Page last updated: 2024-12-04

(alpha-carboxycyclopropyl)glycine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

**(alpha-Carboxycyclopropyl)glycine** is a non-proteinogenic amino acid, meaning it's not naturally found in proteins. It's a unique molecule with a cyclopropane ring attached to the alpha-carbon of glycine, giving it interesting structural and chemical properties.

Here's why it's important for research:

* **Probing protein structure and function:** The unique shape of the cyclopropyl ring allows it to act as a probe for studying protein structure and function. This amino acid can be incorporated into proteins through genetic code expansion techniques. By monitoring the effects of its presence on protein folding, stability, and activity, researchers can gain valuable insights into the structure-function relationships of proteins.

* **Developing new drugs and therapeutic agents:** The non-natural structure of (alpha-carboxycyclopropyl)glycine can be exploited to create novel drugs and therapeutic agents. Its unusual chemical properties might allow it to bind to specific protein targets with high affinity, potentially leading to the development of new treatments for diseases.

* **Exploring chemical synthesis and catalysis:** The synthesis of this amino acid involves interesting synthetic strategies. The cyclopropane ring can also be used as a platform to create catalysts for various chemical reactions.

**Current research focus on (alpha-carboxycyclopropyl)glycine:**

* **Incorporation into peptides and proteins:** Researchers are actively developing methods to efficiently incorporate this amino acid into peptides and proteins, using genetic code expansion techniques.
* **Exploring its effect on protein stability and function:** Studies are ongoing to investigate how the presence of (alpha-carboxycyclopropyl)glycine influences the folding, stability, and activity of proteins.
* **Developing new drug candidates:** Researchers are exploring the potential of (alpha-carboxycyclopropyl)glycine as a scaffold for developing novel drug candidates for various diseases.

Overall, (alpha-carboxycyclopropyl)glycine is a promising molecule with a wide range of potential applications in research areas related to protein structure, function, and drug discovery. Its unique structural features and chemical properties make it a valuable tool for advancing our understanding of biological processes and developing new therapeutic strategies.

(alpha-carboxycyclopropyl)glycine: structure given in first source; glutamate receptor agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1271
CHEBI ID173420
SCHEMBL ID10379762
MeSH IDM0108181

Synonyms (26)

Synonym
CHEBI:173420
l-trans-alpha-amino-2-carboxycyclopropaneacetic acid
22255-17-0
2-[amino(carboxy)methyl]cyclopropane-1-carboxylic acid
PDSP2_000797
PDSP1_000810
(alpha-carboxycyclopropyl)glycine
ccpg
alpha-amino-2-carboxycyclopropaneacetic acid
alpha-(carboxycyclopropyl)glycine
l-2-(carboxypropyl)glycine
cyclopropaneacetic acid, alpha-amino-2-carboxy-
3,4-cyclopropylglutamate
L000347
FT-0694129
117857-95-1
cyclopropaneaceticacid, a-amino-2-carboxy-
SCHEMBL10379762
l-ccg iii
l-ccg i
2-(amino(carboxy)methyl)cyclopropanecarboxylic acid
GZOVEPYOCJWRFC-UHFFFAOYSA-N
AKOS030592508
DTXSID20944912
2-[amino(carboxy)methyl]cyclopropanecarboxylic acid
2-(amino(carboxy)methyl)cyclopropane-1-carboxylic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
alpha-amino acidAn amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (93)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (3.23)18.7374
1990's52 (55.91)18.2507
2000's31 (33.33)29.6817
2010's6 (6.45)24.3611
2020's1 (1.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.37 (24.57)
Research Supply Index4.56 (2.92)
Research Growth Index5.93 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (2.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other93 (97.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]