Page last updated: 2024-11-02

oxidopamine and Allodynia

oxidopamine has been researched along with Allodynia in 40 studies

Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).

Research Excerpts

ExcerptRelevanceReference
"Continuous SGB prevention inhibited mechanical hyperalgesia at 2, 3 and 4 weeks post modeling, and significantly reversed mechanical hyperalgesia at 3 and 4 weeks post modeling, compared with those of Saline group (p < 0."1.91Continuous SGB Inhibits Occurrence and Maintenance of Mechanical Hyperalgesia via Reducing Inflammatory Cytokines in Striatum and PAG of PD Nociception Rat Models. ( Huang, W; Li, M; Liu, G; Shi, Y; Zeng, Y, 2023)
"We hypothesized that hyperalgesia of 6-OHDA rats may be related to increased excitability of SDH neurons, and functional change of 5-HT3 receptor may reverse the hyperalgesia of 6-OHDA lesioned rats and decrease cell excitability of SDH neurons."1.72Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. ( An, MQ; Dai, YP; Dong, LG; Gu, HY; Li, CJ; Liu, CF; Liu, LB; Mao, CJ; Wang, F; Zhang, LG, 2022)
"6-OHDA-lesioned rats also showed cold allodynia as demonstrated by a significant difference in the number of flinches, latency and reaction time to acetone stimulus."1.62Behavioral, Cellular and Molecular Responses to Cold and Mechanical Stimuli in Rats with Bilateral Dopamine Depletion in the Mesencephalic Dopaminergic Neurons. ( Aissouni, Y; Durif, F; Elshennawy, M; Hafidi, A; Ouachikh, O; Youssef, S; Zaki, SS, 2021)
"CBD therapy is effective for parkinsonism-induced orofacial nociception."1.62Cannabidiol has therapeutic potential for myofascial pain in female and male parkinsonian rats. ( Del-Bel, E; Dos-Santos-Pereira, M; Guimaraes, FS; Nascimento, GCD; Vivanco-Estela, AN, 2021)
"Pain is a prevalent PD's non-motor symptom with a higher prevalence of analgesic drugs prescription for patients."1.56Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. ( Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS, 2020)
"On the other hand, to investigate allodynia and hyperalgesia induced by 6-OHDA, we used the von Frey filaments."1.56Unilateral lesion of the nigroestriatal pathway with 6-OHDA induced allodynia and hyperalgesia reverted by pramipexol in rats. ( Austrich-Olivares, AM; Benitez-Diaz Mirón, M; Coen, A; Garza-Mouriño, G; Godínez-Chaparro, B; Mendieta, L; Romero-Sánchez, HA, 2020)
"Dopamine is implicated in different orofacial pain-related diseases."1.43Nigrostriatal dopaminergic depletion produces orofacial static mechanical allodynia. ( Dieb, W; Durif, F; Hafidi, A; Ouachikh, O, 2016)
"NTP inhibited both tactile allodynia and mechanical and thermal hyperalgesia in a dose-dependent manner."1.33The antiallodynic and antihyperalgesic effects of neurotropin in mice with spinal nerve ligation. ( Li, YH; Mashimo, T; Suzuki, T, 2005)
"We conclude that serotonin produces hyperalgesia by a direct action on the primary afferent neuron via the 5-HT1A subset of serotonin receptors."1.28Serotonin is a directly-acting hyperalgesic agent in the rat. ( Levine, JD; Taiwo, YO, 1992)
"A similar neuropathic hyperalgesia, with an associated pain syndrome, is seen in man following peripheral nerve section."1.28Adjacent neuropathic hyperalgesia in rats: a model for sympathetic independent pain. ( Kingery, WS; Vallin, JA, 1991)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.50)18.7374
1990's4 (10.00)18.2507
2000's11 (27.50)29.6817
2010's14 (35.00)24.3611
2020's10 (25.00)2.80

