Page last updated: 2024-10-24

caffeine and Allodynia

caffeine has been researched along with Allodynia in 24 studies

Research Excerpts

ExcerptRelevanceReference
"The aim of this work was to study whether caffeine treatment during brain growth spurt produces long-term effects on the adenosine receptor-regulated behaviors including nociception, anxiety, learning, and memory."7.74Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats. ( Chen, HH; Pan, HZ, 2007)
"In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain."7.70Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000)
"Furthermore, caffeine treatment during pregnancy and lactation causes long-term behavioral changes in the mice offspring that manifest later in life."5.43Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine. ( Côrtes, Wda S; da Conceição, RR; da Rocha, FF; da Silva-Almeida, C; da Silveira, AL; de Azevedo Cruz Seara, F; Laureano-Melo, R; Marinho, BG; Reis, LC, 2016)
" This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress hyperalgesia in a model of localized inflammation."3.79Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA, 2013)
"This study investigated the involvement of the adenosinergic system in antiallodynia induced by exercise in an animal model of complex regional pain syndrome type I (CRPS-I)."3.79High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system. ( Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J, 2013)
"The aim of this work was to study whether caffeine treatment during brain growth spurt produces long-term effects on the adenosine receptor-regulated behaviors including nociception, anxiety, learning, and memory."3.74Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats. ( Chen, HH; Pan, HZ, 2007)
" The aim of the present investigation was to evaluate, firstly, the peripheral and systemic effects of amitriptyline on tactile allodynia in the streptozotocin (STZ)-induced diabetic rat model of neuropathic pain and, secondly, whether caffeine coadministration affects the actions of amitriptyline."3.71Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats. ( Aslantas, A; Dokmeci, I; Firat, Z; Karadag, HC; Tamer, M; Ulugol, A, 2002)
" In the present study, we examined the antinociceptive and anti-inflammatory effects produced by the peripheral (intraplantar) administration of 5'-amino-5'-deoxyadenosine (an adenosine kinase inhibitor), 2'-deoxycoformycin (an adenosine deaminase inhibitor), and combinations of both agents in the carrageenan-induced thermal hyperalgesia and paw oedema model in the rat."3.70Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. ( Poon, A; Sawynok, J, 1999)
"In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain."3.70Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000)
"Efficacy of acute OTC medications for migraine varies greatly."1.91Predictors of treatment-response to caffeine combination products, acetaminophen, acetylsalicylic acid (aspirin), and nonsteroidal anti-inflammatory drugs in acute treatment of episodic migraine. ( Ezzati, A; Fanning, KM; Lipton, RB; Reed, ML, 2023)
"It is associated with allodynia and hyperalgesia."1.48Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. ( Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS, 2018)
"The consequences of chronic insufficient sleep for health remain uncertain."1.46Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017)
"Furthermore, caffeine treatment during pregnancy and lactation causes long-term behavioral changes in the mice offspring that manifest later in life."1.43Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine. ( Côrtes, Wda S; da Conceição, RR; da Rocha, FF; da Silva-Almeida, C; da Silveira, AL; de Azevedo Cruz Seara, F; Laureano-Melo, R; Marinho, BG; Reis, LC, 2016)
"Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures."1.42Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. ( Batisti, AP; Daruge-Neto, E; Emer, AA; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Prado, MR; Santos, AR, 2015)
"The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine."1.39Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013)
"Cizolirtine-induced antihyperalgesia was compared before and after pretreatment with ADO A(1)-A(2A) and 5-HT(1B/1D) receptor ligands in rats rendered diabetic by streptozotocin pretreatment and suffering from neuropathic pain."1.34Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy. ( Aubel, B; Bourgoin, S; Farré, A; Hamon, M; Kayser, V, 2007)
"The etiology of painful diabetic neuropathy is poorly understood, but may result from neuronal hyperexcitability secondary to alterations of Ca2+ signaling in sensory neurons."1.33Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats. ( Abatan, O; Larkin, D; Li, F; Obrosova, IG; Stevens, MJ; Stuenkel, EL; Tian, D, 2005)
"In a second model, hyperalgesia was induced by the i."1.31Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. ( Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C, 2002)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.17)18.7374
1990's2 (8.33)18.2507
2000's12 (50.00)29.6817
2010's8 (33.33)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Ezzati, A1
Fanning, KM1
Reed, ML1
Lipton, RB1
Alexandre, C1
Latremoliere, A1
Ferreira, A1
Miracca, G1
Yamamoto, M1
Scammell, TE1
Woolf, CJ1
Hambrecht-Wiedbusch, VS1
Gabel, M1
Liu, LJ1
Imperial, JP1
Colmenero, AV1
Vanini, G1
Souza, A1
Martins, DF4
Medeiros, LF1
Nucci-Martins, C1
Martins, TC1
Siteneski, A1
Caumo, W1
Dos Santos, ARS1
Torres, ILS1
Tomić, MA3
Micov, AM1
Stepanović-Petrović, RM3
Prado, MR1
Daruge-Neto, E1
Batisti, AP1
Emer, AA1
Mazzardo-Martins, L3
Santos, AR3
Piovezan, AP2
Laureano-Melo, R1
da Silveira, AL1
de Azevedo Cruz Seara, F1
da Conceição, RR1
da Silva-Almeida, C1
Marinho, BG1
da Rocha, FF1
Reis, LC1
Côrtes, Wda S1
Rigaud, M1
Gemes, G1
Weyker, PD1
Cruikshank, JM1
Kawano, T1
Wu, HE1
Hogan, QH1
Cidral-Filho, FJ1
Stramosk, J2
Soldi, F1
Ulugol, A1
Karadag, HC1
Tamer, M1
Firat, Z1
Aslantas, A1
Dokmeci, I1
Galeotti, N1
Ghelardini, C1
Grazioli, I1
Uslenghi, C1
Vučković, SM2
Ugrešić, N3
Prostran, MŠ2
Bošković, B3
Li, F1
Obrosova, IG1
Abatan, O1
Tian, D1
Larkin, D1
Stuenkel, EL1
Stevens, MJ1
Vuckovic, S1
Tomic, M1
Stepanovic-Petrovic, R1
Prostran, M1
Aubel, B1
Kayser, V1
Farré, A1
Hamon, M1
Bourgoin, S1
Pan, HZ1
Chen, HH1
Savegnago, L1
Jesse, CR1
Nogueira, CW1
Behbehani, MM1
Dollberg-Stolik, O1
Poon, A1
Sawynok, J2
Esser, MJ1
Johansson, B1
Halldner, L1
Dunwiddie, TV1
Masino, SA1
Poelchen, W1
Giménez-Llort, L1
Escorihuela, RM1
Fernández-Teruel, A1
Wiesenfeld-Hallin, Z1
Xu, XJ1
Hårdemark, A1
Betsholtz, C1
Herlenius, E1
Fredholm, BB1
DeLander, GE1
Hopkins, CJ1

