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prazosin and Allodynia

prazosin has been researched along with Allodynia in 20 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Research Excerpts

ExcerptRelevanceReference
"Prazosin cream inhibited adrenergic axon reflex vasodilatation in healthy volunteers, and also inhibited dynamic allodynia and punctate hyperalgesia in the CRPS-affected limb of some patients."7.83Topical prazosin attenuates sensitivity to tactile stimuli in patients with complex regional pain syndrome. ( Birklein, F; Drummond, ES; Drummond, PD; Finch, PM; Maker, G, 2016)
") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0."7.73Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005)
"Prazosin cream inhibited adrenergic axon reflex vasodilatation in healthy volunteers, and also inhibited dynamic allodynia and punctate hyperalgesia in the CRPS-affected limb of some patients."3.83Topical prazosin attenuates sensitivity to tactile stimuli in patients with complex regional pain syndrome. ( Birklein, F; Drummond, ES; Drummond, PD; Finch, PM; Maker, G, 2016)
"Analgesic activity of brimonidine, clonidine, and tizanidine was investigated in wild-type C57B/6, alpha-2A, and alpha-2C knockout mice with allodynia induced by N-methyl-D-aspartate or sulprostone."3.75Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia. ( Cheevers, CV; Donello, JE; Gil, DW; Kedzie, KM; Manlapaz, CA; Rao, S; Tang, E, 2009)
"5, and 2 mg/kg) of alpha1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas alpha2-AR antagonist yohimbine exacerbated it."3.73Effects of alpha1- and alpha2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005)
") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0."3.73Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005)
"The involvement of the sympathetic postganglionic neuron in secondary hyperalgesia was evaluated using a model of secondary hyperalgesia induced by a small intradermal injection of capsaicin in the rat, a procedure known to produce mechanical hyperalgesia/allodynia in humans."3.69Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat. ( Kinnman, E; Levine, JD, 1995)
"Hyperalgesia was induced by intraplantar injection of prostaglandin E2 (2μg)."1.42Angiotensin-(1-7) through Mas receptor activation induces peripheral antinociception by interaction with adrenoreceptors. ( Castor, MG; Duarte, ID; Romero, TR; Santos, RA, 2015)
"Established allodynia (by day 21) was partly reversed by the re-uptake inhibitor reboxetine (5 μg, i."1.39Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. ( Hickey, L; Hughes, SW; Hulse, RP; Lumb, BM; Pickering, AE, 2013)
"Terazosin was administered before the burn injury at one site, and after the burn injury at the other site."1.35alpha(1)-Adrenoceptors augment thermal hyperalgesia in mildly burnt skin. ( Drummond, PD, 2009)
"gabapentin were strongly suppressed."1.33Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse. ( Honda, M; Kasuya, N; Ono, H; Shimizu, S; Takasu, K; Tanabe, M, 2005)
"Mechanical hyperalgesia was quantified with von Frey hairs applied either for 3 s or repetitively to the plantar surface of the hindpaw."1.30Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists. ( Choi, Y; Grethel, EJ; Meyer, RA; Raja, SN; Ringkamp, M, 1999)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.00)18.2507
2000's9 (45.00)29.6817
2010's9 (45.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, H1
Altenbach, RJ1
Carr, TL1
Chandran, P1
Hsieh, GC1
Lewis, LG1
Manelli, AM1
Milicic, I1
Marsh, KC1
Miller, TR1
Strakhova, MI1
Vortherms, TA1
Wakefield, BD1
Wetter, JM1
Witte, DG1
Honore, P1
Esbenshade, TA1
Brioni, JD1
Cowart, MD1
Romero, TRL1
Soares Santos, RR1
Castor, MGME1
Petrocchi, JA1
Guzzo, LS1
Klein, A1
Duarte, IDG1
Choi, S1
Chae, HK1
Heo, H1
Hahm, DH1
Kim, W1
Kim, SK3
Hughes, SW1
Hickey, L1
Hulse, RP1
Lumb, BM1
Pickering, AE1
Song, Z1
Ansah, OB1
Meyerson, BA1
Pertovaara, A2
Linderoth, B1
Park, PE1
Schlosburg, JE1
Vendruscolo, LF1
Schulteis, G1
Edwards, S1
Koob, GF1
Wei, H1
Jin, CY1
Viisanen, H1
You, HJ1
Castor, MG1
Santos, RA1
Duarte, ID1
Romero, TR1
Drummond, ES1
Maker, G1
Birklein, F1
Finch, PM1
Drummond, PD2
Gil, DW1
Cheevers, CV1
Kedzie, KM1
Manlapaz, CA1
Rao, S1
Tang, E1
Donello, JE1
Chen, HS1
Qu, F1
He, X1
Wang, Y1
Wen, WW1
Tanabe, M1
Takasu, K1
Kasuya, N1
Shimizu, S1
Honda, M1
Ono, H1
Min, BI2
Kim, JH2
Hwang, BG2
Yoo, GY2
Park, DS2
Na, HS2
Akada, Y1
Mori, R1
Kato, Y1
Yamasaki, F1
Mochizuki, H1
Dogrul, A1
Coskun, I1
Uzbay, T1
Kinnman, E1
Levine, JD1
Ringkamp, M1
Grethel, EJ1
Choi, Y1
Meyer, RA1
Raja, SN1
Hord, AH1
Denson, DD1
Stowe, B1
Haygood, RM1

