Page last updated: 2024-10-31

mianserin and Allodynia

mianserin has been researched along with Allodynia in 7 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Research Excerpts

ExcerptRelevanceReference
" The present study was designed to explore the effects and most appropriate dosage of mirtazapine in treating neuropathic pain and its possible neuroimmune mechanisms."5.35Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain. ( Feng, X; Hu, Y; Song, J; Wei, X; Xu, J; Zhu, J, 2008)
"The effect of mianserin on hyperalgesia occurring in connection with peripheral diabetic neuropathy was examined using the Randall-Selitto (mechanical nociceptive stimulus), Hargreaves (thermal nociceptive stimulus), and cold-plate (4°C, thermal nociceptive stimulus) tests."1.42Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: a study on mechanism of action. ( Can, ÖD; Demir Özkay, Ü; Öztürk, Y; Üçel, Uİ, 2015)
"Mirtazapine (MTZ) is an antidepressant, which is considered to enhance noradrenergic and serotonergic neurotransmission via antagonistic action at central α2-adrenergic autoreceptors and heteroreceptors."1.38Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. ( Enomoto, T; Hirayama, S; Horiuchi, H; Ikegami, D; Inada, E; Iseki, M; Nagase, H; Nakahara, K; Narita, M; Sakai, H; Suzuki, T; Torigoe, K; Yamashita, A; Yanase, M, 2012)
" All substances were dosed between 0."1.35Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats. ( Driehsen, C; Freynhagen, R; Hermanns, H; Lipfert, P; Muth-Selbach, U, 2009)
"Mirtazapine was orally administered to rats that had been operated on daily for 14 days."1.35Interaction of glia activation and neurotransmission in hippocampus of neuropathic rats treated with mirtazapine. ( Hu, Y; Liu, J; Wei, X; Xu, J; Zhu, J, 2009)
" The present study was designed to explore the effects and most appropriate dosage of mirtazapine in treating neuropathic pain and its possible neuroimmune mechanisms."1.35Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain. ( Feng, X; Hu, Y; Song, J; Wei, X; Xu, J; Zhu, J, 2008)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, X1
Zhang, G1
Dong, L1
Wang, X1
Sun, H1
Shen, J1
Li, W1
Xu, J3
Üçel, Uİ1
Can, ÖD1
Demir Özkay, Ü1
Öztürk, Y1
Muth-Selbach, U1
Hermanns, H1
Driehsen, C1
Lipfert, P1
Freynhagen, R1
Zhu, J2
Wei, X2
Liu, J1
Hu, Y2
Enomoto, T1
Yamashita, A1
Torigoe, K1
Horiuchi, H1
Hirayama, S1
Nakahara, K1
Yanase, M1
Sakai, H1
Ikegami, D1
Nagase, H1
Suzuki, T1
Iseki, M1
Inada, E1
Narita, M1
Feng, X1
Song, J1
Kudriashova, MF1
Andreev, BV1

Other Studies

7 other studies available for mianserin and Allodynia

ArticleYear
Repeated administration of mirtazapine attenuates oxaliplatin-induced mechanical allodynia and spinal NR2B up-regulation in rats.
    Neurochemical research, 2013, Volume: 38, Issue:9

    Topics: Animals; Antidepressive Agents, Tricyclic; Hyperalgesia; Mianserin; Mirtazapine; Organoplatinum Comp

2013
Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: a study on mechanism of action.
    European journal of pharmacology, 2015, Jun-05, Volume: 756

    Topics: Analgesics; Animals; Catecholamines; Diabetic Neuropathies; Hyperalgesia; Male; Mianserin; Neuralgia

2015
Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats.
    Brain research bulletin, 2009, Apr-06, Volume: 79, Issue:1

    Topics: Analgesics; Animals; Antidepressive Agents; Hot Temperature; Hyperalgesia; Injections, Spinal; Male;

2009
Interaction of glia activation and neurotransmission in hippocampus of neuropathic rats treated with mirtazapine.
    Experimental and clinical psychopharmacology, 2009, Volume: 17, Issue:3

    Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Astrocytes; Glial Fibrillary Acidic Protein;

2009
Effects of mirtazapine on sleep disturbance under neuropathic pain-like state.
    Synapse (New York, N.Y.), 2012, Volume: 66, Issue:6

    Topics: Animals; Disease Models, Animal; Histamine H1 Antagonists; Hyperalgesia; Male; Mianserin; Mice; Mice

2012
Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain.
    Neuroscience letters, 2008, Mar-05, Volume: 433, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cytokines; Denervation; Disease Models, Animal; Do

2008
[Neuropharmacological analysis of participation of the serotoninergic system in hyperalgesia in neurotized rats].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2000, Volume: 86, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Buspirone; Fluoxetine; Hyperalgesia; Male; Mian

2000