isoflurane has been researched along with Allodynia in 15 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
| Excerpt | Relevance | Reference |
|---|---|---|
| "F 13640 is a newly discovered high-efficacy 5-HT(1A) receptor agonist that produces exceptional analgesia in animal models of tonic and chronic, nociceptive and neuropathic pains by novel molecular and neuroadaptive mechanisms." | 7.73 | The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain. ( Bardin, L; Colpaert, FC; Degryse, AD; Gomez de Segura, IA; Kiss, I, 2005) |
| "F 13640 is a newly discovered high-efficacy 5-HT(1A) receptor agonist that produces exceptional analgesia in animal models of tonic and chronic, nociceptive and neuropathic pains by novel molecular and neuroadaptive mechanisms." | 3.73 | The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain. ( Bardin, L; Colpaert, FC; Degryse, AD; Gomez de Segura, IA; Kiss, I, 2005) |
| "Mechanical allodynia induced by plantar incision peaked at 1 hr and lasted for 3 days after incision." | 1.51 | Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain. ( Cheung, CW; Gu, P; Li, Q; Qiu, Q; Sun, L; Wang, XM; Wong, SS, 2019) |
| "Opioid receptor antagonists increase hyperalgesia in humans and animals, which indicates that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive." | 1.39 | Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. ( Corder, G; Donahue, RR; Doolen, S; He, Y; Hu, X; Jutras, BL; McCarson, KE; Mogil, JS; Storm, DR; Taylor, BK; Wang, ZJ; Wieskopf, JS; Winter, MK, 2013) |
| "Immediately upon arousal, a hind paw tactile allodynia, as measured with von Frey hairs (pre 1." | 1.37 | Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling. ( Corr, M; Stokes, JA; Yaksh, TL, 2011) |
| "However, halothane-induced hyperalgesia during learning clouds interpreting enhanced retention performance solely as a memory consolidation effect." | 1.33 | Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats. ( Alkire, MT; McReynolds, JR; Nathan, SV, 2005) |
| "Mecamylamine treatment caused a biphasic nociceptive response similar to that caused by isoflurane." | 1.31 | Isoflurane hyperalgesia is modulated by nicotinic inhibition. ( Coates, KM; Flood, P; Gong, D; Sonner, JM, 2002) |
| "The development of neuropathic heat hyperalgesia required the presence of both the alpha(2A) adrenoceptor and the sympathetic postganglionic neuron (SPGN), but the development of mechanical hyperalgesia did not require either the alpha(2A) adrenoceptor or the SPGN, indicating different mechanisms of sensitization." | 1.31 | The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. ( Davies, FM; Guo, TZ; Kingery, WS; Limbird, L; Maze, M, 2000) |
| "Hyperalgesia was assessed as a decrease in the time to withdrawal of a rat hind paw exposed to heat." | 1.31 | Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration. ( Dutton, RC; Eger, EI; Sonner, JM; Zhang, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raithel, SJ | 1 |
| Sapio, MR | 1 |
| Iadarola, MJ | 1 |
| Mannes, AJ | 1 |
| Wong, SS | 1 |
| Sun, L | 1 |
| Qiu, Q | 1 |
| Gu, P | 1 |
| Li, Q | 1 |
| Wang, XM | 1 |
| Cheung, CW | 1 |
| Corder, G | 1 |
| Doolen, S | 1 |
| Donahue, RR | 1 |
| Winter, MK | 1 |
| Jutras, BL | 1 |
| He, Y | 1 |
| Hu, X | 1 |
| Wieskopf, JS | 1 |
| Mogil, JS | 1 |
| Storm, DR | 1 |
| Wang, ZJ | 1 |
| McCarson, KE | 1 |
| Taylor, BK | 1 |
| Vanini, G | 1 |
| Nemanis, K | 1 |
| Baghdoyan, HA | 1 |
| Lydic, R | 1 |
| Zhang, H | 1 |
| Li, Y | 1 |
| de Carvalho-Barbosa, M | 1 |
| Kavelaars, A | 1 |
| Heijnen, CJ | 1 |
| Albrecht, PJ | 1 |
| Dougherty, PM | 1 |
| LeBlanc, BW | 1 |
| Bowary, PM | 1 |
| Chao, YC | 1 |
| Lii, TR | 1 |
| Saab, CY | 1 |
| Stokes, JA | 1 |
| Corr, M | 1 |
| Yaksh, TL | 1 |
| Flood, P | 1 |
| Sonner, JM | 2 |
| Gong, D | 1 |
| Coates, KM | 1 |
| Chaaben, K | 1 |
| Marret, E | 1 |
| Lamonerie, L | 1 |
| Lembert, N | 1 |
| Bonnet, F | 1 |
| Kiss, I | 1 |
| Degryse, AD | 1 |
| Bardin, L | 1 |
| Gomez de Segura, IA | 1 |
| Colpaert, FC | 1 |
| Weber, NC | 1 |
| Toma, O | 1 |
| Awan, S | 1 |
| Frässdorf, J | 1 |
| Preckel, B | 1 |
| Schlack, W | 1 |
| Alkire, MT | 1 |
| Nathan, SV | 1 |
| McReynolds, JR | 1 |
| Abram, SE | 1 |
| Olson, EE | 1 |
| Kingery, WS | 1 |
| Guo, TZ | 1 |
| Davies, FM | 1 |
| Limbird, L | 1 |
| Maze, M | 1 |
| Zhang, Y | 1 |
| Eger, EI | 1 |
| Dutton, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury. A Randomized, Placebo-controlled, Double-blind Crossover Study[NCT02684669] | Phase 2 | 80 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperal-gesia in Patients Following Recovery From Impacted Mandibular Third Molar Extraction. A Randomized, Placebo-controlled, Double-blind Crossover Study.[NCT02976337] | Phase 2 | 14 participants (Anticipated) | Interventional | 2017-10-12 | Recruiting | ||
