Page last updated: 2024-10-27

gabapentin and Allodynia

gabapentin has been researched along with Allodynia in 206 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Research Excerpts

ExcerptRelevanceReference
"This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster."9.11A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005)
"In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life."7.85Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017)
"Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action."7.85Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017)
"In the present work, we investigated the antinociceptive effect of gabapentin in a chronic myositis model and its interference in spinal glial cells."7.85Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis. ( Chacur, M; Freitas, MF; Rocha, IR; Rosa, AS, 2017)
"Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase."7.83The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016)
" We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model."7.78The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012)
" The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i."7.78Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. ( Amin, B; Hosseinzadeh, H, 2012)
"The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain."7.74A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007)
"Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration."7.74Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007)
"The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear."7.73Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005)
"Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats."7.73CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005)
"Hindpaw mechanical allodynia was dose-dependently reversed by gabapentin (50 and 100 mg/kg, s."7.73Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006)
"The effects of systemic and local injections of gabapentin, a novel anticonvulsant agent, were tested on nociceptive behaviors in mice with acute herpetic pain."7.71Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection. ( Andoh, T; Kuraishi, Y; Nojima, H; Shiraki, K; Takasaki, I, 2001)
"Haloperidol (HAL) is a compound that shows a high affinity with these receptors, acting as an antagonist."5.46Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017)
"Gabapentin (GBP) is an effective analgesic for neuropathic pain conditions but its clinical efficacy in cisplatin-induced neuropathic pain (CINP) is limited, in addition to generating unwanted side-effects."5.46Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model. ( Ahmad, N; Islam, NU; Rahman, FU; Sewell, RDE; Shahid, M; Subhan, F, 2017)
"Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models."5.43Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016)
"Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset."5.42A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015)
"Bortezomib (0."5.40Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice. ( Andoh, T; Kitamura, R; Kuraishi, Y; Mizoguchi, S; Saito, Y; Takahata, H, 2014)
"Chronic muscle pain is a problem with high prevalence in clinical practice and its pharmacological treatment is difficult."5.34Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF. ( Beyreuther, BK; Geis, C; Sommer, C; Stöhr, T, 2007)
"The degree of allodynia was most marked following 10 min of irradiation."5.32Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003)
" The analgesic activity of CHF3381 was investigated in the heat-capsaicin human pain model and compared with those of gabapentin."5.12CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model. ( Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O, 2006)
"Gabapentin significantly reduced the area of brush allodynia compared with placebo (P 5.11Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia. ( Bach, FW; Brown, J; Chizh, BA; Gottrup, H; Jensen, TS; Juhl, G; Kristensen, AD; Lai, R, 2004)
"This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster."5.11A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005)
"CCI increased mechanical allodynia, cold allodynia, and thermal hyperalgesia in rats which were reduced by treatment with EA (50 or 100 mg/kg), gabapentin, or their combination."4.31Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain. ( Esmaeili, M; Forouzanfar, F; Ghazavi, H; Mahdianpour, S; Pourbagher-Shahri, AM; Tanha, NK, 2023)
"This study aims to evaluate the anti-nociceptive effects of ECa 233 and its synergistic effect with gabapentin on chronic neuropathic orofacial pain after 3 weeks infraorbital nerve chronic constriction injury in mice."4.12Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice. ( Buapratoom, A; Khongsombat, O; Tantisira, MH; Wanasuntronwong, A, 2022)
" Acute morphine or gabapentin treatment partly attenuated allodynia in males, but not females."4.12Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein. ( Bagdas, D; Bigbee, J; Caillaud, M; Damaj, MI; Hauser, KF; Knapp, PE; McKiver, B; Nass, SR; Ondo, O; Paris, JJ; Toma, W; Warncke, UO, 2022)
" Potent analgesic activity was observed in models of neuropathic pain, and the compound blocked capsaicin induced allodynia, showing dermal accumulation with little transdermal absorption."3.96Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. ( Ann, J; Blumberg, PM; Choi, K; Esch, TE; Ha, HJ; Hwang, SW; Kim, H; Kim, HS; Kim, M; Kim, YH; Lee, J; Pearce, LV; Thorat, SA; Turcios, NA, 2020)
"This study investigated the effect of gabapentin on lower urinary tract dysfunction focusing on urethral activities and cystitis-induced hyperalgesia in a mouse model of painful bladder syndrome/interstitial cystitis (PBS/IC)."3.91Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin. ( Chang, HH; Chen, JJ; Choi, H; Do, R; Ghoniem, G; Lin, CT; Yeh, JC; Zi, X, 2019)
" Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment."3.88Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018)
"In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life."3.85Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017)
"The combination of low-dose KML29:gabapentin additively attenuated mechanical allodynia and synergistically reduced cold allodynia."3.85The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice. ( Banks, ML; Bradshaw, HB; Crowe, MS; Kinsey, SG; Leishman, E; Prather, PL; Wilson, CD, 2017)
"Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action."3.85Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017)
"In the present work, we investigated the antinociceptive effect of gabapentin in a chronic myositis model and its interference in spinal glial cells."3.85Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis. ( Chacur, M; Freitas, MF; Rocha, IR; Rosa, AS, 2017)
" Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats."3.85An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017)
"Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase."3.83The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016)
" Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)."3.83Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016)
" Sleep disruption-induced hypersensitivity was pharmacologically characterized with drugs relevant for pain treatment, including gabapentin (30 mg/kg and 50 mg/kg), Ica-6p (Kv7."3.81Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat. ( Gilmour, G; Kennedy, JD; Schuh-Hofer, S; Treede, RD; Wafford, KA; Wodarski, R; Yurek, DA, 2015)
" Two distinct FAAH inhibitory compounds, URB597 and PF-3845 were tested, and contrasted with standard antinociceptive gabapentin or vehicle treatment, for attenuation of tactile allodynia, cold allodynia, and mechanical hyperalgesia."3.81Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. ( Jergova, S; Nasirinezhad, F; Pearson, JP; Sagen, J, 2015)
"To evaluate the antinociceptive and hypnotic effects of pregabalin, we established a neuropathic pain-like model in mice using partial sciatic nerve ligation (PSNL), and examined thermal hyperalgesia, mechanical allodynia, electroencephalogram, rota-rod testing, and c-Fos expression in the anterior cingulate cortex."3.81Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. ( Guo, W; Han, WJ; Hong, ZY; Huang, ZL; Li, YD; Liu, YY; Qu, WM; Wang, TX; Yin, D, 2015)
"Mechanical allodynia in SNL rats was attenuated by gabapentin (100 mg/kg) and AQU-118 (in a dose-dependent manner)."3.81Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. ( Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R, 2015)
"Cisplatintreated mice display allodynia and an activation of DRG activated transcription factor 3, which is paralleled by its effects on behavior in the CPP system, wherein gabapentin, but not ketorolac, in the presence of the cisplatin polyneuropathy, is positively rewarding, confirming that this neuropathy is an aversive (painful) state that is ameliorated by gabapentin."3.79Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. ( Park, HJ; Pirie, E; Shtaerman, Y; Skahen, J; Stokes, JA; Yaksh, TL, 2013)
"The study showed that gabapentin can significantly prevented opioid-induced hyperalgesia (OIH) induced caused by fentanyl and morphine, suggesting a role for the addition of gabapentin in the perioperative period and during chronic pain treatment as an effective drug to prevent OIH."3.78Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats. ( Wei, W; Wei, X, 2012)
"Lysophosphatidic acid (LPA), an initiator of neuropathic pain, causes allodynia."3.78Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs. ( Kato, A; Ogawa, K; Shinohara, S; Takasu, K; Yoneda, Y, 2012)
" We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model."3.78The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012)
" The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i."3.78Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. ( Amin, B; Hosseinzadeh, H, 2012)
" A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for multiple neuropathic conditions, could also efficiently antagonize thermal hyperalgesia evoked by complete Freund's adjuvant (CFA)-induced monoarthritis (MA)."3.78Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. ( Deng, XM; Li, SS; Xu, B; Xu, H; Yang, JL; Zhang, WS; Zhang, YQ, 2012)
"We showed a preventative effect of intrathecal gabapentin on the development of nerve injury-induced mechanical allodynia and thermal hyperalgesia."3.77Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. ( Chen, CC; Cheng, JK; Chu, LC; Hung, YC; Lin, CS; Tsaur, ML; Wang, TY, 2011)
"The present study investigated the effects of systemic administration of dexmedetomidine, a selective alpha2 adrenergic receptor (alpha2AR) agonist, and gabapentin either alone or in combination on thermal hyperalgesia evoked by ankle joint inflammation."3.75Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. ( Deng, XM; Sun, S; Xu, B; Xu, H; Zhang, WS; Zhang, YQ, 2009)
"The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain."3.74A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007)
"Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration."3.74Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007)
" The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine."3.74Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008)
