metformin has been researched along with Allodynia in 22 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models." | 7.91 | Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019) |
| "Metformin is an oral hypoglycemic drug widely used in the management of type 2 diabetes mellitus." | 5.72 | Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production. ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022) |
| "Metformin is a prescription drug with a wide range of pharmacological effects, which can augment the anti-cancer efficacy of chemotherapy drugs." | 5.56 | Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia. ( Liu, Y; Xu, N; Zhou, G, 2020) |
| "Thus far, the treatment of painful diabetic neuropathy remains unsatisfactory." | 5.42 | Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin. ( Chen, Y; Liu, J; Ma, J; Wang, Q; Xiang, L; Yu, H, 2015) |
| "Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models." | 3.91 | Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019) |
| "Metformin could be considered as an alternative therapeutic agent for SCI, as it potentially attenuates neuroinflammation, sensory and locomotor complications of cord injury." | 3.88 | Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy. ( Afshari, K; Dehdashtian, A; Dehpour, AR; Ebrahimi, MA; Faghir-Ghanesefat, H; Haddadi, NS; Haj-Mirzaian, A; Iranmehr, A; Javidan, AN; Mohammadi, F; Rahimi, N; Tavangar, SM, 2018) |
| "Co-administration of pioglitazone or metformin with low-dose fluoxetine improved mechanical allodynia, thermal hyperalgesia, and neurohistopathological changes while co-administration of pioglitazone, but not metformin, improved the depressive-like behavior in the peripheral nerve injury model of neuropathic pain in rats." | 3.81 | Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats. ( Ayuob, N; Murad, H, 2015) |
| "Metformin is an oral hypoglycemic drug widely used in the management of type 2 diabetes mellitus." | 1.72 | Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production. ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022) |
| "Chemotherapy-induced neuropathic pain is a major clinical problem with limited treatment options." | 1.72 | Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn. ( Li, D; Lin, SY; Liu, M; Lv, YY; Xin, WJ; Xiong, YC; Xu, T; Zhao, YT, 2022) |
| "In the study of the complex etiology of neuropathic pain (NeP), male and female individuals exhibit quite different responses characterized by higher pain sensitivity and greater NeP incidence in women." | 1.72 | Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin. ( Coccurello, R; De Angelis, F; Giacovazzo, G; Marinelli, S; Pavone, F; Strimpakos, G; Tofanicchio, J; Vacca, V, 2022) |
| "Neuropathic pain is a common complication of diabetes mellitus with poorly relieved by conventional analgesics." | 1.62 | Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats. ( Cao, XJ; Chen, X; Qian, HY; Sun, YZ; Wu, R; Xu, GY; Zhang, PA; Zhu, HY, 2021) |
| "Metformin is a prescription drug with a wide range of pharmacological effects, which can augment the anti-cancer efficacy of chemotherapy drugs." | 1.56 | Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia. ( Liu, Y; Xu, N; Zhou, G, 2020) |
| "Metformin is a widely prescribed drug used in the treatment of type II diabetes." | 1.51 | The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice. ( Burton, MD; Dussor, G; Inyang, KE; McDougal, TA; Price, TJ; Szabo-Pardi, T; Wentworth, E, 2019) |
| "LDH evoked persistent thermal hyperalgesia and mechanical allodynia on the ipsilateral paw, as indicated by the decreased PWL and 50% PWT." | 1.51 | AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. ( Guo, Y; Li, H; Li, J; Li, Z; Liu, Y; Liu, Z; Shang, Y, 2019) |
