| Assay ID | Title | Year | Journal | Article |
|---|
| AID408640 | Inhibition of CYP2D6 | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID619917 | Binding affinity to human recombinant DAAO assessed as drug-enzyme complex half life | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID620008 | Volume of distribution in Swiss mouse plasma at 1 mg/kg, iv | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID620082 | Plasma clearance in Swiss mouse plasma at 1 mg/kg, iv | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619919 | Octanol-water partition coefficient, log P of the neutral compound by pH-metric method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619910 | Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescence assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID726206 | Effect on L-alanine level in G418-resistant HEK293 cells at 17 uM by HPLC analysis relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID619916 | Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp technique | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID371729 | Binding affinity to biotinylated human recombinant DAAO by Biacore assay | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID371709 | Inhibition of rat recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID408637 | Inhibition of human DAO | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID408643 | Ex vivo inhibition of DAO in ip dosed rat kidney | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID371708 | Inhibition of human recombinant DDO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID620004 | Terminal half life in Swiss mouse brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID726215 | Inhibition of human recombinant N-terminal His-tagged DAO Y224F mutant expressed in Escherichia coli BL21(DE3) using D-alanine as substrate after 10 mins by Lineweaver-Burk plot analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID619992 | Ratio of drug level (0 to last) in brain to plasma in Swiss mouse at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619913 | Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID371722 | Fraction unbound in Sprague-Dawley CD rat plasma at 10 mg/kg, sc after 4 hrs | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID620000 | Tmax in Swiss mouse brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID726221 | Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by colorimetric assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID371725 | Fraction unbound in Sprague-Dawley CD rat brain at 10 mg/kg, sc after 4 hrs | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID619918 | Dissociation constant, pKa of the compound by dip probe absorption spectroscopy technique | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID371707 | Inhibition of human recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID726209 | Inhibition of human recombinant DAO expressed in G418-resistant HEK293/NEO cells assessed as effect on D-alanine level at 17 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID619986 | AUC (0 to last) in Wistar rat brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID408642 | Increase in D-serine level in ip dosed rat plasma after 4 to 24 hrs | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID619921 | Thermodynamic solubility of the compound in phosphate buffer at pH 7.4 after 24 hrs by HPLC analysis | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID726213 | Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by Lineweaver-Burk plot analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID619998 | Tmax in Wistar rat brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID408644 | Ex vivo inhibition of DAO in ip dosed rat cerebellum | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID619923 | Kinetic solubility of the compound in 0.01 M phosphate buffered saline at pH 7.4 assessed as maximum solubility after 2 hrs | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619982 | Cmax in Wistar rat brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID726222 | Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID726207 | Effect on L-alanine level in G418-resistant HEK293/NEO cells at 17 uM by HPLC analysis relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID726214 | Inhibition of human recombinant N-terminal His-tagged DAO Y224A mutant expressed in Escherichia coli BL21(DE3) using D-alanine as substrate after 10 mins by Lineweaver-Burk plot analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID371724 | Drug level in Sprague-Dawley CD rat brain at 10 mg/kg, sc after 4 hrs | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID620002 | Terminal half life in Wistar rat brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619996 | Oral bioavailability (0 to last) in Swiss mouse plasma at 10 mg/kg | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID371730 | Dissociation constant, pKa of the compound | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID726220 | Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID371723 | Free plasma concentration in Sprague-Dawley CD rat at 10 mg/kg, sc after 4 hrs | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID619988 | AUC (0 to last) in Swiss mouse brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID726223 | Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID619914 | Binding affinity to human recombinant DAAO by steady state study scintillation proximity assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619990 | Ratio of drug level (0 to last) in brain to plasma in Wistar rat at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID726217 | Binding affinity to human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) at 200 uM after 2 to 30 mins by absorption spectra analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID619922 | Kinetic solubility of the compound in 0.01 M phosphate buffered saline at pH 7.4 assessed as minimum solubility after 2 hrs | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID726216 | Competitive inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by Lineweaver-Burk plot analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID408638 | Inhibition of human DDO | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID371727 | Ratio of drug level in brain to plasma in Sprague-Dawley CD rat at 10 mg/kg, sc after 4 hrs | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID619984 | Cmax in Swiss mouse brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID371728 | Selectivity ratio of IC50 for rat DAAO to IC50 for human DAAO | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID619920 | Octanol-water partition coefficient, log P of the anionic compound by pH-metric method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID371721 | Plasma concentration in Sprague-Dawley CD rat at 10 mg/kg, sc after 4 hrs | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID726208 | Inhibition of N-terminal HA-tagged human recombinant DAO overexpressed in HEK293 cells assessed as increase in D-alanine levels at 17 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to vehicle-treated c | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID408639 | Inhibition of CYP3A4 | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID619994 | Oral bioavailability (0 to last) in Wistar rat plasma at 10 mg/kg | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID620006 | Volume of distribution in Wistar rat plasma at 1 mg/kg, iv | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID371726 | Free drug level in Sprague-Dawley CD rat brain at 10 mg/kg, sc after 4 hrs | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID620010 | Plasma clearance in Wistar rat plasma at 1 mg/kg, iv | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID408645 | Ex vivo inhibition of DAO in rat cerebellum at 25 mg/kg, ip after 1 hr | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID619915 | Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID408641 | Inhibition of CYP3C9 | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID619912 | Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysis | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID1799106 | DAAO in Vitro Activity Assay from Article 10.1021/jm900128w: \\Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.\\ | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID1799107 | Biacore Binding of DAAO Inhibitors from Article 10.1021/jm900128w: \\Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.\\ | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |