oxidopamine has been researched along with Allodynia in 40 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Continuous SGB prevention inhibited mechanical hyperalgesia at 2, 3 and 4 weeks post modeling, and significantly reversed mechanical hyperalgesia at 3 and 4 weeks post modeling, compared with those of Saline group (p < 0." | 1.91 | Continuous SGB Inhibits Occurrence and Maintenance of Mechanical Hyperalgesia via Reducing Inflammatory Cytokines in Striatum and PAG of PD Nociception Rat Models. ( Huang, W; Li, M; Liu, G; Shi, Y; Zeng, Y, 2023) |
| "We hypothesized that hyperalgesia of 6-OHDA rats may be related to increased excitability of SDH neurons, and functional change of 5-HT3 receptor may reverse the hyperalgesia of 6-OHDA lesioned rats and decrease cell excitability of SDH neurons." | 1.72 | Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. ( An, MQ; Dai, YP; Dong, LG; Gu, HY; Li, CJ; Liu, CF; Liu, LB; Mao, CJ; Wang, F; Zhang, LG, 2022) |
| "6-OHDA-lesioned rats also showed cold allodynia as demonstrated by a significant difference in the number of flinches, latency and reaction time to acetone stimulus." | 1.62 | Behavioral, Cellular and Molecular Responses to Cold and Mechanical Stimuli in Rats with Bilateral Dopamine Depletion in the Mesencephalic Dopaminergic Neurons. ( Aissouni, Y; Durif, F; Elshennawy, M; Hafidi, A; Ouachikh, O; Youssef, S; Zaki, SS, 2021) |
| "CBD therapy is effective for parkinsonism-induced orofacial nociception." | 1.62 | Cannabidiol has therapeutic potential for myofascial pain in female and male parkinsonian rats. ( Del-Bel, E; Dos-Santos-Pereira, M; Guimaraes, FS; Nascimento, GCD; Vivanco-Estela, AN, 2021) |
| "Pain is a prevalent PD's non-motor symptom with a higher prevalence of analgesic drugs prescription for patients." | 1.56 | Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. ( Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS, 2020) |
| "On the other hand, to investigate allodynia and hyperalgesia induced by 6-OHDA, we used the von Frey filaments." | 1.56 | Unilateral lesion of the nigroestriatal pathway with 6-OHDA induced allodynia and hyperalgesia reverted by pramipexol in rats. ( Austrich-Olivares, AM; Benitez-Diaz Mirón, M; Coen, A; Garza-Mouriño, G; Godínez-Chaparro, B; Mendieta, L; Romero-Sánchez, HA, 2020) |
| "Dopamine is implicated in different orofacial pain-related diseases." | 1.43 | Nigrostriatal dopaminergic depletion produces orofacial static mechanical allodynia. ( Dieb, W; Durif, F; Hafidi, A; Ouachikh, O, 2016) |
| "NTP inhibited both tactile allodynia and mechanical and thermal hyperalgesia in a dose-dependent manner." | 1.33 | The antiallodynic and antihyperalgesic effects of neurotropin in mice with spinal nerve ligation. ( Li, YH; Mashimo, T; Suzuki, T, 2005) |
| "We conclude that serotonin produces hyperalgesia by a direct action on the primary afferent neuron via the 5-HT1A subset of serotonin receptors." | 1.28 | Serotonin is a directly-acting hyperalgesic agent in the rat. ( Levine, JD; Taiwo, YO, 1992) |
| "A similar neuropathic hyperalgesia, with an associated pain syndrome, is seen in man following peripheral nerve section." | 1.28 | Adjacent neuropathic hyperalgesia in rats: a model for sympathetic independent pain. ( Kingery, WS; Vallin, JA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.50) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 11 (27.50) | 29.6817 |
| 2010's | 14 (35.00) | 24.3611 |
