Page last updated: 2024-11-03

propofol and Allodynia

propofol has been researched along with Allodynia in 24 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"During administration, propofol significantly decreased pain scores and areas of hyperalgesia and allodynia compared with both 10% Intralipid and saline (placebo-corrected mean Numerical Rating Scale score reduction by propofol: 38 +/- 28%)."9.14Analgesic and antihyperalgesic properties of propofol in a human pain model. ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010)
"Two hundred and fourteen women undergoing breast cancer surgery under remifentanil-based general anaesthesia were randomly included in this prospective and double-blind trial."9.14Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. ( Byeon, GJ; Cho, AR; Kim, HJ; Kim, KH; Kwon, JY; Lee, HJ; Shin, SW; Yoon, JW, 2010)
"This study evaluated the effects of dexmedetomidine and propofol on brain-derived neurotrophic factor level in the cerebrospinal fluid (c-BDNF) and mechanical allodynia in a mild traumatic brain injury (TBI) rat model."8.31Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model. ( Baik, J; Do, W; Jeon, S; Kim, E; Kim, H; Kim, J; Lee, HJ; Lee, J, 2023)
"During administration, propofol significantly decreased pain scores and areas of hyperalgesia and allodynia compared with both 10% Intralipid and saline (placebo-corrected mean Numerical Rating Scale score reduction by propofol: 38 +/- 28%)."5.14Analgesic and antihyperalgesic properties of propofol in a human pain model. ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010)
"Two hundred and fourteen women undergoing breast cancer surgery under remifentanil-based general anaesthesia were randomly included in this prospective and double-blind trial."5.14Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. ( Byeon, GJ; Cho, AR; Kim, HJ; Kim, KH; Kwon, JY; Lee, HJ; Shin, SW; Yoon, JW, 2010)
"This study evaluated the effects of dexmedetomidine and propofol on brain-derived neurotrophic factor level in the cerebrospinal fluid (c-BDNF) and mechanical allodynia in a mild traumatic brain injury (TBI) rat model."4.31Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model. ( Baik, J; Do, W; Jeon, S; Kim, E; Kim, H; Kim, J; Lee, HJ; Lee, J, 2023)
"Intra-operative dosing of sufentanil significantly influenced post-operative morphine consumption, pain and hyperalgesia."2.78The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery. ( Fechner, J; Ihmsen, H; Jeleazcov, C; Schüttler, J, 2013)
"Peri-incisional hyperalgesia was assessed by measuring pain threshold to pressure using an algometer before operation and at 24-48 h postoperatively."2.74[The effects of lornoxicam in preventing remifentanil-induced postoperative hyperalgesia]. ( Alper, Y; Reisli, R; Tuncer, S; Yalçin, N, 2009)
"Pain intensities and areas of hyperalgesia were assessed before, during and after a 30 min target-controlled infusion of propofol (1."2.73Modulation of remifentanil-induced postinfusion hyperalgesia by propofol. ( Koppert, W; Manering, N; Schüttler, J; Singler, B; Tröster, A, 2007)
"Propofol acts as an intravenous anesthetic cure which is widely used as a therapy for the craniocerebral injury that comprised surgical anesthesia as well as the sedation done in the intensive care units."1.62Propofol Alleviates Neuropathic Pain Induced by Chronic Contractile Injury by Regulating the Spinal glun2b-p38mapkepac1 Pathway. ( Li, W; Qin, C; Yan, J; Yang, Y; You, L; Zhao, Q, 2021)
"Mechanical allodynia induced by plantar incision peaked at 1 hr and lasted for 3 days after incision."1.51Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain. ( Cheung, CW; Gu, P; Li, Q; Qiu, Q; Sun, L; Wang, XM; Wong, SS, 2019)
" In the three models, dose-response curves were established and their respective ED50 (50% effective dose) values were determined separately for each agent."1.42Synergistic antinociceptive interactions between fospropofol and alfentanil in mice. ( Cao, S; Cui, J; Jia, N; Li, R; Li, Y; Wang, C; Wang, L; Wen, A; Wu, Y; Zhao, C, 2015)
"In a peripheral nerve ligation model of neuropathic pain, 2,6-DTBP and subhypnotic propofol are antihyperalgesic."1.39HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. ( Andersen, OS; Flood, PD; Goldstein, PA; Hemmings, HC; Herold, KF; Proekt, A; Rowley, TJ; Sanford, RL; Tibbs, GR, 2013)
"The results support the hypothesis that hyperalgesia is a property of different anaesthetic agents when administered at sub-hynotic concentrations."1.29Hyperalgesia during sedation: effects of barbiturates and propofol in the rat. ( Archer, DP; Ewen, A; Roth, SH; Samanani, N, 1995)
" Dose-response curves were monophasic and linear over this range."1.28Propofol and barbiturate depression of spinal nociceptive neurotransmission. ( Gibbs, LM; Jewett, BA; Kendig, JJ; Tarasiuk, A, 1992)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (8.33)18.2507
2000's5 (20.83)29.6817
2010's14 (58.33)24.3611
2020's3 (12.50)2.80

