Page last updated: 2024-10-27

fentanyl and Allodynia

fentanyl has been researched along with Allodynia in 110 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Research Excerpts

ExcerptRelevanceReference
"Our results showed that patients undergoing coronary artery bypass surgery receiving fentanyl anesthesia developed postoperative tactile allodynia and thermal hyperalgesia and this was more prominent in high dose group."9.19Acute high dose-fentanyl exposure produces hyperalgesia and tactile allodynia after coronary artery bypass surgery. ( Cinar, S; Doganci, S; Dogrul, A; Eksert, S; Eskin, MB; Ince, ME; Ozkan, G; Yildirim, V, 2014)
"The opioids buprenorphine and fentanyl significantly potentiate the effect of descending pain inhibition in healthy volunteers."9.16A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Malver, LP; Mansikka, H; Oksche, A, 2012)
"3°C cold water), nerve growth factor-induced muscle soreness and intradermal capsaicin-induced hyperalgesia and allodynia."9.15Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models. ( Andresen, T; Arendt-Nielsen, L; Christrup, LL; Drewes, AM; Foster, DJ; Upton, RN, 2011)
"To determine the effects of systemic fentanyl analgesia in preventing the pain related to the administration of retrobulbar anesthesia and cataract surgery."9.10Effects of fentanyl on pain and hemodynamic response after retrobulbar block in patients having phacoemulsification. ( Ermis, SS; Inan, UU; Oztürk, F; Sivaci, RG, 2003)
"Fentanyl is an opioid commonly prescribed for cancer pain."7.88Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice. ( Andoh, T; Kuraishi, Y; Saiki, I; Shinohara, A, 2018)
" Here, by using a chronic inflammation model, namely subplantar injection of Complete Freund's adjuvant, we show a peripheral synergistic interaction between the histamine H(3) receptor agonist R-(alpha)-methylhistamine and fentanyl on the inhibition of thermal hyperalgesia and of peripheral substance P accumulation."7.76Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S, 2010)
"Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties."7.75Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. ( Chateauraynaud, J; Laboureyras, E; Richebé, P; Simonnet, G, 2009)
"A 62-year-old man receiving subcutaneous fentanyl for the management of cancer pain developed generalized central excitation after an overdose of 5000 micrograms of fentanyl."7.69Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain. ( Bruera, E; Pereira, J, 1997)
"Opioid-induced hyperalgesia is a phenomenon defined by increasing pain after opioid exposure with the worsening of pain occurring when opioid doses are increased."6.52Fentanyl-induced hyperalgesia in acute pain management. ( Kane-Gill, SL; Lyons, PJ; Nery, JP; Rivosecchi, RM, 2015)
"Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine."5.91A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons. ( Chang, L; Chen, J; Li, Q; Liu, P; Luo, Q; Shu, H; Wang, L; Wu, G; Xiong, Y; Zhou, X, 2023)
"Withdrawal symptoms are severely unpleasant, prolonged, and frequently hinder recovery or lead to relapse."5.62Divergent profiles of fentanyl withdrawal and associated pain in mice and rats. ( Arakawa, K; Cramer, N; Fox, ME; Jenne, C; Keller, A; Uddin, O, 2021)
"Remifentanil infusion has been strongly linked to both tolerance and OIH in these patients; however, the impact of using an intraoperative fentanyl infusion has not been well studied."5.51Fentanyl versus remifentanil-based TIVA for pediatric scoliosis repair: does it matter? ( Ahn, S; Gecelter, R; Kars, MS; Merwin, S; Poon, S; Rothman, A; Villacres Mori, B; Wendolowski, S, 2019)
"In contrast to the opioid, chronic hyperalgesia did not interfere with the reinforcing effect of food."5.39Effect of chronic pain on fentanyl self-administration in mice. ( Fairbanks, CA; Kitto, KF; Krumenacher, P; Peterson, CD; Wade, CL; Wilcox, GL, 2013)
"Pain was well controlled."5.35Fentanyl-induced neurotoxicity and paradoxic pain. ( George, ML; Okon, TR, 2008)
"Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES."5.34Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007)
"A higher dose of fentanyl led to significantly decreased pain scores as measured by the numeric rating scale (0."5.22Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial. ( Bandschapp, O; Dolder, P; Filitz, J; Mauermann, E; Rentsch, KM; Ruppen, W, 2016)
"Our results showed that patients undergoing coronary artery bypass surgery receiving fentanyl anesthesia developed postoperative tactile allodynia and thermal hyperalgesia and this was more prominent in high dose group."5.19Acute high dose-fentanyl exposure produces hyperalgesia and tactile allodynia after coronary artery bypass surgery. ( Cinar, S; Doganci, S; Dogrul, A; Eksert, S; Eskin, MB; Ince, ME; Ozkan, G; Yildirim, V, 2014)
"The opioids buprenorphine and fentanyl significantly potentiate the effect of descending pain inhibition in healthy volunteers."5.16A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Malver, LP; Mansikka, H; Oksche, A, 2012)
"Buprenorphine, but not fentanyl, showed analgesic effects against experimentally induced, bone-associated pain and primary hyperalgesia compared with placebo."5.15Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain. ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Mansikka, H; Oksche, A; Staahl, C, 2011)
"3°C cold water), nerve growth factor-induced muscle soreness and intradermal capsaicin-induced hyperalgesia and allodynia."5.15Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models. ( Andresen, T; Arendt-Nielsen, L; Christrup, LL; Drewes, AM; Foster, DJ; Upton, RN, 2011)
"To determine the effects of systemic fentanyl analgesia in preventing the pain related to the administration of retrobulbar anesthesia and cataract surgery."5.10Effects of fentanyl on pain and hemodynamic response after retrobulbar block in patients having phacoemulsification. ( Ermis, SS; Inan, UU; Oztürk, F; Sivaci, RG, 2003)
" His pain and agitation were difficult to manage but improved after he received ketamine."4.12Suspected opioid-induced hyperalgesia in an infant following surgery: A case report. ( Efune, PN; Rebstock, SE, 2022)
"Opioids like fentanyl remain the mainstay treatment for chronic pain."4.12Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia. ( Barko, K; Logan, RW; Puig, S; Seney, ML; Shelton, MA, 2022)
"We report the case of a 60 year old patient on chronic Intrathecal combined fentanyl and Bupivacaine who had worsening pain with increasing doses and improved after weaning off intrathecal opioids."3.91Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl. ( Acquadro, MA; Cheng, Y; Farah, F; Gerges, FJ; Kalaydjian, A, 2019)
"Fentanyl is an opioid commonly prescribed for cancer pain."3.88Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice. ( Andoh, T; Kuraishi, Y; Saiki, I; Shinohara, A, 2018)
"Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model."3.80Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state. ( Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Watanabe, C, 2014)