| "Metformin was administered per os (p." | 1.51 | Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms. ( Augusto, PSA; Batista, CRA; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF, 2019) |
| "Metformin was the only AMPK activator to have sex-specific effects." | 1.51 | Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice. ( Burton, MD; Dussor, G; Inyang, KE; McDougal, TA; Pradhan, G; Price, TJ; Ramirez, ED; Szabo-Pardi, T; Wentworth, E, 2019) |
| "Von Frey filaments were used to assess tactile allodynia." | 1.48 | Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018) |
| "Metformin is a widely used and safe antidiabetic drug that has recently been shown to possess analgesic properties in models of inflammatory pain." | 1.46 | Metformin Synergizes With Conventional and Adjuvant Analgesic Drugs to Reduce Inflammatory Hyperalgesia in Rats. ( Micov, AM; Pecikoza, UB; Stepanović-Petrović, RM; Tomić, MA, 2017) |
| "Thus far, the treatment of painful diabetic neuropathy remains unsatisfactory." | 1.42 | Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin. ( Chen, Y; Liu, J; Ma, J; Wang, Q; Xiang, L; Yu, H, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (72.73) | 24.3611 |
| 2020's | 6 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, XJ | 1 |
| Wu, R | 1 |
| Qian, HY | 1 |
| Chen, X | 1 |
| Zhu, HY | 1 |
| Xu, GY | 1 |
| Sun, YZ | 1 |
| Zhang, PA | 1 |
| Augusto, PSA | 2 |
| Matsui, TC | 1 |
| Braga, AV | 2 |
| Rodrigues, FF | 2 |
| Morais, MI | 2 |
| Dutra, MMGB | 2 |
| Batista, CRA | 2 |
| Melo, ISF | 2 |
| Costa, SOAM | 2 |
| Bertollo, CM | 1 |
| Coelho, MM | 2 |
| Machado, RR | 2 |
| Liu, M | 1 |
| Zhao, YT | 1 |
| Lv, YY | 1 |
| Xu, T | 1 |
| Li, D | 1 |
| Xiong, YC | 1 |
| Xin, WJ | 1 |
| Lin, SY | 1 |
| De Angelis, F | 2 |
| Vacca, V | 2 |
| Tofanicchio, J | 2 |
| Strimpakos, G | 2 |
| Giacovazzo, G | 2 |
| Pavone, F | 2 |
| Coccurello, R | 2 |
| Marinelli, S | 2 |
| Pușcașu, C | 1 |
| Ungurianu, A | 1 |
| Șeremet, OC | 1 |
| Andrei, C | 1 |
| Mihai, DP | 1 |
| Negreș, S | 1 |
| Liu, Y | 2 |
| Zhou, G | 1 |
| Xu, N | 1 |
| Burton, MD | 3 |
| Tillu, DV | 1 |
| Mazhar, K | 1 |
| Mejia, GL | 1 |
| Asiedu, MN | 1 |
| Inyang, K | 1 |
| Hughes, T | 1 |
| Lian, B | 1 |
| Dussor, G | 3 |
| Price, TJ | 5 |
| Raafat, K | 1 |
| El-Lakany, A | 1 |
| Barragán-Iglesias, P | 1 |
| Oidor-Chan, VH | 1 |
| Loeza-Alcocer, E | 1 |
| Pineda-Farias, JB | 1 |
| Velazquez-Lagunas, I | 1 |
| Salinas-Abarca, AB | 1 |
| Hong, E | 1 |
| Sánchez-Mendoza, A | 1 |
| Delgado-Lezama, R | 1 |
| Granados-Soto, V | 1 |
| Afshari, K | 1 |
| Dehdashtian, A | 1 |
| Haddadi, NS | 1 |
| Haj-Mirzaian, A | 1 |
| Iranmehr, A | 1 |
| Ebrahimi, MA | 1 |
| Tavangar, SM | 1 |
| Faghir-Ghanesefat, H | 1 |
| Mohammadi, F | 1 |
| Rahimi, N | 1 |
| Javidan, AN | 1 |
| Dehpour, AR | 1 |
| Nozu, T | 1 |
| Miyagishi, S | 1 |
| Kumei, S | 1 |
| Nozu, R | 1 |
| Takakusaki, K | 1 |
| Okumura, T | 1 |
| Inyang, KE | 2 |
| Szabo-Pardi, T | 2 |
| Wentworth, E | 2 |
| McDougal, TA | 2 |
| Li, J | 1 |
| Li, H | 1 |
| Shang, Y | 1 |
| Guo, Y | 1 |
| Li, Z | 1 |
| Liu, Z | 1 |
| Goulart, FA | 1 |
| Ramirez, ED | 1 |
| Pradhan, G | 1 |
| Russe, OQ | 1 |
| Möser, CV | 1 |
| Kynast, KL | 1 |
| King, TS | 1 |
| Stephan, H | 1 |
| Geisslinger, G | 1 |
| Niederberger, E | 1 |
| Mao-Ying, QL | 1 |
| Kavelaars, A | 2 |
| Krukowski, K | 1 |
| Huo, XJ | 1 |
| Zhou, W | 2 |
| Cleeland, C | 1 |
| Heijnen, CJ | 2 |
| Ma, J | 1 |
| Yu, H | 1 |
| Liu, J | 1 |
| Chen, Y | 1 |
| Wang, Q | 1 |
| Xiang, L | 1 |
| Murad, H | 1 |
| Ayuob, N | 1 |
| Pecikoza, UB | 1 |
| Tomić, MA | 1 |
| Micov, AM | 1 |
| Stepanović-Petrović, RM | 1 |
| Guzmán-Priego, CG | 1 |
| Méndez-Mena, R | 1 |
| Baños-González, MA | 1 |
| Araiza-Saldaña, CI | 1 |
| Castañeda-Corral, G | 1 |