| Intranasal Nicotine for Postoperative Pain Treatment: A Comparison of Its Effects in the Context of Isoflurane-induced Anesthesia Versus Propofol Anesthesia[NCT00232817] | Phase 4 | 80 participants (Actual) | Interventional | 2003-07-31 | Completed | ||
| The Effects of Propofol vs. Sevoflurane Administered During Anesthesia Maintenance on Early and Late Recovery After Gynecological Surgery[NCT01755234] | Phase 4 | 90 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total opioid use in the post operative care unit (Mg of morphine equivalents) (NCT01755234)
Timeframe: PACU admission to discharge
| Intervention | miligrams of morphine equivalents (Median) |
|---|---|
| Sevoflurane | 9 |
| Propofol | 9.4 |
Opioid use in mg of morphine equivalents from discharge from the post anesthesia care unit to 24 hours after PACU discharge. (NCT01755234)
Timeframe: Discharge from PACU to 24 hours post operative after PACU discharge.
| Intervention | mg morphine equivalents (Median) |
|---|---|
| Sevoflurane | 30 |
| Propofol | 25 |
"Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve in the post anesthesia care unit ( score * min). A higher value indicates more pain and time in the Post Anesthesia Care Unit.~The range is 0 pain to x time in minutes x 1 hour to 5 hour ( 60-300 minutes) . The pain scores were collected at 15 minute intervals from the time of admission to the PACU. The area under the NRS pain scale versus time curve was calculated using the trapezoidal method as an indicator of pain burden during early recovery (Graph Pad Prism ver 5.03, Graph Pad Software INC." (NCT01755234)
Timeframe: Time in the post anesthesia care unit
| Intervention | Pain Score * minutes in PACU (Median) |
|---|---|
| Sevoflurane | 270 |
| Propofol | 240 |
Quality of recovery score 24 hours after the surgical procedure.Score of 40 is poor recovery and a score of 200 is good recovery. (NCT01755234)
Timeframe: 24 hours after the surgical procedure
| Intervention | units on a scale (Median) |
|---|---|
| Sevoflurane | 175 |
| Propofol | 176 |
15 other studies available for isoflurane and Allodynia
| Article | Year |
|---|---|
Thermal A-δ Nociceptors, Identified by Transcriptomics, Express Higher Levels of Anesthesia-Sensitive Receptors Than Thermal C-Fibers and Are More Suppressible by Low-Dose Isoflurane.
Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Behavior, Animal; Disease Models, Anim | 2018 |
Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Guanine Nucleoti | 2019 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima | 2013 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima | 2013 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima | 2013 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Anima | 2013 |
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inh | 2014 |
Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy.
Topics: Anesthetics; Animals; Antibodies; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineopl | 2016 |
Electroencephalographic signatures of pain and analgesia in rats.
Topics: Anesthetics, Inhalation; Animals; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencep | 2016 |
Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling.
Topics: Adaptor Proteins, Vesicular Transport; Anesthetics, Inhalation; Animals; Crosses, Genetic; Dura Mate | 2011 |
Isoflurane hyperalgesia is modulated by nicotinic inhibition.
Topics: Animals; Female; Hyperalgesia; Isoflurane; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Rece | 2002 |
[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhal | 2004 |
The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain.
Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anesthetics, Inhalati | 2005 |
Effects of nitrous oxide on the rat heart in vivo: another inhalational anesthetic that preconditions the heart?
Topics: Amygdala; Anesthetics, Inhalation; Animals; Avoidance Learning; Desflurane; Excitatory Amino Acid Ag | 2005 |
Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats.
Topics: Amygdala; Anesthetics, Inhalation; Animals; Avoidance Learning; Desflurane; Excitatory Amino Acid Ag | 2005 |
Systemic opioids do not suppress spinal sensitization after subcutaneous formalin in rats.
Topics: Alfentanil; Animals; Drug Administration Schedule; Formaldehyde; Hot Temperature; Hyperalgesia; Inje | 1994 |
The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Anesthetics, Inha | 2000 |
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia; | 2000 |
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia; | 2000 |
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia; | 2000 |
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia; | 2000 |