"The study showed that gabapentin can significantly prevented opioid-induced hyperalgesia (OIH) induced caused by fentanyl and morphine, suggesting a role for the addition of gabapentin in the perioperative period and during chronic pain treatment as an effective drug to prevent OIH."3.78Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats. ( Wei, W; Wei, X, 2012)
" Here, by using a chronic inflammation model, namely subplantar injection of Complete Freund's adjuvant, we show a peripheral synergistic interaction between the histamine H(3) receptor agonist R-(alpha)-methylhistamine and fentanyl on the inhibition of thermal hyperalgesia and of peripheral substance P accumulation."3.76Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S, 2010)
"Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties."3.75Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. ( Chateauraynaud, J; Laboureyras, E; Richebé, P; Simonnet, G, 2009)
" After the treatment of mice for 6 days with implanted morphine pellets followed by their removal, both thermal hyperalgesia and mechanical allodynia were documented."3.71A murine model of opioid-induced hyperalgesia. ( Angst, MS; Clark, JD; Li, X, 2001)
"In this experimental pain model, activation of peripheral mu or kappa opioid receptors can attenuate capsaicin-induced thermal hyperalgesia in rats."3.70Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats. ( Johnson, MD; Ko, MC; Tuchman, JE; Wiesenauer, K; Woods, JH, 2000)
"A 62-year-old man receiving subcutaneous fentanyl for the management of cancer pain developed generalized central excitation after an overdose of 5000 micrograms of fentanyl."3.69Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain. ( Bruera, E; Pereira, J, 1997)
"The dosage of fentanyl-nefopam IV-PCA was significantly less in C group than R group for postoperative 24 h."3.11Effect of remifentanil on post-operative analgesic consumption in patients undergoing shoulder arthroplasty after interscalene brachial plexus block: a randomized controlled trial. ( Bae, H; Kim, JT; Kim, Y; Lim, YJ; Park, SK; Sakura, S; Yoo, S, 2022)
"Following extubation, withdrawal symptoms were assessed by a modification of the Finnegan score."2.78Remifentanil-induced tolerance, withdrawal or hyperalgesia in infants: a randomized controlled trial. RAPIP trial: remifentanil-based analgesia and sedation of paediatric intensive care patients. ( Harnischmacher, U; Junghaenel, S; Link, F; Oberthuer, A; Roth, B; Stuetzer, H; Welzing, L, 2013)
"The intensity of postoperative pain was similar in both groups (VAS, <3) CONCLUSIONS: Remifentanil showed good analgesic properties during laparoscopic gastric banding surgery."2.77Comparison of different anesthetic regimens in patients undergoing laparoscopic adjustable gastric banding operations: a prospective randomized trial. ( Aksionova, D; Brimas, G; Cincilevičiūtė, G; Kontrimavičiūtė, E; Sipylaitė, J, 2012)
"Pre-treatment with fentanyl 1."2.73Administration of fentanyl before remifentanil-based anaesthesia has no influence on post-operative pain or analgesic consumption. ( Hoymork, SC; Lenz, H; Raeder, J, 2008)
"Ketamine failed to inhibit both secondary hyperalgesia and axon reflex flare as long as nonlocal anesthetic concentrations were applied."2.69The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction. ( Blunk, JA; Koppert, W; Likar, R; Schmelz, M; Sittl, R; Zeck, S, 1999)
"These results suggest that hyperalgesia induced by a tourniquet may be a useful technique for the investigation of the anti-nociceptive effects of analgesic drugs in sheep."2.67Effects of non-steroidal anti-inflammatory drugs on the hyperalgesia to noxious mechanical stimulation induced by the application of a tourniquet to a forelimb of sheep. ( Nolan, AM; Welsh, EM, 1994)
"The surgical wound hyperalgesia was assessed by measuring pain threshold to pressure on the wound by using an algometer, and also by measuring the intensity of pain to suprathreshold pressure on the wound with the visual analog self-rating method."2.67Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. ( Bradley, EL; Finger, J; Isakson, A; Kissin, I; Oz, Y; Tverskoy, M, 1994)
"Opioid-induced hyperalgesia is a phenomenon defined by increasing pain after opioid exposure with the worsening of pain occurring when opioid doses are increased."2.52Fentanyl-induced hyperalgesia in acute pain management. ( Kane-Gill, SL; Lyons, PJ; Nery, JP; Rivosecchi, RM, 2015)
"Inhibition of these neurons alleviates hyperalgesia in male OIH rats but exerts an opposite effect in male control rats."1.91HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats. ( Gan, S; Li, CH; Luo, F; Wang, X; Zhang, Z; Zhu, P, 2023)
"Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine."1.91A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons. ( Chang, L; Chen, J; Li, Q; Liu, P; Luo, Q; Shu, H; Wang, L; Wu, G; Xiong, Y; Zhou, X, 2023)
"Opioid-induced hyperalgesia (OIH) is a problem associated with prolonged use of opioids in chronic pain management, and its effective treatment has been hampered by lack of mechanistic evidence."1.72Inhibition of Oligodendrocyte Apoptosis in the Prelimbic Medial Prefrontal Cortex Prevents Fentanyl-induced Hyperalgesia in Rats. ( Cui, LL; Gan, SF; Li, CH; Luo, F; Wang, XX; Xiao, J; Zhang, ZR, 2022)
"Withdrawal symptoms are severely unpleasant, prolonged, and frequently hinder recovery or lead to relapse."1.62Divergent profiles of fentanyl withdrawal and associated pain in mice and rats. ( Arakawa, K; Cramer, N; Fox, ME; Jenne, C; Keller, A; Uddin, O, 2021)
"Remifentanil infusion has been strongly linked to both tolerance and OIH in these patients; however, the impact of using an intraoperative fentanyl infusion has not been well studied."1.51Fentanyl versus remifentanil-based TIVA for pediatric scoliosis repair: does it matter? ( Ahn, S; Gecelter, R; Kars, MS; Merwin, S; Poon, S; Rothman, A; Villacres Mori, B; Wendolowski, S, 2019)
"The fentanyl or surgical incision upregulated the expression of IL-1β, IL-6, and TNF-α in the spinal cord and bilateral DRG for more than 7 days and increase of ionized calcium-binding adapter molecule 1 in the spinal cord."1.48Increased Hyperalgesia and Proinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion After Surgery and/or Fentanyl Administration in Rats. ( Chang, L; Luo, Q; Shu, H; Tao, Y; Ye, F, 2018)
"Mechanical and thermal hyperalgesia were tested by von Frey test or Hargreaves test, respectively."1.46CaMKIIα may modulate fentanyl-induced hyperalgesia via a CeLC-PAG-RVM-spinal cord descending facilitative pain pathway in rats. ( Chen, J; Jin, S; Li, Z; Liu, J; Luo, F; Yin, P, 2017)
"Opioid-induced hyperalgesia (OIH) is a less-studied phenomenon that has been reported in both preclinical and clinical studies."1.43Inhibition of CaMKIIα in the Central Nucleus of Amygdala Attenuates Fentanyl-Induced Hyperalgesia in Rats. ( Li, C; Li, Z; Luo, F; Wang, ZJ; Yin, P, 2016)
