pentoxifylline has been researched along with Allodynia in 12 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "This double-blind randomized controlled study was designed to evaluate the analgesic effects of topical treatments with clonidine (CLON) and pentoxifylline (PTX) tested alone or as low- and high-dose combinations in a human experimental model of pain." | 9.22 | Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study. ( Bennett, GJ; Bley, K; Coderre, TJ; Gandhi, W; Laferrière, A; Ragavendran, JV; Schweinhardt, P; Ware, MA, 2016) |
| "The antihyperalgesic effect of pentoxifylline was investigated in three experimental pain models." | 7.72 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| "Pentoxifylline (PTX) has strong antyinflamatory effects, decreases TNF-alpha and other proinflammatory cytokines production." | 5.38 | Pentoxifylline modifies central and peripheral vagal mechanism in acute and chronic pain models. ( Dobrogowski, J; Nowak, Ł; Thor, PJ; Wordliczek, J; Zurowski, D, 2012) |
| "This double-blind randomized controlled study was designed to evaluate the analgesic effects of topical treatments with clonidine (CLON) and pentoxifylline (PTX) tested alone or as low- and high-dose combinations in a human experimental model of pain." | 5.22 | Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study. ( Bennett, GJ; Bley, K; Coderre, TJ; Gandhi, W; Laferrière, A; Ragavendran, JV; Schweinhardt, P; Ware, MA, 2016) |
| "After the rats developed neuropathic pain behavior, a single intraperitoneal injection and continuous infusion of pentoxifylline ameliorated paclitaxel-induced mechanical allodynia." | 3.83 | Pentoxifylline Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain. ( Abdi, S; Hwang, SH; Kim, HK; Kim, SH; Lee, SO, 2016) |
| "We examined the effect of pentoxifylline on existing mechanical allodynia, observing glial activation and proinflammatory cytokine expression in the lumbar spinal cord, when given 7 days after L5 spinal nerve transection." | 3.74 | The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy. ( Feng, X; Guan, R; Li, W; Liu, J; Xu, J; Zhang, J; Zhu, J, 2008) |
| "The antihyperalgesic effect of pentoxifylline was investigated in three experimental pain models." | 3.72 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| "Postoperative pain was measured within 24 hours after surgery using a VAS, and the area of secondary hyperalgesia was measured 24 hours after surgery using the Stubhaug et al." | 3.01 | The Effect of Preoperative Pentoxifylline on Postoperative Pain and Development of Secondary Hyperalgesia in Patients Undergoing Laparoscopic Appendectomy: A Randomized, Double-Blind, Placebo-Controlled Trial Study. ( Abdolalizadeh, A; Jafarpour, M; Khajeh, M; Nazemi, S; Sahebkar, M; Shahrestanaki, E; Taherian, A, 2021) |
| "G-CSF-induced mechanical hyperalgesia was inhibited by systemic and local treatment with etanercept and IL-1 receptor antagonist (IL-1ra) or TNF receptor 1 (TNFR1) deficiency and increased in IL-10 deficient mice." | 1.42 | Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10. ( Borghi, SM; Carvalho, TT; Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Mizokami, SS; Pinho-Ribeiro, FA; Verri, WA, 2015) |
| "Pentoxifylline (PTX) has strong antyinflamatory effects, decreases TNF-alpha and other proinflammatory cytokines production." | 1.38 | Pentoxifylline modifies central and peripheral vagal mechanism in acute and chronic pain models. ( Dobrogowski, J; Nowak, Ł; Thor, PJ; Wordliczek, J; Zurowski, D, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Fulas, OA | 1 |
| Laferrière, A | 2 |
| Coderre, TJ | 2 |
| Nazemi, S | 1 |
| Taherian, A | 1 |
| Khajeh, M | 1 |
| Shahrestanaki, E | 1 |
| Jafarpour, M | 1 |
| Abdolalizadeh, A | 1 |
| Sahebkar, M | 1 |
| Nowak, Ł | 1 |
