phentolamine has been researched along with Allodynia in 28 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 7.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 3.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| "The effects of transcutaneous electrical stimulation and systemic injection of phentolamine, a non-specific alpha-adrenergic antagonist, on the behavioral signs of mechanical allodynia and cold hyperalgesia in rats with nerve injury were investigated." | 3.71 | Differential antinociceptive effect of transcutaneous electrical stimulation on pain behavior sensitive or insensitive to phentolamine in neuropathic rats. ( Choi, Y; Leem, JW; Nam, TS; Paik, KS; Yeon, DS, 2001) |
| "The involvement of the sympathetic postganglionic neuron in secondary hyperalgesia was evaluated using a model of secondary hyperalgesia induced by a small intradermal injection of capsaicin in the rat, a procedure known to produce mechanical hyperalgesia/allodynia in humans." | 3.69 | Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat. ( Kinnman, E; Levine, JD, 1995) |
| "Mechanical hyperalgesia in sympathetically-maintained pain can be explained by central sensitization so that the activation of A-beta mechanoreceptors now causes pain." | 2.38 | The adrenergic pharmacology of sympathetically-maintained pain. ( Campbell, JN; Davis, KD; Raja, SN, 1992) |
| "Therapeutic potential of agomelatine on neuropathic pain was suppressed with α-methyl-para-tyrosine methyl ester (an inhibitor of catecholamine synthesis), phentolamine (a nonselective α-adrenoceptor antagonist), and propranolol (a nonselective β-adrenoceptor antagonist) administrations." | 1.43 | Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms. ( Aydın, TH; Can, ÖD; Demir Özkay, Ü; Turan, N, 2016) |
| "Cold allodynia [evaluated by immersing the tail into cold water (4 °C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i." | 1.40 | Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats. ( Bae, H; Kim, SK; Lee, DI; Lee, G; Lim, BS; Min, BI; Moon, HJ; Na, HS; Ye, MS, 2014) |
| "Epinephrine (EPI) contributes to hyperalgesia in inflammatory and stress conditions." | 1.37 | GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia. ( Carbajal, AG; Dantzer, R; Eijkelkamp, N; Heijnen, CJ; Kavelaars, A; Kelley, KW; Schedlowski, M; Wang, H, 2011) |
| "The effect of NE on mechanical hyperalgesia was mediated by both peripheral alpha(1)- and alpha(2)-adrenoceptors." | 1.32 | Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia. ( Baik, E; Chung, JM; Chung, K, 2003) |
| "Mechanical hyperalgesia was evaluated by determining the frequency of withdrawal to von Frey monofilaments applied to the hind paws." | 1.31 | Nerve injury-induced mechanical but not thermal hyperalgesia is attenuated in neurokinin-1 receptor knockout mice. ( DeVries, C; Lee, H; Mansikka, H; Raja, SN; Sheth, RN; Winchurch, R, 2000) |
| "The pain and hyperalgesia persisted during a phentolamine infusion, which produced a sympathetic blockade." | 1.31 | Neuropathic pain after C7 spinal nerve transection in man. ( Ali, Z; Belzberg, AJ; Meyer, RA, 2002) |
| "Mechanical hyperalgesia, however, was less sensitive to inhibition by propranolol and guanethedine but significantly inhibited by phentolamine." | 1.31 | The role of the sympathetic efferents in endotoxin-induced localized inflammatory hyperalgesia and cytokine upregulation. ( Haddad, JJ; Jabbur, SJ; Massaad, CA; Poole, S; Saadé, NE; Safieh-Garabedian, B, 2002) |
