Page last updated: 2024-10-30

metformin and Allodynia

metformin has been researched along with Allodynia in 22 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Research Excerpts

ExcerptRelevanceReference
"Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models."7.91Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019)
"Metformin is an oral hypoglycemic drug widely used in the management of type 2 diabetes mellitus."5.72Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production. ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022)
"Metformin is a prescription drug with a wide range of pharmacological effects, which can augment the anti-cancer efficacy of chemotherapy drugs."5.56Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia. ( Liu, Y; Xu, N; Zhou, G, 2020)
"Thus far, the treatment of painful diabetic neuropathy remains unsatisfactory."5.42Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin. ( Chen, Y; Liu, J; Ma, J; Wang, Q; Xiang, L; Yu, H, 2015)
"Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models."3.91Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019)
"Metformin could be considered as an alternative therapeutic agent for SCI, as it potentially attenuates neuroinflammation, sensory and locomotor complications of cord injury."3.88Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy. ( Afshari, K; Dehdashtian, A; Dehpour, AR; Ebrahimi, MA; Faghir-Ghanesefat, H; Haddadi, NS; Haj-Mirzaian, A; Iranmehr, A; Javidan, AN; Mohammadi, F; Rahimi, N; Tavangar, SM, 2018)
"Co-administration of pioglitazone or metformin with low-dose fluoxetine improved mechanical allodynia, thermal hyperalgesia, and neurohistopathological changes while co-administration of pioglitazone, but not metformin, improved the depressive-like behavior in the peripheral nerve injury model of neuropathic pain in rats."3.81Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats. ( Ayuob, N; Murad, H, 2015)
"Metformin is an oral hypoglycemic drug widely used in the management of type 2 diabetes mellitus."1.72Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production. ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022)
"Chemotherapy-induced neuropathic pain is a major clinical problem with limited treatment options."1.72Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn. ( Li, D; Lin, SY; Liu, M; Lv, YY; Xin, WJ; Xiong, YC; Xu, T; Zhao, YT, 2022)
"In the study of the complex etiology of neuropathic pain (NeP), male and female individuals exhibit quite different responses characterized by higher pain sensitivity and greater NeP incidence in women."1.72Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin. ( Coccurello, R; De Angelis, F; Giacovazzo, G; Marinelli, S; Pavone, F; Strimpakos, G; Tofanicchio, J; Vacca, V, 2022)
"Neuropathic pain is a common complication of diabetes mellitus with poorly relieved by conventional analgesics."1.62Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats. ( Cao, XJ; Chen, X; Qian, HY; Sun, YZ; Wu, R; Xu, GY; Zhang, PA; Zhu, HY, 2021)
"Metformin is a prescription drug with a wide range of pharmacological effects, which can augment the anti-cancer efficacy of chemotherapy drugs."1.56Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia. ( Liu, Y; Xu, N; Zhou, G, 2020)
"Metformin is a widely prescribed drug used in the treatment of type II diabetes."1.51The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice. ( Burton, MD; Dussor, G; Inyang, KE; McDougal, TA; Price, TJ; Szabo-Pardi, T; Wentworth, E, 2019)
"LDH evoked persistent thermal hyperalgesia and mechanical allodynia on the ipsilateral paw, as indicated by the decreased PWL and 50% PWT."1.51AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. ( Guo, Y; Li, H; Li, J; Li, Z; Liu, Y; Liu, Z; Shang, Y, 2019)
"Metformin was administered per os (p."1.51Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms. ( Augusto, PSA; Batista, CRA; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF, 2019)
"Metformin was the only AMPK activator to have sex-specific effects."1.51Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice. ( Burton, MD; Dussor, G; Inyang, KE; McDougal, TA; Pradhan, G; Price, TJ; Ramirez, ED; Szabo-Pardi, T; Wentworth, E, 2019)
"Von Frey filaments were used to assess tactile allodynia."1.48Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018)
"Metformin is a widely used and safe antidiabetic drug that has recently been shown to possess analgesic properties in models of inflammatory pain."1.46Metformin Synergizes With Conventional and Adjuvant Analgesic Drugs to Reduce Inflammatory Hyperalgesia in Rats. ( Micov, AM; Pecikoza, UB; Stepanović-Petrović, RM; Tomić, MA, 2017)
"Thus far, the treatment of painful diabetic neuropathy remains unsatisfactory."1.42Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin. ( Chen, Y; Liu, J; Ma, J; Wang, Q; Xiang, L; Yu, H, 2015)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's16 (72.73)24.3611
2020's6 (27.27)2.80

