prazosin has been researched along with Allodynia in 20 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prazosin cream inhibited adrenergic axon reflex vasodilatation in healthy volunteers, and also inhibited dynamic allodynia and punctate hyperalgesia in the CRPS-affected limb of some patients." | 7.83 | Topical prazosin attenuates sensitivity to tactile stimuli in patients with complex regional pain syndrome. ( Birklein, F; Drummond, ES; Drummond, PD; Finch, PM; Maker, G, 2016) |
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 7.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| "Prazosin cream inhibited adrenergic axon reflex vasodilatation in healthy volunteers, and also inhibited dynamic allodynia and punctate hyperalgesia in the CRPS-affected limb of some patients." | 3.83 | Topical prazosin attenuates sensitivity to tactile stimuli in patients with complex regional pain syndrome. ( Birklein, F; Drummond, ES; Drummond, PD; Finch, PM; Maker, G, 2016) |
| "Analgesic activity of brimonidine, clonidine, and tizanidine was investigated in wild-type C57B/6, alpha-2A, and alpha-2C knockout mice with allodynia induced by N-methyl-D-aspartate or sulprostone." | 3.75 | Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia. ( Cheevers, CV; Donello, JE; Gil, DW; Kedzie, KM; Manlapaz, CA; Rao, S; Tang, E, 2009) |
| "5, and 2 mg/kg) of alpha1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas alpha2-AR antagonist yohimbine exacerbated it." | 3.73 | Effects of alpha1- and alpha2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 3.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| "The involvement of the sympathetic postganglionic neuron in secondary hyperalgesia was evaluated using a model of secondary hyperalgesia induced by a small intradermal injection of capsaicin in the rat, a procedure known to produce mechanical hyperalgesia/allodynia in humans." | 3.69 | Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat. ( Kinnman, E; Levine, JD, 1995) |
| "Hyperalgesia was induced by intraplantar injection of prostaglandin E2 (2μg)." | 1.42 | Angiotensin-(1-7) through Mas receptor activation induces peripheral antinociception by interaction with adrenoreceptors. ( Castor, MG; Duarte, ID; Romero, TR; Santos, RA, 2015) |
| "Established allodynia (by day 21) was partly reversed by the re-uptake inhibitor reboxetine (5 μg, i." | 1.39 | Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. ( Hickey, L; Hughes, SW; Hulse, RP; Lumb, BM; Pickering, AE, 2013) |
| "Terazosin was administered before the burn injury at one site, and after the burn injury at the other site." | 1.35 | alpha(1)-Adrenoceptors augment thermal hyperalgesia in mildly burnt skin. ( Drummond, PD, 2009) |
| "gabapentin were strongly suppressed." | 1.33 | Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse. ( Honda, M; Kasuya, N; Ono, H; Shimizu, S; Takasu, K; Tanabe, M, 2005) |
| "Mechanical hyperalgesia was quantified with von Frey hairs applied either for 3 s or repetitively to the plantar surface of the hindpaw." | 1.30 | Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists. ( Choi, Y; Grethel, EJ; Meyer, RA; Raja, SN; Ringkamp, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Romero, TRL | 1 |
| Soares Santos, RR | 1 |
| Castor, MGME | 1 |
| Petrocchi, JA | 1 |
| Guzzo, LS | 1 |
| Klein, A | 1 |
| Duarte, IDG | 1 |
| Choi, S | 1 |
| Chae, HK | 1 |
| Heo, H | 1 |
| Hahm, DH | 1 |
| Kim, W | 1 |
| Kim, SK | 3 |
| Hughes, SW | 1 |
| Hickey, L | 1 |
| Hulse, RP | 1 |
| Lumb, BM | 1 |
| Pickering, AE | 1 |
| Song, Z | 1 |
| Ansah, OB | 1 |
| Meyerson, BA | 1 |
| Pertovaara, A | 2 |
| Linderoth, B | 1 |
| Park, PE | 1 |
| Schlosburg, JE | 1 |
| Vendruscolo, LF | 1 |
| Schulteis, G | 1 |
| Edwards, S | 1 |
| Koob, GF | 1 |
| Wei, H | 1 |
| Jin, CY | 1 |
| Viisanen, H | 1 |
| You, HJ | 1 |
| Castor, MG | 1 |
| Santos, RA | 1 |
| Duarte, ID | 1 |
| Romero, TR | 1 |
| Drummond, ES | 1 |
| Maker, G | 1 |
| Birklein, F | 1 |
| Finch, PM | 1 |
| Drummond, PD | 2 |
| Gil, DW | 1 |
| Cheevers, CV | 1 |
| Kedzie, KM | 1 |
| Manlapaz, CA | 1 |
| Rao, S | 1 |
| Tang, E | 1 |
| Donello, JE | 1 |
| Chen, HS | 1 |
| Qu, F | 1 |
| He, X | 1 |
| Wang, Y | 1 |
| Wen, WW | 1 |
| Tanabe, M | 1 |
| Takasu, K | 1 |
| Kasuya, N | 1 |
| Shimizu, S | 1 |
| Honda, M | 1 |
| Ono, H | 1 |
| Min, BI | 2 |
| Kim, JH | 2 |
| Hwang, BG | 2 |
| Yoo, GY | 2 |
| Park, DS | 2 |
| Na, HS | 2 |
| Akada, Y | 1 |
| Mori, R | 1 |
| Kato, Y | 1 |
| Yamasaki, F | 1 |
| Mochizuki, H | 1 |
| Dogrul, A | 1 |
| Coskun, I | 1 |
| Uzbay, T | 1 |
| Kinnman, E | 1 |
| Levine, JD | 1 |
| Ringkamp, M | 1 |
| Grethel, EJ | 1 |
| Choi, Y | 1 |
| Meyer, RA | 1 |
| Raja, SN | 1 |
| Hord, AH | 1 |
| Denson, DD | 1 |
| Stowe, B | 1 |
| Haygood, RM | 1 |
20 other studies available for prazosin and Allodynia
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Noradrenaline induces peripheral antinociception by endogenous opioid release.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Leuci | 2018 |
Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animal | 2019 |
Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Analysis of Varian | 2013 |
Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; | 2013 |
Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antag | 2015 |
Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; A | 2014 |
Angiotensin-(1-7) through Mas receptor activation induces peripheral antinociception by interaction with adrenoreceptors.
Topics: Adrenergic beta-Antagonists; Analgesics; Angiotensin I; Animals; Dinoprostone; Hyperalgesia; Norepin | 2015 |
Topical prazosin attenuates sensitivity to tactile stimuli in patients with complex regional pain syndrome.
Topics: Administration, Topical; Adrenergic alpha-1 Receptor Antagonists; Adult; Complex Regional Pain Syndr | 2016 |
alpha(1)-Adrenoceptors augment thermal hyperalgesia in mildly burnt skin.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Burns; Clonidine; Female | 2009 |
Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analg | 2009 |
Chemical or surgical sympathectomy prevents mechanical hyperalgesia induced by intraplantar injection of bee venom in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 2010 |
Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2005 |
Effects of alpha1- and alpha2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Cold Tempe | 2005 |
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima | 2005 |
Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2005 |
The contribution of alpha-1 and alpha-2 adrenoceptors in peripheral imidazoline and adrenoceptor agonist-induced nociception.
Topics: Adrenergic alpha-Agonists; Agmatine; Analgesics; Animals; Clonidine; Dose-Response Relationship, Dru | 2006 |
Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat.
Topics: Animals; Capsaicin; Hindlimb; Hyperalgesia; Male; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley | 1995 |
Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 1999 |
alpha-1 and alpha-2 Adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2001 |