| "The chronic allodynia-like behavior was stable for months without signs of remission and i." | 1.30 | Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury. ( Haegerstrand, A; Hao, JX; Hökfelt, T; Saydoff, J; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W, 1998) |
| "Mechanical hyperalgesia was quantified with von Frey hairs applied either for 3 s or repetitively to the plantar surface of the hindpaw." | 1.30 | Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists. ( Choi, Y; Grethel, EJ; Meyer, RA; Raja, SN; Ringkamp, M, 1999) |
| "Intrathecal amitriptyline reversed thermal hyperalgesia in a dose-dependent manner, but had no effect on withdrawal latency of the contralateral, noninjected paw." | 1.29 | Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats. ( Eisenach, JC; Gebhart, GF, 1995) |
| "A peripheral neuropathy with hyperalgesia and allodynia was produced by loosely tying constrictive ligature around the left sciatic nerve of rats, i." | 1.29 | Inhibitory effect of anisodamine on the neuropathic hyperalgesia following peripheral nerve injury (II). ( Xiao, WH; Xie, YK, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (42.86) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 5 (17.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moon, HJ | 1 |
| Lim, BS | 1 |
| Lee, DI | 1 |
| Ye, MS | 1 |
| Lee, G | 1 |
| Min, BI | 2 |
| Bae, H | 1 |
| Na, HS | 2 |
| Kim, SK | 2 |
| Aydın, TH | 1 |
| Can, ÖD | 1 |
| Demir Özkay, Ü | 1 |
| Turan, N | 1 |
| Kim, HY | 1 |
| Wang, J | 1 |
| Lee, I | 1 |
| Kim, HK | 1 |
| Chung, K | 2 |
| Chung, JM | 2 |
| Chen, HS | 1 |
| Qu, F | 1 |
| He, X | 1 |
| Wang, Y | 1 |
| Wen, WW | 1 |
| Wang, H | 1 |
| Heijnen, CJ | 1 |
| Eijkelkamp, N | 1 |
| Carbajal, AG | 1 |
| Schedlowski, M | 1 |
| Kelley, KW | 1 |
| Dantzer, R | 1 |
| Kavelaars, A | 1 |
| Barchini, J | 1 |
| Tchachaghian, S | 1 |
| Shamaa, F | 1 |
| Jabbur, SJ | 2 |
| Meyerson, BA | 1 |
| Song, Z | 1 |
| Linderoth, B | 1 |
| Saadé, NE | 2 |
| Jasmin, L | 1 |
| Rabkin, SD | 1 |
| Granato, A | 1 |
| Boudah, A | 1 |
| Ohara, PT | 1 |
| Baik, E | 1 |
| Waldron, JB | 1 |
| Reid, AR | 1 |
| Sawynok, J | 1 |
| Kim, JH | 1 |
| Hwang, BG | 1 |
| Yoo, GY | 1 |
| Park, DS | 1 |
| Eisenach, JC | 1 |
| Gebhart, GF | 1 |
| Siegan, JB | 1 |
| Sagen, J | 1 |
| Kinnman, E | 1 |
| Levine, JD | 1 |
| Xie, YK | 2 |
| Xiao, WH | 2 |
| Liu, M | 1 |
| Max, MB | 1 |
| Parada, S | 1 |
| Rowan, JS | 1 |
| Bennett, GJ | 1 |
| Breivik, H | 1 |
| Liu, J | 1 |
| Wang, KM | 1 |
| He, LZ | 1 |
| Cao, DY | 1 |
| Yu, W | 1 |
| Hao, JX | 1 |
| Xu, XJ | 1 |
| Saydoff, J | 1 |
| Haegerstrand, A | 1 |
| Hökfelt, T | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Ringkamp, M | 1 |
| Grethel, EJ | 1 |
| Choi, Y | 2 |
| Meyer, RA | 3 |
| Raja, SN | 5 |
| Mansikka, H | 1 |
| Sheth, RN | 1 |
| DeVries, C | 1 |
| Lee, H | 1 |
| Winchurch, R | 1 |
| Ali, Z | 2 |
| Wesselmann, U | 1 |
| Fuchs, PN | 1 |
| Campbell, JN | 3 |
| Nam, TS | 1 |
| Yeon, DS | 1 |
| Leem, JW | 1 |
| Paik, KS | 1 |
| Hord, AH | 1 |
| Denson, DD | 1 |
| Stowe, B | 1 |
| Haygood, RM | 1 |
| Belzberg, AJ | 1 |
| Safieh-Garabedian, B | 1 |
| Poole, S | 1 |
| Haddad, JJ | 1 |
| Massaad, CA | 1 |
| Davis, KD | 2 |
| Treede, RD | 1 |
1 review available for phentolamine and Allodynia
| Article | Year |
|---|---|
The adrenergic pharmacology of sympathetically-maintained pain.
