Page last updated: 2024-10-25

clonazepam and Allodynia

clonazepam has been researched along with Allodynia in 3 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Research Excerpts

ExcerptRelevanceReference
"We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain."3.70The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999)
"Clobazam was chosen because of its relatively low sedative properties and CLN because of its use in neuropathic pain."2.80GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers. ( Besson, M; Curatolo, M; Daali, Y; Desmeules, J; Matthey, A; Poncet, A; Vuillemier, P; Zeilhofer, HU, 2015)
"The area of static hyperalgesia after intradermal capsaicin injection was the primary endpoint."2.78Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study. ( Arendt-Nielsen, L; Besson, M; Curatolo, M; Desmeules, J; Vuilleumier, PH, 2013)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vuilleumier, PH1
Besson, M2
Desmeules, J2
Arendt-Nielsen, L1
Curatolo, M2
Matthey, A1
Daali, Y1
Poncet, A1
Vuillemier, P1
Zeilhofer, HU1
Yasuda, T1
Iwamoto, T1
Ohara, M1
Sato, S1
Kohri, H1
Noguchi, K1
Senba, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Gaba-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers[NCT01011036]Phase 317 participants (Actual)Interventional2009-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for clonazepam and Allodynia

ArticleYear
Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Analgesics; Benzodiazepines; Clobazam; Clonazepam; Cross-Sectional Studies; Doubl

2013
GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers.
    Pain, 2015, Volume: 156, Issue:3

    Topics: Adolescent; Adult; Benzodiazepines; Clobazam; Clonazepam; Cross-Over Studies; Cytochrome P-450 CYP2C

2015

Other Studies

1 other study available for clonazepam and Allodynia

ArticleYear
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:1

    Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide

1999