"Duloxetine, a selective but balanced serotonergic and noradrenergic reuptake inhibitor, was evaluated in the acute nociceptive pain models of tail flick and hot plate in mice and in the persistent and/or inflammatory pain models of acetic acid-induced writhing in mice, carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats, and capsaicin-induced mechanical allodynia in rats."3.73Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2005)
"The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear."3.73Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005)
"Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats."3.73CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005)
"Hindpaw mechanical allodynia was dose-dependently reversed by gabapentin (50 and 100 mg/kg, s."3.73Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006)
"Intrathecal gabapentin (30, 100, 200 microg) dose-dependently reduced incision-induced allodynia."3.72Magnesium chloride and ruthenium red attenuate the antiallodynic effect of intrathecal gabapentin in a rat model of postoperative pain. ( Chen, CC; Cheng, CR; Cheng, JK; Chiou, LC; Lai, YJ, 2003)
" Oxcarbazepine and carbamazepine (3-100 mg x kg(-1)) did not affect mechanical hyperalgesia or tactile allodynia induced by partial sciatic nerve ligation in the rat following oral administration."3.72Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. ( Bevan, S; Fox, A; Gentry, C; Kesingland, A; Patel, S, 2003)
"The effects of systemic and local injections of gabapentin, a novel anticonvulsant agent, were tested on nociceptive behaviors in mice with acute herpetic pain."3.71Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection. ( Andoh, T; Kuraishi, Y; Nojima, H; Shiraki, K; Takasaki, I, 2001)
"Only gabapentin suppressed the secondary mechanical hyperalgesia-evoked neural response in a region of the brainstem's descending pain modulatory system (right nucleus cuneiformis) and left (contralateral) posterior insular cortex and secondary somatosensory cortex."2.82Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development. ( Andersson, J; Kong, Y; Mezue, M; Tracey, I; Wanigasekera, V, 2016)
"Interestingly, opioids induce hyperalgesia via many of the same neuro-inflammatory and central sensitization processes that occur with the development of neuropathic pain."2.75Gabapentin improves cold-pressor pain responses in methadone-maintained patients. ( Compton, P; Kehoe, P; Ling, W; Sinha, K; Torrington, MA, 2010)
"Gabapentin was administered orally and intracerebroventricularly to rats on the day after paw incision, and withdrawal threshold to paw pressure was measured."2.73Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. ( Curry, R; DeGoes, S; Eisenach, JC; Hayashida, K, 2007)
"Gabapentin pre-treatment reduced sensitivity to electrical induction of skin pain by 14%, p=0."2.72Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers. ( Segerdahl, M, 2006)
"Further, large areas of mechanical hyperalgesia to pinprick adjacent to the erythema spots developed in all subjects."2.71The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers. ( Felouzis, E; Gustorff, B; Hoechtl, K; Kress, HG; Lehr, S; Sycha, T, 2004)
"Secondary hyperalgesia shares clinical characteristics with neurogenic hyperalgesia in patients with neuropathic pain."2.71Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. ( Buchanan, TJ; Huggins, JP; Iannetti, GD; Smart, TS; Tracey, I; Vennart, W; Wise, RG; Zambreanu, L, 2005)
"Opioid-induced hyperalgesia has recently been described as representing a challenge for physicians in the clinical setting."2.50Managing difficult pain conditions in the cancer patient. ( Mercadante, S, 2014)
"Three types of hyperalgesia can occur during the postoperative period: primary hyperalgesia, which disappears with wound healing, secondary or central hyperalgesia, which can lead to chronic pain, and opiate-induced hyperalgesia."2.48[Prevention of postoperative hyperalgesia]. ( Mamie, C, 2012)
"Once established, postherpetic neuralgia is particularly difficult to treat, and is often resistant to conventional analgesics."2.47[Development of animal models of herpetic pain and postherpetic neuralgia and elucidation of the mechanisms of the onset and inhibition of allodynia]. ( Takasaki, I, 2011)
"Gabapentin was designed as a lipophilic GABA analog and was first synthesized as a potential anticonvulsant and was launched in 1994 as add-on therapy for the treatment of epilepsy."2.403-substituted GABA analogs with central nervous system activity: a review. ( Bryans, JS; Wustrow, DJ, 1999)
"Gabapentin treatment has shown promise for symptomatic improvement for visceral hyperalgesia in some patients."1.91Gabapentin Can Improve Irritability and Feeding Tolerance in Single Ventricle Interstage Patients: A Case Series. ( Allen, CC; Bartlett, H; Canada, K; Schlueter, S; Zhang, X, 2023)
"Musculoskeletal pain is a widespread complex regional pain syndrome associated with altered emotional and cognitive functioning along with heightened physical disability that has become a global health concern."1.62Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin. ( Bhatti, R; Garg, S; Kaur, A; Kaur, H; Singh, L; Singh, N, 2021)
"In behavioral studies, mechanical allodynia was induced by intraplantar injection of cisplatin (40 μg/paw) in Sprague Dawley rats, and behavioral assessments were made 24 h after injection."1.62Involvement of selective GABA-A receptor subtypes in amelioration of cisplatin-induced neuropathic pain by 2'-chloro-6-methyl flavone (2'-Cl-6MF). ( Abdelhalim, A; Ahmad, W; Al-Harrasi, A; Altaf, N; Ghaffar, R; Halim, SA; Karim, N; Khan, A; Khan, I, 2021)
"Gabapentin (GBP) is an established drug that has been used in the management of symptoms of neuropathy but it is associated with unwanted side effects such as sedation and motor incoordination."1.62A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021)
"Many patients with chronic pain conditions suffer from depression."1.62Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain. ( Chao, D; Feng, Y; Hillard, CJ; Hogan, QH; Mecca, CM; Pan, B; Pawela, CP; Rodriguez-Garcia, DM; Segel, I; Yu, G; Zhang, Z, 2021)
"Pre-treatment with modafinil prevented sensorimotor neuropathy by raising latencies, MNCV and excitation, reducing TRPA1, TNF-α and IL-1β levels."1.56The protective effect of modafinil on vincristine-induced peripheral neuropathy in rats: A possible role for TRPA1 receptors. ( Abdollahi, A; Amirkhanloo, F; Dehpour, AR; Karimi, G; Roohbakhsh, A; Yousefi-Manesh, H, 2020)
"Gabapentin has antihyperalgesic action, decreasing central sensitization in neuropathic pain models; this effect depends on the mobilization of endogenous pain control pathways."1.56Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation. ( Buffon, AC; Heymanns, AC; Horewicz, VV; Javornik, MA; Martins, DF; Piovezan, AP; Salm, DC, 2020)
"Gabapentin gel (10% w/w) was applied three-times daily on the hind paws while in a concurrent systemic study, gabapentin was administered daily (75 mg/kg, intraperitoneally) for 4 weeks."1.51Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy. ( Ahmad, N; Sewell, RDE; Shahid, M; Subhan, F, 2019)
"Chronic neuropathic pain following traumatic brachial plexus injury could be successfully managed by chemical neurolysis and oral gabapentin."1.51Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report. ( Aaron, OI; Adetoye, AO; Orimolade, EA; P Adetifa, KA, 2019)
"Static and dynamic mechanical allodynia was evaluated using von Frey hair filaments and cotton buds, respectively."1.51Attenuation of vincristine-induced neuropathy by synthetic cyclohexenone-functionalized derivative in mice model. ( Ali, G; Khan, J; Khan, R; Ullah, R; Ullah, S, 2019)
"Von Frey filaments were used to assess tactile allodynia."1.48Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018)
"Treatment of postoperative pain remains a challenge in clinic."1.48Botulinum toxin type A and gabapentin attenuate postoperative pain and NK1 receptor internalization in rats. ( Guan, Y; Guo, R; Li, H; Li, J; Li, X; Ma, D; Sun, Y; Wang, Y; Zhang, C, 2018)
"A distinct acute, severe form of neuropathic pain, called insulin neuritis or treatment-induced painful neuropathy of diabetes (TIND), may also occur shortly after initiation of intensive glycemic control, with an incidence rate of up to 10."1.46Murine model and mechanisms of treatment-induced painful diabetic neuropathy. ( Anaya, CJ; Enriquez, C; Jolivalt, CG; Marquez, A; Nicodemus, JM, 2017)
"Haloperidol (HAL) is a compound that shows a high affinity with these receptors, acting as an antagonist."1.46Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017)
"Gabapentin (GBP) is an effective analgesic for neuropathic pain conditions but its clinical efficacy in cisplatin-induced neuropathic pain (CINP) is limited, in addition to generating unwanted side-effects."1.46Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model. ( Ahmad, N; Islam, NU; Rahman, FU; Sewell, RDE; Shahid, M; Subhan, F, 2017)
"The rat model of neuropathic pain was successfully established."1.46[Effects of HCN2 in the development of peripheral neuropathic pain in rats]. ( Fu, B; Huang, T; Liu, SJ; Wang, B; Wang, J; Weng, XC, 2017)
"Treatment with gabapentin, but not amitriptyline, was associated with a complete attenuation of hind paw mechanical hypersensitivity observed with indinavir treatment."1.46A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. ( Bennett, DLH; Calvo, M; Huang, W; Pheby, T; Rice, ASC, 2017)
"CFA-induced hyperalgesia and sensitivity to morphine (0."1.46Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter? ( Bjerrum, OJ; Heegaard, AM; Hestehave, S; Jeggo, RD; Kristensen, PJ; Munro, G, 2017)
"Using 3 rat models of neuropathic pain of toxic (oxaliplatin/OXA), metabolic (streptozocin/STZ), and traumatic (sciatic nerve ligation/CCI [chronic constriction nerve injury]) etiologies, we investigated the antihypersensitivity effect of acute and repeated agomelatine administration."1.46Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence. ( Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E, 2017)
"Gabapentin was used for the treatment of term and preterm infants with suspected visceral hyperalgesia caused by a variety of neurologic and gastrointestinal morbidities."1.43Gabapentin Use in the Neonatal Intensive Care Unit. ( Bidegain, M; Cotten, CM; DeMeo, S; Edwards, L; Hauer, JM; Hornik, CD; Pizoli, C; Smith, PB, 2016)
"Gabapentin displays non-linear drug disposition, which complicates dosing for optimal therapeutic effect."1.43Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model. ( Holm, R; Keizer, R; Kreilgaard, M; Larsen, MS; Munro, G; Mørk, A; Savic, R, 2016)
"The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test."1.43Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016)
"After MPNL, mechanical allodynia was established, and mice quickly recovered from the surgery without any significant motor impairment."1.43Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. ( Alves-Filho, JC; Bassi, GS; Bozzo, TA; Cunha, FQ; Cunha, TM; Ferreira, SH; Kusuda, R; Sant'Anna, MB; Souza, GR, 2016)
"Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models."1.43Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016)
