baclofen has been researched along with Allodynia in 26 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia." | 3.79 | Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. ( Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A, 2013) |
| "Specifically, postsurgical pain continues to be a frequent and undermanaged condition." | 1.51 | Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. ( Alewood, PF; Cheneval, O; Dekan, Z; Deuis, JR; Morgan, M; Mueller, A; Schroeder, CI; Starobova, H; Vetter, I, 2019) |
| "These phases of neuropathic pain involve changes in the GABAergic control of descending pathways that travel through the dorsolateral funiculus (DLF)." | 1.43 | The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats. ( Dias, QM; Prado, WA, 2016) |
| "It may be associated with allodynia and increased pain sensitivity." | 1.40 | Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. ( Caffino, L; Castelnovo, LF; Cavalli, E; Colciago, A; Faroni, A; Magnaghi, V; Pajardi, G; Procacci, P, 2014) |
| "The induction of hyperalgesia by co-exposure to MFs and diazepam was also blocked by flumazenil." | 1.33 | Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields. ( Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD, 2005) |
| "Mechanical allodynia was maximal by 1 week and persisted at blunted levels for at least 18 weeks after injury." | 1.33 | Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat. ( Bettler, B; Engle, MP; Gassman, M; Hammond, DL; Sykes, KT, 2006) |
| "Secondary hyperalgesia in the monoarthritic rat is accompanied by a decrease in nociceptive activation of spinal neurons expressing GABA(B) receptors and by the opposite effect in the cells expressing neurokinin 1 (NK1)-receptors." | 1.33 | Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behavior and c-fos study. ( Castro, AR; Lima, D; Pinto, M; Tavares, I, 2006) |
| "0 microg) were administered to obtain the dose-response curve and the 50% effective dose (ED(50))." | 1.31 | The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury. ( Choi, IC; Han, SM; Hwang, JH; Hwang, KS; Kim, JU; Park, PH, 2001) |
| "These data also suggest that the hyperalgesia produced by high doses of baclofen does not result from disinhibition of a serotonergic pain facilitatory pathway, but rather from direct inhibition of tonically-active pain inhibitory neurons in the NRM and NGCpalpha." | 1.30 | Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat. ( Hammond, DL; Nelson, V; Thomas, DA, 1998) |
| "Rats developed mechanical hyperalgesia as soon as 2 weeks after STZ injection." | 1.30 | A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats. ( Malcangio, M; Tomlinson, DR, 1998) |
| "Diabetic animals displayed marked mechanical hyperalgesia, and some thermal hypoalgesia." | 1.30 | Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat. ( Eastwood, C; Fox, A; Gentry, C; Manning, D; Urban, L, 1999) |
| "Morphine pre-treatment was less effective in preventing development of hyperalgesia; however, whilst the ipsilateral (146 +/- 18 g) paw withdrawal threshold tended to be lower than the contralateral (183 +/- 8 g), this was not significant." | 1.29 | Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat. ( Birch, PJ; Elliott, PJ; Harrison, SM; Smith, GD; Wiseman, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 9 (34.62) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Nieto, FR | 1 |
| Cobos, EJ | 1 |
| Entrena, JM | 1 |
| Parra, A | 1 |
| García-Granados, A | 1 |
| Baeyens, JM | 1 |
| Zhang, Y | 1 |
| Yang, J | 1 |
| Sevilla, A | 1 |
| Weller, R | 1 |
| Wu, J | 1 |
| Su, C | 1 |
| Zheng, C | 1 |
| Rodriguez-Blanco, YF | 1 |
| Gitlin, M | 1 |
| Candiotti, KA | 1 |
| Kopsky, DJ | 1 |
| Keppel Hesselink, JM | 1 |
| Migita, K | 1 |
| Matsuzaki, Y | 1 |
| Koga, K | 1 |
| Matsumoto, T | 1 |
| Mishima, K | 1 |
| Hara, S | 1 |
| Honda, K | 1 |
| Mueller, A | 1 |
| Starobova, H | 1 |
| Morgan, M | 1 |
| Dekan, Z | 1 |
| Cheneval, O | 1 |
| Schroeder, CI | 1 |
| Alewood, PF | 1 |
| Deuis, JR | 1 |
| Vetter, I | 1 |
| Magnaghi, V | 1 |
| Castelnovo, LF | 1 |
| Faroni, A | 1 |
| Cavalli, E | 1 |
| Caffino, L | 1 |
| Colciago, A | 1 |
| Procacci, P | 1 |
| Pajardi, G | 1 |
| Dias, QM | 1 |
| Prado, WA | 1 |
| Landry, M | 1 |
| Nagy, F | 1 |
| Lee, IO | 1 |
| Son, JK | 1 |
| Lim, ES | 1 |
| Kim, YS | 1 |
| Reichl, S | 1 |
| Augustin, M | 1 |
| Zahn, PK | 1 |
| Pogatzki-Zahn, EM | 1 |
| Barchini, J | 1 |
| Tchachaghian, S | 1 |
| Shamaa, F | 1 |
| Jabbur, SJ | 1 |
| Meyerson, BA | 1 |
| Song, Z | 1 |
| Linderoth, B | 1 |
| Saadé, NE | 1 |
| Jasmin, L | 1 |
| Rabkin, SD | 1 |
| Granato, A | 1 |
| Boudah, A | 1 |
| Ohara, PT | 1 |
| Liu, J | 1 |
| Wolfe, D | 1 |
| Hao, S | 1 |
| Huang, S | 1 |
| Glorioso, JC | 1 |
| Mata, M | 1 |
| Fink, DJ | 1 |
| Jeong, JH | 1 |
| Choi, KB | 1 |
| Moon, NJ | 1 |
| Park, ES | 1 |
| Sohn, UD | 1 |
| Akada, Y | 1 |
| Mori, R | 1 |
| Kato, Y | 1 |
| Yamasaki, F | 1 |
| Mochizuki, H | 1 |
| Engle, MP | 1 |
| Gassman, M | 1 |
| Sykes, KT | 1 |
| Bettler, B | 2 |
| Hammond, DL | 3 |
| Castro, AR | 1 |
| Pinto, M | 1 |
| Lima, D | 1 |
| Tavares, I | 1 |
