Page last updated: 2024-10-27

fp 83 and Allodynia

fp 83 has been researched along with Allodynia in 2 studies

FP 83: structure given in first source

Research Excerpts

ExcerptRelevanceReference
"Postoperative pain was managed by sufentanil titration in the postanesthetic care unit, followed by sufentanil infusion via patient-controlled analgesia."2.84Preoperative But Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil-induced Hyperalgesia After Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial. ( Li, Y; Shu, R; Wang, C; Wang, G; Wang, H; Yu, Y; Zhang, L; Zhao, Q, 2017)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, L2
Shu, R2
Zhao, Q2
Li, Y2
Wang, C1
Wang, H1
Yu, Y2
Wang, G2

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Postoperative Hyperalgesia Induced by Remifentanil in Patients Undergoing Lower Abdomimal Surgery[NCT02043366]180 participants (Actual)Interventional2014-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Mechanical Hyperalgesia Threshold on the Dominant Inner Forearm

The mechanical hyperalgesia threshold was defined as the lowest force (g) necessary to bend a Von Frey filament, which was perceived to be painful by the patient and measured by Von Frey filament at 24 hours postoperatively (NCT02043366)
Timeframe: 24 hours after surgery

Interventiong (Mean)
Normal Saline60.57
Flurbiprofen AxetilⅠ78.29
Flurbiprofen AxetilⅡ68.50
Butorphanol79.7
Butorphanol-Flurbiprofen Axetil81.64
Sufentanil89.5

Normalized Area of Hyperalgesia Around the Incision

The skin around the incision is stimulated in steps of 5 mm at intervals of 1 s starting outside of the hyperalgesic area in the direction of the incision. The distance from the incision to the first point where a 'painful', 'sore' or 'sharper' feeling occurred is measured and noted. This measurement is repeated at predefined radial lines around the incision. To eliminate the variable length of incision, this length is subtracted from the longer diameter leaving four radial distances from the end and from the middle of the incision. The normalized area of hyperalgesia is calculated by summing up the areas of the remaining four triangles measured by and Von Frey filament. (NCT02043366)
Timeframe: 24 hours after surgery

Interventioncm^2 (Mean)
Normal Saline60.46
Flurbiprofen AxetilⅠ53.64
Flurbiprofen AxetilⅡ56.57
Butorphanol54.00
Butorphanol-Flurbiprofen Axetil52.5
Sufentanil49.89

Trials

2 trials available for fp 83 and Allodynia

ArticleYear
Preoperative But Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil-induced Hyperalgesia After Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial.
    The Clinical journal of pain, 2017, Volume: 33, Issue:5

    Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Female

2017
Preoperative butorphanol and flurbiprofen axetil therapy attenuates remifentanil-induced hyperalgesia after laparoscopic gynaecological surgery: a randomized double-blind controlled trial.
    British journal of anaesthesia, 2016, Volume: 117, Issue:4

    Topics: Adult; Butorphanol; Double-Blind Method; Drug Therapy, Combination; Female; Flurbiprofen; Gynecologi

2016