Authors

AuthorsStudies
Elshennawy, M1
Ouachikh, O3
Aissouni, Y1
Youssef, S1
Zaki, SS1
Durif, F3
Hafidi, A3
Bouchatta, O1
Aby, F1
Sifeddine, W1
Bouali-Benazzouz, R2
Brochoire, L1
Manouze, H1
Fossat, P2
Ba M'Hamed, S1
Bennis, M1
Landry, M2
Li, CJ2
Zhang, LG2
Liu, LB1
An, MQ2
Dong, LG2
Gu, HY2
Dai, YP1
Wang, F3
Mao, CJ3
Liu, CF3
Li, M2
Huang, W1
Shi, Y1
Zeng, Y1
Liu, G1
Zhang, JB1
Crivelaro do Nascimento, G1
Ferrari, DP1
Guimaraes, FS2
Del Bel, EA1
Bortolanza, M1
Ferreira-Junior, NC1
Zhu, M1
Xu, Q1
Ding, F1
Tian, Y1
Zhang, M1
Romero-Sánchez, HA1
Mendieta, L1
Austrich-Olivares, AM1
Garza-Mouriño, G1
Benitez-Diaz Mirón, M1
Coen, A1
Godínez-Chaparro, B1
Maegawa, H2
Usami, N1
Kudo, C2
Hanamoto, H2
Niwa, H2
Vivanco-Estela, AN1
Dos-Santos-Pereira, M1
Del-Bel, E1
Nascimento, GCD1
Wang, CT1
Zhang, XQ1
Zhang, CY1
Lv, DJ1
Yang, YP1
Xia, KL1
Liu, JY1
Hu, LF1
Xu, GY1
Charles, KA1
Naudet, F1
De Deurwaerdère, P1
Benazzouz, A1
Chen, HS2
Li, FP1
Li, XQ1
Liu, BJ1
Qu, F2
Wen, WW2
Wang, Y2
Lin, Q1
Li, W1
Shi, X1
Wang, L1
Guo, T1
Wei, T1
Cheng, K1
Rice, KC1
Kingery, WS2
Clark, JD1
da Rocha, JT1
Pinton, S1
Gai, BM1
Nogueira, CW1
Takeda, R1
Ishida, Y1
Ebihara, K1
Abe, H1
Matsuo, H1
Ikeda, T1
Koganemaru, G1
Kuramashi, A1
Funahashi, H1
Magata, Y1
Kawai, K1
Nishimori, T1
Dieb, W2
Ogata, M1
Noda, K1
Akita, H1
Ishibashi, H2
Morimoto, Y1
Boku, A1
Sugimura, M1
Kato, T1
Yoshida, A1
Gee, LE2
Chen, N1
Ramirez-Zamora, A1
Shin, DS2
Pilitsis, JG2
Kaszuba, BC1
Walling, I1
Greco, R2
Tassorelli, C2
Armentero, MT2
Sandrini, G2
Nappi, G2
Blandini, F2
Maeda, M1
Tsuruoka, M1
Hayashi, B1
Nagasawa, I1
Inoue, T1
Arsenault, A1
Sawynok, J3
He, X1
Eto, K1
Kim, SK1
Nabekura, J1
Liu, XJ1
White, TD1
Baliki, M1
Al-Amin, HA1
Atweh, SF1
Jaber, M1
Hawwa, N1
Jabbur, SJ1
Apkarian, AV1
Saadé, NE1
Waldron, JB1
Suzuki, T1
Li, YH1
Mashimo, T1
Fancellu, R1
Takeuchi, Y1
Takasu, K1
Ono, H1
Tanabe, M1
Chudler, EH1
Lu, Y1
Ahlgren, SC1
Levine, JD3
Liu, J1
Wang, KM1
He, LZ1
Cao, DY1
Kalmari, J1
Niissalo, S1
Konttinen, YT1
Pertovaara, A1
Taiwo, YO2
Vallin, JA1
Gonzales, R1
Goldyne, ME1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Preemptive Analgesia With Amitryptyline for Prevention of Post-operative Pain in Women After Total Abdominal Hysterectomy: a Randomized Clinical Trial[NCT03587025]Phase 3150 participants (Actual)Interventional2015-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

40 other studies available for oxidopamine and Allodynia

ArticleYear
Behavioral, Cellular and Molecular Responses to Cold and Mechanical Stimuli in Rats with Bilateral Dopamine Depletion in the Mesencephalic Dopaminergic Neurons.
    Neuroscience, 2021, 12-15, Volume: 479

    Topics: Animals; Cold Temperature; Dopamine; Dopaminergic Neurons; Hyperalgesia; Oxidopamine; Rats

2021
Pain hypersensitivity in a pharmacological mouse model of attention-deficit/hyperactivity disorder.
    Proceedings of the National Academy of Sciences of the United States of America, 2022, 07-26, Volume: 119, Issue:30

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Gyrus Cinguli; Hyper

2022
Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease.
    Molecular neurobiology, 2022, Volume: 59, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Hyperalgesia; Ondansetron; Oxidopamine; P

2022
Continuous SGB Inhibits Occurrence and Maintenance of Mechanical Hyperalgesia via Reducing Inflammatory Cytokines in Striatum and PAG of PD Nociception Rat Models.
    Turkish neurosurgery, 2023, Volume: 33, Issue:4

