caffeine has been researched along with Allodynia in 24 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this work was to study whether caffeine treatment during brain growth spurt produces long-term effects on the adenosine receptor-regulated behaviors including nociception, anxiety, learning, and memory." | 7.74 | Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats. ( Chen, HH; Pan, HZ, 2007) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 7.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "Furthermore, caffeine treatment during pregnancy and lactation causes long-term behavioral changes in the mice offspring that manifest later in life." | 5.43 | Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine. ( Côrtes, Wda S; da Conceição, RR; da Rocha, FF; da Silva-Almeida, C; da Silveira, AL; de Azevedo Cruz Seara, F; Laureano-Melo, R; Marinho, BG; Reis, LC, 2016) |
| " This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress hyperalgesia in a model of localized inflammation." | 3.79 | Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA, 2013) |
| "This study investigated the involvement of the adenosinergic system in antiallodynia induced by exercise in an animal model of complex regional pain syndrome type I (CRPS-I)." | 3.79 | High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system. ( Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J, 2013) |
| "The aim of this work was to study whether caffeine treatment during brain growth spurt produces long-term effects on the adenosine receptor-regulated behaviors including nociception, anxiety, learning, and memory." | 3.74 | Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats. ( Chen, HH; Pan, HZ, 2007) |
| " The aim of the present investigation was to evaluate, firstly, the peripheral and systemic effects of amitriptyline on tactile allodynia in the streptozotocin (STZ)-induced diabetic rat model of neuropathic pain and, secondly, whether caffeine coadministration affects the actions of amitriptyline." | 3.71 | Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats. ( Aslantas, A; Dokmeci, I; Firat, Z; Karadag, HC; Tamer, M; Ulugol, A, 2002) |
| " In the present study, we examined the antinociceptive and anti-inflammatory effects produced by the peripheral (intraplantar) administration of 5'-amino-5'-deoxyadenosine (an adenosine kinase inhibitor), 2'-deoxycoformycin (an adenosine deaminase inhibitor), and combinations of both agents in the carrageenan-induced thermal hyperalgesia and paw oedema model in the rat." | 3.70 | Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. ( Poon, A; Sawynok, J, 1999) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 3.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "Efficacy of acute OTC medications for migraine varies greatly." | 1.91 | Predictors of treatment-response to caffeine combination products, acetaminophen, acetylsalicylic acid (aspirin), and nonsteroidal anti-inflammatory drugs in acute treatment of episodic migraine. ( Ezzati, A; Fanning, KM; Lipton, RB; Reed, ML, 2023) |
| "It is associated with allodynia and hyperalgesia." | 1.48 | Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. ( Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS, 2018) |
| "The consequences of chronic insufficient sleep for health remain uncertain." | 1.46 | Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017) |
| "Furthermore, caffeine treatment during pregnancy and lactation causes long-term behavioral changes in the mice offspring that manifest later in life." | 1.43 | Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine. ( Côrtes, Wda S; da Conceição, RR; da Rocha, FF; da Silva-Almeida, C; da Silveira, AL; de Azevedo Cruz Seara, F; Laureano-Melo, R; Marinho, BG; Reis, LC, 2016) |
| "Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures." | 1.42 | Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. ( Batisti, AP; Daruge-Neto, E; Emer, AA; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Prado, MR; Santos, AR, 2015) |
| "The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine." | 1.39 | Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013) |
| "Cizolirtine-induced antihyperalgesia was compared before and after pretreatment with ADO A(1)-A(2A) and 5-HT(1B/1D) receptor ligands in rats rendered diabetic by streptozotocin pretreatment and suffering from neuropathic pain." | 1.34 | Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy. ( Aubel, B; Bourgoin, S; Farré, A; Hamon, M; Kayser, V, 2007) |
| "The etiology of painful diabetic neuropathy is poorly understood, but may result from neuronal hyperexcitability secondary to alterations of Ca2+ signaling in sensory neurons." | 1.33 | Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats. ( Abatan, O; Larkin, D; Li, F; Obrosova, IG; Stevens, MJ; Stuenkel, EL; Tian, D, 2005) |
| "In a second model, hyperalgesia was induced by the i." | 1.31 | Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. ( Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 12 (50.00) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Ezzati, A | 1 |
| Fanning, KM | 1 |
| Reed, ML | 1 |
| Lipton, RB | 1 |
| Alexandre, C | 1 |
| Latremoliere, A | 1 |
| Ferreira, A | 1 |
| Miracca, G | 1 |
| Yamamoto, M | 1 |
| Scammell, TE | 1 |
| Woolf, CJ | 1 |
| Hambrecht-Wiedbusch, VS | 1 |