Other Studies

24 other studies available for caffeine and Allodynia

ArticleYear
Predictors of treatment-response to caffeine combination products, acetaminophen, acetylsalicylic acid (aspirin), and nonsteroidal anti-inflammatory drugs in acute treatment of episodic migraine.
    Headache, 2023, Volume: 63, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Female

2023
Decreased alertness due to sleep loss increases pain sensitivity in mice.
    Nature medicine, 2017, Volume: 23, Issue:6

    Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas

2017
Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions.
    Sleep, 2017, 09-01, Volume: 40, Issue:9

    Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Female; Hyperalgesia; Male; Pain, Postoperativ

2017
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
    Brain research, 2018, 03-01, Volume: 1682

    Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Mod

2018
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.
    The journal of pain, 2013, Volume: 14, Issue:11

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Dr

2013
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.
    Journal of the peripheral nervous system : JPNS, 2015, Volume: 20, Issue:4

    Topics: Amines; Analgesics; Animals; Caffeine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent

2015
Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine.
    Metabolic brain disease, 2016, Volume: 31, Issue:5

    Topics: Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Female; Hyperalgesia; Lactation; Male

2016
Axotomy depletes intracellular calcium stores in primary sensory neurons.
    Anesthesiology, 2009, Volume: 111, Issue:2

    Topics: Animals; Axons; Axotomy; Caffeine; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Central N

2009
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
    Physical therapy, 2013, Volume: 93, Issue:3

    Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal;

2013
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
    Neuroscience, 2013, Mar-27, Volume: 234

    Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine

2013
Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats.
    Neuroscience letters, 2002, Aug-09, Volume: 328, Issue:2

    Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Diabetes

2002
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
    Pharmacological research, 2002, Volume: 46, Issue:3

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug

2002
The anti-hyperalgesic effects of carbamazepine and oxcarbazepine are attenuated by treatment with adenosine receptor antagonists.
    Pain, 2004, Volume: 111, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug I

2004
Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats.
    American journal of physiology. Endocrinology and metabolism, 2005, Volume: 288, Issue:1

    Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Caffeine; Calcium Signaling; Central Ne

2005
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
    Journal of pharmacological sciences, 2006, Volume: 100, Issue:4

    Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response

2006
Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A1 receptors.
    Die Pharmazie, 2006, Volume: 61, Issue:6

    Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Caffein

2006
Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Adenosine; Analgesics; Animals; Area Under Curve; Caffeine; Diabetes Mellitus, Experimental; Diabeti

2007
Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats.
    Psychopharmacology, 2007, Volume: 191, Issue:1

    Topics: Adenosine; Animals; Animals, Newborn; Anxiety; Avoidance Learning; Behavior, Animal; Body Temperatur

2007
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice.
    Neuroscience letters, 2008, May-09, Volume: 436, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzene Derivatives; Benzofurans; Caffeine;

2008
Partial sciatic nerve ligation results in an enlargement of the receptive field and enhancement of the response of dorsal horn neurons to noxious stimulation by an adenosine agonist.
    Pain, 1994, Volume: 58, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Caffeine; Causalgia; Electr

1994
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
    European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3

    Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Analgesics; Animals; Anti-Inf

1999
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
    European journal of pharmacology, 2000, Jul-07, Volume: 399, Issue:2-3

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System

2000
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Jul-31, Volume: 98, Issue:16

    Topics: Adenosine; Animals; Anxiety; Autoradiography; Behavior, Animal; Caffeine; Hippocampus; Hyperalgesia;

2001
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intr

1986