| Thomas, DA | 2 |
| McGowan, MK | 1 |
| Smith, GD | 2 |
| Harrison, SM | 2 |
| Birch, PJ | 2 |
| Elliott, PJ | 2 |
| Malcangio, M | 2 |
| Bowery, NG | 1 |
| Wiseman, J | 1 |
| Nelson, V | 1 |
| Tomlinson, DR | 1 |
| Fox, A | 3 |
| Eastwood, C | 1 |
| Gentry, C | 2 |
| Manning, D | 1 |
| Urban, L | 3 |
| Patel, S | 1 |
| Naeem, S | 1 |
| Kesingland, A | 1 |
| Froestl, W | 2 |
| Capogna, M | 1 |
| Schuler, V | 1 |
| Lüscher, C | 1 |
| Blanchet, C | 1 |
| Klix, N | 1 |
| Sansig, G | 1 |
| Klebs, K | 1 |
| Schmutz, M | 1 |
| Heid, J | 1 |
| Spooren, W | 1 |
| Jaton, AL | 1 |
| Vigouret, J | 1 |
| Pozza, M | 1 |
| Kelly, PH | 1 |
| Mosbacher, J | 1 |
| Käslin, E | 1 |
| Korn, R | 1 |
| Bischoff, S | 1 |
| Kaupmann, K | 1 |
| van der Putten, H | 1 |
| Hwang, JH | 1 |
| Hwang, KS | 1 |
| Kim, JU | 1 |
| Choi, IC | 1 |
| Park, PH | 1 |
| Han, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815] | Phase 1/Phase 2 | 272 participants (Actual) | Interventional | 2017-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for baclofen and Allodynia
| Article | Year |
|---|---|
[GABA(B) receptors and sensitization to pain].
Topics: 14-3-3 Proteins; Allosteric Regulation; Animals; Baclofen; Calcium Channels; Calcium-Binding Protein | 2009 |
25 other studies available for baclofen and Allodynia
| Article | Year |
|---|---|
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular | 2013 |
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobuty | 2020 |
Phenytoin in topical formulations augments pain reduction of other topically applied analgesics in the treatment of trigeminal neuralgia.
Topics: Administration, Cutaneous; Aged; Analgesics; Baclofen; Drug Synergism; Humans; Hyperalgesia; Ketamin | 2017 |
Involvement of GABA
Topics: Animals; Baclofen; Disease Models, Animal; GABA-B Receptor Agonists; Gyrus Cinguli; Hyperalgesia; Li | 2018 |
Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen.
Topics: Analgesics, Opioid; Animals; Baclofen; Disease Models, Animal; Drug Synergism; GABA-B Receptor Agoni | 2019 |
Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain.
Topics: Animals; Baclofen; gamma-Aminobutyric Acid; Gene Expression; Humans; Hyperalgesia; Ligands; Myelin P | 2014 |
The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats.
Topics: Animals; Baclofen; Bicuculline; Functional Laterality; GABA Agents; Hyperalgesia; Injections, Spinal | 2016 |
Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice.
Topics: Animals; Baclofen; Drug Delivery Systems; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; | 2011 |
Peripheral and spinal GABAergic regulation of incisional pain in rats.
Topics: Animals; Baclofen; Behavior, Animal; Chronic Pain; gamma-Aminobutyric Acid; Hyperalgesia; Muscimol; | 2012 |
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; | 2012 |
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.
Topics: Animals; Baclofen; Bupivacaine; Cerebral Cortex; gamma-Aminobutyric Acid; Hot Temperature; Hyperalge | 2003 |
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Topics: Animals; Baclofen; Bicuculline; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Ganglia, S | 2004 |
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; G | 2005 |
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima | 2005 |
Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat.
Topics: Animals; Baclofen; Denervation; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Gang | 2006 |
Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behavior and c-fos study.
Topics: Animals; Arthritis; Baclofen; Behavior, Animal; Drug Interactions; Freund's Adjuvant; GABA Agonists; | 2006 |
Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; Hyperalgesia; Male; Medulla Oblo | 1995 |
Increased sensitivity to the antinociceptive activity of (+/-)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia.
Topics: Analgesics; Animals; Autoradiography; Baclofen; Dose-Response Relationship, Drug; GABA-B Receptor Ag | 1994 |
Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat.
Topics: Analysis of Variance; Animals; Baclofen; Carbamazepine; Clonidine; Disease Models, Animal; Hyperalge | 1993 |
Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat.
Topics: Analgesics; Animals; Baclofen; GABA-B Receptor Antagonists; Hyperalgesia; Injections, Spinal; Male; | 1998 |
A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats.
Topics: Animals; Baclofen; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dizocilpine Maleate; | 1998 |
Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat.
Topics: Animals; Baclofen; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; H | 1999 |
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat.
Topics: Acetates; Amines; Analgesics; Animals; Baclofen; Cyclohexanecarboxylic Acids; Electric Stimulation; | 2001 |
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).
Topics: Animals; Animals, Newborn; Avoidance Learning; Baclofen; Body Temperature Regulation; Delta Rhythm; | 2001 |
The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury.
Topics: Animals; Baclofen; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; G | 2001 |