propofol has been researched along with Allodynia in 24 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During administration, propofol significantly decreased pain scores and areas of hyperalgesia and allodynia compared with both 10% Intralipid and saline (placebo-corrected mean Numerical Rating Scale score reduction by propofol: 38 +/- 28%)." | 9.14 | Analgesic and antihyperalgesic properties of propofol in a human pain model. ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010) |
| "Two hundred and fourteen women undergoing breast cancer surgery under remifentanil-based general anaesthesia were randomly included in this prospective and double-blind trial." | 9.14 | Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. ( Byeon, GJ; Cho, AR; Kim, HJ; Kim, KH; Kwon, JY; Lee, HJ; Shin, SW; Yoon, JW, 2010) |
| "This study evaluated the effects of dexmedetomidine and propofol on brain-derived neurotrophic factor level in the cerebrospinal fluid (c-BDNF) and mechanical allodynia in a mild traumatic brain injury (TBI) rat model." | 8.31 | Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model. ( Baik, J; Do, W; Jeon, S; Kim, E; Kim, H; Kim, J; Lee, HJ; Lee, J, 2023) |
| "During administration, propofol significantly decreased pain scores and areas of hyperalgesia and allodynia compared with both 10% Intralipid and saline (placebo-corrected mean Numerical Rating Scale score reduction by propofol: 38 +/- 28%)." | 5.14 | Analgesic and antihyperalgesic properties of propofol in a human pain model. ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010) |
| "Two hundred and fourteen women undergoing breast cancer surgery under remifentanil-based general anaesthesia were randomly included in this prospective and double-blind trial." | 5.14 | Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. ( Byeon, GJ; Cho, AR; Kim, HJ; Kim, KH; Kwon, JY; Lee, HJ; Shin, SW; Yoon, JW, 2010) |
| "This study evaluated the effects of dexmedetomidine and propofol on brain-derived neurotrophic factor level in the cerebrospinal fluid (c-BDNF) and mechanical allodynia in a mild traumatic brain injury (TBI) rat model." | 4.31 | Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model. ( Baik, J; Do, W; Jeon, S; Kim, E; Kim, H; Kim, J; Lee, HJ; Lee, J, 2023) |
| "Intra-operative dosing of sufentanil significantly influenced post-operative morphine consumption, pain and hyperalgesia." | 2.78 | The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery. ( Fechner, J; Ihmsen, H; Jeleazcov, C; Schüttler, J, 2013) |
| "Peri-incisional hyperalgesia was assessed by measuring pain threshold to pressure using an algometer before operation and at 24-48 h postoperatively." | 2.74 | [The effects of lornoxicam in preventing remifentanil-induced postoperative hyperalgesia]. ( Alper, Y; Reisli, R; Tuncer, S; Yalçin, N, 2009) |
| "Pain intensities and areas of hyperalgesia were assessed before, during and after a 30 min target-controlled infusion of propofol (1." | 2.73 | Modulation of remifentanil-induced postinfusion hyperalgesia by propofol. ( Koppert, W; Manering, N; Schüttler, J; Singler, B; Tröster, A, 2007) |
| "Propofol acts as an intravenous anesthetic cure which is widely used as a therapy for the craniocerebral injury that comprised surgical anesthesia as well as the sedation done in the intensive care units." | 1.62 | Propofol Alleviates Neuropathic Pain Induced by Chronic Contractile Injury by Regulating the Spinal glun2b-p38mapkepac1 Pathway. ( Li, W; Qin, C; Yan, J; Yang, Y; You, L; Zhao, Q, 2021) |
| "Mechanical allodynia induced by plantar incision peaked at 1 hr and lasted for 3 days after incision." | 1.51 | Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain. ( Cheung, CW; Gu, P; Li, Q; Qiu, Q; Sun, L; Wang, XM; Wong, SS, 2019) |
