isoxazoles has been researched along with Allodynia in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (42.11) | 29.6817 |
| 2010's | 17 (44.74) | 24.3611 |
| 2020's | 5 (13.16) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, L; Wang, C; Wu, Z; Xu, H; Yao, Y; Zheng, F; Zhou, J | 1 |
| Feng, Z; Li, Y; Zhang, N | 1 |
| Berman, R; Collins, J; Kellett, E; Morgan, H | 1 |
| Lucena, F; McDougall, JJ | 1 |
| Cruz, JV; Maba, IK; Zampronio, AR | 1 |
| Augusto, PSA; Brito, AMS; Coelho, MM; Costa, SOAM; Dutra, MGMB; Godin, AM; Goulart, FA; Ísis Morais, M; Machado, RR; Melo, ISF; Menezes, RR; Rodrigues, FF | 1 |
| Cheng, X; Dougherty, PM; Heijnen, CJ; Huo, X; Kavelaars, A; Li, Y; Mei, F; Singhmar, P | 1 |
| Bo, J; Gu, X; Hou, B; Huo, W; Lei, Y; Liu, Y; Liu, Z; Ma, Z; Mao, Y; Sun, R; Sun, Y; Zhang, W; Zhang, Y; Zhang, Z | 1 |
| Chen, J; Cong, X; Zhan, X; Zheng, W; Zhou, Z | 1 |
| Arslan, R; Bektas, N; Ozturk, Y | 1 |
| Lin, W; Liu, BL; Pan, HL; Zhang, YQ | 1 |
| Brack, A; Broscheit, JA; Rittner, HL; Roewer, N; Sauer, RS; Shityakov, S; Sohajda, T | 1 |
| Filippini-de Moor, GP; Steegers, MA; van Helmond, N; Vissers, KC; Wilder-Smith, OH | 1 |
| Cai, J; Chen, RX; Liao, FF; Liu, FY; Wan, Y; Wang, J; Xu, FQ; Yi, M; Zhang, C; Zhang, Y | 1 |
| Herschman, HR; Ishikawa, TO; Jain, NK; Spigelman, I | 1 |
| Herrndobler, F; Koppert, W; Maihöfner, C; Ringler, R | 1 |
| Greer, JJ; Ren, J | 1 |
| Guo, X; Liu, Y; Peng, Y; Shen, X; Wang, F; Xu, S; Yang, J | 1 |
| Howard, DJ; Iczkowski, KA; Jiang, L; Meyer-Siegler, KL; Vera, PL | 1 |
| Baker, JF; Ballentine, SK; Colburn, RW; Damiano, BP; Flores, CM; Hutchinson, TL; Illig, CR; Liu, Y; Lubin, ML; Ma, J; Meegalla, SK; Parks, DJ; Parsons, WH; Player, MR; Qin, N; Schneider, CR; Stone, DJ | 1 |
| Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A | 1 |
| Abernethy, L; Ansari, N; Cameron, K; Clarkson, T; Dempster, M; Dunn, D; Easson, AM; Edwards, D; Everett, K; Feilden, H; Ho, KK; Kultgen, S; Littlewood, P; Maclean, J; McArthur, D; McGregor, D; McLuskey, H; Neagu, I; Nimz, O; Nisbet, LA; Ohlmeyer, M; Palin, R; Pham, Q; Ratcliffe, P; Rong, Y; Roughton, A; Sammons, M; Swanson, R; Tracey, H; Walker, G | 1 |
| Gong, N; Lu, JM; Wang, YC; Wang, YX | 1 |
| Christensen, J; Erichsen, H; Hansen, H; Hansen, R; Munro, G; Timmermann, D | 1 |
| Chen, XL; Guo, C; Huang, JL; Wang, YX | 1 |
| Azevedo, MI; Chalfoun, AG; Denson, DD; Hord, AH | 1 |
| Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L | 1 |
| Jain, NK; Kulkarni, SK; Satyanarayana, PS; Singh, S | 1 |
| Jain, NK; Kulkarni, SK; Padi, SS; Singh, S | 1 |
| Albrecht, S; Koppert, W; Körber, N; Schmelz, M; Schüttler, J; Sittl, R; Wehrfritz, A | 1 |
| Gierse, JK; Hood, WF; Isakson, PC; Koboldt, CM; Masferrer, JL; Maziasz, TJ; Muhammad, JL; Seibert, K; Trigg, JS; Walker, MC; Zhang, Y; Zweifel, BS | 1 |
| Kulkarni, SK; Padi, SS | 1 |
| Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M | 1 |
| Koppert, W; Schmelz, M; Schüttler, J; Singler, B; Sittl, R; Tröster, A | 1 |
| Chizh, BA; Göhring, M; Koppert, W; Quartey, GK; Schmelz, M; Tröster, A | 1 |
| Ilavarasan, R; Kesavanarayanan, KS; Nappinnai, M | 1 |
| Kamerman, P; Koller, A; Loram, L | 1 |