| Gabel, M | 1 |
| Liu, LJ | 1 |
| Imperial, JP | 1 |
| Colmenero, AV | 1 |
| Vanini, G | 1 |
| Souza, A | 1 |
| Martins, DF | 4 |
| Medeiros, LF | 1 |
| Nucci-Martins, C | 1 |
| Martins, TC | 1 |
| Siteneski, A | 1 |
| Caumo, W | 1 |
| Dos Santos, ARS | 1 |
| Torres, ILS | 1 |
| Tomić, MA | 3 |
| Micov, AM | 1 |
| Stepanović-Petrović, RM | 3 |
| Prado, MR | 1 |
| Daruge-Neto, E | 1 |
| Batisti, AP | 1 |
| Emer, AA | 1 |
| Mazzardo-Martins, L | 3 |
| Santos, AR | 3 |
| Piovezan, AP | 2 |
| Laureano-Melo, R | 1 |
| da Silveira, AL | 1 |
| de Azevedo Cruz Seara, F | 1 |
| da Conceição, RR | 1 |
| da Silva-Almeida, C | 1 |
| Marinho, BG | 1 |
| da Rocha, FF | 1 |
| Reis, LC | 1 |
| Côrtes, Wda S | 1 |
| Rigaud, M | 1 |
| Gemes, G | 1 |
| Weyker, PD | 1 |
| Cruikshank, JM | 1 |
| Kawano, T | 1 |
| Wu, HE | 1 |
| Hogan, QH | 1 |
| Cidral-Filho, FJ | 1 |
| Stramosk, J | 2 |
| Soldi, F | 1 |
| Ulugol, A | 1 |
| Karadag, HC | 1 |
| Tamer, M | 1 |
| Firat, Z | 1 |
| Aslantas, A | 1 |
| Dokmeci, I | 1 |
| Galeotti, N | 1 |
| Ghelardini, C | 1 |
| Grazioli, I | 1 |
| Uslenghi, C | 1 |
| Vučković, SM | 2 |
| Ugrešić, N | 3 |
| Prostran, MŠ | 2 |
| Bošković, B | 3 |
| Li, F | 1 |
| Obrosova, IG | 1 |
| Abatan, O | 1 |
| Tian, D | 1 |
| Larkin, D | 1 |
| Stuenkel, EL | 1 |
| Stevens, MJ | 1 |
| Vuckovic, S | 1 |
| Tomic, M | 1 |
| Stepanovic-Petrovic, R | 1 |
| Prostran, M | 1 |
| Aubel, B | 1 |
| Kayser, V | 1 |
| Farré, A | 1 |
| Hamon, M | 1 |
| Bourgoin, S | 1 |
| Pan, HZ | 1 |
| Chen, HH | 1 |
| Savegnago, L | 1 |
| Jesse, CR | 1 |
| Nogueira, CW | 1 |
| Behbehani, MM | 1 |
| Dollberg-Stolik, O | 1 |
| Poon, A | 1 |
| Sawynok, J | 2 |
| Esser, MJ | 1 |
| Johansson, B | 1 |
| Halldner, L | 1 |
| Dunwiddie, TV | 1 |
| Masino, SA | 1 |
| Poelchen, W | 1 |
| Giménez-Llort, L | 1 |
| Escorihuela, RM | 1 |
| Fernández-Teruel, A | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Xu, XJ | 1 |
| Hårdemark, A | 1 |
| Betsholtz, C | 1 |
| Herlenius, E | 1 |
| Fredholm, BB | 1 |
| DeLander, GE | 1 |
| Hopkins, CJ | 1 |
24 other studies available for caffeine and Allodynia
| Article | Year |
|---|---|
Predictors of treatment-response to caffeine combination products, acetaminophen, acetylsalicylic acid (aspirin), and nonsteroidal anti-inflammatory drugs in acute treatment of episodic migraine.
Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Female | 2023 |
Decreased alertness due to sleep loss increases pain sensitivity in mice.
Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas | 2017 |
Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Female; Hyperalgesia; Male; Pain, Postoperativ | 2017 |
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Mod | 2018 |
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Dr | 2013 |
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.
Topics: Amines; Analgesics; Animals; Caffeine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent | 2015 |
Behavioral profile assessment in offspring of Swiss mice treated during pregnancy and lactation with caffeine.
Topics: Animals; Anxiety; Caffeine; Central Nervous System Stimulants; Female; Hyperalgesia; Lactation; Male | 2016 |
Axotomy depletes intracellular calcium stores in primary sensory neurons.
Topics: Animals; Axons; Axotomy; Caffeine; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Central N | 2009 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; | 2013 |
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine | 2013 |
Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats.
Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Diabetes | 2002 |
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug | 2002 |
The anti-hyperalgesic effects of carbamazepine and oxcarbazepine are attenuated by treatment with adenosine receptor antagonists.
Topics: Analgesics, Non-Narcotic; Animals; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug I | 2004 |
Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Caffeine; Calcium Signaling; Central Ne | 2005 |
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response | 2006 |
Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Caffein | 2006 |
Evidence for adenosine- and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy.
Topics: Adenosine; Analgesics; Animals; Area Under Curve; Caffeine; Diabetes Mellitus, Experimental; Diabeti | 2007 |
Hyperalgesia, low-anxiety, and impairment of avoidance learning in neonatal caffeine-treated rats.
Topics: Adenosine; Animals; Animals, Newborn; Anxiety; Avoidance Learning; Behavior, Animal; Body Temperatur | 2007 |
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzene Derivatives; Benzofurans; Caffeine; | 2008 |
Partial sciatic nerve ligation results in an enlargement of the receptive field and enhancement of the response of dorsal horn neurons to noxious stimulation by an adenosine agonist.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Caffeine; Causalgia; Electr | 1994 |
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Analgesics; Animals; Anti-Inf | 1999 |
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System | 2000 |
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor.
Topics: Adenosine; Animals; Anxiety; Autoradiography; Behavior, Animal; Caffeine; Hippocampus; Hyperalgesia; | 2001 |
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intr | 1986 |