Authors

AuthorsStudies
Li, W1
Qin, C1
Yan, J1
Zhao, Q1
You, L1
Yang, Y1
Jeon, S1
Baik, J1
Kim, J1
Lee, J1
Do, W1
Kim, E1
Lee, HJ2
Kim, H1
Su, X1
Zhu, W1
Tian, Y1
Tan, L1
Wu, H1
Wu, L1
Wong, SS1
Sun, L1
Qiu, Q1
Gu, P1
Li, Q1
Wang, XM1
Cheung, CW1
Tibbs, GR1
Rowley, TJ1
Sanford, RL1
Herold, KF1
Proekt, A1
Hemmings, HC1
Andersen, OS1
Goldstein, PA1
Flood, PD1
Corris, R1
Chou, J1
Riedel, B1
Collins, M1
Cho, AR2
Kwon, JY2
Kim, C1
Vanini, G1
Nemanis, K1
Baghdoyan, HA1
Lydic, R1
Zhao, C1
Jia, N1
Wang, C1
Li, Y1
Li, R1
Cui, J1
Cao, S1
Wang, L1
Wu, Y1
Wen, A1
Angst, MS1
Nickel, FT1
Ott, S1
Möhringer, S1
Münster, T1
Rieß, S1
Filitz, J2
Koppert, W3
Maihöfner, C1
Ben-David, B1
Chelly, JE1
Tuncer, S1
Yalçin, N1
Reisli, R1
Alper, Y1
Bandschapp, O1
Ihmsen, H2
Berset, A1
Urwyler, A1
Ruppen, W1
Shin, SW1
Kim, HJ1
Byeon, GJ1
Yoon, JW1
Kim, KH1
Echevarría, G1
Elgueta, F1
Fierro, C1
Bugedo, D1
Faba, G1
Iñiguez-Cuadra, R1
Muñoz, HR1
Cortínez, LI1
Martinez, V1
Fletcher, D1
Fechner, J1
Schüttler, J2
Jeleazcov, C1
Takechi, K1
Carstens, MI1
Klein, AH1
Carstens, E1
Chaaben, K1
Marret, E1
Lamonerie, L1
Lembert, N1
Bonnet, F1
Wang, QY1
Cao, JL1
Zeng, YM1
Dai, TJ1
Singler, B1
Tröster, A1
Manering, N1
Ewen, A1
Archer, DP1
Samanani, N1
Roth, SH1
Jewett, BA1
Gibbs, LM1
Tarasiuk, A1
Kendig, JJ1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT02495363]50 participants (Actual)Observational2015-03-31Completed
Development of Pharmacokinetic / Pharmacodynamic (pk/pd) Model of Propofol in Patients With Severe Burns[NCT03704285]15 participants (Actual)Observational2018-09-29Terminated (stopped due to Outbreak COVID 19)
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938]Phase 450 participants (Actual)Interventional2016-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for propofol and Allodynia

ArticleYear
Intraoperative Use of Remifentanil for TIVA: Postoperative Pain, Acute Tolerance, and Opioid-Induced Hyperalgesia.
    Journal of cardiothoracic and vascular anesthesia, 2015, Volume: 29 Suppl 1

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Drug Delivery Systems; Drug Tolerance; Humans; Hyperalg

2015

Trials

7 trials available for propofol and Allodynia

ArticleYear
Regulatory effects of propofol on high-dose remifentanil-induced hyperalgesia.
    Physiological research, 2020, 02-19, Volume: 69, Issue:1