| Czugler, M; Erdélyi, P; Fischer, J; Fodor, T; Gere, A; Varga, AK | 1 |
6 trial(s) available for isoxazoles and Allodynia
| Article | Year |
|---|---|
Hyperalgesia and Persistent Pain after Breast Cancer Surgery: A Prospective Randomized Controlled Trial with Perioperative COX-2 Inhibition.
Topics: Adult; Aged; Breast Neoplasms; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Hyperalgesia; Isoxazoles; Mastectomy; Mastectomy, Segmental; Middle Aged; Pain Measurement; Pain Threshold; Pain, Postoperative; Perioperative Period; Prospective Studies; Quality of Life; Surveys and Questionnaires; Treatment Outcome | 2016 |
[Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study].
Topics: Acute Disease; Adult; Analgesics; Aspirin; Brain Mapping; Cerebral Cortex; Cyclooxygenase Inhibitors; Dominance, Cerebral; Double-Blind Method; Female; Frontal Lobe; Gyrus Cinguli; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Isoxazoles; Magnetic Resonance Imaging; Male; Motor Cortex; Pain; Pain Measurement; Pain Threshold; Parietal Lobe; Psychophysics; Somatosensory Cortex | 2009 |
Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.
Topics: Adult; Analgesics, Opioid; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Humans; Hyperalgesia; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Remifentanil; Time Factors; Young Adult | 2011 |
The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Electric Stimulation; Humans; Hyperalgesia; Isoenzymes; Isoxazoles; Membrane Proteins; Physical Stimulation; Prostaglandin-Endoperoxide Synthases | 2004 |
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
Topics: Adult; Analgesia; Analgesics, Opioid; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Humans; Hyperalgesia; Infusions, Intravenous; Isoxazoles; Ketamine; Male; Middle Aged; Pain Threshold; Piperidines; Remifentanil | 2006 |
Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers.
Topics: Administration, Oral; Adult; Analgesics; Aprepitant; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Electric Stimulation; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Isoxazoles; Male; Middle Aged; Morpholines; Pain Measurement; Pregabalin; Treatment Outcome | 2007 |
32 other study(ies) available for isoxazoles and Allodynia
| Article | Year |
|---|---|
Nano-Carbon-Based Application of Parecoxib Sodium Combined with Hydromorphone in Preventing Anesthesia Hyperalgesia Caused by Remifentanil after Thyroidectomy.
Topics: Analgesics, Opioid; Anesthesia; Humans; Hydromorphone; Hyperalgesia; Isoxazoles; Pain; Piperidines; Remifentanil; Thyroidectomy | 2022 |
Inhibition effect of choline and parecoxib sodium on chronic constriction nerve injury-induced neuropathic pain in rats.
Topics: Analgesics; Animals; Choline; Constriction; HMGB1 Protein; Hyperalgesia; Isoxazoles; Neuralgia; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2023 |
Parecoxib for opioid-induced hyperalgesia.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Humans; Hyperalgesia; Isoxazoles; Male; Treatment Outcome | 2021 |
Pain responses to protease-activated receptor-2 stimulation in the spinal cord of naïve and arthritic rats.