| Torres-López, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN)[NCT04780854] | Phase 2 | 68 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | ||
| Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients[NCT04089813] | 200 participants (Anticipated) | Observational | 2019-09-10 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
22 other studies available for metformin and Allodynia
| Article | Year |
|---|---|
Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; | 2021 |
Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.
Topics: Adenosine Triphosphate; Animals; Carrageenan; Diabetes Mellitus, Type 2; Disease Models, Animal; Ede | 2022 |
Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn.
Topics: Animals; Autophagy; Beclin-1; Bortezomib; Hyperalgesia; Metformin; Neuralgia; Rats; RNA, Small Inter | 2022 |
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu | 2022 |
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu | 2022 |
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu | 2022 |
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu | 2022 |
The Influence of Sildenafil-Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice.
Topics: Animals; Biomarkers; Diabetes Mellitus; Diabetic Neuropathies; Hyperalgesia; Hypoglycemic Agents; In | 2023 |
Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia.
Topics: Animals; Carrier Proteins; Hyperalgesia; Metformin; Mice; Nanoparticles; Neuralgia; Oxaliplatin; Thi | 2020 |
Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; | 2017 |
Combination of Rheum ribes and Metformin Against Diabetes, Thermal Hyperalgesia, and Tactile Allodynia in a Mice Model.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypera | 2018 |
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy | 2018 |
Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy.
Topics: Animals; Central Nervous System Agents; Disease Models, Animal; Hyperalgesia; Inflammation; Locomoti | 2018 |
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
Topics: AMP-Activated Protein Kinases; Animals; Colon; Disease Models, Animal; Domperidone; Dopamine Antagon | 2019 |
The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice.
Topics: Animals; Cold Temperature; Female; Ganglia, Spinal; Hyperalgesia; Hypoglycemic Agents; Male; Metform | 2019 |
AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Inter | 2019 |
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Glyburide; Hyperalgesia; Metformin; Mice; Naltr | 2019 |
Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice.
Topics: Allosteric Regulation; Amaryllidaceae Alkaloids; AMP-Activated Protein Kinase Kinases; Animals; Benz | 2019 |
Activation of the AMP-activated protein kinase reduces inflammatory nociception.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Behavior, Animal; Enzyme Activat | 2013 |
The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.
Topics: Animals; Cisplatin; Disease Models, Animal; Hyperalgesia; Hypoglycemic Agents; Metformin; Mice, Inbr | 2014 |
Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzy | 2015 |
Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Chronic Pain; Constriction, Pathologi | 2015 |
Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice.
Topics: Animals; Behavior, Animal; Brain; Brain Injuries; Cisplatin; Cognition Disorders; Disease Models, An | 2016 |
Metformin Synergizes With Conventional and Adjuvant Analgesic Drugs to Reduce Inflammatory Hyperalgesia in Rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotherapy, Adjuvant; Drug Synergism | 2017 |
Antihyperalgesic Effects of Indomethacin, Ketorolac, and Metamizole in Rats: Effects of Metformin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dipyrone; Dose-Response Relationship, | 2017 |