"Neuropathic pain is a severe and unbearable condition which arises due to activation of peripheral nociceptors after tissue damage, neuropathic pain is caused from anomalous physiology of central or peripheral nervous system and it may not be related to the ongoing tissue damage or inflammation."1.43Potential Contribution of Antioxidant Mechanism in the Defensive Effect of Lycopene Against Partial Sciatic Nerve Ligation Induced Behavioral, Biochemical and Histopathological Modification in Wistar Rats. ( Goel, R; Tyagi, N, 2016)
"Robust allodynia was observed in all three ligation groups."1.42Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit. ( Baker, KB; Lanthorn, TH; Mason, S; Rajan, I; Savelieva, KV; Vogel, P; Ye, GL, 2015)
"Gabapentin was effective in transiently reversing mechanical allodynia in those mice with lowered thresholds."1.42Differences in cisplatin-induced mechanical allodynia in male and female mice. ( Corr, M; Woller, SA; Yaksh, TL, 2015)
"A hallmark of peripheral neuropathic pain (PNP) is chronic spontaneous pain and/or hypersensitivity to normally painful stimuli (hyperalgesia) or normally nonpainful stimuli (allodynia)."1.42Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats. ( Al Otaibi, M; Djouhri, L; Sathish, J; Smith, T, 2015)
"Treatment with gabapentin achieved complete remission."1.42Pressure pain sensitivity map of multifocal nummular headache: a case report. ( Barón, J; Carreres, A; Cuadrado, ML; Fernández-de-Las-Peñas, C; Guerrero, AL; Herrero-Velázquez, S; Madeleine, P; Rodríguez, C; Rodríguez-Valencia, E; Ruiz, M, 2015)
"Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset."1.42A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015)
"Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures."1.42Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. ( Batisti, AP; Daruge-Neto, E; Emer, AA; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Prado, MR; Santos, AR, 2015)
"In addition, PLSN-induced mechanical and thermal hyperalgesia was prevented by systemic (i."1.40The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice. ( Calixto, JB; Costa, R; Manjavachi, MN; Quintão, NL, 2014)
"Oxaliplatin induced mechanical allodynia, cold hyperalgesia and chemical/inflammatory supersensitivity at both hindpaw and vibrissal levels in mice and rats."1.40Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents. ( Bastian, G; Bourgoin, S; Hamon, M; Kayser, V; Michot, B, 2014)
"Bortezomib (0."1.40Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice. ( Andoh, T; Kitamura, R; Kuraishi, Y; Mizoguchi, S; Saito, Y; Takahata, H, 2014)
"Koumine treatment of diabetic rats decreased neuropathic pain behavior as early as after the first administration."1.40Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014)
"Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course."1.40Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014)
"Mechanical allodynia in paclitaxel-treated Sprague Dawley (SD) rats was measured using a dynamic plantar aesthesiometer before and after treatment with E139 (10 and 20 mg/kg) or its vehicle for four consecutive days from day 7 after first administration of paclitaxel (16 mg/kg on two alternate days)."1.39The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents. ( Edafiogho, IO; Masocha, W; Thangamani, D, 2013)
"The threshold of mechanical hyperalgesia was also significantly elevated."1.38Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats. ( Ahmed, AA; Al-Rasheed, NM; Attia, HN; Kenawy, SA; Maklad, YA, 2012)
"The L5 spinal nerve ligation induced tactile allodynia, an increase of CD11b expression, and an increase in the protein expression level of the voltage-dependent Ca(2+) channel α(2)/δ-1 subunit in the spinal dorsal horn on the injured side."1.38Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model. ( Adachi-Akahane, S; Ito, M; Kuroda, M; Morimoto, S; Oda, S; Sugiyama, A, 2012)
"Gabapentin 400 μg attenuated mechanical hyperalgesia for 7 days compared with the control group."1.38Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model. ( Imamachi, N; Narai, Y; Saito, Y, 2012)
"Gabapentin has been shown to be effective in reducing postoperative narcotic usage, a reduction that may be associated with a reduction in opioid-induced tolerance and hyperalgesia."1.38The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats. ( Abreu, M; Aguado, D; Benito, J; Garcia-Fernandez, J; Gómez de Segura, IA, 2012)
"Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system."1.37Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones. ( Arjun, M; Menon, N; Semwal, A; Sriram, D; Yogeeswari, P, 2011)
"The effect of disc degeneration on behavioral measures of chronic pain has not been evaluated in this model."1.37Behavioral signs of chronic back pain in the SPARC-null mouse. ( Millecamps, M; Sage, EH; Stone, LS; Tajerian, M, 2011)
"Mechanical allodynia was assessed by measuring the forepaw withdrawal threshold to von Frey filaments, and cold allodynia was evaluated by measuring the time spent in lifting or licking the forepaw after applying acetone to it."1.37A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves. ( Back, SK; Eun, JS; Kim, MA; Na, HS; Yi, H, 2011)
"Accordingly, we hypothesized that tactile allodynia post SCI is mediated by an upregulation of Ca(v)α2δ-1 in dorsal spinal cord."1.37Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. ( Boroujerdi, A; Kim, D; Luo, DZ; Sharp, K; Steward, O; Zeng, J, 2011)
"Long-lasting hyperalgesia was induced in male Sprague Dawley rats with subcutaneous fentanyl (4 injections, 60 μg/kg per injection at 15-minute intervals) resulting in a total dose of 240 μg/kg."1.37The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2011)
"In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures."1.37Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011)
"Mechanical hyperalgesia was fully reversed by three analgesic drugs used in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)≫morphine (6 h)>gabapentin (2 h)."1.36Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. ( Densmore, VS; Kalous, A; Keast, JR; Osborne, PB, 2010)
" The PWT in PSL mice was dose-dependently increased by intraperitoneal injection of gabapentin, but the anti-allodynic effects varied according to its dosing time."1.36Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. ( Hamamura, K; Inoue, K; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Tsuda, M; Uchida, T; Yoshida, M, 2010)
"CCI also evoked mechanical allodynia that was fully developed on a week post-operation, but showed no recovery for at least 8 weeks."1.35Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E, 2009)
"Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model."1.35Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009)
"Vgx rats showed sustained hyperalgesia in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma creatine phosphokinase or lactose dehydrogenase levels) accompanied by hypersensitivity to colonic distension."1.35Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. ( Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T, 2009)
"Inhibition of herpetic allodynia by repeated oral administration of gabapentin (100 mg/kg) alleviated the overexpression of mRNA of pronociceptin, as well as the severity of postherpetic allodynia."1.35Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice. ( Andoh, T; Kuraishi, Y; Sasaki, A; Shiraki, K; Takahata, H; Takasaki, I; Takeshima, H, 2008)
"Opioid-induced hyperalgesia can develop rapidly after opioid exposure."1.35Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2008)
"Chronic muscle pain is a problem with high prevalence in clinical practice and its pharmacological treatment is difficult."1.34Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF. ( Beyreuther, BK; Geis, C; Sommer, C; Stöhr, T, 2007)
"Gabapentin is a structural analogue of gamma-aminobutyric acid with strong anticonvulsant and analgesic activities."1.34The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia. ( Curros-Criado, MM; Herrero, JF, 2007)
"gabapentin were strongly suppressed."1.33Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse. ( Honda, M; Kasuya, N; Ono, H; Shimizu, S; Takasu, K; Tanabe, M, 2005)
"Similar bilateral hyperalgesia was observed when axotomy was performed using silk thread instead of chromic gut."1.33Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. ( Miki, S; Senba, E; Yasuda, T; Yoshinaga, N, 2005)
"Signs of allodynia also extended to the sciatic nerve territory."1.33Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. ( Beaulieu, P; Desbiens, K; Leblond, F; Pichette, V; Walczak, JS, 2005)
"Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, allodynia and hyperalgesia."1.33Development and expression of neuropathic pain in CB1 knockout mice. ( Castañé, A; Célérier, E; Ledent, C; Maldonado, R; Martín, M; Parmentier, M; Valverde, O, 2006)
"Pretreatment with atropine (0."1.33Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury. ( Honda, M; Ono, H; Takasu, K; Tanabe, M, 2006)
"The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)."1.33Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006)
"The degree of allodynia was most marked following 10 min of irradiation."1.32Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003)
"Gabapentin has been shown to be useful in treatment of different conditions which may be caused by increased neuronal excitability."1.32Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin. ( Haller, H; Leblhuber, F; Schmidhammer, R; Trenkler, J, 2003)
" Hill slope coefficients for the tested anticonvulsants indicate that the dose-response curve was less steep for gabapentin than for phenytoin, carbamazepine and ethosuximide."1.32Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. ( Jevtovic-Todorovic, V; Rastogi, AJ; Todorovic, SM, 2003)
"3."1.32Pharmacological characterisation of a rat model of incisional pain. ( Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT, 2004)
"The human experimental hyperalgesia model, the heat-capsaicin sensitization model, was induced in 25 healthy male volunteers."1.31Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization. ( Dahl, JB; Dirks, J; Petersen, KL; Rowbotham, MC, 2002)
"The initial hyperalgesia induced by 0."1.31Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002)
"Allodynia and hyperalgesia appeared on day 5 post-inoculation."1.31Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000)
"1."1.30Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. ( Field, MJ; Hughes, J; Lewis, AS; McCleary, S; Oles, RJ; Singh, L, 1997)
"Gabapentin is an anticonvulsant that may represent a novel class of drugs, which has novel spinal antihyperalgesic activity."1.30The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. ( Jun, JH; Yaksh, TL, 1998)
"Secondary hyperalgesia exhibited a tendency toward recovery over time."1.30Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia. ( Jones, DL; Sorkin, LS, 1998)
"Gabapentin displays efficacy against abnormal sensory processing in diabetic rats and may be of benefit for treating painful diabetic neuropathy."1.30Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. ( Calcutt, NA; Ceseña, RM, 1999)