| 2020's | 10 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elshennawy, M | 1 |
| Ouachikh, O | 3 |
| Aissouni, Y | 1 |
| Youssef, S | 1 |
| Zaki, SS | 1 |
| Durif, F | 3 |
| Hafidi, A | 3 |
| Bouchatta, O | 1 |
| Aby, F | 1 |
| Sifeddine, W | 1 |
| Bouali-Benazzouz, R | 2 |
| Brochoire, L | 1 |
| Manouze, H | 1 |
| Fossat, P | 2 |
| Ba M'Hamed, S | 1 |
| Bennis, M | 1 |
| Landry, M | 2 |
| Li, CJ | 2 |
| Zhang, LG | 2 |
| Liu, LB | 1 |
| An, MQ | 2 |
| Dong, LG | 2 |
| Gu, HY | 2 |
| Dai, YP | 1 |
| Wang, F | 3 |
| Mao, CJ | 3 |
| Liu, CF | 3 |
| Li, M | 2 |
| Huang, W | 1 |
| Shi, Y | 1 |
| Zeng, Y | 1 |
| Liu, G | 1 |
| Zhang, JB | 1 |
| Crivelaro do Nascimento, G | 1 |
| Ferrari, DP | 1 |
| Guimaraes, FS | 2 |
| Del Bel, EA | 1 |
| Bortolanza, M | 1 |
| Ferreira-Junior, NC | 1 |
| Zhu, M | 1 |
| Xu, Q | 1 |
| Ding, F | 1 |
| Tian, Y | 1 |
| Zhang, M | 1 |
| Romero-Sánchez, HA | 1 |
| Mendieta, L | 1 |
| Austrich-Olivares, AM | 1 |
| Garza-Mouriño, G | 1 |
| Benitez-Diaz Mirón, M | 1 |
| Coen, A | 1 |
| Godínez-Chaparro, B | 1 |
| Maegawa, H | 2 |
| Usami, N | 1 |
| Kudo, C | 2 |
| Hanamoto, H | 2 |
| Niwa, H | 2 |
| Vivanco-Estela, AN | 1 |
| Dos-Santos-Pereira, M | 1 |
| Del-Bel, E | 1 |
| Nascimento, GCD | 1 |
| Wang, CT | 1 |
| Zhang, XQ | 1 |
| Zhang, CY | 1 |
| Lv, DJ | 1 |
| Yang, YP | 1 |
| Xia, KL | 1 |
| Liu, JY | 1 |
| Hu, LF | 1 |
| Xu, GY | 1 |
| Charles, KA | 1 |
| Naudet, F | 1 |
| De Deurwaerdère, P | 1 |
| Benazzouz, A | 1 |
| Chen, HS | 2 |
| Li, FP | 1 |
| Li, XQ | 1 |
| Liu, BJ | 1 |
| Qu, F | 2 |
| Wen, WW | 2 |
| Wang, Y | 2 |
| Lin, Q | 1 |
| Li, W | 1 |
| Shi, X | 1 |
| Wang, L | 1 |
| Guo, T | 1 |
| Wei, T | 1 |
| Cheng, K | 1 |
| Rice, KC | 1 |
| Kingery, WS | 2 |
| Clark, JD | 1 |
| da Rocha, JT | 1 |
| Pinton, S | 1 |
| Gai, BM | 1 |
| Nogueira, CW | 1 |
| Takeda, R | 1 |
| Ishida, Y | 1 |
| Ebihara, K | 1 |
| Abe, H | 1 |
| Matsuo, H | 1 |
| Ikeda, T | 1 |
| Koganemaru, G | 1 |
| Kuramashi, A | 1 |
| Funahashi, H | 1 |
| Magata, Y | 1 |
| Kawai, K | 1 |
| Nishimori, T | 1 |
| Dieb, W | 2 |
| Ogata, M | 1 |
| Noda, K | 1 |
| Akita, H | 1 |
| Ishibashi, H | 2 |
| Morimoto, Y | 1 |
| Boku, A | 1 |
| Sugimura, M | 1 |
| Kato, T | 1 |
| Yoshida, A | 1 |
| Gee, LE | 2 |
| Chen, N | 1 |
| Ramirez-Zamora, A | 1 |
| Shin, DS | 2 |
| Pilitsis, JG | 2 |
| Kaszuba, BC | 1 |
| Walling, I | 1 |
| Greco, R | 2 |
| Tassorelli, C | 2 |
| Armentero, MT | 2 |
| Sandrini, G | 2 |
| Nappi, G | 2 |
| Blandini, F | 2 |
| Maeda, M | 1 |
| Tsuruoka, M | 1 |
| Hayashi, B | 1 |
| Nagasawa, I | 1 |
| Inoue, T | 1 |
| Arsenault, A | 1 |
| Sawynok, J | 3 |
| He, X | 1 |
| Eto, K | 1 |
| Kim, SK | 1 |
| Nabekura, J | 1 |
| Liu, XJ | 1 |
| White, TD | 1 |
| Baliki, M | 1 |
| Al-Amin, HA | 1 |
| Atweh, SF | 1 |
| Jaber, M | 1 |
| Hawwa, N | 1 |
| Jabbur, SJ | 1 |
| Apkarian, AV | 1 |
| Saadé, NE | 1 |
| Waldron, JB | 1 |
| Suzuki, T | 1 |
| Li, YH | 1 |
| Mashimo, T | 1 |
| Fancellu, R | 1 |
| Takeuchi, Y | 1 |
| Takasu, K | 1 |
| Ono, H | 1 |
| Tanabe, M | 1 |
| Chudler, EH | 1 |
| Lu, Y | 1 |
| Ahlgren, SC | 1 |
| Levine, JD | 3 |
| Liu, J | 1 |
| Wang, KM | 1 |
| He, LZ | 1 |
| Cao, DY | 1 |
| Kalmari, J | 1 |
| Niissalo, S | 1 |
| Konttinen, YT | 1 |
| Pertovaara, A | 1 |
| Taiwo, YO | 2 |
| Vallin, JA | 1 |
| Gonzales, R | 1 |
