Page last updated: 2024-10-29

isoflurane and Allodynia

isoflurane has been researched along with Allodynia in 15 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Research Excerpts

ExcerptRelevanceReference
"F 13640 is a newly discovered high-efficacy 5-HT(1A) receptor agonist that produces exceptional analgesia in animal models of tonic and chronic, nociceptive and neuropathic pains by novel molecular and neuroadaptive mechanisms."7.73The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain. ( Bardin, L; Colpaert, FC; Degryse, AD; Gomez de Segura, IA; Kiss, I, 2005)
"F 13640 is a newly discovered high-efficacy 5-HT(1A) receptor agonist that produces exceptional analgesia in animal models of tonic and chronic, nociceptive and neuropathic pains by novel molecular and neuroadaptive mechanisms."3.73The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain. ( Bardin, L; Colpaert, FC; Degryse, AD; Gomez de Segura, IA; Kiss, I, 2005)
"Mechanical allodynia induced by plantar incision peaked at 1 hr and lasted for 3 days after incision."1.51Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain. ( Cheung, CW; Gu, P; Li, Q; Qiu, Q; Sun, L; Wang, XM; Wong, SS, 2019)
"Opioid receptor antagonists increase hyperalgesia in humans and animals, which indicates that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive."1.39Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. ( Corder, G; Donahue, RR; Doolen, S; He, Y; Hu, X; Jutras, BL; McCarson, KE; Mogil, JS; Storm, DR; Taylor, BK; Wang, ZJ; Wieskopf, JS; Winter, MK, 2013)
"Immediately upon arousal, a hind paw tactile allodynia, as measured with von Frey hairs (pre 1."1.37Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling. ( Corr, M; Stokes, JA; Yaksh, TL, 2011)
"However, halothane-induced hyperalgesia during learning clouds interpreting enhanced retention performance solely as a memory consolidation effect."1.33Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats. ( Alkire, MT; McReynolds, JR; Nathan, SV, 2005)
"Mecamylamine treatment caused a biphasic nociceptive response similar to that caused by isoflurane."1.31Isoflurane hyperalgesia is modulated by nicotinic inhibition. ( Coates, KM; Flood, P; Gong, D; Sonner, JM, 2002)
"The development of neuropathic heat hyperalgesia required the presence of both the alpha(2A) adrenoceptor and the sympathetic postganglionic neuron (SPGN), but the development of mechanical hyperalgesia did not require either the alpha(2A) adrenoceptor or the SPGN, indicating different mechanisms of sensitization."1.31The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. ( Davies, FM; Guo, TZ; Kingery, WS; Limbird, L; Maze, M, 2000)
"Hyperalgesia was assessed as a decrease in the time to withdrawal of a rat hind paw exposed to heat."1.31Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration. ( Dutton, RC; Eger, EI; Sonner, JM; Zhang, Y, 2000)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's7 (46.67)29.6817
2010's7 (46.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Raithel, SJ1
Sapio, MR1
Iadarola, MJ1
Mannes, AJ1
Wong, SS1
Sun, L1
Qiu, Q1
Gu, P1
Li, Q1
Wang, XM1
Cheung, CW1
Corder, G1
Doolen, S1
Donahue, RR1
Winter, MK1
Jutras, BL1
He, Y1
Hu, X1
Wieskopf, JS1
Mogil, JS1
Storm, DR1
Wang, ZJ1
McCarson, KE1
Taylor, BK1
Vanini, G1
Nemanis, K1
Baghdoyan, HA1
Lydic, R1
Zhang, H1
Li, Y1
de Carvalho-Barbosa, M1
Kavelaars, A1
Heijnen, CJ1
Albrecht, PJ1
Dougherty, PM1
LeBlanc, BW1
Bowary, PM1
Chao, YC1
Lii, TR1
Saab, CY1
Stokes, JA1
Corr, M1
Yaksh, TL1
Flood, P1
Sonner, JM2
Gong, D1
Coates, KM1
Chaaben, K1
Marret, E1
Lamonerie, L1
Lembert, N1
Bonnet, F1
Kiss, I1
Degryse, AD1
Bardin, L1
Gomez de Segura, IA1
Colpaert, FC1
Weber, NC1
Toma, O1
Awan, S1
Frässdorf, J1
Preckel, B1
Schlack, W1
Alkire, MT1
Nathan, SV1
McReynolds, JR1
Abram, SE1
Olson, EE1
Kingery, WS1
Guo, TZ1
Davies, FM1
Limbird, L1
Maze, M1
Zhang, Y1
Eger, EI1
Dutton, RC1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury. A Randomized, Placebo-controlled, Double-blind Crossover Study[NCT02684669]Phase 280 participants (Actual)Interventional2016-02-29Completed
Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperal-gesia in Patients Following Recovery From Impacted Mandibular Third Molar Extraction. A Randomized, Placebo-controlled, Double-blind Crossover Study.[NCT02976337]Phase 214 participants (Anticipated)Interventional2017-10-12Recruiting
Intranasal Nicotine for Postoperative Pain Treatment: A Comparison of Its Effects in the Context of Isoflurane-induced Anesthesia Versus Propofol Anesthesia[NCT00232817]Phase 480 participants (Actual)Interventional2003-07-31Completed
The Effects of Propofol vs. Sevoflurane Administered During Anesthesia Maintenance on Early and Late Recovery After Gynecological Surgery[NCT01755234]Phase 490 participants (Actual)Interventional2012-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Mg of Morphine Equivalents (IV)

Total opioid use in the post operative care unit (Mg of morphine equivalents) (NCT01755234)
Timeframe: PACU admission to discharge

Interventionmiligrams of morphine equivalents (Median)
Sevoflurane9
Propofol9.4

Opioid Use Discharge From Post Anesthesia Care Unit to 24 Hours After PACU Discharge.

