propentofylline has been researched along with Allodynia in 18 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " The markedly delayed efficacy of all 3 glial modulatory drugs may prove instructive for interpretation of apparent drug failures after shorter dosing regimens." | 5.40 | Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain. ( Ellis, A; Falci, S; Favret, J; Johnson, KW; Maier, SF; Rice, KC; Watkins, LR; Wieseler, J, 2014) |
| " Among the many therapeutic agents that have been tested for anti-allodynia through immune modulation is the atypical methylxanthine propentofylline." | 3.81 | Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush. ( Damblon, J; De Kock, M; Des Rieux, A; Deumens, R; Dimiziani, A; Gallo, A; Hermans, E; Michot, B, 2015) |
| " Intrathecal treatment with propentofylline (PPF, 10 mM) for 7 consecutive days immediately after spinal injury attenuated the development of mechanical allodynia and thermal hyperalgesia in both hind limbs in a dose-related reduction compared to vehicle treatments (* P<0." | 3.75 | Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. ( Gwak, YS; Hulsebosch, CE, 2009) |
| "In the present study, we examined whether activation of p-38alpha MAPK modulates mechanical allodynia and neuronal hyperexcitability, and if propentofylline (PPF, a glial modulator) modulates specifically localized activated p-38alpha MAPK expression in caudal regions remote from a low thoracic hemisection injury in rats." | 3.75 | Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury. ( Gwak, YS; Hulsebosch, CE; Unabia, GC, 2009) |
| "We have previously shown that the atypical methylxanthine, propentofylline, reduces mechanical allodynia after peripheral nerve transection in a rodent model of neuropathy." | 3.74 | Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. ( DeLeo, JA; Haenggeli, C; Lacroix-Fralish, ML; Nutile-McMenemy, N; Perez, N; Regan, MR; Rothstein, JD; Tawfik, VL, 2008) |
| " The present study utilized a rodent model of vincristine-induced neuropathy to determine whether a glial modulating agent, propentofylline, could attenuate vincristine-induced mechanical allodynia." | 3.73 | Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat. ( DeLeo, JA; Pahl, JL; Sweitzer, SM, 2006) |
| "Injury to peripheral nerves often produces non-physiological, long-lasting spontaneous pain, hyperalgesia and allodynia that are refractory to standard treatment and often insensitive to opioids, such as morphine." | 3.72 | Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines. ( DeLeo, JA; Raghavendra, V; Rutkowski, MD; Tanga, F, 2003) |
| "The present study was undertaken to determine whether propentofylline, a glial modulating agent, could both prevent the induction of mechanical allodynia and attenuate existing mechanical allodynia in a rodent L5 spinal nerve transection model of neuropathic pain." | 3.71 | Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. ( DeLeo, JA; Schubert, P; Sweitzer, SM, 2001) |
| "Our findings showed that the mechanical allodynia, and synaptically-evoked firing were caused LTP in the Aδ-fiber, C-fiber and lesser in the Aβ-fiber after high frequency stimulation." | 1.51 | Role of spinal glial cells in excitability of wide dynamic range neurons and the development of neuropathic pain with the L5 spinal nerve transection in the rats: Behavioral and electrophysiological study. ( Haghparast, A; Manaheji, H; Rezaee, L, 2019) |
