qx-314 has been researched along with Allodynia in 8 studies
QX-314: triethyl analog of lidocaine; RN & NM refer to ion
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 7.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 3.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| " We concluded that only peripheral blockade of transient receptor potential vanilloid receptor 1-expressing nociceptive afferents by the QX-314/capsaicin combination was effective at reducing neuropathic allodynia and hyperalgesia." | 3.78 | Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats. ( Cheng, J; Fox, LE; Shen, J, 2012) |
| "Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represents a cardinal feature of neuropathic pain." | 1.42 | Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. ( Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kamada, H | 1 |
| Emura, K | 1 |
| Yamamoto, R | 1 |
| Kawahara, K | 1 |
| Uto, S | 1 |
| Minami, T | 1 |
| Ito, S | 1 |
| Matsumoto, KI | 1 |
| Okuda-Ashitaka, E | 1 |
| Peters, CM | 1 |
| Ririe, D | 1 |
| Houle, TT | 1 |
| Aschenbrenner, CA | 1 |
| Eisenach, JC | 1 |
| Xu, ZZ | 1 |
| Kim, YH | 1 |
| Bang, S | 1 |
| Zhang, Y | 1 |
| Berta, T | 1 |
| Wang, F | 1 |
| Oh, SB | 1 |
| Ji, RR | 1 |
| Peirs, C | 1 |
| Seal, RP | 1 |
| Yamaguchi, K | 1 |
| Ono, K | 1 |
| Hitomi, S | 2 |
| Ito, M | 1 |
| Nodai, T | 1 |
| Goto, T | 1 |
| Harano, N | 1 |
| Watanabe, S | 1 |
| Inoue, H | 1 |
| Miyano, K | 1 |
| Uezono, Y | 1 |
| Matoba, M | 1 |
| Inenaga, K | 1 |
| Shen, J | 1 |
| Fox, LE | 1 |
| Cheng, J | 1 |
| Zakir, HM | 1 |
| Mostafeezur, RM | 1 |
| Suzuki, A | 1 |
| Suzuki, I | 1 |
| Maeda, T | 1 |
| Seo, K | 1 |
| Yamada, Y | 1 |
| Yamamura, K | 1 |
| Lev, S | 1 |
| Binshtok, AM | 1 |
| Iwata, K | 1 |
| Kitagawa, J | 1 |
| Kawamata, M | 1 |
| Sugino, S | 1 |
| Narimatsu, E | 1 |
| Yamauchi, M | 1 |
| Kiya, T | 1 |
| Furuse, S | 1 |
| Namiki, A | 1 |
8 other studies available for qx-314 and Allodynia
| Article | Year |
|---|---|
Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
Topics: Animals; Ehlers-Danlos Syndrome; Extracellular Matrix; Flagellin; Humans; Hyperalgesia; Mice; Nerve | 2023 |
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Behavior, Animal; Capsaicin; Disease Models, Ani | 2014 |
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; F | 2015 |
Targeting Toll-like receptors to treat chronic pain.
Topics: Anesthetics, Local; Animals; Chronic Pain; Flagellin; Humans; Hyperalgesia; Lidocaine; Mice; Nerve F | 2015 |
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; C | 2016 |
Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.
Topics: Anesthetics, Local; Animals; Antipruritics; Capsaicin; Disease Models, Animal; Drug Administration R | 2012 |
Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation.
Topics: Anesthetics, Local; Animals; Capsaicin; Gene Expression; Hyperalgesia; Lidocaine; Male; Mandibular N | 2012 |
Effects of systemic administration of lidocaine and QX-314 on hyperexcitability of spinal dorsal horn neurons after incision in the rat.
Topics: Action Potentials; Anesthetics, Local; Animals; Denervation; Dose-Response Relationship, Drug; Hyper | 2006 |