| Goldyne, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preemptive Analgesia With Amitryptyline for Prevention of Post-operative Pain in Women After Total Abdominal Hysterectomy: a Randomized Clinical Trial[NCT03587025] | Phase 3 | 150 participants (Actual) | Interventional | 2015-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
40 other studies available for oxidopamine and Allodynia
| Article | Year |
|---|---|
Behavioral, Cellular and Molecular Responses to Cold and Mechanical Stimuli in Rats with Bilateral Dopamine Depletion in the Mesencephalic Dopaminergic Neurons.
Topics: Animals; Cold Temperature; Dopamine; Dopaminergic Neurons; Hyperalgesia; Oxidopamine; Rats | 2021 |
Pain hypersensitivity in a pharmacological mouse model of attention-deficit/hyperactivity disorder.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Gyrus Cinguli; Hyper | 2022 |
Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Hyperalgesia; Ondansetron; Oxidopamine; P | 2022 |
Continuous SGB Inhibits Occurrence and Maintenance of Mechanical Hyperalgesia via Reducing Inflammatory Cytokines in Striatum and PAG of PD Nociception Rat Models.
Topics: Animals; Cytokines; Hyperalgesia; Interleukin-6; Nociception; Oxidopamine; Pain Threshold; Parkinson | 2023 |
PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson's disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Humans; Hyperalgesia; Oxidopamine; Pain; Parkin | 2023 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecox | 2020 |
Sensation of TRPV1 via 5-hydroxytryptamine signaling modulates pain hypersensitivity in a 6-hydroxydopamine induced mice model of Parkinson's disease.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Hyperalgesia; | 2020 |
Unilateral lesion of the nigroestriatal pathway with 6-OHDA induced allodynia and hyperalgesia reverted by pramipexol in rats.
Topics: Analgesics; Animals; Antiparkinson Agents; Dopamine Agonists; Hyperalgesia; Male; Oxidopamine; Pars | 2020 |
Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury.
Topics: Animals; Cranial Nerves; Dopamine; Extracellular Signal-Regulated MAP Kinases; Facial Nerve Injuries | 2020 |
Cannabidiol has therapeutic potential for myofascial pain in female and male parkinsonian rats.
Topics: Analgesics; Animals; Anticonvulsants; Cannabidiol; Estrous Cycle; Facial Pain; Female; Hyperalgesia; | 2021 |
Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 5,7-Dihydroxytryptamine; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; Ind | 2017 |
Alteration of nociceptive integration in the spinal cord of a rat model of Parkinson's disease.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine; Functional Laterality; Hyperalgesia; H | 2018 |
Acute stress regulates nociception and inflammatory response induced by bee venom in rats: possible mechanisms.
Topics: Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Edema; Hindlimb; Hyperalgesia; Inflammation; | 2013 |
Epidermal adrenergic signaling contributes to inflammation and pain sensitization in a rat model of complex regional pain syndrome.
Topics: Adrenergic Agents; Animals; Bufanolides; Complex Regional Pain Syndromes; Disease Models, Animal; Do | 2013 |
Diphenyl diselenide reduces mechanical and thermal nociceptive behavioral responses after unilateral intrastriatal administration of 6-hydroxydopamine in rats.
Topics: Administration, Oral; Animals; Benzene Derivatives; Corpus Striatum; Formaldehyde; Hot Temperature; | 2013 |
Intrastriatal grafts of fetal ventral mesencephalon improve allodynia-like withdrawal response to mechanical stimulation in a rat model of Parkinson's disease.