Topics: Animals; Arthritis; Dipeptides; Disease Models, Animal; Hyperalgesia; Isoxazoles; Male; Nociception; Pain Threshold; Rats, Wistar; Receptor, PAR-2; Spinal Cord | 2020 |
Change in prostaglandin signaling during sickness syndrome hyperalgesia after ovariectomy in female rats.
Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Disease Models, Animal; Estrous Cycle; Female; Guanine Nucleotide Exchange Factors; Hydrazones; Hyperalgesia; Illness Behavior; Isoquinolines; Isoxazoles; Lipopolysaccharides; Ovariectomy; Rats; Rats, Wistar; Signal Transduction; Sulfonamides | 2021 |
Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1.
Topics: Animals; Chemokine CXCL1; Glyburide; Hyperalgesia; Isoxazoles; Leflunomide; Male; Mice; Naltrexone; Neuralgia; Tumor Necrosis Factor-alpha | 2018 |
Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Astrocytes; Disease Models, Animal; Female; Ganglia, Spinal; Guanine Nucleotide Exchange Factors; Hydrazones; Hyperalgesia; Isoxazoles; Male; Mice; Mice, Knockout; Nerve Fibers; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Spinal Cord | 2018 |
Perioperative activation of spinal α7 nAChR promotes recovery from preoperative stress-induced prolongation of postsurgical pain.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Anxiety; Astrocytes; Bridged Bicyclo Compounds, Heterocyclic; Chronic Pain; Cytokines; Hyperalgesia; Isoxazoles; Male; Microglia; Nicotinic Agonists; Phenylurea Compounds; Preoperative Period; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spine; Stress, Psychological | 2019 |
Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1β, IL-6 and TNF-
Topics: Animals; Bone Neoplasms; Cancer Pain; Cyclooxygenase 2 Inhibitors; Down-Regulation; Female; Hyperalgesia; Inflammation; Interleukin-1beta; Interleukin-6; Isoxazoles; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord; Tumor Necrosis Factor-alpha | 2019 |
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Isoxazoles; Ketanserin; Male; Morphine; Ondansetron; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT3; Streptozocin; Zonisamide | 2014 |
Modulation of Nav1.8 by Lysophosphatidic Acid in the Induction of Bone Cancer Pain.
Topics: Animals; Biophysics; Bone Neoplasms; Cancer Pain; Carcinoma; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Ganglia, Spinal; Gene Expression Regulation, Neoplastic; Hyperalgesia; Isoxazoles; Lysophospholipids; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Pain Measurement; Patch-Clamp Techniques; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid | 2016 |
A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated β-Cyclodextrins.
Topics: Animals; beta-Cyclodextrins; Computer Simulation; Cyclooxygenase 2 Inhibitors; Dinoprostone; Electrophoresis, Capillary; Hyperalgesia; Inflammation; Inflammation Mediators; Isoxazoles; Male; Methylation; Pain; Pain Measurement; Pain Threshold; Postural Balance; Rats; Rats, Wistar | 2017 |
Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.
Topics: Animals; Chronic Pain; Extracellular Space; Freund's Adjuvant; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Knockout Techniques; Hyperalgesia; Inflammation; Isoxazoles; Male; Muscimol; Optogenetics; Patch-Clamp Techniques; Protein Subunits; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission; Thalamus | 2017 |
COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.
Topics: Animals; Blotting, Western; Brain; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Gene Expression Regulation, Enzymologic; Hindlimb; Hyperalgesia; Inflammation; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Zymosan | 2008 |
Ampakine therapy to counter fentanyl-induced respiratory depression.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Administration Schedule; Fentanyl; Heart Rate; Hyperalgesia; Isoxazoles; Male; Pain Measurement; Phrenic Nerve; Plethysmography; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Respiratory Insufficiency; Time Factors | 2009 |
Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats.
