baclofen has been researched along with Allodynia in 26 studies
Excerpt | Relevance | Reference |
---|---|---|
" Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia." | 3.79 | Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. ( Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A, 2013) |
"Specifically, postsurgical pain continues to be a frequent and undermanaged condition." | 1.51 | Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. ( Alewood, PF; Cheneval, O; Dekan, Z; Deuis, JR; Morgan, M; Mueller, A; Schroeder, CI; Starobova, H; Vetter, I, 2019) |
"These phases of neuropathic pain involve changes in the GABAergic control of descending pathways that travel through the dorsolateral funiculus (DLF)." | 1.43 | The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats. ( Dias, QM; Prado, WA, 2016) |
"It may be associated with allodynia and increased pain sensitivity." | 1.40 | Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. ( Caffino, L; Castelnovo, LF; Cavalli, E; Colciago, A; Faroni, A; Magnaghi, V; Pajardi, G; Procacci, P, 2014) |
"The induction of hyperalgesia by co-exposure to MFs and diazepam was also blocked by flumazenil." | 1.33 | Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields. ( Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD, 2005) |
"Mechanical allodynia was maximal by 1 week and persisted at blunted levels for at least 18 weeks after injury." | 1.33 | Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat. ( Bettler, B; Engle, MP; Gassman, M; Hammond, DL; Sykes, KT, 2006) |
"Secondary hyperalgesia in the monoarthritic rat is accompanied by a decrease in nociceptive activation of spinal neurons expressing GABA(B) receptors and by the opposite effect in the cells expressing neurokinin 1 (NK1)-receptors." | 1.33 | Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behavior and c-fos study. ( Castro, AR; Lima, D; Pinto, M; Tavares, I, 2006) |
"0 microg) were administered to obtain the dose-response curve and the 50% effective dose (ED(50))." | 1.31 | The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury. ( Choi, IC; Han, SM; Hwang, JH; Hwang, KS; Kim, JU; Park, PH, 2001) |
"These data also suggest that the hyperalgesia produced by high doses of baclofen does not result from disinhibition of a serotonergic pain facilitatory pathway, but rather from direct inhibition of tonically-active pain inhibitory neurons in the NRM and NGCpalpha." | 1.30 | Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat. ( Hammond, DL; Nelson, V; Thomas, DA, 1998) |
"Rats developed mechanical hyperalgesia as soon as 2 weeks after STZ injection." | 1.30 | A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats. ( Malcangio, M; Tomlinson, DR, 1998) |
"Diabetic animals displayed marked mechanical hyperalgesia, and some thermal hypoalgesia." | 1.30 | Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat. ( Eastwood, C; Fox, A; Gentry, C; Manning, D; Urban, L, 1999) |
"Morphine pre-treatment was less effective in preventing development of hyperalgesia; however, whilst the ipsilateral (146 +/- 18 g) paw withdrawal threshold tended to be lower than the contralateral (183 +/- 8 g), this was not significant." | 1.29 | Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat. ( Birch, PJ; Elliott, PJ; Harrison, SM; Smith, GD; Wiseman, J, 1993) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 6 (23.08) | 18.2507 |
2000's | 10 (38.46) | 29.6817 |
2010's | 9 (34.62) | 24.3611 |
2020's | 1 (3.85) | 2.80 |
Authors | Studies |
---|---|
Nieto, FR | 1 |
Cobos, EJ | 1 |
Entrena, JM | 1 |
Parra, A | 1 |
García-Granados, A | 1 |
Baeyens, JM | 1 |
Zhang, Y | 1 |
Yang, J | 1 |
Sevilla, A | 1 |
Weller, R | 1 |
Wu, J | 1 |
Su, C | 1 |
Zheng, C | 1 |
Rodriguez-Blanco, YF | 1 |
Gitlin, M | 1 |
Candiotti, KA | 1 |
Kopsky, DJ | 1 |
Keppel Hesselink, JM | 1 |
Migita, K | 1 |
Matsuzaki, Y | 1 |
Koga, K | 1 |
Matsumoto, T | 1 |
Mishima, K | 1 |
Hara, S | 1 |
Honda, K | 1 |
Mueller, A | 1 |
Starobova, H | 1 |
Morgan, M | 1 |
Dekan, Z | 1 |
Cheneval, O | 1 |
Schroeder, CI | 1 |
Alewood, PF | 1 |
Deuis, JR | 1 |
Vetter, I | 1 |
Magnaghi, V | 1 |
Castelnovo, LF | 1 |
Faroni, A | 1 |
Cavalli, E | 1 |
Caffino, L | 1 |
Colciago, A | 1 |
Procacci, P | 1 |
Pajardi, G | 1 |
Dias, QM | 1 |
Prado, WA | 1 |
Landry, M | 1 |
Nagy, F | 1 |
Lee, IO | 1 |
Son, JK | 1 |
Lim, ES | 1 |
Kim, YS | 1 |
Reichl, S | 1 |
Augustin, M | 1 |
Zahn, PK | 1 |
Pogatzki-Zahn, EM | 1 |
Barchini, J | 1 |
Tchachaghian, S | 1 |
Shamaa, F | 1 |
Jabbur, SJ | 1 |
Meyerson, BA | 1 |
Song, Z | 1 |
Linderoth, B | 1 |
Saadé, NE | 1 |
Jasmin, L | 1 |
Rabkin, SD | 1 |
Granato, A | 1 |
Boudah, A | 1 |
Ohara, PT | 1 |
Liu, J | 1 |
Wolfe, D | 1 |
Hao, S | 1 |
Huang, S | 1 |
Glorioso, JC | 1 |
Mata, M | 1 |
Fink, DJ | 1 |
Jeong, JH | 1 |
Choi, KB | 1 |
Moon, NJ | 1 |
Park, ES | 1 |
Sohn, UD | 1 |
Akada, Y | 1 |
Mori, R | 1 |
Kato, Y | 1 |
Yamasaki, F | 1 |
Mochizuki, H | 1 |
Engle, MP | 1 |
Gassman, M | 1 |
Sykes, KT | 1 |
Bettler, B | 2 |
Hammond, DL | 3 |
Castro, AR | 1 |
Pinto, M | 1 |
Lima, D | 1 |
Tavares, I | 1 |