Research

Studies (206)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (4.37)18.2507
2000's58 (28.16)29.6817
2010's121 (58.74)24.3611
2020's18 (8.74)2.80

Authors

AuthorsStudies
Yogeeswari, P3
Ragavendran, JV1
Sriram, D3
Nageswari, Y1
Kavya, R1
Sreevatsan, N1
Vanitha, K1
Stables, J1
Blakemore, DC2
Bryans, JS3
Carnell, P2
Chessum, NE1
Field, MJ3
Kinsella, N2
Kinsora, JK2
Osborne, SA2
Williams, SC2
Meltzer, LT1
Thompson, LR1
Menon, N1
Semwal, A2
Arjun, M1
Woo, HM1
Lee, YS1
Roh, EJ1
Seo, SH1
Song, CM1
Chung, HJ1
Pae, AN1
Shin, KJ1
Shao, PP1
Ye, F1
Chakravarty, PK1
Varughese, DJ1
Herrington, JB1
Dai, G1
Bugianesi, RM1
Haedo, RJ1
Swensen, AM1
Warren, VA1
Smith, MM1
Garcia, ML1
McManus, OB1
Lyons, KA1
Li, X3
Green, M1
Jochnowitz, N1
McGowan, E1
Mistry, S1
Sun, SY1
Abbadie, C1
Kaczorowski, GJ1
Duffy, JL1
Sharma, M1
Samala, G1
Gangadhar, M1
Karthick, S1
Mallipeddi, S1
Skogh, A1
Lesniak, A1
Sköld, C1
Karlgren, M1
Gaugaz, FZ1
Svensson, R1
Diwakarla, S1
Jonsson, A1
Fransson, R1
Nyberg, F1
Hallberg, M1
Sandström, A1
Bertamino, A1
Iraci, N1
Ostacolo, C1
Ambrosino, P1
Musella, S1
Di Sarno, V1
Ciaglia, T1
Pepe, G1
Sala, M1
Soldovieri, MV1
Mosca, I1
Gonzalez-Rodriguez, S1
Fernandez-Carvajal, A1
Ferrer-Montiel, A1
Novellino, E1
Taglialatela, M1
Campiglia, P1
Gomez-Monterrey, I1
Osuma, AT1
Xu, X1
Wang, Z2
Van Camp, JA1
Freiberg, GM1
Ann, J1
Kim, HS1
Thorat, SA1
Kim, H1
Ha, HJ1
Choi, K1
Kim, YH1
Kim, M1
Hwang, SW1
Pearce, LV1
Esch, TE1
Turcios, NA1
Blumberg, PM1
Lee, J1
Belgi, A1
Burnley, JV1
MacRaild, CA1
Chhabra, S1
Elnahriry, KA1
Robinson, SD1
Gooding, SG1
Tae, HS1
Bartels, P1
Sadeghi, M1
Zhao, FY2
Wei, H2
Spanswick, D1
Adams, DJ1
Norton, RS1
Robinson, AJ1
Brito, BE1
García, MA1
De Gouveia, YM1
Bolaños, P1
Devis, S1
Bernal, G1
Tortorici-Brito, VA1
Baute, L1
Díaz-Serrano, G1
Tortorici, V1
Buapratoom, A1
Wanasuntronwong, A1
Khongsombat, O1
Tantisira, MH1
Ozcan, S1
Kelestemur, MM1
Hekim, MG1
Bulmus, O1
Bulut, F1
Bilgin, B1
Canpolat, S1
Ozcan, M1
Khan, FA1
Ali, G5
Rahman, K1
Khan, Y1
Ayaz, M1
Mosa, OF1
Nawaz, A1
Hassan, SSU1
Bungau, S1
Padín, JF1
Maroto, M1
Entrena, JM1
Egea, J1
Montell, E1
Vergés, J1
López, MG1
Cobos, EJ1
García, AG1
Toma, W1
Paris, JJ1
Warncke, UO1
Nass, SR1
Caillaud, M1
McKiver, B1
Ondo, O1
Bagdas, D1
Bigbee, J1
Knapp, PE1
Hauser, KF1
Damaj, MI2
Allen, CC1
Canada, K1
Schlueter, S1
Zhang, X2
Bartlett, H1
Forouzanfar, F1
Tanha, NK1
Pourbagher-Shahri, AM1
Mahdianpour, S1
Esmaeili, M1
Ghazavi, H1
Shahid, M7
Subhan, F7
Ahmad, N6
Sewell, RDE4
Adetoye, AO1
Aaron, OI1
Orimolade, EA1
P Adetifa, KA1
Amirkhanloo, F1
Karimi, G1
Yousefi-Manesh, H1
Abdollahi, A1
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Koek, W1
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Vacher, B1
Iida, Y1
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Nojima, H3
Murata, J1
Saiki, I1
Ouchi, H1
Lai, YJ1
Cheng, CR1
Chiou, LC1
Gustorff, B2
Kozek-Langenecker, S1
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Flood, K1
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Juhl, G1
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Lai, R1
Chizh, BA1
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Shimizu, S1
Honda, M2
Urban, MO1
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Park, KT1
Campbell, B1
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Aiyar, J1
Belley, M1
Cohen, C1
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Yoon, MH1
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Yasuda, T2
Miki, S2
Yoshinaga, N2
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Hunter, JC1
LaBuda, CJ1
Fuchs, PN1
Patel, MK1
Gonzalez, MI1
Bramwell, S1
Pinnock, RD1
Lee, K1
Nitta, M1
Nemoto, H1
Naeem, S1
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Sato, S1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pain Phenotyping of Patients With Bone Cancer Pain[NCT03908853]70 participants (Anticipated)Observational2019-02-05Recruiting
Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting[NCT05475769]98 participants (Anticipated)Observational2022-03-01Recruiting
Opioid-Induced Hyperalgesia in Prescription Opioid Abusers: Effects of Pregabalin[NCT01821430]Phase 24 participants (Actual)Interventional2013-03-31Terminated (stopped due to poor recruitment)
Randomized Phase II Trial Evaluating Activity and Tolerability of Fixed Dose of Oxycodone and Increasing Dose of Pregabalin Versus Increasing Dose of Oxycodone and Fixed Dose of Pregabalin for the Treatment of Oncological Neuropathic Pain[NCT00637975]Phase 280 participants (Anticipated)Interventional2007-09-30Completed
Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures[NCT02957097]Phase 40 participants (Actual)Interventional2019-09-30Withdrawn (stopped due to Original PI left institution and the PI who took over was not able to initiate the study so it was never started.)
Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain[NCT05311774]400 participants (Anticipated)Interventional2022-04-30Not yet recruiting
Randomized Clinical Trial Comparing the Use of Perioperative Epidural Analgesia to Conventional Intravenous Narcotics and NSAIDS for Patients Undergoing Laparoscopic Colorectal Resection[NCT02086123]87 participants (Actual)Interventional2012-05-31Completed
Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568]Phase 238 participants (Anticipated)Interventional2013-12-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for gabapentin and Allodynia