Topics: Analysis of Variance; Animals; CD47 Antigen; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Functional Laterality; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Injections, Spinal; Intramolecular Oxidoreductases; Isoxazoles; Lectins; Macrophage Migration-Inhibitory Factors; Male; Microglia; Mitogen-Activated Protein Kinase Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; tau Proteins; Up-Regulation | 2010 |
Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice.
Topics: Animals; Cyclophosphamide; Cystitis; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalgesia; Inflammation Mediators; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Sensory Thresholds; Urinary Bladder; Urination | 2010 |
Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Topics: Administration, Oral; Analgesics; Animals; Benzimidazoles; Biological Availability; Constriction, Pathologic; Dogs; HEK293 Cells; Humans; Hyperalgesia; In Vitro Techniques; Isoxazoles; Macaca fascicularis; Microsomes, Liver; Neuralgia; Rats; Structure-Activity Relationship; TRPM Cation Channels | 2011 |
Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.
Topics: Administration, Oral; Amides; Animals; Capsaicin; Cyclohexanols; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Isoxazoles; Microsomes, Liver; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2011 |
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.
Topics: Analgesics; Animals; Behavior, Animal; D-Amino-Acid Oxidase; Formaldehyde; Hydrogen Peroxide; Hyperalgesia; Isoxazoles; Male; Mice; Pain; Rats; Rats, Wistar; Serine; Spine | 2012 |
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicyclo Compounds; Carrageenan; Cytokines; Diclofenac; Freund's Adjuvant; Gene Expression Regulation; Hyperalgesia; Inflammation; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thiophenes | 2012 |
Contributions of spinal D-amino acid oxidase to bone cancer pain.
Topics: Analgesia; Analgesics, Opioid; Animals; Astrocytes; Bone Neoplasms; Carcinoma 256, Walker; D-Amino-Acid Oxidase; Enzyme Inhibitors; Female; Gene Expression; Hyperalgesia; Injections, Spinal; Isoxazoles; Morphine; Nerve Tissue Proteins; Pain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord; Tibia | 2012 |
The effect of systemic zonisamide (Zonegran) on thermal hyperalgesia and mechanical allodynia in rats with an experimental mononeuropathy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Constriction; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Isoxazoles; Male; Motor Activity; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Zonisamide | 2003 |
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Isoenzymes; Isoxazoles; Organic Chemicals; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Radiology; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Tumor Cells, Cultured | 2004 |
Effect of selective inhibition of cyclooxygenase-2 on lipopolysaccharide-induced hyperalgesia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Hyperalgesia; Isoenzymes; Isoxazoles; Lipopolysaccharides; Male; Mice; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar | 2004 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Endotoxins; Female; Fever; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Mice; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach | 2004 |
Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Hyperalgesia; Inflammation; Isoxazoles; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sulfonamides | 2005 |
Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Disease Models, Animal; Female; Hyperalgesia; Isoenzymes; Isoxazoles; Ketorolac; Lipopolysaccharides; Male; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Salmonella typhimurium | 2005 |
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide | 2005 |
Topical dosage form of valdecoxib: preparation and pharmacological evaluation.
Topics: Acrylic Resins; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dose-Response Relationship, Drug; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Edema; Gels; Hindlimb; Hydrogen-Ion Concentration; Hyperalgesia; Isoxazoles; Male; Ointments; Pain Measurement; Rats; Rats, Wistar; Skin Irritancy Tests; Sulfonamides; Surface Properties; Time Factors; Treatment Outcome | 2007 |
Postoperative administration of the analgesic tramadol, but not the selective cyclooxygenase-2 inhibitor parecoxib, abolishes postoperative hyperalgesia in a new model of postoperative pain in rats.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hyperalgesia; Isoxazoles; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Tramadol | 2007 |
Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cattle; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; Hyperalgesia; Inflammation; Isoxazoles; Male; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Rabbits; Rats; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Sulfonamides; Time Factors | 2008 |