| Zurowski, D | 1 |
| Dobrogowski, J | 1 |
| Wordliczek, J | 2 |
| Thor, PJ | 1 |
| Carvalho, TT | 1 |
| Borghi, SM | 1 |
| Pinho-Ribeiro, FA | 1 |
| Mizokami, SS | 1 |
| Cunha, TM | 1 |
| Ferreira, SH | 2 |
| Cunha, FQ | 2 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Kim, HK | 1 |
| Hwang, SH | 1 |
| Lee, SO | 1 |
| Kim, SH | 1 |
| Abdi, S | 1 |
| Ragavendran, JV | 1 |
| Bennett, GJ | 1 |
| Ware, MA | 1 |
| Gandhi, W | 1 |
| Bley, K | 1 |
| Schweinhardt, P | 1 |
| Osikowicz, M | 2 |
| Skup, M | 1 |
| Mika, J | 2 |
| Makuch, W | 2 |
| Czarkowska-Bauch, J | 1 |
| Przewlocka, B | 3 |
| Vale, ML | 1 |
| Benevides, VM | 1 |
| Sachs, D | 1 |
| Brito, GA | 1 |
| da Rocha, FA | 1 |
| Poole, S | 1 |
| Ribeiro, RA | 1 |
| Liu, J | 2 |
| Feng, X | 2 |
| Yu, M | 1 |
| Xie, W | 1 |
| Zhao, X | 1 |
| Li, W | 2 |
| Guan, R | 2 |
| Xu, J | 2 |
| Zhu, J | 1 |
| Zhang, J | 1 |
| Szczepanik, AM | 1 |
| Banach, M | 1 |
| Turchan, J | 1 |
| Zembala, M | 1 |
| Siedlar, M | 1 |
| Przewlocki, R | 1 |
| Serednicki, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Topical Treatment With Clonidine + Pentoxifylline in Patients With Neuropathic Pain[NCT03342950] | Phase 2 | 4 participants (Actual) | Interventional | 2019-02-19 | Terminated (stopped due to Low recruitment due to the COVID-19 pandemic) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for pentoxifylline and Allodynia
| Article | Year |
|---|---|
The Effect of Preoperative Pentoxifylline on Postoperative Pain and Development of Secondary Hyperalgesia in Patients Undergoing Laparoscopic Appendectomy: A Randomized, Double-Blind, Placebo-Controlled Trial Study.
Topics: Adult; Appendectomy; Appendicitis; Double-Blind Method; Female; Humans; Hyperalgesia; Iran; Laparosc | 2021 |
Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study.
Topics: Adolescent; Adult; Analgesics; Capsaicin; Clonidine; Double-Blind Method; Drug Therapy, Combination; | 2016 |
The effect of pentoxifiline on post-injury hyperalgesia in rats and postoperative pain in patients.
Topics: Adult; Animals; Cholecystectomy; Formaldehyde; Humans; Hyperalgesia; Injections, Intraperitoneal; In | 2000 |
9 other studies available for pentoxifylline and Allodynia
| Article | Year |
|---|---|
Novel Co-crystal of Pentoxifylline and Protocatechuic Acid Relieves Allodynia in Rat Models of Peripheral Neuropathic Pain and CRPS by Alleviating Local Tissue Hypoxia.
Topics: Animals; Complex Regional Pain Syndromes; Disease Models, Animal; Hydroxybenzoates; Hyperalgesia; Hy | 2021 |
Pentoxifylline modifies central and peripheral vagal mechanism in acute and chronic pain models.
Topics: Acetic Acid; Acute Pain; Animals; Anti-Inflammatory Agents; Chronic Pain; Cytokines; Hyperalgesia; I | 2012 |
Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10.
Topics: Analgesics, Opioid; Animals; Etanercept; Granulocyte Colony-Stimulating Factor; Hyperalgesia; Immuno | 2015 |
Pentoxifylline Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Cytokines; Disease Models, Animal; Ganglia, Spinal; Hype | 2016 |
Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain.
Topics: Amino Acids; Analysis of Variance; Animals; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heteroc | 2009 |
Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Carrageenan; Hot Temperature; Hyperalgesia; Iloprost; | 2004 |
Pentoxifylline attenuates the development of hyperalgesia in a rat model of neuropathic pain.
Topics: Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Hyper | 2007 |
Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain.
Topics: Animals; Disease Models, Animal; Drug Synergism; Hyperalgesia; Male; Mice; Minocycline; Morphine; Ne | 2007 |
The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Nervous System Diseases; Pain; Pentoxifylline; | 2008 |