"Fentanyl-induced neurotoxicity is an uncommon adverse effect of fentanyl and is seldom seen in pediatric palliative care practice."1.42Fentanyl-Induced Neurotoxicity in Children. ( Deodhar, J; Muckaden, MA; Ostwal, S; Salins, N, 2015)
"Carrageenan-induced hyperalgesia is a widely used pain model in rodents."1.40Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain. ( Ko, MC; Lee, H; Rice, KC; Sukhtankar, DD, 2014)
"Rats exhibited significant mechanical allodynia following 2 weeks of chronic oxaliplatin administration."1.40The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model. ( Hasegawa, M; Kanbara, T; Kanemasa, T; Mori, T; Nakamura, A; Ogawa, K; Sakaguchi, G; Shibasaki, M; Suzuki, T; Takasu, K, 2014)
"The fentanyl-induced increase in analgesia was minimally affected by a 1."1.40Role of central and peripheral opiate receptors in the effects of fentanyl on analgesia, ventilation and arterial blood-gas chemistry in conscious rats. ( Baby, SM; Discala, JF; Gruber, RB; Henderson, F; Lewis, SJ; May, WJ; Puskovic, V; Young, AP, 2014)
"Hyperalgesia is a cardinal symptom of opioid withdrawal."1.39Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. ( Endres-Becker, J; Fischer, O; Schäfer, M; Spahn, V; Stein, C; Zöllner, C, 2013)
"In contrast to the opioid, chronic hyperalgesia did not interfere with the reinforcing effect of food."1.39Effect of chronic pain on fentanyl self-administration in mice. ( Fairbanks, CA; Kitto, KF; Krumenacher, P; Peterson, CD; Wade, CL; Wilcox, GL, 2013)
"Von Frey filaments were used to measure mechanical allodynia of the hind paw and abdomen."1.38Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain. ( Feng, XM; Jiang, JW; Mao-Ying, QL; Mi, WL; Wang, YQ; Wang, ZF; Wu, GC; Xia, F; Xiao, S, 2012)
"The patient also developed hyperalgesia, allodynia, and photophobia and became extremely irritable upon handling."1.38Suspected opioid-induced hyperalgesia in an infant. ( Chalkiadis, GA; Hallett, BR, 2012)
"Long-lasting hyperalgesia was induced in male Sprague Dawley rats with subcutaneous fentanyl (4 injections, 60 μg/kg per injection at 15-minute intervals) resulting in a total dose of 240 μg/kg."1.37The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2011)
"In prestressed rats, fULD-induced hyperalgesia and the exaggerated inflammatory hyperalgesia were prevented NMDA receptor antagonists."1.37Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process. ( Chateauraynaud, J; Gavello-Baudy, S; Laboureyras, E; Laulin, JP; Le Roy, C; Simonnet, G, 2011)
"Fentanyl-induced hyperalgesia and antinociception after systemic administration has been shown in previous clinical and experimental studies."1.35Magnesium modifies fentanyl-induced local antinociception and hyperalgesia. ( Gunay, I; Gunes, Y; Mert, T; Ozcengiz, D, 2009)
"MK-801 blocked and reversed hyperalgesia caused by the acute injection and continuous infusion of fentanyl, respectively, in naltrexone-treated CD-1 mice, indicating the contribution of NMDA receptors to fentanyl hyperalgesia."1.35Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. ( Arout, C; Caldwell, M; Dahan, A; Kest, B; Waxman, AR, 2009)
"Sevoflurane effects on hyperalgesia were evaluated in Sprague-Dawley rats: opioid-naive rats, rats treated with fentanyl (4 x 60 microg kg(-1)) and rats with inflammatory pain (carrageenan) treated with fentanyl (4 x 60 microg kg(-1))."1.35Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. ( Janvier, G; Laulin, JP; Maurette, P; Richebé, P; Rivalan, B; Rivat, C; Simonnet, G, 2009)
"Pain was well controlled."1.35Fentanyl-induced neurotoxicity and paradoxic pain. ( George, ML; Okon, TR, 2008)
"Hyperalgesia was induced in male Sprague-Dawley rats with subcutaneous fentanyl (four injections, 20, 60, or 100 microg/kg per injection at 15-min intervals)."1.35Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2008)
"The opiate tolerance was complicated by tactile hyperalgesia at the site of the surgical wound."1.35[Acute opiate tolerance and postoperative hyperalgesia after a brief infusion of remifentanil managed with multimodal analgesia]. ( Cortiñas Sáenz, M; Cortiñas Sáenz, ML; Gerónimo Pardo, M; Hernández Vallecillo, MT; Ibarra Martí, ML; Mateo Cerdán, CM, 2008)
"Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES."1.34Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007)
"Differences in postoperative pain sensitivity were assessed by the observational pain measures COMFORT and VAS, and by morphine intake and (nor)epinephrine plasma concentrations."1.33Does neonatal surgery lead to increased pain sensitivity in later childhood? ( Anand, KJS; Duivenvoorden, HJ; Peters, JWB; Schouw, R; Tibboel, D; van Dijk, M, 2005)
"In fentanyl-treated rats with inflammatory or incisional pain, nitrous oxide strongly limited both magnitude and duration of hyperalgesia."1.33Nitrous oxide revisited: evidence for potent antihyperalgesic properties. ( Creton, C; Laulin, JP; Lemaire, M; Maurette, P; Richebé, P; Rivat, C; Simonnet, G, 2005)
"Subcutaneous fentanyl led to delayed hyperalgesia associated with a decrease in the nociceptive threshold lasting two days (35% decrease for the maximum effect)."1.33Protective effect of prior administration of magnesium on delayed hyperalgesia induced by fentanyl in rats. ( Benhamou, D; Conti, M; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2006)
"Opioid-induced delayed hyperalgesia and allodynia have been reported in human and animal models."1.33Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase. ( Cabañero, D; Célérier, E; González, JR; Maldonado, R; Puig, MM, 2006)
"hyperalgesia was unaltered by liposome injection (P > 0."1.32Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception. ( Brack, A; Labuz, D; Machelska, H; Reszka, R; Rittner, HL; Schäfer, M; Schiltz, A; Stein, C, 2004)
"The initial hyperalgesia induced by 0."1.31Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002)
"Ketamine pretreatment, which had no analgesic effect on its own, enhanced the earlier response (analgesia) and prevented the development of long-lasting hyperalgesia."1.31Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. ( Célèrier, E; Jun, Y; Larcher, A; Laulin, JP; Reynier, P; Rivat, C; Simonnet, G, 2000)
"The long-lasting hyperalgesia induced by the first carrageenan injection was dose-dependently enhanced in both duration and magnitude in 4 x 60 or 4 x 100 microg/kg fentanyl-treated rats: 5 or 10 days, respectively, as compared with 2 days in saline-treated rats."1.31Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine. ( Célèrier, E; Corcuff, JB; Laulin, JP; Pain, L; Rivat, C; Simonnet, G, 2002)
"Ketamine pretreatment (10 mg/kg) increased the fentanyl analgesic effect (4 x 60 microg/kg), suppressed the immediate hyperalgesic phase, and restored the full effect of a subsequent morphine injection."1.31The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. ( Chauvin, M; Corcuff, JB; Laulin, JP; Maurette, P; Rivat, C; Simonnet, G, 2002)

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.91)18.7374
1990's4 (3.64)18.2507
2000's40 (36.36)29.6817
2010's52 (47.27)24.3611
2020's13 (11.82)2.80

Authors

AuthorsStudies
Araldi, D3
Bonet, IJM2
Green, PG1
Levine, JD3
Wang, XX1
Cui, LL1
Gan, SF1
Zhang, ZR1
Xiao, J1
Li, CH2
Luo, F6
Kim, Y1
Bae, H1
Yoo, S1
Park, SK1
Lim, YJ1
Sakura, S1
Kim, JT1
Bai, T1
Chen, H1
Hu, W1
Liu, J2
Lin, X1
Chen, S1
Yang, X1
Chen, J3
Li, C2
Efune, PN1
Rebstock, SE1
Puig, S1
Shelton, MA1
Barko, K1
Seney, ML1
Logan, RW1
Wang, X1
Gan, S1
Zhang, Z2
Zhu, P1
Zhou, X1
Li, Q1
Luo, Q3
Wang, L1
Xiong, Y1
Wu, G1
Chang, L5
Liu, P1
Shu, H4
Manohar, S1
Adler, HJ1
Radziwon, K1
Salvi, R1
Baamonde, A1
Menéndez, L1
González-Rodríguez, S1
Lastra, A1
Seitz, V1
Stein, C3
Machelska, H2
Khomula, EV2
Uddin, O1
Jenne, C1
Fox, ME1
Arakawa, K1
Keller, A1
Cramer, N1
Quillet, R2
Schneider, S3
Utard, V2
Drieu la Rochelle, A1
Elhabazi, K3
Henningsen, JB1
Gizzi, P1
Schmitt, M4
Kugler, V1
Simonneaux, V2
Ilien, B2
Simonin, F4
Bihel, F4
Li, Z2
Yin, P2
Jin, S1
Nguyen, T1
Decker, AM1
Langston, TL1
Mathews, KM1
Siemian, JN1
Li, JX1
Harris, DL1
Runyon, SP1
Zhang, Y1
Ye, F3
Tao, Y1
Ferrari, LF1
Srinivas, NR1
Li, QB1
Luo, QH1
Tao, YX1
Shu, HH1
Wang, Z1
Wang, Y1
Xia, Z1
Shinohara, A1
Andoh, T1
Saiki, I1
Kuraishi, Y1
Rangappa, S1
Rangan, KK1
Sudarshan, TS1
Murthy, SN1
Kalaydjian, A1
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Gerges, FJ1
Kars, MS1
Villacres Mori, B1
Ahn, S1
Merwin, S1
Wendolowski, S1
Gecelter, R1
Rothman, A1
Poon, S1
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Junghaenel, S1
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Stuetzer, H1
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Fairbanks, CA1
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Gruber, RB1
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Puskovic, V1
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Lewis, SJ1
Aoki, Y1
Mizoguchi, H1
Watanabe, C1
Sakurada, T1
Sakurada, S1
Tanaka, K1
Nakanishi, Y1
Sekino, S1
Ikegami, M1
Ikeda, H1
Kamei, J1
Kanbara, T1
Nakamura, A2
Takasu, K1
Ogawa, K1
Shibasaki, M1
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Hasegawa, M1
Sakaguchi, G1
Kanemasa, T1
Yildirim, V1
Doganci, S1
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Eskin, MB1
Ozkan, G1
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Humbert, JP2
Bertin, I2
Wagner, P1
Laboureyras, E6
Petit-Demoulière, B3
Schneider, E2
Mollereau, C2
Simonnet, G11
Bourguignon, JJ3
Marcus, DJ1
Zee, M1
Hughes, A1
Yuill, MB1
Hohmann, AG1
Mackie, K1
Guindon, J1
Morgan, DJ1
Lyons, PJ1
Rivosecchi, RM1
Nery, JP1
Kane-Gill, SL1
Ostwal, S1
Salins, N1
Deodhar, J1
Muckaden, MA1
Mauermann, E2
Filitz, J2
Dolder, P1
Rentsch, KM1
Bandschapp, O2
Ruppen, W2
You, HJ1
Lei, J1
Xiao, Y1
Ye, G1
Sun, ZH1
Yang, L2
Niu, N1
Dmytriyev, DV2
Konoplytskyi, VS2
Wang, ZJ1
Kong, M1
Li, J1
Zhong, Z1
Wu, Z1
Guo, R1
Blum, CA1
Lurati Buse, G1
Ben Boujema, M1
Ancel, C1
Beltramo, M1
Bucher, B1
Sorg, T1
Meziane, H2
Bujalska, M1
Malinowska, E1
Makulska-Nowak, H1
Gumułka, SW1
Kouvaras, E1
Asprodini, EK1
Asouchidou, I1
Vasilaki, A1
Kilindris, T1
Michaloudis, D1
Koukoutianou, I1
Papatheodoropoulos, C1
Kostopoulos, G1
Pranevicius, M1
Pranevicius, O1
Richebé, P5
Rivalan, B1
Rivat, C6
Laulin, JP8
Janvier, G1
Maurette, P3
Waxman, AR1
Arout, C1
Caldwell, M1
Dahan, A1
Kest, B1
Chateauraynaud, J2
Mert, T1
Gunes, Y1
Ozcengiz, D1
Gunay, I1
Greer, JJ1
Ren, J1
Fernández-Dueñas, V1
Ciruela, F1
Gandía, J1
Sánchez, S1
Planas, E1
Poveda, R1
Andresen, T3
Upton, RN1
Foster, DJ1
Christrup, LL1
Arendt-Nielsen, L3
Drewes, AM3
Staahl, C1
Oksche, A2
Mansikka, H2
Van Elstraete, AC3
Sitbon, P3
Benhamou, D3
Mazoit, JX3
Saunders, DL1
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Bockel, F1
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Narita, M1
Imai, S1
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Sudo, Y1
Hojo, M1
Uezono, Y1
Devi, LA1
Kuzumaki, N1
Tramullas, M1
Dinan, TG1
Cryan, JF1
Hallett, BR1
Chalkiadis, GA1
Wei, X1
Wei, W1
Malver, LP1
Tröster, A1
Ihmsen, H1
Singler, B1
Koppert, W3
Juba, KM1
Wahler, RG1
Daron, SM1
Feng, XM1
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Jiang, JW1
Xiao, S1
Wang, ZF1
Wang, YQ1
Wu, GC1
Mousa, SA1
Shaqura, M1
Khalefa, BI1
Zöllner, C2
Schaad, L1
Schneider, J1
Shippenberg, TS1
Richter, JF1
Hellweg, R1
Shakibaei, M1
Schäfer, M3
Spahn, V1
Fischer, O1
Endres-Becker, J1
Price, DD1
Staud, R1
Robinson, ME1
Mauderli, AP1
Cannon, R1
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Colpaert, FC1
Tarayre, JP1
Koek, W1
Pauwels, PJ1
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Xu, XJ1
Wiesenfeld-Hallin, Z1
Cosi, C1
Carilla-Durand, E1
Assié, MB1
Vacher, B1
Kang, YJ1
Vincler, M1
Li, X2
Conklin, D1
Eisenach, JC1
Katz, J2
Cohen, L2
Schmid, R1
Chan, VW1
Wowk, A1
Inan, UU1
Sivaci, RG1
Ermis, SS1
Oztürk, F1
Maegawa, FA1
Tonussi, CR1
Brack, A1
Labuz, D1
Schiltz, A1
Rittner, HL1
Reszka, R1
Peters, JWB1
Schouw, R1
Anand, KJS1
van Dijk, M1
Duivenvoorden, HJ1
Tibboel, D1
Gaitán, G1
Ahuir, FJ1
Herrero, JF1
Creton, C1
Lemaire, M1
Célérier, E3
González, JR1
Cabañero, D1
Puig, MM1
Guntz, E1
Talla, G1
Roman, A1
Dumont, H1
Segers, B1
Sosnowski, M1
Baad-Hansen, L1
Juhl, GI1
Jensen, TS1
Brandsborg, B1
Svensson, P1
Conti, M1
Robertson, LJ1
Drummond, PD1
Hammond, GR1
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Bessière, B1
Contarino, A1
Davis, MP1
Shaiova, LA1
Angst, MS2
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Raeder, J1
Hoymork, SC1
Okon, TR1
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Cortiñas Sáenz, M1
Gerónimo Pardo, M1
Cortiñas Sáenz, ML1
Hernández Vallecillo, MT1
Ibarra Martí, ML1
Mateo Cerdán, CM1
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Tverskoy, M1
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Tuchman, JE1
Johnson, MD1
Wiesenauer, K1
Woods, JH1
Jun, Y1
Larcher, A1
Reynier, P1
Ta, LE1
Dionne, RA1
Fricton, JR1
Hodges, JS1
Kajander, KC1
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Pain, L1
Chauvin, M1
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Hargreaves, KM1

Clinical Trials (12)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study[NCT04894864]Phase 440 participants (Anticipated)Interventional2020-10-08Recruiting
Effect of Intraoperative and Post-operative Opioids on Persistent Opioid Use in the Surgical Patient[NCT03367988]Phase 2/Phase 3100 participants (Anticipated)Interventional2018-12-01Recruiting
Can Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers? A Prospective, Randomized, Double-blinded Crossover Study[NCT02252458]21 participants (Actual)Interventional2014-08-31Completed
Effect of Fentanyl on Expression of Main Opioid Receptor (OPRM1) on Human Granulosa Cells During Ultrasound-guided Transvaginal Oocyte Retrieval.[NCT03248076]30 participants (Anticipated)Observational2017-04-01Recruiting
Contribution of COMT Haplotypes in Propranolol Analgesic Efficacy for Treating Post-surgical Pain After Laparoscopic Hemicolectomy[NCT02511483]Phase 210 participants (Actual)Interventional2015-05-18Terminated (stopped due to Difficulty with recruitment)
Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperal-gesia in Patients Following Recovery From Impacted Mandibular Third Molar Extraction. A Randomized, Placebo-controlled, Double-blind Crossover Study.[NCT02976337]Phase 214 participants (Anticipated)Interventional2017-10-12Recruiting
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573]10,000 participants (Anticipated)Observational2012-08-03Active, not recruiting
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia Using Filaments, an Algometer, and Interleukins: a Double-blind, Randomized Study[NCT01301079]Phase 360 participants (Actual)Interventional2010-09-30Completed
Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461]137 participants (Actual)Observational2009-07-31Completed
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702]Phase 124 participants (Anticipated)Interventional2023-03-17Recruiting
Fentanyl Ultra Low Doses Effects on Human Volunteer's Nociceptive Threshold. Towards a Simple Pharmacological Test Able to Predict Pain Vulnerability, Post Operative Hyperalgesia Development Risk?[NCT00454259]Phase 448 participants (Actual)Interventional2007-03-31Completed
Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091]Phase 210 participants (Actual)Interventional2009-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Allodynia as Detected With a Soft Brush in the Periumbilical Region 24 h After the Procedure

The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure

Interventionparticipants (Number)
Ketamine1
Saline0

Allodynia as Detected With a Soft Brush in the Periumbilical Region Before the Procedure

The evaluations using the soft brush were performed 2-3 cm from the incision in the periumbilical region (where the large trocar was placed) before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)

Interventionparticipants (Number)
Ketamine1
Saline0

Allodynia as Detected With a Soft Brush in the Thenar Eminence 24 h After the Procedure

The evaluations using the soft brush were performed in the thenar eminence of the non dominant hand 24 h after the procedure (NCT01301079)
Timeframe: 24 h after the procedure

Interventionparticipants (Number)
Ketamine1
Saline3

Allodynia as Detected With a Soft Brush in the Thenar Eminence Before the Procedure

The evaluations using the soft brush were performed in the thenar eminence of the nondominant hand before the procedure (NCT01301079)
Timeframe: Before the procedure (Baseline)

Interventionparticipants (Number)
Ketamine1
Saline0

Extension of Hyperalgesia

The 300-g filament was used 24 hours after the operation to induce a stimulus and delineate the extent of hyperalgesia from the periumbilical region. The stimulus was started outside the periumbilical region, where no pain sensation was reported, and continued every 0.5 cm until the 4 points of the periumbilical scar were reached (top, right side, left side, and bottom). The first point where the patient complained of pain was marked. If no pain sensation was reported, the stimulus was terminated 0.5 cm from the incision. The distance of each point from the surgical incision was measured, and the sum of the distances of the points was determined. (NCT01301079)
Timeframe: 24 hours after the procedure

Interventioncentimeter (Mean)
Ketamine10.61
Saline11.82

Hyperalgesia in the Postoperative Period as Measured With Algometer in the Periumbilical Region

The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionkilogram force/second (Mean)
Ketamine3.5
Saline3.7

Hyperalgesia in the Postoperative Period as Measured With Algometer in Thenar Eminence

The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionkilogram force/second (Mean)
Ketamine0.56
Saline0.51

Hyperalgesia in the Postoperative Period as Measured With Monofilaments in the Periumbilical Region

The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the postoperative period (24h after the procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24h after the procedure

Interventiongram (Mean)
Ketamine248
Saline205

Hyperalgesia in the Postoperative Period as Measured With Monofilaments in Thenar Eminence

The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the postoperative period (24 hours after procedure). The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: 24 hours after procedure

Interventiongram (Mean)
Ketamine290
Saline247

Hyperalgesia in the Preoperative Period as Measured With Algometer in the Periumbilical Region

The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the surgery)

Interventionkilogram force/second (Mean)
Ketamine3.6
Saline3.9

Hyperalgesia in the Preoperative Period as Measured With Algometer in Thenar Eminence

The mechanical pain threshold was evaluated using an algometer. The pressure was increased by 0.1 kgf/second until the patient complained of pain. The mean of three determinations was calculated. (NCT01301079)
Timeframe: Baseline (before the procedure)

Interventionkilogram force/second (Mean)
Ketamine2.51
Saline2.19

Hyperalgesia in the Preoperative Period as Measured With Monofilaments in the Periumbilical Region

The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in the periumbilical region in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)

Interventiongram (Mean)
Ketamine279
Saline269

Hyperalgesia in the Preoperative Period as Measured With Monofilaments in Thenar Eminence

The pain threshold was assessed using six von Frey monofilaments (0,05 g; 0,2 g; 2 g; 4 g; 10 g e 300 g) in thenar eminence in the preoperative period. The use of different von Frey monofilaments, starting with the lightest and ending with the heaviest, was separated by at least 30 seconds to reduce any anticipated responses due to a new stimulation that was performed too soon after the preceding stimulation. Three assessments were made for each monofilament, and this was considered positive when the patient responded to two of the determinations for each monofilament. (NCT01301079)
Timeframe: Before the procedure (Baseline)

Interventiongram (Mean)
Ketamine300
Saline300

Morphine Consumption Within 24 h

(NCT01301079)
Timeframe: 24 hours

Interventionmilligram (Mean)
Ketamine27.40
Saline27.70

Pain 12 Hours

The scale measure pain after 12 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 12 hours

Interventionunits on a scale (Mean)
Ketamine1.6
Saline1.4

Pain 120 Minutes

The scale measure pain after 120 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 120 minutes

Interventionunits on a scale (Mean)
Ketamine2.2
Saline2.0

Pain 150 Minutes

The scale measure pain after 150 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 150 minutes

Interventionunits on a scale (Mean)
Ketamine1.4
Saline1.4

Pain 18 Hours

The scale measure pain after 18 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 18 hours

Interventionunits on a scale (Mean)
Ketamine1.5
Saline1.3

Pain 180 Minutes

The scale measure pain after 180 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 180 minutes

Interventionunits on a scale (Mean)
Ketamine1.1
Saline1.3

Pain 210 Minutes

The scale measure pain after 210 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 210 minutes

Interventionunits on a scale (Mean)
Ketamine0.9
Saline1.2

Pain 24 Hours

The scale measure pain after 24 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 24 hours

Interventionunits on a scale (Mean)
Ketamine1.4
Saline0.8

Pain 240 Minutes

The scale measure pain after 240 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 240 minutes

Interventionunits on a scale (Mean)
Ketamine1.0
Saline1.1

Pain 30 Minutes

The scale measure pain after 30 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 30 minutes

Interventionunits on a scale (Mean)
Ketamine5.5
Saline6.2

Pain 6 Hours

The scale measure pain after 6 hours (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 6 hours

Interventionunits on a scale (Mean)
Ketamine0.9
Saline0.7

Pain 60 Minutes

The scale measure pain after 60 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 60 minutes

Interventionunits on a scale (Mean)
Ketamine4.6
Saline5.1

Pain 90 Minutes

The scale measure pain after 90 minutes (0 - without pain and 10 worst pain possible). The individual can choose any number between 0 - 10. (NCT01301079)
Timeframe: 90 minutes

Interventionunits on a scale (Mean)
Ketamine3.4
Saline3.4

Serum Level of Interleukin (IL)-10 24 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine8.6
Saline5.0

Serum Level of Interleukin (IL)-10 5h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-10 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine9.1
Saline5.5

Serum Level of Interleukin (IL)-10 Before the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)

Interventionpicogram/milliliter (Mean)
Ketamine7.8
Saline1.9

Serum Level of Interleukin (IL)-6 24 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine24.1
Saline24.8

Serum Level of Interleukin (IL)-6 5 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine29.3
Saline34.8

Serum Level of Interleukin (IL)-6 Before the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-6 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)

Interventionpicogram/milliliter (Mean)
Ketamine3.3
Saline2.1

Serum Level of Interleukin (IL)-8 24 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 24 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 24 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine6.0
Saline4.5

Serum Level of Interleukin (IL)-8 5 h After the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes 5 h after the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: 5 h after the procedure

Interventionpicogram/milliliter (Mean)
Ketamine8.0
Saline11.3

Serum Level of Interleukin (IL)-8 Before the Procedure

Blood samples were drawn in ethylenediaminetetraacetic acid (EDTA) tubes before the surgery. The blood was centrifuged to separate the plasma and was stored at -70°C. IL-8 was analyzed using the enzyme-linked immunosorbent assay (ELISA) methodology. (NCT01301079)
Timeframe: Baseline (Before the procedure)

Interventionpicogram/milliliter (Mean)
Ketamine3.3
Saline2.2

Time to First Morphine Supplementation

(NCT01301079)
Timeframe: 24 hours

Interventionminutes (Median)
Ketamine18
Saline15

Objective Opioid Withdrawal Scale (OOWS)

OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)

,
Interventionunits on a scale (Mean)
Pretreatment30 min prior to REM infusion15 min after start of REM infusion40 min after start of REM infusion5 minutes after finish of REM infusion15 minutes after finish of REM infusion75 minutes after finish of REM infusion
Placebo1.11.10.80.51.82.11.6
Propranolol1.21.10.10.832.81.7

Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH).

A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion

,
Interventionpercentage of change (Number)
15 min post remifentanil infusion60 min post remifentanil infusion
Placebo-34141.5
Propranolol-28-19

Reviews

2 reviews available for fentanyl and Allodynia

ArticleYear
Fentanyl-induced hyperalgesia in acute pain management.
    Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:2

    Topics: Acute Pain; Analgesics, Opioid; Fentanyl; Humans; Hyperalgesia; Pain Management

2015
The impact of opioid-induced hyperalgesia for postoperative pain.
    Best practice & research. Clinical anaesthesiology, 2007, Volume: 21, Issue:1

    Topics: Alfentanil; Analgesics, Opioid; Animals; Fentanyl; Humans; Hyperalgesia; Morphine; Pain, Postoperati

2007

Trials

21 trials available for fentanyl and Allodynia

ArticleYear
Effect of remifentanil on post-operative analgesic consumption in patients undergoing shoulder arthroplasty after interscalene brachial plexus block: a randomized controlled trial.
    Journal of anesthesia, 2022, Volume: 36, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Shoulder; Brachial Plexus Block; Delirium

2022
Remifentanil-induced tolerance, withdrawal or hyperalgesia in infants: a randomized controlled trial. RAPIP trial: remifentanil-based analgesia and sedation of paediatric intensive care patients.
    Neonatology, 2013, Volume: 104, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Drug Tolerance; Fentanyl; Gestational Age; Humans; Hyperalgesia; Hypn

2013
Comparison of different anesthetic regimens in patients undergoing laparoscopic adjustable gastric banding operations: a prospective randomized trial.
    Medicina (Kaunas, Lithuania), 2012, Volume: 48, Issue:12

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Clinical Protocols; Female; Fentanyl; Gas

2012
Acute high dose-fentanyl exposure produces hyperalgesia and tactile allodynia after coronary artery bypass surgery.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:22

    Topics: Aged; Analgesics, Opioid; Coronary Artery Bypass; Female; Fentanyl; Humans; Hyperalgesia; Male; Midd

2014
Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial.
    Anesthesiology, 2016, Volume: 124, Issue:2

    Topics: Adult; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; D

2016
Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial.
    Anesthesiology, 2016, Volume: 124, Issue:2

    Topics: Adult; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; D

2016
Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial.
    Anesthesiology, 2016, Volume: 124, Issue:2

    Topics: Adult; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; D

2016
Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial.
    Anesthesiology, 2016, Volume: 124, Issue:2

    Topics: Adult; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; D

2016
Low-dose butorphanol alleviates remifetanil-induced hyperalgesia in patients undergoing laparoscopic cholecystectomy.
    Journal of clinical anesthesia, 2016, Volume: 34

    Topics: Adult; Analgesics, Opioid; Anesthesia, General; Butorphanol; Cholecystectomy, Laparoscopic; Double-B

2016
Time course of copeptin during a model of experimental pain and hyperalgesia: A randomised volunteer crossover trial.
    European journal of anaesthesiology, 2017, Volume: 34, Issue:5

    Topics: Adult; Analgesics, Opioid; Biomarkers; Cross-Over Studies; Double-Blind Method; Fentanyl; Glycopepti

2017
Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 108, Issue:4

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Capsaicin; Cold Temperature; Cross-Over Studies; Dose-Resp

2011
Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain.
    British journal of pharmacology, 2011, Volume: 164, Issue:3

    Topics: Administration, Cutaneous; Analgesics; Analgesics, Opioid; Buprenorphine; Capsaicin; Cross-Over Stud

2011
Assessment of the relative potency of fentanyl buccal tablet to intravenous morphine in healthy volunteers using a thermally induced hyperalgesia pain model.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:6

    Topics: Administration, Buccal; Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics

2012
A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study.
    The Clinical journal of pain, 2012, Volume: 28, Issue:7

    Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Buprenorphine; Cross-Over Studies; Double-Blin

2012
Interaction of fentanyl and buprenorphine in an experimental model of pain and central sensitization in human volunteers.
    The Clinical journal of pain, 2012, Volume: 28, Issue:8

    Topics: Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Cross-Over Studies; Double-Blind Met

2012
Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients.
    Pain, 2002, Volume: 99, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Cold Temperature; Female; Fentanyl; Fibromyalgia; Hot Temperature; Humans

2002
Postoperative morphine use and hyperalgesia are reduced by preoperative but not intraoperative epidural analgesia: implications for preemptive analgesia and the prevention of central sensitization.
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Adaptation, Psychological; Adult; Affect; Analgesia, Epidural; Analgesia, Patient-Controlled; Analge

2003
Effects of fentanyl on pain and hemodynamic response after retrobulbar block in patients having phacoemulsification.
    Journal of cataract and refractive surgery, 2003, Volume: 29, Issue:6

    Topics: Adult; Aged; Analgesia; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Intravenous; Anesthet

2003
Preventive analgesia is associated with reduced pain disability 3 weeks but not 6 months after major gynecologic surgery by laparotomy.
    Anesthesiology, 2004, Volume: 101, Issue:1

    Topics: Adaptation, Psychological; Adult; Affect; Analgesia; Analgesics, Opioid; Anesthesia, General; Anesth

2004
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
    Pain, 2007, Volume: 129, Issue:1-2

    Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-B

2007
Administration of fentanyl before remifentanil-based anaesthesia has no influence on post-operative pain or analgesic consumption.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Anesthesia, Intra

2008
Effects of non-steroidal anti-inflammatory drugs on the hyperalgesia to noxious mechanical stimulation induced by the application of a tourniquet to a forelimb of sheep.
    Research in veterinary science, 1994, Volume: 57, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Clonixin; Cross-Over Studies; Disease

1994
Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia.
    Anesthesia and analgesia, 1994, Volume: 78, Issue:2

    Topics: Adult; Analgesia; Double-Blind Method; Female; Fentanyl; Humans; Hyperalgesia; Ketamine; Middle Aged

1994
The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:6

    Topics: Adult; Analgesics; Analgesics, Opioid; Axons; Capsaicin; Erythema; Female; Fentanyl; Humans; Hyperal

1999

Other Studies

87 other studies available for fentanyl and Allodynia

ArticleYear
Contribution of G-Protein α-Subunits to Analgesia, Hyperalgesia, and Hyperalgesic Priming Induced by Subanalgesic and Analgesic Doses of Fentanyl and Morphine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022, 02-16, Volume: 42, Issue:7

    Topics: Analgesia; Analgesics, Opioid; Animals; Fentanyl; GTP-Binding Protein alpha Subunits; Hyperalgesia;

2022
Inhibition of Oligodendrocyte Apoptosis in the Prelimbic Medial Prefrontal Cortex Prevents Fentanyl-induced Hyperalgesia in Rats.
    The journal of pain, 2022, Volume: 23, Issue:6

    Topics: Analgesics, Opioid; Animals; Apoptosis; Fentanyl; Hyperalgesia; Oligodendroglia; Pain; Prefrontal Co

2022
Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats.
    Cellular and molecular neurobiology, 2023, Volume: 43, Issue:3

    Topics: Amygdala; Analgesics, Opioid; Animals; Fentanyl; Hyperalgesia; Rats; Rats, Sprague-Dawley; Receptors

2023
Suspected opioid-induced hyperalgesia in an infant following surgery: A case report.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:9

    Topics: Adult; Analgesics, Opioid; Fentanyl; Humans; Hyperalgesia; Infant; Ketamine; Male; Pain

2022
Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia.
    Genes, brain, and behavior, 2022, Volume: 21, Issue:7

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Dr

2022
HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats.
    Molecular neurobiology, 2023, Volume: 60, Issue:5

    Topics: Animals; Fentanyl; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male;

2023
A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons.
    Drug discoveries & therapeutics, 2023, Sep-15, Volume: 17, Issue:4

    Topics: Animals; Cyclooxygenase 2; Fentanyl; Hyperalgesia; Inflammation; Ketamine; Neurons; NF-kappa B; Rats

2023
Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling.
    Hearing research, 2020, Volume: 393

    Topics: Analgesics, Opioid; Animals; Auditory Threshold; Deafness; Fentanyl; Hearing Loss; Hearing Loss, Noi

2020
A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors.
    Scientific reports, 2020, 10-29, Volume: 10, Issue:1

    Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Fentanyl; Hydrogen-Ion C

2020
Opioid-Induced Hyperalgesic Priming in Single Nociceptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021, 01-06, Volume: 41, Issue:1

    Topics: Analgesics, Opioid; Animals; Deoxyadenosines; Dinoprostone; Fentanyl; Hyperalgesia; Lectins; Male; M

2021
Divergent profiles of fentanyl withdrawal and associated pain in mice and rats.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 200

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Female; Fentanyl; Humans; Hyperalgesia; Locomotion; M

2021
Identification of an
    Journal of medicinal chemistry, 2021, 06-10, Volume: 64, Issue:11

    Topics: Analgesics, Opioid; Animals; Cricetinae; Dipeptides; Female; Fentanyl; Half-Life; Humans; Hyperalges

2021
CaMKIIα may modulate fentanyl-induced hyperalgesia via a CeLC-PAG-RVM-spinal cord descending facilitative pain pathway in rats.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Analgesics, Opioid; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Amygdaloid

2017
Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists.
    ACS chemical neuroscience, 2017, 10-18, Volume: 8, Issue:10

    Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Fentanyl; Hyperalgesia; Narcotic Antagonists; Olig

2017
Increased Hyperalgesia and Proinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion After Surgery and/or Fentanyl Administration in Rats.
    Anesthesia and analgesia, 2018, Volume: 126, Issue:1

    Topics: Analgesics, Opioid; Animals; Cytokines; Fentanyl; Ganglia, Spinal; Hyperalgesia; Inflammation Mediat

2018
Fentanyl Induces Rapid Onset Hyperalgesic Priming: Type I at Peripheral and Type II at Central Nociceptor Terminals.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 02-28, Volume: 38, Issue:9

    Topics: Analgesics, Opioid; Animals; Calcium Signaling; Fentanyl; Hyperalgesia; Male; Neuronal Plasticity; N

2018
Lack of Translatable Proinflammatory Cytokines in Cerebrospinal Fluid in Rats With Increased Hyperalgesia With or Without Fentanyl Treatment.
    Anesthesia and analgesia, 2018, Volume: 126, Issue:6

    Topics: Animals; Cytokines; Fentanyl; Ganglia, Spinal; Hyperalgesia; Rats; Spinal Cord

2018
In Response.
    Anesthesia and analgesia, 2018, Volume: 126, Issue:6

    Topics: Animals; Cytokines; Fentanyl; Ganglia, Spinal; Hyperalgesia; Rats; Spinal Cord

2018
Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats.
    British journal of anaesthesia, 2018, Volume: 120, Issue:4

    Topics: Analgesics, Opioid; Animals; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response R

2018
Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia.
    Bioscience trends, 2018, May-13, Volume: 12, Issue:2

    Topics: Anesthesia, Local; Animals; Disease Models, Animal; Fentanyl; Ganglia, Spinal; Humans; Hyperalgesia;

2018
Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice.
    European journal of pharmacology, 2018, Aug-15, Volume: 833

    Topics: Action Potentials; Analgesics, Opioid; Animals; Cancer Pain; Cell Line, Tumor; Disease Models, Anima

2018
Antiallodynic and Antihyperalgesic Activities of Fentanyl-Loaded Dermal Clay Dressings in Rat Model of Second-Degree Burn Injury.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:10

    Topics: Animals; Bandages; Burns; Clay; Disease Models, Animal; Fentanyl; Hyperalgesia; Male; Pain; Rats; Ra

2018
Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl.
    Pain practice : the official journal of World Institute of Pain, 2019, Volume: 19, Issue:2

    Topics: Analgesics, Opioid; Bupivacaine; Female; Fentanyl; Humans; Hyperalgesia; Infusion Pumps, Implantable

2019
Fentanyl versus remifentanil-based TIVA for pediatric scoliosis repair: does it matter?
    Regional anesthesia and pain medicine, 2019, Volume: 44, Issue:6

    Topics: Adolescent; Analgesics, Opioid; Anesthesia, General; Anesthesia, Intravenous; Child; Drug Tolerance;

2019
[Role of mGluR5 in laterocapcular division of central nucleus of amygdala in fentanyl-induced hyperalgesia in rats].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2019, Apr-28, Volume: 44, Issue:4

    Topics: Animals; Central Amygdaloid Nucleus; Fentanyl; Hyperalgesia; Male; Rats; Rats, Sprague-Dawley; Recep

2019
[Dependency syndrome and hyperalgesia due to an opioid therapy for curative treatable pain. Case report of an apparent palliative patient].
    Schmerz (Berlin, Germany), 2013, Volume: 27, Issue:5

    Topics: Activities of Daily Living; Administration, Cutaneous; Administration, Intranasal; Aged; Analgesics,

2013
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
    Psychopharmacology, 2014, Volume: 231, Issue:7

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Pain

2014
Effect of chronic pain on fentanyl self-administration in mice.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animals; Behavior, Animal; Chronic Pain; Female; Fentanyl; Hyperalgesia; Male; Mice; Motor Activity;

2013
Role of central and peripheral opiate receptors in the effects of fentanyl on analgesia, ventilation and arterial blood-gas chemistry in conscious rats.
    Respiratory physiology & neurobiology, 2014, Jan-15, Volume: 191

    Topics: Analysis of Variance; Animals; Blood Gas Analysis; Blood Pressure; Body Temperature; Consciousness;

2014
Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state.
    Neuroscience letters, 2014, Feb-07, Volume: 560

    Topics: Animals; Fentanyl; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Methadone; Mice; Narcotics;

2014
Fentanyl produces an anti-hyperalgesic effect through the suppression of sodium channels in mice with painful diabetic neuropathy.
    European journal of pharmacology, 2014, Jun-15, Volume: 733

    Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response R

2014
The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model.
    Journal of pharmacological sciences, 2014, Volume: 126, Issue:3

    Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; F

2014
Development of a peptidomimetic antagonist of neuropeptide FF receptors for the prevention of opioid-induced hyperalgesia.
    ACS chemical neuroscience, 2015, Mar-18, Volume: 6, Issue:3

    Topics: Analgesics, Opioid; Animals; Arginine; Chemical Phenomena; Cyclic AMP; Fentanyl; HEK293 Cells; Human

2015
Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.
    Molecular pain, 2015, Jun-12, Volume: 11

    Topics: Analgesics; Animals; Anthracenes; Cisplatin; Drug Tolerance; Fentanyl; Formaldehyde; Hyperalgesia; H

2015
Fentanyl-Induced Neurotoxicity in Children.
    Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:4

    Topics: Akathisia, Drug-Induced; Analgesics, Opioid; Child; Female; Fentanyl; Hallucinations; Headache; Huma

2015
Pre-emptive analgesia and its supraspinal mechanisms: enhanced descending inhibition and decreased descending facilitation by dexmedetomidine.
    The Journal of physiology, 2016, Apr-01, Volume: 594, Issue:7

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dexmedetomidine; Fentanyl; Hyperalgesia; Imid

2016
[MORPHOLOGICAL CHANGES OF SKIN IN OPERATIVE WOUND IN SYNDROME OF OPIOID-INDUCED HYPERALGESIA].
    Klinichna khirurhiia, 2015, Issue:10

    Topics: Abdominal Cavity; Abdominal Neoplasms; Administration, Cutaneous; Adolescent; Analgesics, Opioid; Ch

2015
Inhibition of CaMKIIα in the Central Nucleus of Amygdala Attenuates Fentanyl-Induced Hyperalgesia in Rats.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 359, Issue:1

    Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Amygdaloid Nucleu

2016
[PROPHYLAXIS OF POSTOPERATIVE HYPERALGESIA, BASED ON MORPHOLOGICAL SUBSTANTIATION OF THE ANALGESIA METHOD].
    Klinichna khirurhiia, 2016, Issue:3

    Topics: Abdominal Muscles; Abdominal Neoplasms; Adolescent; Analgesia, Epidural; Analgesics, Opioid; Child;

2016
RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
    Neuropharmacology, 2017, 05-15, Volume: 118

    Topics: Administration, Oral; Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Cricetulus; Disease Models

2017
Magnesium ions and opioid agonist activity in streptozotocin-induced hyperalgesia.
    Pharmacology, 2008, Volume: 82, Issue:3

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Diabetes Mellitus, Experimental; Diabetic Neuropathies;

2008
Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24 h after acute exposure to the drug.
    Neuropharmacology, 2008, Volume: 55, Issue:7

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Bicu

2008
Non-opioid anesthesia with esmolol avoids opioid-induced hyperalgesia and reduces fentanyl requirement after laparoscopy.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:3

    Topics: Adrenergic beta-Antagonists; Analgesics, Opioid; Anesthesia; Fentanyl; Humans; Hyperalgesia; Laparos

2009
Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2009, Volume: 56, Issue:2

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Carrageenan; Disease Models, Animal; Dose-Resp

2009
Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice.
    Neuroscience letters, 2009, Oct-02, Volume: 462, Issue:1

    Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fentanyl; Hot

2009
Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:2

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Carrageenan; Chronic Disease; Fentanyl; Hyper

2009
Magnesium modifies fentanyl-induced local antinociception and hyperalgesia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:5

    Topics: Analgesics, Opioid; Animals; Drug Interactions; Drug Synergism; Female; Fentanyl; Hot Temperature; H

2009
Ampakine therapy to counter fentanyl-induced respiratory depression.
    Respiratory physiology & neurobiology, 2009, Aug-31, Volume: 168, Issue:1-2

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Administration Schedule; Fentanyl; Heart Rat

2009
Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.
    European journal of pharmacology, 2010, Jul-25, Volume: 638, Issue:1-3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fe

2010
The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:3

    Topics: Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids;

2011
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
    British journal of pharmacology, 2012, Volume: 165, Issue:2

    Topics: Adamantane; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Dipeptides; Drug

2012
Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process.
    The journal of pain, 2011, Volume: 12, Issue:10

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Carrageenan; Disease Models, Animal; Excitatory A

2011
Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state.
    Addiction biology, 2013, Volume: 18, Issue:4

    Topics: Analgesics, Opioid; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Drug Tolerance; Femal

2013
Chronic psychosocial stress induces visceral hyperalgesia in mice.
    Stress (Amsterdam, Netherlands), 2012, Volume: 15, Issue:3

    Topics: Adrenal Glands; Analgesics, Opioid; Animals; Anxiety; Atropine; Body Weight; Chronic Disease; Colon;

2012
Suspected opioid-induced hyperalgesia in an infant.
    British journal of anaesthesia, 2012, Volume: 108, Issue:1

    Topics: Abdominal Wall; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Dexmedetomi

2012
Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.
    Journal of anesthesia, 2012, Volume: 26, Issue:2

    Topics: Amines; Analgesics, Opioid; Animals; Chronic Pain; Cyclohexanecarboxylic Acids; Drug Tolerance; Fent

2012
Morphine and hydromorphone-induced hyperalgesia in a hospice patient.
    Journal of palliative medicine, 2013, Volume: 16, Issue:7

    Topics: Adult; Analgesics, Opioid; Carcinoma, Non-Small-Cell Lung; Delayed-Action Preparations; Female; Fent

2013
Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain.
    BMC complementary and alternative medicine, 2012, Nov-22, Volume: 12

    Topics: Abdomen; Acupuncture Points; Analgesia; Animals; Electroacupuncture; Fentanyl; Hindlimb; Hyperalgesi

2012
Rab7 silencing prevents μ-opioid receptor lysosomal targeting and rescues opioid responsiveness to strengthen diabetic neuropathic pain therapy.
    Diabetes, 2013, Volume: 62, Issue:4

    Topics: Analgesics, Opioid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies;

2013
Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner.
    Pain, 2013, Volume: 154, Issue:4

    Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent P

2013
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
    Neuropharmacology, 2002, Volume: 43, Issue:6

    Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell

2002
Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure.
    Anesthesiology, 2002, Volume: 97, Issue:6

    Topics: Anesthetics, Intravenous; Animals; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Fentanyl; Hyper

2002
The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2003, Volume: 36, Issue:12

    Topics: Analgesics, Opioid; Animals; Arginine; Cyclic GMP; Dinoprostone; Dose-Response Relationship, Drug; F

2003
Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception.
    Anesthesiology, 2004, Volume: 101, Issue:1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Clodronic Acid; Fentanyl; Flow Cytometry; Foo

2004
Does neonatal surgery lead to increased pain sensitivity in later childhood?
    Pain, 2005, Volume: 114, Issue:3

    Topics: Analgesics, Opioid; Child, Preschool; Cross-Sectional Studies; Female; Fentanyl; Follow-Up Studies;

2005
Enhancement of fentanyl antinociception by subeffective doses of nitroparacetamol (NCX-701) in acute nociception and in carrageenan-induced monoarthritis.
    Life sciences, 2005, May-20, Volume: 77, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-

2005
Nitrous oxide revisited: evidence for potent antihyperalgesic properties.
    Anesthesiology, 2005, Volume: 103, Issue:4

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagon

2005
Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase.
    Anesthesiology, 2006, Volume: 104, Issue:3

    Topics: Analgesics, Opioid; Animals; Fentanyl; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; N

2006
[Is anti-hyperalgesia clinically relevant? Dosage increase is hardly necessary].
    MMW Fortschritte der Medizin, 2006, Jan-12, Volume: 148, Issue:1-2

    Topics: Administration, Cutaneous; Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Fent

2006
Opioid-induced hyperalgesia.
    European journal of anaesthesiology, 2007, Volume: 24, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Femoral Artery; Fentanyl; Humans; Hyperalgesia; Ketamine; Male; Midd

2007
Protective effect of prior administration of magnesium on delayed hyperalgesia induced by fentanyl in rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2006, Volume: 53, Issue:12

    Topics: Analgesics; Analgesics, Opioid; Animals; Fentanyl; Hyperalgesia; Infusions, Subcutaneous; Magnesium;

2006
Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:10

    Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Excitatory Amino Aci

2007
Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans.
    The journal of pain, 2007, Volume: 8, Issue:6

    Topics: Adolescent; Adult; Analgesics, Opioid; Burns; Dose-Response Relationship, Drug; Female; Fentanyl; Hu

2007
Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats.
    Neuropharmacology, 2007, Volume: 53, Issue:6

    Topics: Analgesics, Opioid; Animals; Anxiety; Atmosphere Exposure Chambers; Behavior, Animal; Disease Models

2007
When opioids cause pain.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Oct-01, Volume: 25, Issue:28

    Topics: Analgesics, Opioid; Back Pain; Carcinoma, Hepatocellular; Drug Therapy, Combination; Fentanyl; Human

2007
Fentanyl-induced neurotoxicity and paradoxic pain.
    Journal of pain and symptom management, 2008, Volume: 35, Issue:3

    Topics: Aged; Analgesics, Opioid; Fatal Outcome; Female; Fentanyl; Humans; Hyperalgesia; Leiomyosarcoma; Neu

2008
Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats.
    Anesthesiology, 2008, Volume: 108, Issue:3

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Fentanyl; Gabapentin

2008
[Acute opiate tolerance and postoperative hyperalgesia after a brief infusion of remifentanil managed with multimodal analgesia].
    Revista espanola de anestesiologia y reanimacion, 2008, Volume: 55, Issue:1

    Topics: Acetaminophen; Adnexal Diseases; Amides; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics,

2008
Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain.
    Pain, 1997, Volume: 69, Issue:1-2

    Topics: Adenocarcinoma; Akathisia, Drug-Induced; Analgesics, Opioid; Confusion; Fentanyl; Hallucinations; Hu

1997
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
    Psychopharmacology, 2000, Volume: 148, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics

2000
Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine.
    Anesthesiology, 2000, Volume: 92, Issue:2

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fe

2000
SYM-2081 a kainate receptor antagonist reduces allodynia and hyperalgesia in a freeze injury model of neuropathic pain.
    Brain research, 2000, Mar-06, Volume: 858, Issue:1

    Topics: Animals; Axons; Behavior, Animal; Cell Count; Fentanyl; Frostbite; Glutamates; Hindlimb; Hyperalgesi

2000
Can epidural fentanyl induce selective spinal hyperalgesia?
    Anesthesiology, 2000, Volume: 93, Issue:4

    Topics: Analgesics, Opioid; Animals; Fentanyl; Humans; Hyperalgesia; Injections, Epidural; Spinal Cord

2000
A murine model of opioid-induced hyperalgesia.
    Brain research. Molecular brain research, 2001, Jan-31, Volume: 86, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heme Oxygenase (Decyclizing); Hyperal

2001
A murine model of opioid-induced hyperalgesia.
    Brain research. Molecular brain research, 2001, Jan-31, Volume: 86, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heme Oxygenase (Decyclizing); Hyperal

2001
A murine model of opioid-induced hyperalgesia.
    Brain research. Molecular brain research, 2001, Jan-31, Volume: 86, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heme Oxygenase (Decyclizing); Hyperal

2001
A murine model of opioid-induced hyperalgesia.
    Brain research. Molecular brain research, 2001, Jan-31, Volume: 86, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heme Oxygenase (Decyclizing); Hyperal

2001
Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine.
    Anesthesiology, 2002, Volume: 96, Issue:2

    Topics: Analgesics, Opioid; Animals; Carrageenan; Drug Synergism; Fentanyl; Foot; Hyperalgesia; Male; Pain T

2002
The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:5

    Topics: Analgesics, Opioid; Animals; Drug Tolerance; Excitatory Amino Acid Antagonists; Fentanyl; Hyperalges

2002
Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation?
    Anesthesia and analgesia, 1987, Volume: 66, Issue:12

    Topics: Analgesics, Opioid; Animals; Carrageenan; Cyclazocine; Dextrorphan; Ethylketocyclazocine; Fentanyl;

1987