ArticleYear
Managing difficult pain conditions in the cancer patient.
    Current pain and headache reports, 2014, Volume: 18, Issue:2

    Topics: Amines; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Breakthrough Pain; Cyclohexanec

2014
[Development of animal models of herpetic pain and postherpetic neuralgia and elucidation of the mechanisms of the onset and inhibition of allodynia].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2011, Volume: 131, Issue:2

    Topics: Amines; Analgesics; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclooxygenase Inhibitors

2011
[Prevention of postoperative hyperalgesia].
    Annales francaises d'anesthesie et de reanimation, 2012, Volume: 31, Issue:1

    Topics: Amantadine; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Excit

2012
Postoperative pain--clinical implications of basic research.
    Best practice & research. Clinical anaesthesiology, 2007, Volume: 21, Issue:1

    Topics: Amines; Analgesia; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapentin; gamma

2007
3-substituted GABA analogs with central nervous system activity: a review.
    Medicinal research reviews, 1999, Volume: 19, Issue:2

    Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gam

1999

Trials

9 trials available for gabapentin and Allodynia

ArticleYear
Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development.
    Anesthesiology, 2016, Volume: 124, Issue:1

    Topics: Adult; Amines; Analgesics; Analgesics, Non-Narcotic; Brain; Capsaicin; Cyclohexanecarboxylic Acids;

2016
Gabapentin improves cold-pressor pain responses in methadone-maintained patients.
    Drug and alcohol dependence, 2010, Jun-01, Volume: 109, Issue:1-3

    Topics: Adult; Amines; Analgesics, Non-Narcotic; Cold Temperature; Cyclohexanecarboxylic Acids; Double-Blind

2010
The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics, Opioid; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diazep

2004
Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia.
    Anesthesiology, 2004, Volume: 101, Issue:6

    Topics: Adult; Amines; Analgesics; Capsaicin; Central Nervous System; Cyclohexanecarboxylic Acids; Double-Bl

2004
A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster.
    Neurology, 2005, Aug-09, Volume: 65, Issue:3

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Anticonvulsants; Cross-Over Studi

2005
Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Dec-13, Volume: 102, Issue:50

    Topics: Adult; Amines; Analgesics; Analysis of Variance; Capsaicin; Central Nervous System; Cross-Over Studi

2005
Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers.
    Pain, 2006, Volume: 125, Issue:1-2

    Topics: Adult; Amines; Analgesics; Central Nervous System; Cyclohexanecarboxylic Acids; Dose-Response Relati

2006
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
    The journal of pain, 2006, Volume: 7, Issue:8

    Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind

2006
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Analgesics, Opioid; Animals; Bee Venoms; Behavior,

2007

Other Studies

192 other studies available for gabapentin and Allodynia

ArticleYear
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
    Journal of medicinal chemistry, 2007, May-17, Volume: 50, Issue:10

    Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia;

2007
Synthesis and in vivo evaluation of 3-substituted gababutins.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: Amines; Amino Acids; Animals; Anti-Anxiety Agents; Calcium Channels; Carrageenan; Cyclohexanecarboxy

2010
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: Amines; Amino Acids; Animals; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Cyclopentanes; Disea

2010
Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:7

    Topics: Analgesics; Animals; Disease Models, Animal; Drug Discovery; Female; Furans; Humans; Hydrazones; Hyp

2011
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Drug Design; Dr

2011
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.
    Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cells, Cultured; Chronic Pain; Dogs; Hu

2012
Discovery of novel tetrahydro-pyrazolo [4,3-c] pyridines for the treatment of neuropathic pain: synthesis and neuropharmacology.
    European journal of medicinal chemistry, 2013, Volume: 66

    Topics: Animals; Chemistry Techniques, Synthetic; Drug Discovery; Female; Hyperalgesia; Male; Mice; Neuralgi

2013
An imidazole based H-Phe-Phe-NH
    Bioorganic & medicinal chemistry letters, 2018, 08-01, Volume: 28, Issue:14

    Topics: Amides; Animals; Cell Death; Cell Survival; Cells, Cultured; Dipeptides; Dose-Response Relationship,

2018
Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity.
    Journal of medicinal chemistry, 2018, Jul-26, Volume: 61, Issue:14

    Topics: Analgesics; Animals; Drug Design; HEK293 Cells; Humans; Hyperalgesia; Mice; Models, Molecular; Struc

2018
Design and evaluation of pyrazolopyrimidines as KCNQ channel modulators.
    Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19

    Topics: Drug Design; Humans; Hyperalgesia; Ion Channel Gating; KCNQ Potassium Channels; Potassium Channel Bl

2019
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
    Journal of medicinal chemistry, 2020, 01-09, Volume: 63, Issue:1

    Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetulus; Drug Discovery; Hyperalgesia; Mice, Inbred IC

2020
Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models.
    Journal of medicinal chemistry, 2021, 03-25, Volume: 64, Issue:6

    Topics: Alkynes; Analgesics; Animals; Cells, Cultured; Conotoxins; Conus Snail; Disease Models, Animal; Fema

2021
Concomitant Antihyperalgesic and Antitumor Effects of Gabapentin in a Murine Cancer Pain Model.
    International journal of molecular sciences, 2021, Sep-07, Volume: 22, Issue:18

    Topics: Analgesics; Animals; Antineoplastic Agents; Cancer Pain; Cell Line, Tumor; Disease Models, Animal; D

2021
Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice.
    Journal of ethnopharmacology, 2022, Jan-30, Volume: 283

    Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Chronic Pain; Disease Models, Animal; Dose-Res

2022
Asprosin, a novel therapeutic candidate for painful neuropathy: an experimental study in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2022, Volume: 395, Issue:3

    Topics: Analgesics; Animals; Disease Models, Animal; Fibrillin-1; Gabapentin; Hyperalgesia; Male; Mice; Mice

2022
Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms.
    Molecules (Basel, Switzerland), 2022, Aug-25, Volume: 27, Issue:17

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cisplatin; Disease Models, Animal; Edema; Flavanones;

2022
Small Synthetic Hyaluronan Disaccharide BIS014 Mitigates Neuropathic Pain in Mice.
    The journal of pain, 2023, Volume: 24, Issue:1

    Topics: Animals; Capsaicin; Gabapentin; Hyaluronic Acid; Hyperalgesia; Mice; Neuralgia; TRPV Cation Channels

2023
Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein.
    Experimental neurology, 2022, Volume: 358

    Topics: Animals; Cryopyrin-Associated Periodic Syndromes; Doxycycline; Female; Gabapentin; Gene Products, ta

2022
Gabapentin Can Improve Irritability and Feeding Tolerance in Single Ventricle Interstage Patients: A Case Series.
    Pediatric cardiology, 2023, Volume: 44, Issue:2

    Topics: Child; Gabapentin; Heart Defects, Congenital; Heart Ventricles; Humans; Hyperalgesia; Hypoplastic Le

2023
Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain.
    Metabolic brain disease, 2023, Volume: 38, Issue:4

    Topics: Animals; Ellagic Acid; Gabapentin; Hyperalgesia; Neuralgia; Rats; Rats, Sprague-Dawley; Spinal Cord;

2023
Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy.
    BMC pharmacology & toxicology, 2019, 08-28, Volume: 20, Issue:1

    Topics: Administration, Topical; Animals; Antineoplastic Agents; Cisplatin; Gabapentin; Hyperalgesia; Male;

2019
Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report.
    Nigerian journal of clinical practice, 2019, Volume: 22, Issue:9

    Topics: Adult; Aged; Analgesics; Brachial Plexus; Brachial Plexus Neuropathies; Bupivacaine; Gabapentin; Hum

2019
The protective effect of modafinil on vincristine-induced peripheral neuropathy in rats: A possible role for TRPA1 receptors.
    Basic & clinical pharmacology & toxicology, 2020, Volume: 127, Issue:5

    Topics: Animals; Cytokines; Gabapentin; Hyperalgesia; Interleukin-1beta; Modafinil; Neural Conduction; Neura

