clonazepam has been researched along with Allodynia in 3 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "Clobazam was chosen because of its relatively low sedative properties and CLN because of its use in neuropathic pain." | 2.80 | GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers. ( Besson, M; Curatolo, M; Daali, Y; Desmeules, J; Matthey, A; Poncet, A; Vuillemier, P; Zeilhofer, HU, 2015) |
| "The area of static hyperalgesia after intradermal capsaicin injection was the primary endpoint." | 2.78 | Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study. ( Arendt-Nielsen, L; Besson, M; Curatolo, M; Desmeules, J; Vuilleumier, PH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vuilleumier, PH | 1 |
| Besson, M | 2 |
| Desmeules, J | 2 |
| Arendt-Nielsen, L | 1 |
| Curatolo, M | 2 |
| Matthey, A | 1 |
| Daali, Y | 1 |
| Poncet, A | 1 |
| Vuillemier, P | 1 |
| Zeilhofer, HU | 1 |
| Yasuda, T | 1 |
| Iwamoto, T | 1 |
| Ohara, M | 1 |
| Sato, S | 1 |
| Kohri, H | 1 |
| Noguchi, K | 1 |
| Senba, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Gaba-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers[NCT01011036] | Phase 3 | 17 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for clonazepam and Allodynia
| Article | Year |
|---|---|
Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study.
Topics: Adolescent; Adult; Analgesics; Benzodiazepines; Clobazam; Clonazepam; Cross-Sectional Studies; Doubl | 2013 |
GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers.
Topics: Adolescent; Adult; Benzodiazepines; Clobazam; Clonazepam; Cross-Over Studies; Cytochrome P-450 CYP2C | 2015 |
1 other study available for clonazepam and Allodynia
| Article | Year |
|---|---|
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |