iodoacetic acid has been researched along with Allodynia in 31 studies
Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute oral toxicity of m-PGA resulted in LD50 values in excess of 2000 mg/kg." | 5.51 | Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| " Osteoarthritis was induced in male adult control Wistar rats without any interventions and in Wisket rats after juvenile social isolation and ketamine treatment." | 3.96 | Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia. ( Banki, L; Büki, A; Horvath, G; Jancsó, G; Kekesi, G; Kis, G; Somogyvári, F; Tuboly, G; Varga, E; Vécsei, L, 2020) |
| "Acute oral toxicity of m-PGA resulted in LD50 values in excess of 2000 mg/kg." | 1.51 | Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| "Osteoarthritic pain is a chronic disabling condition lacking effective treatment." | 1.51 | Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. ( Cabañero, D; Carcolé, M; Dickenson, AH; Fernández-Pastor, B; Gonçalves, L; Kummer, S; Maldonado, R; Merlos, M; Zamanillo, D, 2019) |
| "It manifests as mechanical allodynia, a painful response to innocuous stimuli such as joint movement." | 1.46 | Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis. ( Christin, M; Davidova, A; He, BH; Mouchbahani-Constance, S; Sharif-Naeini, R, 2017) |
| "To assess neural correlates of mechanical hyperalgesia, hindpaws were stimulated with von Frey hairs (8 g: MIA; 15 g: control knee, based on behavioral withdrawal responses)." | 1.43 | Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. ( Abaei, M; Auer, DP; Chapman, V; Prior, M; Sagar, DR; Spicer, CH; Stockley, EG, 2016) |
| "The current treatments for OA pain such as NSAIDS or opiates are neither sufficiently effective nor devoid of detrimental side effects." | 1.43 | The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse. ( Malcangio, M; Pitcher, T; Sousa-Valente, J, 2016) |
| "Joint pain is a common clinical problem for which both inflammatory and degenerative joint diseases are major causes." | 1.39 | Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. ( Aracil-Fernández, A; Bura, SA; La Porta, C; Maldonado, R; Manzanares, J, 2013) |
| "The effect of Nav1." | 1.38 | Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis. ( McDougall, JJ; Schuelert, N, 2012) |
| "MIA injection produced thermal hyperalgesia (assessed by the plantar test) and tactile allodynia (measured with von Frey hairs)." | 1.35 | Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. ( Dolezal, T; Krsiak, M; Prochazkova, M; Prokesova, L; Zanvit, P, 2009) |
| " Furthermore, in an additional study animals were orally dosed vehicle (5 ml/kg), naproxen (0." | 1.34 | Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. ( Ball, AD; Heapy, CG; Ivanavicius, SP; Murray, F; Read, SJ; Westwood, RF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 20 (64.52) | 24.3611 |
| 2020's | 9 (29.03) | 2.80 |
| Authors | Studies |
|---|---|
| Han, FY | 1 |
| Brockman, DA | 1 |
| Nicholson, JR | 1 |
| Corradini, L | 1 |
| Smith, MT | 1 |
| Wang, X | 1 |
| Song, J | 1 |
| Xia, P | 1 |
| Lin, Q | 1 |
| Chen, A | 1 |
| Cheng, K | 1 |
| Kong, F | 1 |
| Shi, Y | 1 |
| Li, X | 1 |
| Sun, J | 1 |
| Wang, XH | 1 |
| Song, FH | 1 |
| Li, DY | 1 |
| Gao, SJ | 1 |
| Zhang, LQ | 1 |
| Wu, JY | 1 |
| Liu, DQ | 1 |
| Wang, LW | 1 |
| Zhou, YQ | 1 |
| Mei, W | 1 |
| Liu, Z | 1 |