    Topics: Animals; Cytokines; Hyperalgesia; Interleukin-6; Nociception; Oxidopamine; Pain Threshold; Parkinson

2023
PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson's disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons.
    Acta pharmacologica Sinica, 2023, Volume: 44, Issue:12

    Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Humans; Hyperalgesia; Oxidopamine; Pain; Parkin

2023
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
    Neuropharmacology, 2020, Volume: 163

    Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecox

2020
Sensation of TRPV1 via 5-hydroxytryptamine signaling modulates pain hypersensitivity in a 6-hydroxydopamine induced mice model of Parkinson's disease.
    Biochemical and biophysical research communications, 2020, 01-22, Volume: 521, Issue:4

    Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Hyperalgesia;

2020
Unilateral lesion of the nigroestriatal pathway with 6-OHDA induced allodynia and hyperalgesia reverted by pramipexol in rats.
    European journal of pharmacology, 2020, Feb-15, Volume: 869

    Topics: Analgesics; Animals; Antiparkinson Agents; Dopamine Agonists; Hyperalgesia; Male; Oxidopamine; Pars

2020
Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury.
    International journal of molecular sciences, 2020, Mar-12, Volume: 21, Issue:6

    Topics: Animals; Cranial Nerves; Dopamine; Extracellular Signal-Regulated MAP Kinases; Facial Nerve Injuries

2020
Cannabidiol has therapeutic potential for myofascial pain in female and male parkinsonian rats.
    Neuropharmacology, 2021, 09-15, Volume: 196

    Topics: Analgesics; Animals; Anticonvulsants; Cannabidiol; Estrous Cycle; Facial Pain; Female; Hyperalgesia;

2021
Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease.
    Molecular pain, 2017, Volume: 13

    Topics: 5,7-Dihydroxytryptamine; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; Ind

2017
Alteration of nociceptive integration in the spinal cord of a rat model of Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2018, Volume: 33, Issue:6

    Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine; Functional Laterality; Hyperalgesia; H

2018
Acute stress regulates nociception and inflammatory response induced by bee venom in rats: possible mechanisms.
    Stress (Amsterdam, Netherlands), 2013, Volume: 16, Issue:5

    Topics: Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Edema; Hindlimb; Hyperalgesia; Inflammation;

2013
Epidermal adrenergic signaling contributes to inflammation and pain sensitization in a rat model of complex regional pain syndrome.
    Pain, 2013, Volume: 154, Issue:8

    Topics: Adrenergic Agents; Animals; Bufanolides; Complex Regional Pain Syndromes; Disease Models, Animal; Do

2013
Diphenyl diselenide reduces mechanical and thermal nociceptive behavioral responses after unilateral intrastriatal administration of 6-hydroxydopamine in rats.
    Biological trace element research, 2013, Volume: 154, Issue:3

    Topics: Administration, Oral; Animals; Benzene Derivatives; Corpus Striatum; Formaldehyde; Hot Temperature;

2013
Intrastriatal grafts of fetal ventral mesencephalon improve allodynia-like withdrawal response to mechanical stimulation in a rat model of Parkinson's disease.
    Neuroscience letters, 2014, Jun-24, Volume: 573

    Topics: Animals; Corpus Striatum; Fetal Tissue Transplantation; Hyperalgesia; Male; Mesencephalon; Oxidopami

2014
Lesion of the dopaminergic nigrostriatal pathway induces trigeminal dynamic mechanical allodynia.
    Brain and behavior, 2014, Volume: 4, Issue:3

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Extracellular Signal-Regulat

2014
Characterization of nociceptive response to chemical, mechanical, and thermal stimuli in adolescent rats with neonatal dopamine depletion.
    Neuroscience, 2015, Mar-19, Volume: 289

    Topics: Animals; Animals, Newborn; Brain Stem; Dopamine; Dopamine Agents; Formaldehyde; Hot Temperature; Hyp

2015
Neural mechanism underlying hyperalgesic response to orofacial pain in Parkinson's disease model rats.
    Neuroscience research, 2015, Volume: 96

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Facial Pain; Formaldehyde; Hyperalgesia; Male; Oxi

2015
Nigrostriatal dopaminergic depletion produces orofacial static mechanical allodynia.
    European journal of pain (London, England), 2016, Volume: 20, Issue:2

    Topics: Animals; Corpus Striatum; Dopamine; Facial Pain; Hyperalgesia; Male; Neuralgia; Oxidopamine; Phospho

2016
The effects of subthalamic deep brain stimulation on mechanical and thermal thresholds in 6OHDA-lesioned rats.
    The European journal of neuroscience, 2015, Volume: 42, Issue:4