Opioid use in mg of morphine equivalents from discharge from the post anesthesia care unit to 24 hours after PACU discharge. (NCT01755234)
Timeframe: Discharge from PACU to 24 hours post operative after PACU discharge.

Interventionmg morphine equivalents (Median)
Sevoflurane30
Propofol25

Pain in Post Anesthesia Care Unit

"Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve in the post anesthesia care unit ( score * min). A higher value indicates more pain and time in the Post Anesthesia Care Unit.~The range is 0 pain to x time in minutes x 1 hour to 5 hour ( 60-300 minutes) . The pain scores were collected at 15 minute intervals from the time of admission to the PACU. The area under the NRS pain scale versus time curve was calculated using the trapezoidal method as an indicator of pain burden during early recovery (Graph Pad Prism ver 5.03, Graph Pad Software INC." (NCT01755234)
Timeframe: Time in the post anesthesia care unit

InterventionPain Score * minutes in PACU (Median)
Sevoflurane270
Propofol240

Quality of Recovery Score 24 Hours Post Operative

Quality of recovery score 24 hours after the surgical procedure.Score of 40 is poor recovery and a score of 200 is good recovery. (NCT01755234)
Timeframe: 24 hours after the surgical procedure

Interventionunits on a scale (Median)
Sevoflurane175
Propofol176

Other Studies

15 other studies available for isoflurane and Allodynia

ArticleYear
Thermal A-δ Nociceptors, Identified by Transcriptomics, Express Higher Levels of Anesthesia-Sensitive Receptors Than Thermal C-Fibers and Are More Suppressible by Low-Dose Isoflurane.
    Anesthesia and analgesia, 2018, Volume: 127, Issue:1

    Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Behavior, Animal; Disease Models, Anim

2018
Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain.
    European journal of pain (London, England), 2019, Volume: 23, Issue:4

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Guanine Nucleoti

2019
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
    Science (New York, N.Y.), 2013, Sep-20, Volume: 341, Issue:6152

    Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima

2013
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
    Science (New York, N.Y.), 2013, Sep-20, Volume: 341, Issue:6152

    Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima

2013
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
    Science (New York, N.Y.), 2013, Sep-20, Volume: 341, Issue:6152

    Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima

2013
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
    Science (New York, N.Y.), 2013, Sep-20, Volume: 341, Issue:6152

    Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima

2013
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
    The European journal of neuroscience, 2014, Volume: 40, Issue:1

    Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inh

2014
Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy.
    The journal of pain, 2016, Volume: 17, Issue:7

    Topics: Anesthetics; Animals; Antibodies; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineopl

2016
Electroencephalographic signatures of pain and analgesia in rats.
    Pain, 2016, Volume: 157, Issue:10

    Topics: Anesthetics, Inhalation; Animals; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencep

2016
Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling.
    Neuroscience letters, 2011, Oct-31, Volume: 504, Issue:3

    Topics: Adaptor Proteins, Vesicular Transport; Anesthetics, Inhalation; Animals; Crosses, Genetic; Dura Mate

2011
Isoflurane hyperalgesia is modulated by nicotinic inhibition.
    Anesthesiology, 2002, Volume: 97, Issue:1

    Topics: Animals; Female; Hyperalgesia; Isoflurane; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Rece

2002
[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
    Annales francaises d'anesthesie et de reanimation, 2004, Volume: 23, Issue:5

    Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhal

2004
The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain.
    European journal of pharmacology, 2005, Oct-31, Volume: 523, Issue:1-3

    Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anesthetics, Inhalati

2005
Effects of nitrous oxide on the rat heart in vivo: another inhalational anesthetic that preconditions the heart?
    Anesthesiology, 2005, Volume: 103, Issue:6

    Topics: Amygdala; Anesthetics, Inhalation; Animals; Avoidance Learning; Desflurane; Excitatory Amino Acid Ag

2005
Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats.
    Anesthesiology, 2005, Volume: 103, Issue:6

    Topics: Amygdala; Anesthetics, Inhalation; Animals; Avoidance Learning; Desflurane; Excitatory Amino Acid Ag

2005
Systemic opioids do not suppress spinal sensitization after subcutaneous formalin in rats.
    Anesthesiology, 1994, Volume: 80, Issue:5

    Topics: Alfentanil; Animals; Drug Administration Schedule; Formaldehyde; Hot Temperature; Hyperalgesia; Inje

1994
The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Anesthetics, Inha

2000
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia;

2000
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia;

2000
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia;

2000
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia;

2000