2020
Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin.
    Journal of molecular neuroscience : MN, 2021, Volume: 71, Issue:2

    Topics: Analgesics; Animals; Anxiety; Brain Chemistry; Cognition Disorders; Cytokines; Drug Evaluation, Prec

2021
The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling.
    Scientific reports, 2020, 09-24, Volume: 10, Issue:1

    Topics: Analgesics; Animals; Arthritis, Experimental; Female; Gabapentin; Ganglia, Spinal; Hyperalgesia; Kne

2020
Synergistic interaction between haloperidol and gabapentin in a model of neuropathic nociception in rat.
    European journal of pharmacology, 2021, Jan-15, Volume: 891

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug

2021
Involvement of selective GABA-A receptor subtypes in amelioration of cisplatin-induced neuropathic pain by 2'-chloro-6-methyl flavone (2'-Cl-6MF).
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:5

    Topics: Analgesics; Animals; Antineoplastic Agents; Benzodiazepines; Cisplatin; Disease Models, Animal; Dose

2021
Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation.
    Anais da Academia Brasileira de Ciencias, 2020, Volume: 92, Issue:4

    Topics: Analgesics; Animals; Disease Models, Animal; Endocannabinoids; Gabapentin; Hyperalgesia; Male; Mice;

2020
A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats.
    Behavioural brain research, 2021, 05-07, Volume: 405

    Topics: Analgesics; Animals; Behavior, Animal; Chronic Disease; Constriction; Disease Models, Animal; Excita

2021
Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression After Neuropathic Pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021, 09-01, Volume: 41, Issue:35

    Topics: Animals; Brain Mapping; Chronic Pain; Depression; Endocannabinoids; Feeding Behavior; Female; GABAer

2021
[
    Neuropharmacology, 2017, 05-15, Volume: 118

    Topics: Amines; Animals; Autoradiography; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-R

2017
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
    The journal of pain, 2017, Volume: 18, Issue:10

    Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine

2017
Murine model and mechanisms of treatment-induced painful diabetic neuropathy.
    Neuroscience, 2017, 06-23, Volume: 354

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease Models, Animal; Enzyme

2017
The Effect of Gabapentin and Tramadol in Cancer Pain Induced by Glioma Cell in Rat Femur.
    Drug development research, 2017, Volume: 78, Issue:5

    Topics: Amines; Analgesics; Animals; Bone Neoplasms; Brain Neoplasms; Cancer Pain; Cell Line, Tumor; Cell Su

2017
Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.
    ACS chemical neuroscience, 2017, 08-16, Volume: 8, Issue:8

    Topics: Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin

2017
Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:6

    Topics: Amines; Analgesics; Animals; Antipsychotic Agents; Chronic Disease; Constriction, Pathologic; Cycloh

2017
Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain.
    Pain physician, 2017, Volume: 20, Issue:5

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Follow-Up Studies;

2017
Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI.
    Experimental animals, 2018, Feb-09, Volume: 67, Issue:1

    Topics: Amines; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Amino

2018
Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model.
    European journal of pharmacology, 2017, Nov-05, Volume: 814

    Topics: Aldehydes; Amines; Animals; Cisplatin; Cyclohexanecarboxylic Acids; Drug Interactions; Female; Gabap

2017
Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats.
    European journal of pain (London, England), 2018, Volume: 22, Issue:1

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-

2018
The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 95

    Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Cisplatin; Cyclohexanecarboxyl

2017
The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.
    British journal of pharmacology, 2017, Volume: 174, Issue:23

    Topics: Amines; Analgesics; Animals; Benzodioxoles; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos

2017
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:2

    Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy

2018
Botulinum toxin type A and gabapentin attenuate postoperative pain and NK1 receptor internalization in rats.
    Neurochemistry international, 2018, Volume: 116

    Topics: Animals; Botulinum Toxins, Type A; Gabapentin; Ganglia, Spinal; Hyperalgesia; Male; Neurokinin-1 Rec

2018
[Effects of HCN2 in the development of peripheral neuropathic pain in rats].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2017, Apr-08, Volume: 33, Issue:4

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal;

2017
Gabapentin and NMDA receptor antagonists interacts synergistically to alleviate allodynia in two rat models of neuropathic pain.
    Scandinavian journal of pain, 2018, 10-25, Volume: 18, Issue:4

    Topics: Animals; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug;

2018
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease.
    European journal of pain (London, England), 2019, Volume: 23, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics; Analgesics, Opioid; Animals; Arthralg

2019
THC and gabapentin interactions in a mouse neuropathic pain model.
    Neuropharmacology, 2019, Volume: 144

    Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Dro

2019
Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin.
    International urology and nephrology, 2019, Volume: 51, Issue:1

    Topics: Analgesics; Animals; Cystitis; Disease Models, Animal; Electromyography; Gabapentin; Hyperalgesia; M

2019
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.
    The journal of pain, 2019, Volume: 20, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Analgesics; Animals; Cerebral Hemorrhage; Disease Models, Animal; Gabap

2019
Comparison of ex vivo and in vitro actions of gabapentin in superficial dorsal horn and the role of extra-spinal sites of drug action.
    Neuroscience letters, 2019, 02-16, Volume: 694

    Topics: Analgesics; Animals; Excitatory Postsynaptic Potentials; Gabapentin; Hyperalgesia; Male; Neural Inhi

2019
α2δ-1-Bound N-Methyl-D-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents.
    Anesthesiology, 2019, Volume: 130, Issue:5

    Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Drug Tolerance; Female; Gabapentin; Ganglia, Sp

2019
Attenuation of vincristine-induced neuropathy by synthetic cyclohexenone-functionalized derivative in mice model.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019, Volume: 40, Issue:9

    Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Behavior, Animal; Disease Mode

2019
Gabapentin alleviates chronic spontaneous pain and acute hypoxia-related pain in a mouse model of sickle cell disease.
    British journal of haematology, 2019, Volume: 187, Issue:2

    Topics: Acute Disease; Anemia, Sickle Cell; Animals; Calcium Channels, L-Type; Chronic Pain; Disease Models,

2019
Multiple foraminal compression in a child with sialidosis type 2.
    Neurology, 2019, 07-23, Volume: 93, Issue:4

    Topics: Analgesics; Child; Female; Gabapentin; Ganglia, Sympathetic; Humans; Hyperalgesia; Mucolipidoses; Ne

2019
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3

    Topics: Amines; Analgesics; Anesthesia; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarb

2013
Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:5

    Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Complications;

2013
The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.
    Neuropharmacology, 2014, Volume: 79

    Topics: Amines; Analgesics; Animals; Antibodies; Chemokines; Cyclohexanecarboxylic Acids; Cyclooxygenase Inh

2014
Gabapentin attenuates morphine tolerance through interleukin-10.
    Neuroreport, 2014, Jan-22, Volume: 25, Issue:2

    Topics: Amines; Analgesics; Analysis of Variance; Animals; Antibodies; Cyclohexanecarboxylic Acids; Cytokine

2014
Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents.
    Neuropharmacology, 2014, Volume: 79

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Analgesics; Animals; Cold Temperature; Cyclohexaneca

2014
The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclohexanes; Female;

2013
Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:4

    Topics: Adrenergic Neurons; Amines; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cyclohexaneca

2014
Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.
    Behavioural brain research, 2015, Jan-01, Volume: 276

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Amin

2015
Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:5

    Topics: Amines; Animals; Blood Glucose; Body Weight; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experim

2014
A method to enhance the magnitude of tactile hypersensitivity following spinal nerve ligation in rats.
    Journal of neuroscience methods, 2014, Aug-15, Volume: 233

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-

2014
Validation and additional support for an experimental animal model of fibromyalgia.
    Modern rheumatology, 2015, Volume: 25, Issue:1

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Female; Fibromya

2015
Gabapentin prevents oxaliplatin-induced mechanical hyperalgesia in mice.
    Journal of pharmacological sciences, 2014, Volume: 125, Issue:3

    Topics: Actin Depolymerizing Factors; Amines; Animals; Antineoplastic Agents; Cold Temperature; Cyclohexanec

2014
Effect of histone deacetylase inhibitor JNJ-26481585 in pain.
    Journal of molecular neuroscience : MN, 2015, Volume: 55, Issue:3

    Topics: Amines; Animals; Antineoplastic Agents; Calcium Channels; Cyclohexanecarboxylic Acids; Gabapentin; g

2015
Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat.
    European journal of pain (London, England), 2015, Volume: 19, Issue:4

    Topics: Amines; Animals; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapenti

2015
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 126

    Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli

2014
Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain.
    Molecular pain, 2014, Sep-25, Volume: 10

    Topics: Amines; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fluorodeoxyglucose F18;

2014
Anesthesia influences neuronal activity and drug effectiveness in neuropathic rats.
    Pain, 2014, Volume: 155, Issue:12

    Topics: Action Potentials; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal;

2014
Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin.
    Neuroscience bulletin, 2014, Volume: 30, Issue:6

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-

2014
Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury.
    Experimental neurology, 2015, Volume: 264

    Topics: Action Potentials; Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Excitatory

2015
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
    Neuropharmacology, 2015, Volume: 95

    Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; D

2015
Differences in cisplatin-induced mechanical allodynia in male and female mice.
    European journal of pain (London, England), 2015, Volume: 19, Issue:10

    Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Cisplatin; Cyclohexanecarboxylic Acids; Disease

2015
Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats.
    Neuroscience, 2015, Jun-04, Volume: 295

    Topics: Amines; Animals; Axotomy; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Amino Acid

2015
Pressure pain sensitivity map of multifocal nummular headache: a case report.
    The journal of headache and pain, 2015, Volume: 16

    Topics: Adolescent; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric

2015
Upregulation of α₂δ-1 Calcium Channel Subunit in the Spinal Cord Contributes to Pelvic Organ Cross-Sensitization in a Rat Model of Experimentally-Induced Endometriosis.
    Neurochemical research, 2015, Volume: 40, Issue:6

    Topics: Amines; Analgesics; Animals; Behavior, Animal; Calcium Channels; Calcium Channels, L-Type; Chronic P

2015
Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 135

    Topics: Amines; Analgesics; Animals; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electroencephalography; G

2015
A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin.
    Naunyn-Schmiedeberg's archives of pharmacology, 2015, Volume: 388, Issue:11

    Topics: Administration, Topical; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus

2015
Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain.
    Journal of oral & facial pain and headache, 2015,Summer, Volume: 29, Issue:3

    Topics: Administration, Oral; Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent

2015
Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats.
    Life sciences, 2009, Apr-24, Volume: 84, Issue:17-18

    Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Disease Models, Animal; G

2009
Peripheral Neuritis Trauma in Pigs: A Neuropathic Pain Model.
    The journal of pain, 2016, Volume: 17, Issue:1

    Topics: Amines; Analgesics; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Re

2016
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.
    Journal of the peripheral nervous system : JPNS, 2015, Volume: 20, Issue:4

    Topics: Amines; Analgesics; Animals; Caffeine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent

2015
The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation.
    European journal of pain (London, England), 2016, Volume: 20, Issue:6

    Topics: Amines; Analgesics; Animals; Arthritis; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapen

2016
Gabapentin Use in the Neonatal Intensive Care Unit.
    The Journal of pediatrics, 2016, Volume: 169

    Topics: Amines; Analgesics; Benzodiazepines; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut

2016
Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016, Jan-20, Volume: 82

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Rela

2016
Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model.
    Pharmaceutical research, 2016, Volume: 33, Issue:5

    Topics: Amines; Analgesics; Animals; Biological Availability; Brain; Computer Simulation; Cyclohexanecarboxy

2016
Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.
    Neuroscience bulletin, 2016, Volume: 32, Issue:1

    Topics: Amines; Analgesics; Animals; Blotting, Western; Calcium Channels; Cyclohexanecarboxylic Acids; Disea

2016
Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury.
    Experimental neurology, 2016, Volume: 278

    Topics: Amines; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Carbenoxolone; Connexin

2016
Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia.
    Brain, behavior, and immunity, 2016, Volume: 56

    Topics: Amines; Animals; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Cyclooxygenase Inhibitors; D

2016
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:5

    Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico

2016
Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization.
    Scientific reports, 2016, 05-27, Volume: 6

    Topics: Activating Transcription Factor 3; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease

2016
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:3

    Topics: Amines; Animals; Behavior, Animal; Cathepsins; Cyclohexanecarboxylic Acids; Dipeptides; Disease Mode

2016
Potential Contribution of Antioxidant Mechanism in the Defensive Effect of Lycopene Against Partial Sciatic Nerve Ligation Induced Behavioral, Biochemical and Histopathological Modification in Wistar Rats.
    Drug research, 2016, Volume: 66, Issue:12

    Topics: Amines; Animals; Antioxidants; Carotenoids; Catalase; Cyclohexanecarboxylic Acids; Gabapentin; gamma

2016
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
    Molecular pain, 2016, Volume: 12

    Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai

2016
Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 359, Issue:2

    Topics: Amides; Amines; Animals; Cyclohexanecarboxylic Acids; Drug Synergism; Ethanolamines; Gabapentin; gam

2016
A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy.
    Pain, 2017, Volume: 158, Issue:1

    Topics: Amines; Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Cyclohexanec

2017
6-Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the streptozotocin-induced diabetic neuropathic pain.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Amines; Animals; Computer Simulation; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Female; Fl

2016
Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter?
    European journal of pain (London, England), 2017, Volume: 21, Issue:4

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Freund's Adjuvant; Gabapentin; gamma-Amino

2017
Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model.
    European journal of pain (London, England), 2017, Volume: 21, Issue:4

    Topics: Administration, Topical; Amines; Analgesics; Animals; Constriction, Pathologic; Cyclohexanecarboxyli

2017
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
    Pain, 2017, Volume: 158, Issue:1

    Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constri

2017
Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis.
    European journal of pharmacology, 2017, Mar-15, Volume: 799

    Topics: Amines; Animals; Astrocytes; Behavior, Animal; Cell Count; Chronic Disease; Cyclohexanecarboxylic Ac

2017
An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve.
    The journal of pain, 2017, Volume: 18, Issue:8

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Functional Lateral

2017
Inhibition of osteosarcoma-induced thermal hyperalgesia in mice by the orally active dual enkephalinase inhibitor PL37. Potentiation by gabapentin.
    European journal of pharmacology, 2008, Oct-31, Volume: 596, Issue:1-3

    Topics: Administration, Oral; Amines; Analgesics; Animals; Bone Neoplasms; Cyclohexanecarboxylic Acids; Disu

2008
Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis.
    Brain research, 2009, Apr-06, Volume: 1264

    Topics: Adjuvants, Immunologic; Amines; Analgesics; Analysis of Variance; Animals; Ankle Joint; Arthritis, E

2009
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
    Brain research, 2009, Oct-27, Volume: 1295

    Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan;

2009
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats.
    Neuroscience, 2009, Dec-15, Volume: 164, Issue:3

    Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease

2009
Neuronal hyperactivity at the spinal cord and periaqueductal grey during painful diabetic neuropathy: effects of gabapentin.
    European journal of pain (London, England), 2010, Volume: 14, Issue:7

    Topics: Amines; Analgesics; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus, E

2010
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
    Planta medica, 2010, Volume: 76, Issue:13

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr

2010
Effect of analgesic standards on persistent postoperative pain evoked by skin/muscle incision and retraction (SMIR).
    Neuroscience letters, 2010, Jun-14, Volume: 477, Issue:1

    Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Dermatologic Surgical Pro

2010
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin.
    Pain, 2010, Volume: 151, Issue:1

    Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Ac

2010
Behavioral signs of chronic back pain in the SPARC-null mouse.
    Spine, 2011, Jan-15, Volume: 36, Issue:2

    Topics: Age Factors; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Chronic Diseas

2011
A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves.
    European journal of pain (London, England), 2011, Volume: 15, Issue:5

    Topics: Amines; Analgesics; Animals; Behavior, Animal; CD11b Antigen; Cold Temperature; Cyclohexanecarboxyli

2011
Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.
    Molecular pain, 2010, Nov-26, Volume: 6

    Topics: Amines; Animals; Calcium Channels; Circadian Rhythm; Cyclohexanecarboxylic Acids; Disease Models, An

2010
Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin.
    Science China. Life sciences, 2010, Volume: 53, Issue:12

    Topics: Amines; Animals; Cerebral Cortex; Cyclohexanecarboxylic Acids; Enkephalins; Excitatory Amino Acid An

2010
Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states.
    Pain, 2011, Volume: 152, Issue:3

    Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids

2011
Analgesic effects of tramadol, tramadol-gabapentin, and buprenorphine in an incisional model of pain in rats (Rattus norvegicus).
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2011, Volume: 50, Issue:2

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Cyclohexanecarb

2011
Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats.
    British journal of anaesthesia, 2011, Volume: 106, Issue:5

    Topics: Amines; Analgesics, Non-Narcotic; Animals; Cauda Equina; Cyclohexanecarboxylic Acids; Disease Models

2011
The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:3

    Topics: Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids;

2011
Manual acupuncture inhibits mechanical hypersensitivity induced by spinal nerve ligation in rats.
    Neuroscience, 2011, Oct-13, Volume: 193

    Topics: Acupuncture Points; Acupuncture Therapy; Amines; Analgesics; Analysis of Variance; Animals; Cyclohex

2011
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2011, Volume: 32, Issue:6

    Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexane

2011
Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.
    Journal of anesthesia, 2012, Volume: 26, Issue:2

    Topics: Amines; Analgesics, Opioid; Animals; Chronic Pain; Cyclohexanecarboxylic Acids; Drug Tolerance; Fent

2012
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
    European journal of pain (London, England), 2012, Volume: 16, Issue:6

    Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Anima

2012
Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs.
    European journal of pain (London, England), 2012, Volume: 16, Issue:7

    Topics: Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal;

2012
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:3

    Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxet

2012
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
    European journal of pain (London, England), 2012, Volume: 16, Issue:4

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec

2012
Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats.
    Behavioural pharmacology, 2012, Volume: 23, Issue:2

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; C-Peptide; Curc

2012
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:1

    Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarb

2012
Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model.
    Journal of pharmacological sciences, 2012, Volume: 118, Issue:4

    Topics: Amines; Analgesics; Animals; Calcium Channels; CD11b Antigen; Cyclohexanecarboxylic Acids; Disease M

2012
Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:1

    Topics: Amines; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarbo

2012
Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats.
    Fitoterapia, 2012, Volume: 83, Issue:5

    Topics: Acetone; Amines; Analgesics; Animals; Behavior, Animal; Carotenoids; Constriction; Crocus; Cyclohexa

2012
The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:1

    Topics: Adjuvants, Anesthesia; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Ani

2012
Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats.
    Molecular brain, 2012, May-30, Volume: 5

    Topics: Amines; Animals; Arthritis; Calcium Channels, L-Type; Chemokine CX3CL1; CX3C Chemokine Receptor 1; C

2012
Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Jul-10, Volume: 109, Issue:28

    Topics: Amines; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Dia

2012
Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats.
    European journal of pain (London, England), 2013, Volume: 17, Issue:4

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; C

2013
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
    Neuropharmacology, 2012, Volume: 63, Issue:8

    Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxy

2012
Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons.
    Brain research, 2013, Feb-01, Volume: 1493

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease Models, Ani

2013
Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept.
    Anesthesia and analgesia, 2013, Volume: 116, Issue:1

    Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineopla

2013
Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization.
    Anesthesiology, 2002, Volume: 97, Issue:1

    Topics: Acetates; Adult; Amines; Analgesics; Capsaicin; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Amino

2002
Is gabapentin a "Broad-spectrum" analgesic?
    Anesthesiology, 2002, Volume: 97, Issue:3

    Topics: Acetates; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Huma

2002
Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia.
    Anesthesiology, 2002, Volume: 97, Issue:5

    Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Calcium Cha

2002
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
    Neuropharmacology, 2002, Volume: 43, Issue:6

    Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell

2002
Suppression by gabapentin of pain-related mechano-responses in mice given orthotopic tumor inoculation.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:4

    Topics: Acetates; Amines; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hyperal

2003
Magnesium chloride and ruthenium red attenuate the antiallodynic effect of intrathecal gabapentin in a rat model of postoperative pain.
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channels; Cyclo

2003
Gabapentin: the first preemptive anti-hyperalgesic for opioid withdrawal hyperalgesia?
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Female; Gabapentin; g

2003
Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice.
    Experimental neurology, 2003, Volume: 182, Issue:2

    Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models

2003
Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin.
    Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:9

    Topics: Acetates; Amines; Amitriptyline; Analgesics; Arm; Carbamazepine; Central Cord Syndrome; Cervical Ver

2003
Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats.
    British journal of pharmacology, 2003, Volume: 140, Issue:2

    Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Cyc

2003
Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig.
    Pain, 2003, Volume: 105, Issue:1-2

    Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Gabapentin;

2003
Pharmacological characterisation of a rat model of incisional pain.
    British journal of pharmacology, 2004, Volume: 141, Issue:1

    Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Model

2004
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 369, Issue:4

    Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease

2004
Differential analgesic sensitivity of two distinct neuropathic pain models.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Cold Temperature; Cyclohexanecarboxylic A

2004
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Age

2005
Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse.
    British journal of pharmacology, 2005, Volume: 144, Issue:5

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A

2005
Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:3

    Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Benzylamines; Chronic Disease; Cyclohexanecarb

2005
Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test.
    Journal of Korean medical science, 2005, Volume: 20, Issue:2

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Drug Interactions; Ex

2005
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy.
    Pain, 2005, Volume: 115, Issue:1-2

    Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxyl

2005
Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain.
    Neuroscience, 2005, Volume: 132, Issue:4

    Topics: Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Benzoxazines; Blotting, Western; Cyclo

2005
Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:1

    Topics: Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob

2005
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
    European journal of pharmacology, 2005, Sep-20, Volume: 519, Issue:3

    Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxyli

2005
Development and expression of neuropathic pain in CB1 knockout mice.
    Neuropharmacology, 2006, Volume: 50, Issue:1

    Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A

2006
Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury.
    British journal of pharmacology, 2006, Volume: 148, Issue:2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Amines; Analgesics; Animals; Atropine; Cholinesterases; Cyc

2006
Motor cortex stimulation for central pain following a traumatic brain injury.
    Pain, 2006, Volume: 123, Issue:1-2

    Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju

2006
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia.
    Osteoarthritis and cartilage, 2006, Volume: 14, Issue:10

    Topics: Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Cyclooxygenase 2 Inhibitors; D

2006
Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain.
    Psychopharmacology, 2006, Volume: 187, Issue:3

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Cyclohexanols; Dose-Response Relationship,

2006
[Post-operative pain therapy of a chronic pain patient].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2006, Volume: 41, Issue:11

    Topics: Adult; Amines; Analgesics; Analgesics, Opioid; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Co

2006
Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs.
    Neuroscience, 2007, Feb-23, Volume: 144, Issue:4

    Topics: Amines; Analgesics; Animals; Anti-Anxiety Agents; Anxiety Disorders; Cells, Cultured; Cyclohexanecar

2007
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
    Journal of neurochemistry, 2007, Volume: 100, Issue:5

    Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease

2007
Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF.
    Neuropharmacology, 2007, Volume: 52, Issue:5

    Topics: Acetamides; Amines; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Excitatory Amino Acid An

2007
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
    Anesthesiology, 2007, Volume: 106, Issue:6

    Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic

2007
The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia.
    Journal of neuroinflammation, 2007, Jun-05, Volume: 4

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapent

2007
Transient allodynia pain models in mice for early assessment of analgesic activity.
    British journal of pharmacology, 2008, Volume: 153, Issue:4

    Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb

2008
Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice.
    Neuroreport, 2008, Jan-08, Volume: 19, Issue:1

    Topics: Acute Disease; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gab

2008
Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats.
    Anesthesiology, 2008, Volume: 108, Issue:3

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Fentanyl; Gabapentin

2008
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
    European journal of pain (London, England), 2008, Volume: 12, Issue:8

    Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di

2008
Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents.
    British journal of pharmacology, 1997, Volume: 121, Issue:8

    Topics: Acetates; Amines; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels; Cyclohexanecarbox

1997
Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.
    Anesthesiology, 1998, Volume: 88, Issue:1

    Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Dose-Response

1998
The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:2

    Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati

1998
Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia.
    Brain research, 1998, Nov-09, Volume: 810, Issue:1-2

    Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati

1998
Gabapentin prevents hyperalgesia during the formalin test in diabetic rats.
    Neuroscience letters, 1999, Mar-05, Volume: 262, Issue:2

    Topics: Acetates; Amines; Analgesics; Animals; Blood Glucose; Body Weight; Cyclohexanecarboxylic Acids; Diab

1999
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
    Neuropharmacology, 1999, Volume: 38, Issue:5

    Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excita

1999
Gabapentin attenuates nociceptive behaviors in an acute arthritis model in rats.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1

    Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimen

1999
Behavioral effects of RS-45041-190, a selective I2 imidazoline ligand, in rats.
    Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881

    Topics: Acetates; Amines; Analgesics; Animals; Carrageenan; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A

1999
Morphine and gabapentin decrease mechanical hyperalgesia and escape/avoidance behavior in a rat model of neuropathic pain.
    Neuroscience letters, 2000, Aug-25, Volume: 290, Issue:2

    Topics: Acetates; Amines; Analgesics; Animals; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Mode

2000
Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord.
    British journal of pharmacology, 2000, Volume: 130, Issue:8

    Topics: Acetates; Amines; Animals; Antimanic Agents; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Exc

2000
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
    Japanese journal of pharmacology, 2000, Volume: 83, Issue:4

    Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants;

2000
Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:2

    Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Drug Tolerance

2001
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat.
    Pain, 2001, Feb-15, Volume: 90, Issue:3

    Topics: Acetates; Amines; Analgesics; Animals; Baclofen; Cyclohexanecarboxylic Acids; Electric Stimulation;

2001
The putative OP(4) antagonist, [Nphe(1)]nociceptin(1-13)NH(2), prevents the effects of nociceptin in neuropathic rats.
    Brain research, 2001, Jun-29, Volume: 905, Issue:1-2

    Topics: Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Res

2001
Antinociceptive effect of the novel compound OT-7100 in a diabetic neuropathy model.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease M

2001