Authors

AuthorsStudies
Cao, XJ1
Wu, R1
Qian, HY1
Chen, X1
Zhu, HY1
Xu, GY1
Sun, YZ1
Zhang, PA1
Augusto, PSA2
Matsui, TC1
Braga, AV2
Rodrigues, FF2
Morais, MI2
Dutra, MMGB2
Batista, CRA2
Melo, ISF2
Costa, SOAM2
Bertollo, CM1
Coelho, MM2
Machado, RR2
Liu, M1
Zhao, YT1
Lv, YY1
Xu, T1
Li, D1
Xiong, YC1
Xin, WJ1
Lin, SY1
De Angelis, F2
Vacca, V2
Tofanicchio, J2
Strimpakos, G2
Giacovazzo, G2
Pavone, F2
Coccurello, R2
Marinelli, S2
Pușcașu, C1
Ungurianu, A1
Șeremet, OC1
Andrei, C1
Mihai, DP1
Negreș, S1
Liu, Y2
Zhou, G1
Xu, N1
Burton, MD3
Tillu, DV1
Mazhar, K1
Mejia, GL1
Asiedu, MN1
Inyang, K1
Hughes, T1
Lian, B1
Dussor, G3
Price, TJ5
Raafat, K1
El-Lakany, A1
Barragán-Iglesias, P1
Oidor-Chan, VH1
Loeza-Alcocer, E1
Pineda-Farias, JB1
Velazquez-Lagunas, I1
Salinas-Abarca, AB1
Hong, E1
Sánchez-Mendoza, A1
Delgado-Lezama, R1
Granados-Soto, V1
Afshari, K1
Dehdashtian, A1
Haddadi, NS1
Haj-Mirzaian, A1
Iranmehr, A1
Ebrahimi, MA1
Tavangar, SM1
Faghir-Ghanesefat, H1
Mohammadi, F1
Rahimi, N1
Javidan, AN1
Dehpour, AR1
Nozu, T1
Miyagishi, S1
Kumei, S1
Nozu, R1
Takakusaki, K1
Okumura, T1
Inyang, KE2
Szabo-Pardi, T2
Wentworth, E2
McDougal, TA2
Li, J1
Li, H1
Shang, Y1
Guo, Y1
Li, Z1
Liu, Z1
Goulart, FA1
Ramirez, ED1
Pradhan, G1
Russe, OQ1
Möser, CV1
Kynast, KL1
King, TS1
Stephan, H1
Geisslinger, G1
Niederberger, E1
Mao-Ying, QL1
Kavelaars, A2
Krukowski, K1
Huo, XJ1
Zhou, W2
Cleeland, C1
Heijnen, CJ2
Ma, J1
Yu, H1
Liu, J1
Chen, Y1
Wang, Q1
Xiang, L1
Murad, H1
Ayuob, N1
Pecikoza, UB1
Tomić, MA1
Micov, AM1
Stepanović-Petrović, RM1
Guzmán-Priego, CG1
Méndez-Mena, R1
Baños-González, MA1
Araiza-Saldaña, CI1
Castañeda-Corral, G1
Torres-López, JE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN)[NCT04780854]Phase 268 participants (Anticipated)Interventional2020-11-03Recruiting
Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients[NCT04089813]200 participants (Anticipated)Observational2019-09-10Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

22 other studies available for metformin and Allodynia

ArticleYear
Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats.
    Brain research, 2021, 12-01, Volume: 1772

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental;

2021
Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.
    Inflammopharmacology, 2022, Volume: 30, Issue:1

    Topics: Adenosine Triphosphate; Animals; Carrageenan; Diabetes Mellitus, Type 2; Disease Models, Animal; Ede

