyperalgesia; KATP Channels; Mice;

2020
Combination of Rheum ribes and Metformin Against Diabetes, Thermal Hyperalgesia, and Tactile Allodynia in a Mice Model.
    Alternative therapies in health and medicine, 2018, Volume: 24, Issue:5

    Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypera

2018
Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1.
    European journal of pharmacology, 2018, Jan-05, Volume: 818

    Topics: Animals; Chemokine CXCL1; Glyburide; Hyperalgesia; Isoxazoles; Leflunomide; Male; Mice; Naltrexone;

2018
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
    European journal of pharmacology, 2019, Sep-05, Volume: 858

    Topics: Analgesics; Animals; Disease Models, Animal; Female; Glyburide; Hyperalgesia; Metformin; Mice; Naltr

2019
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
    Life sciences, 2013, Oct-17, Volume: 93, Issue:17

    Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Re

2013
Phagocytic microglial phenotype induced by glibenclamide improves functional recovery but worsens hyperalgesia after spinal cord injury in adult rats.
    The European journal of neuroscience, 2013, Volume: 38, Issue:12

    Topics: Animals; Cells, Cultured; Female; Glyburide; Hyperalgesia; Locomotion; Microglia; Neuroprotective Ag

2013
Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.
    Brain research, 2014, Mar-20, Volume: 1554

    Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Glyburide; Hyperalgesia;

2014
Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Animals; Cyclic GMP; Female; Freund's Adjuvant; Glyburide; Hyperalgesia; Inflammation; KATP Channels

2010
Adenosine triphosphate-sensitive potassium channel blockers attenuate the antiallodynic effect of R-PIA in neuropathic rats.
    Anesthesia and analgesia, 2011, Volume: 112, Issue:6

    Topics: 4-Aminopyridine; Adenosine; Adenosine Triphosphate; Animals; Glyburide; Humans; Hyperalgesia; Inject

2011
N-palmitoyl-ethanolamine (PEA) induces peripheral antinociceptive effect by ATP-sensitive K+-channel activation.
    Journal of pharmacological sciences, 2012, Volume: 118, Issue:2

    Topics: Amides; Analgesics; Animals; Dequalinium; Dinoprostone; Disease Models, Animal; Dose-Response Relati

2012
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
    Brain research, 2003, Jan-31, Volume: 961, Issue:2

    Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosid

2003
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation.
    Life sciences, 2004, Apr-02, Volume: 74, Issue:20

    Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response

2004
Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat.
    European journal of pharmacology, 2004, May-10, Volume: 492, Issue:1

    Topics: Analgesics; Animals; Carrageenan; Enzyme Inhibitors; Female; Glyburide; Hyperalgesia; Inflammation;

2004
Study of the involvement of K+ channels in the peripheral antinociception of the kappa-opioid receptor agonist bremazocine.
    European journal of pharmacology, 2004, Jun-28, Volume: 494, Issue:2-3

    Topics: 4-Aminopyridine; Analgesics; Animals; ATP-Binding Cassette Transporters; Benzomorphans; Charybdotoxi

2004
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Ad

2007
Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: 4-Aminopyridine; Adenosine Triphosphate; Analgesics; Animals; Apamin; Cesium; Charybdotoxin; Dibutyr

2001