tizanidine has been researched along with Allodynia in 4 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Analgesic activity of brimonidine, clonidine, and tizanidine was investigated in wild-type C57B/6, alpha-2A, and alpha-2C knockout mice with allodynia induced by N-methyl-D-aspartate or sulprostone." | 3.75 | Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia. ( Cheevers, CV; Donello, JE; Gil, DW; Kedzie, KM; Manlapaz, CA; Rao, S; Tang, E, 2009) |
| "Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation." | 3.72 | Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain. ( Kawamata, T; Namiki, A; Omote, K; Toriyabe, M; Wada, K; Yamamoto, H, 2003) |
| "Tizanidine was more effective in female than male neuropathic rats." | 1.72 | Sex-dependent antiallodynic effect of α ( Caram-Salas, NL; Castelo-Flores, DG; Centurión, D; De la Luz-Cuellar, YE; Granados-Soto, V; Rodríguez-Palma, EJ; Salinas-Abarca, AB, 2022) |
| "Tizanidine was effective in reducing sensitivity to heat, as measured by paw withdrawal latency, and did not cause sedation at smaller doses." | 1.31 | Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. ( Azevedo, MI; Chalfoun, AG; Denson, DD; Hord, AH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez-Palma, EJ | 1 |
| Castelo-Flores, DG | 1 |
| Caram-Salas, NL | 1 |
| Salinas-Abarca, AB | 1 |
| Centurión, D | 1 |
| De la Luz-Cuellar, YE | 1 |
| Granados-Soto, V | 1 |
| Gil, DW | 1 |
| Cheevers, CV | 1 |
| Kedzie, KM | 1 |
| Manlapaz, CA | 1 |
| Rao, S | 1 |
| Tang, E | 1 |
| Donello, JE | 1 |
| Kawamata, T | 1 |
| Omote, K | 1 |
| Yamamoto, H | 1 |
| Toriyabe, M | 1 |
| Wada, K | 1 |
| Namiki, A | 1 |
| Hord, AH | 1 |
| Chalfoun, AG | 1 |
| Denson, DD | 1 |
| Azevedo, MI | 1 |
4 other studies available for tizanidine and Allodynia
| Article | Year |
|---|---|
Sex-dependent antiallodynic effect of α
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Female; Hyperalgesia; Male; Neuralgia; Rat | 2022 |
Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analg | 2009 |
Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Cloni | 2003 |
Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Disease Models, Animal; Hot Temperature; Hyperalgesia | 2001 |