Topics: Adrenergic alpha-Agonists; Autonomic Nerve Block; Ganglia, Sympathetic; Humans; Hyperalgesia; Neuron | 1992 |
3 trials available for phentolamine and Allodynia
| Article | Year |
|---|---|
The sympathetic nervous system contributes to capsaicin-evoked mechanical allodynia but not pinprick hyperalgesia in humans.
Topics: Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; P | 1996 |
Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Complex Regional Pain Syndromes; Fem | 2000 |
Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain.
Topics: Adult; Bupivacaine; Chronic Disease; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Hemodyn | 1991 |
24 other studies available for phentolamine and Allodynia
| Article | Year |
|---|---|
Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; beta-Endorphin; Cold Temperature; Disease M | 2014 |
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms.
Topics: Acetamides; Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Diabetic Neurop | 2016 |
Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism.
Topics: Acupuncture Points; Adrenergic alpha-Antagonists; Analgesics, Opioid; Analysis of Variance; Animals; | 2009 |
Chemical or surgical sympathectomy prevents mechanical hyperalgesia induced by intraplantar injection of bee venom in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 2010 |
GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Enzyme I | 2011 |
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; | 2012 |
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.
Topics: Animals; Baclofen; Bupivacaine; Cerebral Cortex; gamma-Aminobutyric Acid; Hot Temperature; Hyperalge | 2003 |
Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Freund's Adjuvan | 2003 |
Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Anima | 2004 |
Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2005 |
Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Anima | 1995 |
Attenuation of NMDA-induced spinal hypersensitivity by adrenal medullary transplants.
Topics: Adrenal Medulla; Animals; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injection | 1995 |
Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat.
Topics: Animals; Capsaicin; Hindlimb; Hyperalgesia; Male; Phentolamine; Prazosin; Rats; Rats, Sprague-Dawley | 1995 |
Inhibitory effect of anisodamine on the neuropathic hyperalgesia following peripheral nerve injury (II).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Electrophysiology; Hyperalgesia; Nerve Fibers; Pai | 1993 |
Chronic pain and the sympathetic nervous system.
Topics: Autonomic Nervous System Diseases; Causalgia; Chronic Disease; Clinical Trials as Topic; Double-Blin | 1997 |
[Effects of sympathetic efferent in diabetic hyperalgesia in rat].
Topics: Alprostadil; Animals; Diabetes Mellitus, Experimental; Dinoprostone; Efferent Pathways; Ganglia, Sym | 1996 |
Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury.
Topics: Animals; Behavior, Animal; Cattle; Cell Transplantation; Chromaffin Cells; Cold Temperature; Disease | 1998 |
Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 1999 |
Nerve injury-induced mechanical but not thermal hyperalgesia is attenuated in neurokinin-1 receptor knockout mice.
Topics: Animals; Behavior, Animal; Cold Temperature; Hot Temperature; Hyperalgesia; Mice; Mice, Inbred BALB | 2000 |
Differential antinociceptive effect of transcutaneous electrical stimulation on pain behavior sensitive or insensitive to phentolamine in neuropathic rats.
Topics: Adrenergic alpha-Antagonists; Animals; Cold Temperature; Hindlimb; Hyperalgesia; Male; Pain Measurem | 2001 |
alpha-1 and alpha-2 Adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2001 |
Neuropathic pain after C7 spinal nerve transection in man.
Topics: Adrenergic alpha-Antagonists; Adult; Brachial Plexus; Child; Cold Temperature; Female; Hot Temperatu | 2002 |
The role of the sympathetic efferents in endotoxin-induced localized inflammatory hyperalgesia and cytokine upregulation.
Topics: Adrenergic alpha-Antagonists; Adrenergic Antagonists; Adrenergic Fibers; Animals; Cytokines; Dose-Re | 2002 |
Electrophysiological evidence for hyperalgesia in the peripheral neuropathy.
Topics: Animals; Electrophysiology; Hyperalgesia; Hyperesthesia; Nerve Fibers; Norepinephrine; Peripheral Ne | 1990 |