    Topics: Adrenergic Agents; Animals; Deep Brain Stimulation; Disease Models, Animal; Functional Laterality; H

2015
Effects of subthalamic deep brain stimulation with duloxetine on mechanical and thermal thresholds in 6OHDA lesioned rats.
    Brain research, 2017, 01-15, Volume: 1655

    Topics: Analgesics; Animals; Antiparkinson Agents; Combined Modality Therapy; Deep Brain Stimulation; Duloxe

2017
Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia.
    Brain research, 2008, Oct-31, Volume: 1238

    Topics: Adrenergic Agents; Animals; Basal Ganglia; Denervation; Dopamine; Formaldehyde; Hyperalgesia; Image

2008
Descending pathways from activated locus coeruleus/subcoeruleus following unilateral hindpaw inflammation in the rat.
    Brain research bulletin, 2009, Mar-16, Volume: 78, Issue:4-5

    Topics: Animals; Carrageenan; Disease Models, Animal; Functional Laterality; Hindlimb; Hyperalgesia; Inflamm

2009
Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury.
    Pain, 2009, Volume: 146, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotroph

2009
Chemical or surgical sympathectomy prevents mechanical hyperalgesia induced by intraplantar injection of bee venom in rats.
    Brain research, 2010, Sep-24, Volume: 1353

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals

2010
Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain.
    Brain research, 2011, Sep-26, Volume: 1414

    Topics: Adrenergic Agents; Animals; Biogenic Monoamines; Disease Models, Animal; Dose-Response Relationship,

2011
Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents.
    Neuroscience, 2002, Volume: 114, Issue:2

    Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Afferent Pathways;

2002
Attenuation of neuropathic manifestations by local block of the activities of the ventrolateral orbito-frontal area in the rat.
    Neuroscience, 2003, Volume: 120, Issue:4

    Topics: Adrenergic Agents; Anesthetics, Local; Animals; Cold Temperature; Disease Models, Animal; Electricit

2003
Peripheral P2X receptors and nociception: interactions with biogenic amine systems.
    Pain, 2004, Volume: 110, Issue:1-2

    Topics: Adenosine Triphosphate; Adrenergic Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio

2004
The antiallodynic and antihyperalgesic effects of neurotropin in mice with spinal nerve ligation.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: 5,7-Dihydroxytryptamine; Analgesics; Animals; Behavior, Animal; Biogenic Monoamines; Hot Temperature

2005
Behavioral responses and Fos activation following painful stimuli in a rodent model of Parkinson's disease.
    Brain research, 2007, Oct-24, Volume: 1176

    Topics: Animals; Behavior, Animal; Biomarkers; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Hyp

2007
Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model.
    Neuropharmacology, 2007, Volume: 53, Issue:7

    Topics: Adrenergic Agents; Afferent Pathways; Analgesics; Animals; Behavior, Animal; Brain Stem; Disease Mod

2007
Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine.
    Brain research, 2008, Jun-05, Volume: 1213

    Topics: Adrenergic Agents; Analysis of Variance; Animals; Behavior, Animal; Functional Laterality; Hyperalge

2008
Mechanical hyperalgesia in streptozotocin-diabetic rats is not sympathetically maintained.
    Brain research, 1993, Jul-09, Volume: 616, Issue:1-2

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Sympathetic; Hyperalgesia;

1993
[Effects of sympathetic efferent in diabetic hyperalgesia in rat].
    Sheng li xue bao : [Acta physiologica Sinica], 1996, Volume: 48, Issue:6

    Topics: Alprostadil; Animals; Diabetes Mellitus, Experimental; Dinoprostone; Efferent Pathways; Ganglia, Sym

1996
Modulation of visceral nociceptive responses of rat spinal dorsal horn neurons by sympathectomy.
    Neuroreport, 2001, Mar-26, Volume: 12, Issue:4

    Topics: Animals; Colitis; Colon; Hyperalgesia; Irritants; Male; Nociceptors; Oxidopamine; Posterior Horn Cel

2001
Serotonin is a directly-acting hyperalgesic agent in the rat.
    Neuroscience, 1992, Volume: 48, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hydroxyurea; Hype

1992
Adjacent neuropathic hyperalgesia in rats: a model for sympathetic independent pain.
    Neuroscience letters, 1991, Dec-09, Volume: 133, Issue:2

    Topics: Animals; Disease Models, Animal; Hot Temperature; Hyperalgesia; Male; Norepinephrine; Oxidopamine; P

1991
Production of hyperalgesic prostaglandins by sympathetic postganglionic neurons.
    Journal of neurochemistry, 1989, Volume: 53, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Dose-Respo

1989