Page last updated: 2024-10-23

baclofen and Allodynia

baclofen has been researched along with Allodynia in 26 studies

Research Excerpts

ExcerptRelevanceReference
" Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia."3.79Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. ( Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A, 2013)
"Specifically, postsurgical pain continues to be a frequent and undermanaged condition."1.51Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. ( Alewood, PF; Cheneval, O; Dekan, Z; Deuis, JR; Morgan, M; Mueller, A; Schroeder, CI; Starobova, H; Vetter, I, 2019)
"These phases of neuropathic pain involve changes in the GABAergic control of descending pathways that travel through the dorsolateral funiculus (DLF)."1.43The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats. ( Dias, QM; Prado, WA, 2016)
"It may be associated with allodynia and increased pain sensitivity."1.40Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. ( Caffino, L; Castelnovo, LF; Cavalli, E; Colciago, A; Faroni, A; Magnaghi, V; Pajardi, G; Procacci, P, 2014)
"The induction of hyperalgesia by co-exposure to MFs and diazepam was also blocked by flumazenil."1.33Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields. ( Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD, 2005)
"Mechanical allodynia was maximal by 1 week and persisted at blunted levels for at least 18 weeks after injury."1.33Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat. ( Bettler, B; Engle, MP; Gassman, M; Hammond, DL; Sykes, KT, 2006)
"Secondary hyperalgesia in the monoarthritic rat is accompanied by a decrease in nociceptive activation of spinal neurons expressing GABA(B) receptors and by the opposite effect in the cells expressing neurokinin 1 (NK1)-receptors."1.33Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behavior and c-fos study. ( Castro, AR; Lima, D; Pinto, M; Tavares, I, 2006)
"0 microg) were administered to obtain the dose-response curve and the 50% effective dose (ED(50))."1.31The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury. ( Choi, IC; Han, SM; Hwang, JH; Hwang, KS; Kim, JU; Park, PH, 2001)
"These data also suggest that the hyperalgesia produced by high doses of baclofen does not result from disinhibition of a serotonergic pain facilitatory pathway, but rather from direct inhibition of tonically-active pain inhibitory neurons in the NRM and NGCpalpha."1.30Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat. ( Hammond, DL; Nelson, V; Thomas, DA, 1998)
"Rats developed mechanical hyperalgesia as soon as 2 weeks after STZ injection."1.30A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats. ( Malcangio, M; Tomlinson, DR, 1998)
"Diabetic animals displayed marked mechanical hyperalgesia, and some thermal hypoalgesia."1.30Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat. ( Eastwood, C; Fox, A; Gentry, C; Manning, D; Urban, L, 1999)
"Morphine pre-treatment was less effective in preventing development of hyperalgesia; however, whilst the ipsilateral (146 +/- 18 g) paw withdrawal threshold tended to be lower than the contralateral (183 +/- 8 g), this was not significant."1.29Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat. ( Birch, PJ; Elliott, PJ; Harrison, SM; Smith, GD; Wiseman, J, 1993)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (23.08)18.2507
2000's10 (38.46)29.6817
2010's9 (34.62)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Nieto, FR1
Cobos, EJ1
Entrena, JM1
Parra, A1
García-Granados, A1
Baeyens, JM1
Zhang, Y1
Yang, J1
Sevilla, A1
Weller, R1
Wu, J1
Su, C1
Zheng, C1
Rodriguez-Blanco, YF1
Gitlin, M1
Candiotti, KA1
Kopsky, DJ1
Keppel Hesselink, JM1
Migita, K1
Matsuzaki, Y1
Koga, K1
Matsumoto, T1
Mishima, K1
Hara, S1
Honda, K1
Mueller, A1
Starobova, H1
Morgan, M1
Dekan, Z1
Cheneval, O1
Schroeder, CI1
Alewood, PF1
Deuis, JR1
Vetter, I1
Magnaghi, V1
Castelnovo, LF1
Faroni, A1
Cavalli, E1
Caffino, L1
Colciago, A1
Procacci, P1
Pajardi, G1
Dias, QM1
Prado, WA1
Landry, M1
Nagy, F1
Lee, IO1
Son, JK1
Lim, ES1
Kim, YS1
Reichl, S1
Augustin, M1
Zahn, PK1
Pogatzki-Zahn, EM1
Barchini, J1
Tchachaghian, S1
Shamaa, F1
Jabbur, SJ1
Meyerson, BA1
Song, Z1
Linderoth, B1
Saadé, NE1
Jasmin, L1
Rabkin, SD1
Granato, A1
Boudah, A1
Ohara, PT1
Liu, J1
Wolfe, D1
Hao, S1
Huang, S1
Glorioso, JC1
Mata, M1
Fink, DJ1
Jeong, JH1
Choi, KB1
Moon, NJ1
Park, ES1
Sohn, UD1
Akada, Y1
Mori, R1
Kato, Y1
Yamasaki, F1
Mochizuki, H1
Engle, MP1
Gassman, M1
Sykes, KT1
Bettler, B2
Hammond, DL3
Castro, AR1
Pinto, M1
Lima, D1
Tavares, I1
Thomas, DA2
McGowan, MK1
Smith, GD2
Harrison, SM2
Birch, PJ2
Elliott, PJ2
Malcangio, M2
Bowery, NG1
Wiseman, J1
Nelson, V1
Tomlinson, DR1
Fox, A3
Eastwood, C1
Gentry, C2
Manning, D1
Urban, L3
Patel, S1
Naeem, S1
Kesingland, A1
Froestl, W2
Capogna, M1
Schuler, V1
Lüscher, C1
Blanchet, C1
Klix, N1
Sansig, G1
Klebs, K1
Schmutz, M1
Heid, J1
Spooren, W1
Jaton, AL1
Vigouret, J1
Pozza, M1
Kelly, PH1
Mosbacher, J1
Käslin, E1
Korn, R1
Bischoff, S1
Kaupmann, K1
van der Putten, H1
Hwang, JH1
Hwang, KS1
Kim, JU1
Choi, IC1
Park, PH1
Han, SM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815]Phase 1/Phase 2272 participants (Actual)Interventional2017-02-13Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for baclofen and Allodynia