| "Ibudilast is a phosphodiesterase inhibitor with anti-inflammatory activity, but its effect on activated microglia in chronic neuropathic pain is poorly understood." | 1.48 | Ibudilast produces anti-allodynic effects at the persistent phase of peripheral or central neuropathic pain in rats: Different inhibitory mechanism on spinal microglia from minocycline and propentofylline. ( Asaki, T; Fujita, M; Hasegawa, M; Omachi, S; Rokushima, M; Sakaguchi, G; Shinohara, S; Tamano, R; Yogo, E; Yoneda, S, 2018) |
| "We studied sensitivity of mechanical hyperalgesia induced by a single intrathecal (i." | 1.46 | Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study. ( Constandil, L; Galleguillos, D; Hernández, A; Marcos, JL; Pelissier, T; Velásquez, L; Villanueva, L, 2017) |
| " The markedly delayed efficacy of all 3 glial modulatory drugs may prove instructive for interpretation of apparent drug failures after shorter dosing regimens." | 1.40 | Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain. ( Ellis, A; Falci, S; Favret, J; Johnson, KW; Maier, SF; Rice, KC; Watkins, LR; Wieseler, J, 2014) |
| "Rats underwent SNL surgery to induce neuropathic pain." | 1.39 | Tramadol and propentofylline coadministration exerted synergistic effects on rat spinal nerve ligation-induced neuropathic pain. ( Liu, R; Mei, XP; Wang, H; Wang, W; Wu, D; Xie, C; Xu, LX; Zhang, H; Zhang, J, 2013) |
| "Although visceral hyperalgesia was blocked by pharmacological inhibition of spinal NMDARs, we observed no stress effects on NMDAR subunit expression or phosphorylation." | 1.37 | Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. ( Bakirtzi, K; Bradesi, S; Ennes, HS; Golovatscka, V; Karagiannides, I; Karagiannidis, I; Mayer, EA; McRoberts, JA; Pothoulakis, C, 2011) |
| " The combination of low dosage of propentofylline and EA produced more potent anti-allodynia than propentofylline or EA alone." | 1.36 | Synergetic analgesia of propentofylline and electroacupuncture by interrupting spinal glial function in rats. ( Gu, XY; Liang, LL; Lü, N; Yang, JL; Zhang, YQ; Zhao, ZQ, 2010) |
| "Propentofylline treatment on days 14-21 or 60-67 did not reverse existing allodynia." | 1.36 | Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats. ( Kimura, M; Obata, H; Saito, S; Sakurazawa, S, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marcos, JL | 1 |
| Galleguillos, D | 1 |
| Pelissier, T | 2 |
| Hernández, A | 2 |
| Velásquez, L | 1 |
| Villanueva, L | 2 |
| Constandil, L | 2 |
| Fujita, M | 1 |
| Tamano, R | 1 |
| Yoneda, S | 1 |
| Omachi, S | 1 |
| Yogo, E | 1 |
| Rokushima, M | 1 |
| Shinohara, S | 1 |
| Sakaguchi, G | 1 |
| Hasegawa, M | 1 |
| Asaki, T | 1 |
| Rezaee, L | 1 |
| Manaheji, H | 1 |
| Haghparast, A | 1 |
| Wu, F | 1 |
| Miao, X | 1 |
| Chen, J | 1 |
| Liu, Z | 1 |
| Tao, Y | 1 |
| Yu, W | 1 |
| Sun, Y | 1 |
| Zhang, J | 1 |
| Wu, D | 1 |
| Xie, C | 1 |
| Wang, H | 1 |
| Wang, W | 1 |
| Zhang, H | 1 |
| Liu, R | 1 |
| Xu, LX | 1 |
| Mei, XP | 1 |
| Ellis, A | 1 |
| Wieseler, J | 1 |
| Favret, J | 1 |
| Johnson, KW | 1 |
| Rice, KC | 1 |
| Maier, SF | 1 |
| Falci, S | 1 |
| Watkins, LR | 1 |
| Gallo, A | 1 |
| Dimiziani, A | 1 |
| Damblon, J | 1 |
| Michot, B | 1 |
| Des Rieux, A | 1 |
| De Kock, M | 1 |
| Hermans, E | 1 |
| Deumens, R | 1 |
| Gwak, YS | 2 |
| Hulsebosch, CE | 2 |
| Unabia, GC | 1 |
| Liang, LL | 1 |
| Yang, JL | 1 |
| Lü, N | 1 |
| Gu, XY | 1 |
| Zhang, YQ | 1 |
| Zhao, ZQ | 1 |
| Obata, H | 1 |
| Sakurazawa, S | 1 |
| Kimura, M | 1 |
| Saito, S | 1 |
| Bradesi, S | 1 |
| Golovatscka, V | 1 |
| Ennes, HS | 1 |
| McRoberts, JA | 1 |
| Karagiannides, I | 1 |
| Karagiannidis, I | 1 |
| Bakirtzi, K | 1 |
| Pothoulakis, C | 1 |
| Mayer, EA | 1 |
| Goich, M | 1 |
| Bourgeais, L | 1 |
| Cazorla, M | 1 |
| Hamon, M | 1 |
| Raghavendra, V | 2 |
| Tanga, F | 1 |
| Rutkowski, MD | 1 |
| DeLeo, JA | 5 |
| Tanga, FY | 1 |
| Sweitzer, SM | 2 |