2022
Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn.
    Neurochemical research, 2022, Volume: 47, Issue:7

    Topics: Animals; Autophagy; Beclin-1; Bortezomib; Hyperalgesia; Metformin; Neuralgia; Rats; RNA, Small Inter

2022
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
    International journal of molecular sciences, 2022, Nov-22, Volume: 23, Issue:23

    Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu

2022
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
    International journal of molecular sciences, 2022, Nov-22, Volume: 23, Issue:23

    Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu

2022
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
    International journal of molecular sciences, 2022, Nov-22, Volume: 23, Issue:23

    Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu

2022
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
    International journal of molecular sciences, 2022, Nov-22, Volume: 23, Issue:23

    Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu

2022
The Influence of Sildenafil-Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice.
    Medicina (Kaunas, Lithuania), 2023, Jul-27, Volume: 59, Issue:8

    Topics: Animals; Biomarkers; Diabetes Mellitus; Diabetic Neuropathies; Hyperalgesia; Hypoglycemic Agents; In

2023
Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia.
    Journal of nanoscience and nanotechnology, 2020, 10-01, Volume: 20, Issue:10

    Topics: Animals; Carrier Proteins; Hyperalgesia; Metformin; Mice; Nanoparticles; Neuralgia; Oxaliplatin; Thi

2020
Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice.
    Neuroscience, 2017, 09-17, Volume: 359

    Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Cells, Cultured; Ganglia, Spinal; Hyperalgesia;

2017
Combination of Rheum ribes and Metformin Against Diabetes, Thermal Hyperalgesia, and Tactile Allodynia in a Mice Model.
    Alternative therapies in health and medicine, 2018, Volume: 24, Issue:5

    Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypera

2018
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:2

    Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy

2018
Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy.
    Spinal cord, 2018, Volume: 56, Issue:11

    Topics: Animals; Central Nervous System Agents; Disease Models, Animal; Hyperalgesia; Inflammation; Locomoti

2018
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
    Journal of gastroenterology and hepatology, 2019, Volume: 34, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Colon; Disease Models, Animal; Domperidone; Dopamine Antagon

2019
The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice.
    Pharmacological research, 2019, Volume: 139

    Topics: Animals; Cold Temperature; Female; Ganglia, Spinal; Hyperalgesia; Hypoglycemic Agents; Male; Metform

2019
AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model.
    Spine, 2019, Aug-01, Volume: 44, Issue:15

    Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Inter

2019
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
    European journal of pharmacology, 2019, Sep-05, Volume: 858

    Topics: Analgesics; Animals; Disease Models, Animal; Female; Glyburide; Hyperalgesia; Metformin; Mice; Naltr

2019
Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice.
    The Journal of pharmacology and experimental therapeutics, 2019, Volume: 371, Issue:1

    Topics: Allosteric Regulation; Amaryllidaceae Alkaloids; AMP-Activated Protein Kinase Kinases; Animals; Benz

2019
Activation of the AMP-activated protein kinase reduces inflammatory nociception.
    The journal of pain, 2013, Volume: 14, Issue:11

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Behavior, Animal; Enzyme Activat

2013
The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Animals; Cisplatin; Disease Models, Animal; Hyperalgesia; Hypoglycemic Agents; Metformin; Mice, Inbr

2014
Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin.
    European journal of pharmacology, 2015, Oct-05, Volume: 764

    Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzy

2015
Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats.
    Pain physician, 2015, Volume: 18, Issue:6

    Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Chronic Pain; Constriction, Pathologi

2015
Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Animals; Behavior, Animal; Brain; Brain Injuries; Cisplatin; Cognition Disorders; Disease Models, An

2016
Metformin Synergizes With Conventional and Adjuvant Analgesic Drugs to Reduce Inflammatory Hyperalgesia in Rats.
    Anesthesia and analgesia, 2017, Volume: 124, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotherapy, Adjuvant; Drug Synergism

2017
Antihyperalgesic Effects of Indomethacin, Ketorolac, and Metamizole in Rats: Effects of Metformin.
    Drug development research, 2017, Volume: 78, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dipyrone; Dose-Response Relationship,

2017