ArticleYear
[GABA(B) receptors and sensitization to pain].
    Journal de la Societe de biologie, 2009, Volume: 203, Issue:1

    Topics: 14-3-3 Proteins; Allosteric Regulation; Animals; Baclofen; Calcium Channels; Calcium-Binding Protein

2009

Other Studies

25 other studies available for baclofen and Allodynia

ArticleYear
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
    Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4

    Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular

2013
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
    Neuroscience letters, 2020, 01-10, Volume: 715

    Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobuty

2020
Phenytoin in topical formulations augments pain reduction of other topically applied analgesics in the treatment of trigeminal neuralgia.
    Journal of clinical anesthesia, 2017, Volume: 38

    Topics: Administration, Cutaneous; Aged; Analgesics; Baclofen; Drug Synergism; Humans; Hyperalgesia; Ketamin

2017
Involvement of GABA
    Journal of pharmacological sciences, 2018, Volume: 137, Issue:2

    Topics: Animals; Baclofen; Disease Models, Animal; GABA-B Receptor Agonists; Gyrus Cinguli; Hyperalgesia; Li

2018
Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen.
    Pain, 2019, Volume: 160, Issue:8

    Topics: Analgesics, Opioid; Animals; Baclofen; Disease Models, Animal; Drug Synergism; GABA-B Receptor Agoni

2019
Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain.
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Baclofen; gamma-Aminobutyric Acid; Gene Expression; Humans; Hyperalgesia; Ligands; Myelin P

2014
The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats.
    Brain research bulletin, 2016, Volume: 124

    Topics: Animals; Baclofen; Bicuculline; Functional Laterality; GABA Agents; Hyperalgesia; Injections, Spinal

2016
Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice.
    Journal of Korean medical science, 2011, Volume: 26, Issue:10

    Topics: Animals; Baclofen; Drug Delivery Systems; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid;

2011
Peripheral and spinal GABAergic regulation of incisional pain in rats.
    Pain, 2012, Volume: 153, Issue:1

    Topics: Animals; Baclofen; Behavior, Animal; Chronic Pain; gamma-Aminobutyric Acid; Hyperalgesia; Muscimol;

2012
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
    Neuroscience, 2012, Jul-26, Volume: 215

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen;

2012
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.
    Nature, 2003, Jul-17, Volume: 424, Issue:6946

    Topics: Animals; Baclofen; Bupivacaine; Cerebral Cortex; gamma-Aminobutyric Acid; Hot Temperature; Hyperalge

2003
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 10, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Ganglia, S

2004
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
    Archives of pharmacal research, 2005, Volume: 28, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; G

2005
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
    European journal of pharmacology, 2005, Oct-31, Volume: 523, Issue:1-3

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima

2005
Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat.
    Neuroscience, 2006, Volume: 138, Issue:4

    Topics: Animals; Baclofen; Denervation; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Gang

2006
Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behavior and c-fos study.
    Neuroscience, 2006, Sep-15, Volume: 141, Issue:4

    Topics: Animals; Arthritis; Baclofen; Behavior, Animal; Drug Interactions; Freund's Adjuvant; GABA Agonists;

2006
Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; Hyperalgesia; Male; Medulla Oblo

1995
Increased sensitivity to the antinociceptive activity of (+/-)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia.
    Neuropharmacology, 1994, Volume: 33, Issue:9

    Topics: Analgesics; Animals; Autoradiography; Baclofen; Dose-Response Relationship, Drug; GABA-B Receptor Ag

1994
Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat.
    Brain research, 1993, Dec-31, Volume: 632, Issue:1-2

    Topics: Analysis of Variance; Animals; Baclofen; Carbamazepine; Clonidine; Disease Models, Animal; Hyperalge

1993
Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat.
    Neuroscience letters, 1998, Mar-13, Volume: 244, Issue:2

    Topics: Analgesics; Animals; Baclofen; GABA-B Receptor Antagonists; Hyperalgesia; Injections, Spinal; Male;

1998
A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats.
    Pain, 1998, Volume: 76, Issue:1-2

    Topics: Animals; Baclofen; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dizocilpine Maleate;

1998
Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat.
    Pain, 1999, Volume: 81, Issue:3

    Topics: Animals; Baclofen; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; H

1999
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat.
    Pain, 2001, Feb-15, Volume: 90, Issue:3

    Topics: Acetates; Amines; Analgesics; Animals; Baclofen; Cyclohexanecarboxylic Acids; Electric Stimulation;

2001
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).
    Neuron, 2001, Jul-19, Volume: 31, Issue:1

    Topics: Animals; Animals, Newborn; Avoidance Learning; Baclofen; Body Temperature Regulation; Delta Rhythm;

2001
The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:5

    Topics: Animals; Baclofen; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; G

2001