Other Studies

20 other studies available for prazosin and Allodynia

ArticleYear
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal;

2008
Noradrenaline induces peripheral antinociception by endogenous opioid release.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:4

    Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Leuci

2018
Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats.
    Toxins, 2019, 07-08, Volume: 11, Issue:7

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animal

2019
Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
    Pain, 2013, Volume: 154, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Analysis of Varian

2013
Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus.
    Neuroscience, 2013, Dec-03, Volume: 253

    Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists;

2013
Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.
    Addiction biology, 2015, Volume: 20, Issue:2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antag

2015
Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity.
    Pharmacological research, 2014, Volume: 90

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; A

2014
Angiotensin-(1-7) through Mas receptor activation induces peripheral antinociception by interaction with adrenoreceptors.
    Peptides, 2015, Volume: 69

    Topics: Adrenergic beta-Antagonists; Analgesics; Angiotensin I; Animals; Dinoprostone; Hyperalgesia; Norepin

2015
Topical prazosin attenuates sensitivity to tactile stimuli in patients with complex regional pain syndrome.
    European journal of pain (London, England), 2016, Volume: 20, Issue:6

    Topics: Administration, Topical; Adrenergic alpha-1 Receptor Antagonists; Adult; Complex Regional Pain Syndr

2016
alpha(1)-Adrenoceptors augment thermal hyperalgesia in mildly burnt skin.
    European journal of pain (London, England), 2009, Volume: 13, Issue:3

    Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Burns; Clonidine; Female

2009
Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.
    Anesthesiology, 2009, Volume: 110, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analg

2009
Chemical or surgical sympathectomy prevents mechanical hyperalgesia induced by intraplantar injection of bee venom in rats.
    Brain research, 2010, Sep-24, Volume: 1353

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals

2010
Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse.
    British journal of pharmacology, 2005, Volume: 144, Issue:5

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A

2005
Effects of alpha1- and alpha2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain.
    Brain research, 2005, Mar-28, Volume: 1039, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Cold Tempe

2005
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
    European journal of pharmacology, 2005, Oct-31, Volume: 523, Issue:1-3

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima

2005
Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.
    European journal of pharmacology, 2005, Oct-31, Volume: 523, Issue:1-3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A

2005
The contribution of alpha-1 and alpha-2 adrenoceptors in peripheral imidazoline and adrenoceptor agonist-induced nociception.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:2

    Topics: Adrenergic alpha-Agonists; Agmatine; Analgesics; Animals; Clonidine; Dose-Response Relationship, Dru

2006
Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat.
    Neuroscience, 1995, Volume: 65, Issue:1

    Topics: Animals; Capsaicin; Hindlimb; Hyperalgesia; Male; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley

1995
Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists.
    Pain, 1999, Volume: 79, Issue:2-3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A

1999
alpha-1 and alpha-2 Adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury.
    Anesthesia and analgesia, 2001, Volume: 92, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A

2001