    Topics: Adult; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Cholecystectomy, Lapar

2020
Effects of Different Anesthetics on Pain Processing in an Experimental Human Pain Model.
    Pain practice : the official journal of World Institute of Pain, 2016, Volume: 16, Issue:7

    Topics: Adult; Analgesics, Opioid; Anesthetics; Female; Humans; Hyperalgesia; Ketamine; Male; Pain; Pain Mea

2016
[The effects of lornoxicam in preventing remifentanil-induced postoperative hyperalgesia].
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2009, Volume: 21, Issue:4

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal;

2009
Analgesic and antihyperalgesic properties of propofol in a human pain model.
    Anesthesiology, 2010, Volume: 113, Issue:2

    Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fat Emulsions, Int

2010
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms

2010
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms

2010
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms

2010
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms

2010
The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery.
    European journal of pain (London, England), 2013, Volume: 17, Issue:4

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Coronary Artery Bypass; Double-Blind Method

2013
Modulation of remifentanil-induced postinfusion hyperalgesia by propofol.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:6

    Topics: Adult; Anesthetics; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Infusions, Intrav

2007

Other Studies

16 other studies available for propofol and Allodynia

ArticleYear
Propofol Alleviates Neuropathic Pain Induced by Chronic Contractile Injury by Regulating the Spinal glun2b-p38mapkepac1 Pathway.
    Computational and mathematical methods in medicine, 2021, Volume: 2021

    Topics: Anesthetics, Intravenous; Animals; Computational Biology; Disease Models, Animal; Ganglia, Spinal; G

2021
Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model.
    Korean journal of anesthesiology, 2023, Volume: 76, Issue:1

    Topics: Animals; Brain Concussion; Brain-Derived Neurotrophic Factor; Dexmedetomidine; Down-Regulation; Hype

2023
Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain.
    European journal of pain (London, England), 2019, Volume: 23, Issue:4

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Guanine Nucleoti

2019
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3

    Topics: Algorithms; Anesthetics; Anesthetics, Intravenous; Animals; Behavior, Animal; Biological Availabilit

2013
Sevoflurane and its role in the development of chronic postsurgical pain: where is the smoking gun?
    Anesthesia and analgesia, 2013, Volume: 117, Issue:4

    Topics: Analgesics, Opioid; Anesthetics; Breast Neoplasms; Chronic Pain; Female; Humans; Hyperalgesia; Methy

2013
In response.
    Anesthesia and analgesia, 2013, Volume: 117, Issue:4

    Topics: Analgesics, Opioid; Anesthetics; Breast Neoplasms; Chronic Pain; Female; Humans; Hyperalgesia; Methy

2013
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
    The European journal of neuroscience, 2014, Volume: 40, Issue:1

    Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inh

2014
Synergistic antinociceptive interactions between fospropofol and alfentanil in mice.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:1

    Topics: Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Animals; Dose-Response Relatio

2015
Propofol alters ketamine effect on opiate-induced hyperalgesia.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Drug Interactions; Drug Tolerance; Humans;

2009
Nitrous oxide (N(2)O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans.
    British journal of anaesthesia, 2011, Volume: 107, Issue:6

    Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Lidoc

2011
Prevention of opioid-induced hyperalgesia in surgical patients: does it really matter?
    British journal of anaesthesia, 2012, Volume: 109, Issue:3

    Topics: Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Male; Nitrous Oxide; Pai

2012
The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat.
    Anesthesia and analgesia, 2013, Volume: 116, Issue:4

    Topics: Administration, Topical; Analgesics; Anesthetics, Intravenous; Animals; Behavior, Animal; Cold Tempe

2013
[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
    Annales francaises d'anesthesie et de reanimation, 2004, Volume: 23, Issue:5

    Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhal

2004
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:12

    Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnot

2004
Hyperalgesia during sedation: effects of barbiturates and propofol in the rat.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:6

    Topics: Animals; Barbiturates; Hyperalgesia; Male; Pain; Propofol; Rats; Rats, Sprague-Dawley; Sensory Thres

1995
Propofol and barbiturate depression of spinal nociceptive neurotransmission.
    Anesthesiology, 1992, Volume: 77, Issue:6

    Topics: Animals; Animals, Newborn; Depression, Chemical; Hyperalgesia; In Vitro Techniques; Pain; Pentobarbi

1992