Topics: Animals; Corpus Striatum; Fetal Tissue Transplantation; Hyperalgesia; Male; Mesencephalon; Oxidopami | 2014 |
Lesion of the dopaminergic nigrostriatal pathway induces trigeminal dynamic mechanical allodynia.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Extracellular Signal-Regulat | 2014 |
Characterization of nociceptive response to chemical, mechanical, and thermal stimuli in adolescent rats with neonatal dopamine depletion.
Topics: Animals; Animals, Newborn; Brain Stem; Dopamine; Dopamine Agents; Formaldehyde; Hot Temperature; Hyp | 2015 |
Neural mechanism underlying hyperalgesic response to orofacial pain in Parkinson's disease model rats.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Facial Pain; Formaldehyde; Hyperalgesia; Male; Oxi | 2015 |
Nigrostriatal dopaminergic depletion produces orofacial static mechanical allodynia.
Topics: Animals; Corpus Striatum; Dopamine; Facial Pain; Hyperalgesia; Male; Neuralgia; Oxidopamine; Phospho | 2016 |
The effects of subthalamic deep brain stimulation on mechanical and thermal thresholds in 6OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Deep Brain Stimulation; Disease Models, Animal; Functional Laterality; H | 2015 |
Effects of subthalamic deep brain stimulation with duloxetine on mechanical and thermal thresholds in 6OHDA lesioned rats.
Topics: Analgesics; Animals; Antiparkinson Agents; Combined Modality Therapy; Deep Brain Stimulation; Duloxe | 2017 |
Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia.
Topics: Adrenergic Agents; Animals; Basal Ganglia; Denervation; Dopamine; Formaldehyde; Hyperalgesia; Image | 2008 |
Descending pathways from activated locus coeruleus/subcoeruleus following unilateral hindpaw inflammation in the rat.
Topics: Animals; Carrageenan; Disease Models, Animal; Functional Laterality; Hindlimb; Hyperalgesia; Inflamm | 2009 |
Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotroph | 2009 |
Chemical or surgical sympathectomy prevents mechanical hyperalgesia induced by intraplantar injection of bee venom in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 2010 |
Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain.
Topics: Adrenergic Agents; Animals; Biogenic Monoamines; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Afferent Pathways; | 2002 |
Attenuation of neuropathic manifestations by local block of the activities of the ventrolateral orbito-frontal area in the rat.
Topics: Adrenergic Agents; Anesthetics, Local; Animals; Cold Temperature; Disease Models, Animal; Electricit | 2003 |
Peripheral P2X receptors and nociception: interactions with biogenic amine systems.
Topics: Adenosine Triphosphate; Adrenergic Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio | 2004 |
The antiallodynic and antihyperalgesic effects of neurotropin in mice with spinal nerve ligation.
Topics: 5,7-Dihydroxytryptamine; Analgesics; Animals; Behavior, Animal; Biogenic Monoamines; Hot Temperature | 2005 |
Behavioral responses and Fos activation following painful stimuli in a rodent model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Biomarkers; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Hyp | 2007 |
Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model.
Topics: Adrenergic Agents; Afferent Pathways; Analgesics; Animals; Behavior, Animal; Brain Stem; Disease Mod | 2007 |
Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Behavior, Animal; Functional Laterality; Hyperalge | 2008 |
Mechanical hyperalgesia in streptozotocin-diabetic rats is not sympathetically maintained.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Sympathetic; Hyperalgesia; | 1993 |
[Effects of sympathetic efferent in diabetic hyperalgesia in rat].
Topics: Alprostadil; Animals; Diabetes Mellitus, Experimental; Dinoprostone; Efferent Pathways; Ganglia, Sym | 1996 |
Modulation of visceral nociceptive responses of rat spinal dorsal horn neurons by sympathectomy.
Topics: Animals; Colitis; Colon; Hyperalgesia; Irritants; Male; Nociceptors; Oxidopamine; Posterior Horn Cel | 2001 |
Serotonin is a directly-acting hyperalgesic agent in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hydroxyurea; Hype | 1992 |
Adjacent neuropathic hyperalgesia in rats: a model for sympathetic independent pain.
Topics: Animals; Disease Models, Animal; Hot Temperature; Hyperalgesia; Male; Norepinephrine; Oxidopamine; P | 1991 |
Production of hyperalgesic prostaglandins by sympathetic postganglionic neurons.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Dose-Respo | 1989 |