| Chen, X | 1 |
| Chen, P | 1 |
| Wang, L | 1 |
| Ro, JY | 1 |
| Zhang, Y | 1 |
| Tricou, C | 1 |
| Yang, D | 1 |
| da Silva, JT | 1 |
| Zhang, R | 1 |
| Banki, L | 1 |
| Büki, A | 1 |
| Horvath, G | 1 |
| Kekesi, G | 1 |
| Kis, G | 1 |
| Somogyvári, F | 1 |
| Jancsó, G | 1 |
| Vécsei, L | 1 |
| Varga, E | 1 |
| Tuboly, G | 1 |
| Cordaro, M | 1 |
| Siracusa, R | 1 |
| Impellizzeri, D | 1 |
| D' Amico, R | 1 |
| Peritore, AF | 1 |
| Crupi, R | 1 |
| Gugliandolo, E | 1 |
| Fusco, R | 1 |
| Di Paola, R | 1 |
| Schievano, C | 1 |
| Cuzzocrea, S | 1 |
| Khotib, J | 1 |
| Utami, NW | 1 |
| Gani, MA | 1 |
| Ardianto, C | 1 |
| Micheli, L | 2 |
| Di Cesare Mannelli, L | 2 |
| Mattoli, L | 1 |
| Tamimi, S | 1 |
| Flamini, E | 1 |
| Garetto, S | 1 |
| Lucci, J | 1 |
| Giovagnoni, E | 1 |
| Cinci, L | 1 |
| D'Ambrosio, M | 1 |
| Luceri, C | 1 |
| Ghelardini, C | 2 |
| Tian, Y | 1 |
| Onodera, T | 1 |
| Terkawi, MA | 1 |
| Iwasaki, K | 1 |
| Hishimura, R | 1 |
| Liang, D | 1 |
| Miyazaki, T | 1 |
| Iwasaki, N | 1 |
| Kwok, CHT | 1 |
| Kohro, Y | 1 |
| Mousseau, M | 1 |
| O'Brien, MS | 1 |
| Matyas, JR | 1 |
| McDougall, JJ | 2 |
| Trang, T | 1 |
| Allen, J | 1 |
| Imbert, I | 1 |
| Havelin, J | 1 |
| Henderson, T | 1 |
| Stevenson, G | 1 |
| Liaw, L | 1 |
| King, T | 1 |
| Tenci, B | 1 |
| Maresca, M | 1 |
| Pieraccini, G | 1 |
| Mulinacci, N | 1 |
| He, BH | 1 |
| Christin, M | 1 |
| Mouchbahani-Constance, S | 1 |
| Davidova, A | 1 |
| Sharif-Naeini, R | 1 |
| Karlapudi, V | 1 |
| Prasad Mungara, AVV | 1 |
| Sengupta, K | 1 |
| Davis, BA | 1 |
| Raychaudhuri, SP | 1 |
| Haywood, AR | 1 |
| Hathway, GJ | 1 |
| Chapman, V | 2 |
| Aman, Y | 1 |
| Pitcher, T | 2 |
| Ballard, C | 1 |
| Malcangio, M | 3 |
| Richards, D | 1 |
| Gever, JR | 1 |
| Ford, AP | 1 |
| Fountain, SJ | 1 |
| Hahm, SC | 1 |
| Song, E | 1 |
| Jeon, H | 1 |
| Yoon, YW | 1 |
| Kim, J | 1 |
| Carcolé, M | 1 |
| Kummer, S | 1 |
| Gonçalves, L | 1 |
| Zamanillo, D | 1 |
| Merlos, M | 1 |
| Dickenson, AH | 2 |
| Fernández-Pastor, B | 1 |
| Cabañero, D | 1 |
| Maldonado, R | 2 |
| Rahman, W | 1 |
| Patel, R | 1 |
| Abaei, M | 1 |
| Sagar, DR | 1 |
| Stockley, EG | 1 |
| Spicer, CH | 1 |
| Prior, M | 1 |
| Auer, DP | 1 |
| Sousa-Valente, J | 1 |
| Morais, SV | 1 |
| Czeczko, NG | 1 |
| Malafaia, O | 1 |
| Ribas, JM | 1 |
| Garcia, JB | 1 |
| Miguel, MT | 1 |
| Zini, C | 1 |
| Massignan, AG | 1 |
| Prochazkova, M | 1 |
| Zanvit, P | 1 |
| Dolezal, T | 1 |
| Prokesova, L | 1 |
| Krsiak, M | 1 |
| Schuelert, N | 1 |
| Dhaneshwar, S | 1 |
| Patil, D | 1 |
| Ferland, CE | 1 |
| Beaudry, F | 1 |
| Vachon, P | 1 |
| Ogbonna, AC | 1 |
| Clark, AK | 1 |
| Gentry, C | 1 |
| Hobbs, C | 1 |
| La Porta, C | 1 |
| Bura, SA | 1 |
| Aracil-Fernández, A | 1 |
| Manzanares, J | 1 |
| Ivanavicius, SP | 1 |
| Ball, AD | 1 |
| Heapy, CG | 1 |
| Westwood, RF | 1 |
| Murray, F | 1 |
| Read, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Controlled Trial of Exercise Therapy in Combination With Central Nervous System-targeted Treatment Compared With Exercise Therapy Alone for Treatment of People With Knee Osteoarthritis[NCT03681613] | 104 participants (Anticipated) | Interventional | 2019-01-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for iodoacetic acid and Allodynia
| Article | Year |
|---|---|
A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee.