| Pahl, JL | 1 |
| Tawfik, VL | 1 |
| Regan, MR | 1 |
| Haenggeli, C | 1 |
| Lacroix-Fralish, ML | 1 |
| Nutile-McMenemy, N | 1 |
| Perez, N | 1 |
| Rothstein, JD | 1 |
| Schubert, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Full-Factorial, Parallel-Group Study Evaluating Safety and Efficacy of Naltrexone-Acetaminophen Combination in Acute Migraine Treatment in Adults, With Exploratory Focus on Co-Occurring[NCT05685225] | Phase 2 | 300 participants (Anticipated) | Interventional | 2024-03-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for propentofylline and Allodynia
| Article | Year |
|---|---|
Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Sensitization; Disease Models, An | 2017 |
Ibudilast produces anti-allodynic effects at the persistent phase of peripheral or central neuropathic pain in rats: Different inhibitory mechanism on spinal microglia from minocycline and propentofylline.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Hyperalgesia; Injections, Spin | 2018 |
Role of spinal glial cells in excitability of wide dynamic range neurons and the development of neuropathic pain with the L5 spinal nerve transection in the rats: Behavioral and electrophysiological study.
Topics: Animals; Behavior, Animal; Electrophysiological Phenomena; Hyperalgesia; Ligation; Long-Term Potenti | 2019 |
Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain.
Topics: Animals; Astrocytes; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; F | 2013 |
Tramadol and propentofylline coadministration exerted synergistic effects on rat spinal nerve ligation-induced neuropathic pain.
Topics: Analgesics, Opioid; Animals; Drug Combinations; Drug Synergism; Hyperalgesia; Injections, Spinal; In | 2013 |
Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Neuralgia; Ne | 2014 |
Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush.
Topics: Animals; Calcium-Binding Proteins; Female; Glial Fibrillary Acidic Protein; Hyperalgesia; Injections | 2015 |
Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat.
Topics: Action Potentials; Animals; Astrocytes; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Pr | 2009 |
Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury.
Topics: Animals; Astrocytes; Disease Models, Animal; Enzyme Activation; Gliosis; Hyperalgesia; Male; Microgl | 2009 |
Synergetic analgesia of propentofylline and electroacupuncture by interrupting spinal glial function in rats.
Topics: Analgesia; Animals; Electroacupuncture; Hyperalgesia; Male; Neuroglia; Rats; Rats, Sprague-Dawley; S | 2010 |
Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats.
Topics: Animals; Astrocytes; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Lumbar Vert | 2010 |
Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Dizocilpine Maleate; Glial Fibrillary Acidic | 2011 |
Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice.
Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Sensitization; Cold T | 2012 |
Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines.
Topics: Analgesics; Animals; Cytokines; Dose-Response Relationship, Drug; Hyperalgesia; Male; Morphine; Neur | 2003 |
Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cytokines; Drug Interactions; Drug Tolerance; Enzym | 2004 |
Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat.
Topics: Animals; Antineoplastic Agents; Drug Combinations; Hyperalgesia; Male; Neuroprotective Agents; Pain | 2006 |
Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection.
Topics: Animals; Astrocytes; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Gene | 2008 |
Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Immunohistochemistr | 2001 |