Thomas, DA | 2 |
McGowan, MK | 1 |
Smith, GD | 2 |
Harrison, SM | 2 |
Birch, PJ | 2 |
Elliott, PJ | 2 |
Malcangio, M | 2 |
Bowery, NG | 1 |
Wiseman, J | 1 |
Nelson, V | 1 |
Tomlinson, DR | 1 |
Fox, A | 3 |
Eastwood, C | 1 |
Gentry, C | 2 |
Manning, D | 1 |
Urban, L | 3 |
Patel, S | 1 |
Naeem, S | 1 |
Kesingland, A | 1 |
Froestl, W | 2 |
Capogna, M | 1 |
Schuler, V | 1 |
Lüscher, C | 1 |
Blanchet, C | 1 |
Klix, N | 1 |
Sansig, G | 1 |
Klebs, K | 1 |
Schmutz, M | 1 |
Heid, J | 1 |
Spooren, W | 1 |
Jaton, AL | 1 |
Vigouret, J | 1 |
Pozza, M | 1 |
Kelly, PH | 1 |
Mosbacher, J | 1 |
Käslin, E | 1 |
Korn, R | 1 |
Bischoff, S | 1 |
Kaupmann, K | 1 |
van der Putten, H | 1 |
Hwang, JH | 1 |
Hwang, KS | 1 |
Kim, JU | 1 |
Choi, IC | 1 |
Park, PH | 1 |
Han, SM | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815] | Phase 1/Phase 2 | 272 participants (Actual) | Interventional | 2017-02-13 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for baclofen and Allodynia
Article | Year |
---|---|
[GABA(B) receptors and sensitization to pain].
Topics: 14-3-3 Proteins; Allosteric Regulation; Animals; Baclofen; Calcium Channels; Calcium-Binding Protein | 2009 |
25 other studies available for baclofen and Allodynia
Article | Year |
---|---|
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular | 2013 |
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobuty | 2020 |
Phenytoin in topical formulations augments pain reduction of other topically applied analgesics in the treatment of trigeminal neuralgia.
Topics: Administration, Cutaneous; Aged; Analgesics; Baclofen; Drug Synergism; Humans; Hyperalgesia; Ketamin | 2017 |
Involvement of GABA
Topics: Animals; Baclofen; Disease Models, Animal; GABA-B Receptor Agonists; Gyrus Cinguli; Hyperalgesia; Li | 2018 |
Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen.
Topics: Analgesics, Opioid; Animals; Baclofen; Disease Models, Animal; Drug Synergism; GABA-B Receptor Agoni | 2019 |
Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain.
Topics: Animals; Baclofen; gamma-Aminobutyric Acid; Gene Expression; Humans; Hyperalgesia; Ligands; Myelin P | 2014 |
The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats.
Topics: Animals; Baclofen; Bicuculline; Functional Laterality; GABA Agents; Hyperalgesia; Injections, Spinal | 2016 |
Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice.
Topics: Animals; Baclofen; Drug Delivery Systems; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; | 2011 |
Peripheral and spinal GABAergic regulation of incisional pain in rats.
Topics: Animals; Baclofen; Behavior, Animal; Chronic Pain; gamma-Aminobutyric Acid; Hyperalgesia; Muscimol; | 2012 |
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; | 2012 |
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.
Topics: Animals; Baclofen; Bupivacaine; Cerebral Cortex; gamma-Aminobutyric Acid; Hot Temperature; Hyperalge | 2003 |
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Topics: Animals; Baclofen; Bicuculline; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Ganglia, S | 2004 |
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; G | 2005 |
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima | 2005 |
Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat.
Topics: Animals; Baclofen; Denervation; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Gang | 2006 |
Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behavior and c-fos study.
Topics: Animals; Arthritis; Baclofen; Behavior, Animal; Drug Interactions; Freund's Adjuvant; GABA Agonists; | 2006 |
Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; Hyperalgesia; Male; Medulla Oblo | 1995 |
Increased sensitivity to the antinociceptive activity of (+/-)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia.
Topics: Analgesics; Animals; Autoradiography; Baclofen; Dose-Response Relationship, Drug; GABA-B Receptor Ag | 1994 |
Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat.
Topics: Analysis of Variance; Animals; Baclofen; Carbamazepine; Clonidine; Disease Models, Animal; Hyperalge | 1993 |
Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat.
Topics: Analgesics; Animals; Baclofen; GABA-B Receptor Antagonists; Hyperalgesia; Injections, Spinal; Male; | 1998 |
A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats.
Topics: Animals; Baclofen; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dizocilpine Maleate; | 1998 |
Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat.
Topics: Animals; Baclofen; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; H | 1999 |
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat.
Topics: Acetates; Amines; Analgesics; Animals; Baclofen; Cyclohexanecarboxylic Acids; Electric Stimulation; | 2001 |
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).
Topics: Animals; Animals, Newborn; Avoidance Learning; Baclofen; Body Temperature Regulation; Delta Rhythm; | 2001 |
The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury.
Topics: Animals; Baclofen; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; G | 2001 |