Topics: Aged; Animals; Body Mass Index; Body Weight; Boswellia; Curcuma; Cytokines; Disease Models, Animal; | 2018 |
30 other studies available for iodoacetic acid and Allodynia
| Article | Year |
|---|---|
Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat.
Topics: Animals; Arthralgia; Behavior Observation Techniques; Behavior, Animal; Behavioral Symptoms; Disease | 2022 |
High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; High-Intensity Interval Training; Hyperalgesia; Iodoacetic Acid; Os | 2023 |
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling.
Topics: Animals; Antioxidants; Disease Models, Animal; Humans; Hyperalgesia; Iodoacetic Acid; Neuroinflammat | 2023 |
Transcranial Direct Current Stimulation Attenuates the Chronic Pain of Osteoarthritis in Rats via Reducing NMDAR2B Expressions in the Spinal Cord.
Topics: Analgesics; Animals; Chronic Pain; Hyperalgesia; Iodoacetic Acid; Osteoarthritis; Rats; Spinal Cord; | 2023 |
Age and Sex Differences in Acute and Osteoarthritis-Like Pain Responses in Rats.
Topics: Aging; Animals; Arthritis, Experimental; Behavior, Animal; Capsaicin; Enzyme Inhibitors; Female; Hyp | 2020 |
Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia.
Topics: Analgesics, Opioid; Animals; Ankle Joint; Brain; Brain Stem; Chronic Pain; Diencephalon; Disease Mod | 2020 |
Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain.
Topics: Analgesics; Animals; Carrageenan; Female; Glucosamine; Hyperalgesia; Inflammation; Iodoacetic Acid; | 2019 |
The change of proinflammatory cytokine tumor necrosis factor α level in the use of meloxicam in rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship | 2019 |
Intra-Articular Route for the System of Molecules 14G1862 from
Topics: Analgesics; Animals; Arthritis, Experimental; Cell Survival; Centella; Disease Models, Animal; Hyper | 2020 |
Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model.
Topics: Animals; Antibodies, Monoclonal, Humanized; Arthritis, Experimental; Cartilage, Articular; Dose-Resp | 2021 |
Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity.
Topics: Adenosine Triphosphate; Animals; Arthralgia; Arthritis, Experimental; Disease Models, Animal; Female | 2021 |
Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats.
Topics: Anesthetics, Local; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Models, | 2017 |
Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats.
Topics: Administration, Oral; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Hyperalgesia; Injec | 2017 |
Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis.
Topics: Animals; Enzyme Inhibitors; Hyperalgesia; Injections, Intra-Articular; Iodoacetic Acid; Ion Channels | 2017 |
Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expre | 2018 |
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics; Analgesics, Opioid; Animals; Arthralg | 2019 |
Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation.
Topics: Animals; Carbolines; Cell Line, Tumor; Female; Freund's Adjuvant; Humans; Hyperalgesia; Iodoacetic A | 2019 |
Transcutaneous Electrical Nerve Stimulation Reduces Knee Osteoarthritic Pain by Inhibiting Spinal Glial Cells in Rats.
Topics: Animals; Arthralgia; Astrocytes; Cell Count; Hyperalgesia; Iodoacetic Acid; Knee Joint; Male; Neurog | 2019 |
Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleranc | 2019 |
Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis.
Topics: Animals; Calcium Channel Blockers; Caveolin 2; Disease Models, Animal; Evoked Potentials; Functional | 2015 |
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.
Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Capsaicin; Disease Models, Animal; Electric Stimula | 2016 |
The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Cartilage, Articular; Chondrocytes; Disease Mode | 2016 |
Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Hyperalgesia; Injections, Intra-Articular; Io | 2016 |
Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Hyperalgesia; | 2009 |
Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis.
Topics: Analysis of Variance; Aniline Compounds; Animals; Arthralgia; Disease Models, Animal; Exploratory Be | 2012 |
Chondromodulating chimeric prodrugs of diacetylrhein: synthesis and evaluation in monoiodoacetate-induced hyperalgesia.
Topics: Animals; Anthraquinones; Chondrocytes; Disease Models, Animal; Hyperalgesia; Iodoacetic Acid; Osteoa | 2013 |
Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Clove Oil; Disease Models, Animal; Dynorphins; | 2012 |
Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Calcitonin Gene-Related Peptide; Hyperalgesia; I | 2013 |
Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.
Topics: Animals; Arthralgia; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalges | 2013 |
Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation.
Topics: Activating Transcription Factor 3; Animals; Disease Models, Animal; Gene Expression; Humans; Hyperal | 2007 |