alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Allodynia in 17 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold." | 7.73 | Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. ( Allchorne, A; Amaya, F; Brenner, GJ; Ito, N; Ji, RR; Kohno, T; Wang, H; Woolf, CJ, 2005) |
| "Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing pain threshold." | 3.73 | Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. ( Allchorne, A; Amaya, F; Brenner, GJ; Ito, N; Ji, RR; Kohno, T; Wang, H; Woolf, CJ, 2005) |
| "Homo-AMPA decreased mechanical allodynia in diabetic neuropathic mice." | 1.72 | Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice. ( Bagetta, G; Belardo, C; Boccella, S; De Dominicis, E; Iannotta, M; Infantino, R; Maione, S; Marabese, I; Pagano, M; Palazzo, E; Perrone, M; Scuteri, D, 2022) |
| "Peripheral neuropathic pain is a common complication in the diabetic patients, and the underlying central mechanism remains unclear." | 1.40 | Upregulation of glutamatergic transmission in anterior cingulate cortex in the diabetic rats with neuropathic pain. ( Li, H; Li, W; Wang, P, 2014) |
| "Under SP-induced thermal hyperalgesia, the number of scratchings following SP administration was time-dependently suppressed, whereas the number of scratchings after NMDA or AMPA administration was markedly enhanced and SP-induced thermal hyperalgesia was attenuated by pretreatment with NMDA or AMPA receptor antagonist." | 1.36 | NMDA and AMPA receptors contribute to the maintenance of substance P-induced thermal hyperalgesia. ( Ikeda, T; Nakayama, T; Naono, R; Nishimori, T, 2010) |
| "Secondary mechanical allodynia resulting from a thermal stimulus (52." | 1.33 | Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. ( Jones, TL; Sorkin, LS, 2005) |
| "Thermal hyperalgesia requires NMDA receptor activation and is primarily mediated by production of nitric oxide." | 1.29 | Spinal mediators of hyperalgesia. ( Gebhart, GF; Meller, ST, 1994) |
| "These findings suggest that the hyperalgesia induced by the i." | 1.29 | Pharmacological characterization of AMPA-induced biting behaviour in mice. ( Borsini, F; Brambilla, A; Grippa, N; Prudentino, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Palazzo, E | 1 |
| Boccella, S | 1 |
| Marabese, I | 1 |
| Perrone, M | 1 |
| Belardo, C | 1 |
| Iannotta, M | 1 |
| Scuteri, D | 1 |
| De Dominicis, E | 1 |
| Pagano, M | 1 |
| Infantino, R | 1 |
| Bagetta, G | 1 |
| Maione, S | 1 |
| Li, W | 1 |
| Wang, P | 1 |
| Li, H | 1 |
| Nakayama, T | 1 |
| Naono, R | 1 |
| Ikeda, T | 1 |
| Nishimori, T | 1 |
| Zhang, YH | 1 |
| Wang, XM | 1 |
| Ennis, M | 1 |
| Garry, EM | 1 |
| Moss, A | 1 |
| Rosie, R | 1 |
| Delaney, A | 1 |
| Mitchell, R | 1 |
| Fleetwood-Walker, SM | 1 |
| Hsun Lin, H | 1 |
| Chiu, HY | 1 |
| Lai, CC | 1 |
| Dominguez, E | 1 |
| Iyengar, S | 1 |
| Shannon, HE | 1 |
| Bleakman, D | 1 |
| Alt, A | 1 |
| Arnold, BM | 1 |
| Bell, MG | 1 |
| Bleisch, TJ | 1 |
| Buckmaster, JL | 1 |
| Castano, AM | 1 |
| Del Prado, M | 1 |
| Escribano, A | 1 |
| Filla, SA | 1 |
| Ho, KH | 1 |
| Hudziak, KJ | 1 |
| Jones, CK | 1 |
| Martinez-Perez, JA | 1 |
| Mateo, A | 1 |
| Mathes, BM | 1 |
| Mattiuz, EL | 1 |
| Ogden, AM | 1 |
| Simmons, RM | 1 |
| Stack, DR | 1 |
| Stratford, RE | 1 |
| Winter, MA | 1 |
| Wu, Z | 1 |
| Ornstein, PL | 1 |
| Wang, H | 1 |
| Kohno, T | 1 |
| Amaya, F | 1 |
| Brenner, GJ | 1 |
| Ito, N | 1 |
| Allchorne, A | 1 |
| Ji, RR | 1 |
| Woolf, CJ | 1 |
| Jones, TL | 1 |
| Sorkin, LS | 1 |
| Björkman, R | 1 |
| Hallman, KM | 1 |
| Hedner, J | 1 |
| Hedner, T | 1 |
| Henning, M | 1 |
| Meller, ST | 1 |
| Gebhart, GF | 1 |
| Neugebauer, V | 1 |
| Rumenapp, P | 1 |
| Schaible, HG | 1 |
| Brambilla, A | 1 |
| Prudentino, A | 1 |
| Grippa, N | 1 |
| Borsini, F | 1 |
| Marvizón, JC | 1 |
| Martínez, V | 1 |
| Grady, EF | 1 |
| Bunnett, NW | 1 |
| Mayer, EA | 1 |
| Yamamoto, T | 1 |
| Sakashita, Y | 1 |
| Kitto, KF | 1 |
| Haley, JE | 1 |
| Wilcox, GL | 1 |
| Malmberg, AB | 1 |
| Yaksh, TL | 1 |
17 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Allodynia
| Article | Year |
|---|---|
Homo-AMPA in the periaqueductal grey modulates pain and rostral ventromedial medulla activity in diabetic neuropathic mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Diabetes Mellitus; Diabetic Neuro | 2022 |
Upregulation of glutamatergic transmission in anterior cingulate cortex in the diabetic rats with neuropathic pain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Diabetes Mellitus, Experimental; | 2014 |
NMDA and AMPA receptors contribute to the maintenance of substance P-induced thermal hyperalgesia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Prot | 2010 |
Effects of neonatal inflammation on descending modulation from the rostroventromedial medulla.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Ne | 2010 |
Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carrier Proteins; Cell Membrane; | 2003 |
Potentiation of spinal N-methyl-D-aspartate-mediated nociceptive transmission by cocaine-regulated and amphetamine-regulated transcript peptide in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Analysis of Variance; Animals | 2005 |
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Biologic | 2005 |
Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bradykinin; Drug Synergism; Gluta | 2005 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area | 2005 |
Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P.
Topics: Acetaminophen; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Behavior | 1994 |
Spinal mediators of hyperalgesia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Arginine; Calci | 1994 |
The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Benzamides; Carrageena | 1996 |
Pharmacological characterization of AMPA-induced biting behaviour in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzodiazepines | 1996 |
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1997 |
COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Cyclooxygen | 1998 |
Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Argin | 1992 |
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Dizo | 1992 |