| " In the three models, dose-response curves were established and their respective ED50 (50% effective dose) values were determined separately for each agent." | 1.42 | Synergistic antinociceptive interactions between fospropofol and alfentanil in mice. ( Cao, S; Cui, J; Jia, N; Li, R; Li, Y; Wang, C; Wang, L; Wen, A; Wu, Y; Zhao, C, 2015) |
| "In a peripheral nerve ligation model of neuropathic pain, 2,6-DTBP and subhypnotic propofol are antihyperalgesic." | 1.39 | HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. ( Andersen, OS; Flood, PD; Goldstein, PA; Hemmings, HC; Herold, KF; Proekt, A; Rowley, TJ; Sanford, RL; Tibbs, GR, 2013) |
| "The results support the hypothesis that hyperalgesia is a property of different anaesthetic agents when administered at sub-hynotic concentrations." | 1.29 | Hyperalgesia during sedation: effects of barbiturates and propofol in the rat. ( Archer, DP; Ewen, A; Roth, SH; Samanani, N, 1995) |
| " Dose-response curves were monophasic and linear over this range." | 1.28 | Propofol and barbiturate depression of spinal nociceptive neurotransmission. ( Gibbs, LM; Jewett, BA; Kendig, JJ; Tarasiuk, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 14 (58.33) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Li, W | 1 |
| Qin, C | 1 |
| Yan, J | 1 |
| Zhao, Q | 1 |
| You, L | 1 |
| Yang, Y | 1 |
| Jeon, S | 1 |
| Baik, J | 1 |
| Kim, J | 1 |
| Lee, J | 1 |
| Do, W | 1 |
| Kim, E | 1 |
| Lee, HJ | 2 |
| Kim, H | 1 |
| Su, X | 1 |
| Zhu, W | 1 |
| Tian, Y | 1 |
| Tan, L | 1 |
| Wu, H | 1 |
| Wu, L | 1 |
| Wong, SS | 1 |
| Sun, L | 1 |
| Qiu, Q | 1 |
| Gu, P | 1 |
| Li, Q | 1 |
| Wang, XM | 1 |
| Cheung, CW | 1 |
| Tibbs, GR | 1 |
| Rowley, TJ | 1 |
| Sanford, RL | 1 |
| Herold, KF | 1 |
| Proekt, A | 1 |
| Hemmings, HC | 1 |
| Andersen, OS | 1 |
| Goldstein, PA | 1 |
| Flood, PD | 1 |
| Corris, R | 1 |
| Chou, J | 1 |
| Riedel, B | 1 |
| Collins, M | 1 |
| Cho, AR | 2 |
| Kwon, JY | 2 |
| Kim, C | 1 |
| Vanini, G | 1 |
| Nemanis, K | 1 |
| Baghdoyan, HA | 1 |
| Lydic, R | 1 |
| Zhao, C | 1 |
| Jia, N | 1 |
| Wang, C | 1 |
| Li, Y | 1 |
| Li, R | 1 |
| Cui, J | 1 |
| Cao, S | 1 |
| Wang, L | 1 |
| Wu, Y | 1 |
| Wen, A | 1 |
| Angst, MS | 1 |
| Nickel, FT | 1 |
| Ott, S | 1 |
| Möhringer, S | 1 |
| Münster, T | 1 |
| Rieß, S | 1 |
| Filitz, J | 2 |
| Koppert, W | 3 |
| Maihöfner, C | 1 |
| Ben-David, B | 1 |
| Chelly, JE | 1 |
| Tuncer, S | 1 |
| Yalçin, N | 1 |
| Reisli, R | 1 |
| Alper, Y | 1 |
| Bandschapp, O | 1 |
| Ihmsen, H | 2 |
| Berset, A | 1 |
| Urwyler, A | 1 |
| Ruppen, W | 1 |
| Shin, SW | 1 |
| Kim, HJ | 1 |
| Byeon, GJ | 1 |
| Yoon, JW | 1 |
| Kim, KH | 1 |
| Echevarría, G | 1 |
| Elgueta, F | 1 |
| Fierro, C | 1 |
| Bugedo, D | 1 |
| Faba, G | 1 |
| Iñiguez-Cuadra, R | 1 |
| Muñoz, HR | 1 |
| Cortínez, LI | 1 |
| Martinez, V | 1 |
| Fletcher, D | 1 |
| Fechner, J | 1 |
| Schüttler, J | 2 |
| Jeleazcov, C | 1 |
| Takechi, K | 1 |
| Carstens, MI | 1 |
| Klein, AH | 1 |
| Carstens, E | 1 |
| Chaaben, K | 1 |
| Marret, E | 1 |
| Lamonerie, L | 1 |
| Lembert, N | 1 |
| Bonnet, F | 1 |
| Wang, QY | 1 |
| Cao, JL | 1 |
| Zeng, YM | 1 |
| Dai, TJ | 1 |
| Singler, B | 1 |
| Tröster, A | 1 |
| Manering, N | 1 |
| Ewen, A | 1 |
| Archer, DP | 1 |
| Samanani, N | 1 |
| Roth, SH | 1 |
| Jewett, BA | 1 |
| Gibbs, LM | 1 |
| Tarasiuk, A | 1 |
| Kendig, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02495363] | 50 participants (Actual) | Observational | 2015-03-31 | Completed | |||
| Development of Pharmacokinetic / Pharmacodynamic (pk/pd) Model of Propofol in Patients With Severe Burns[NCT03704285] | 15 participants (Actual) | Observational | 2018-09-29 | Terminated (stopped due to Outbreak COVID 19) | |||
| Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938] | Phase 4 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propofol and Allodynia
| Article | Year |
|---|---|
Intraoperative Use of Remifentanil for TIVA: Postoperative Pain, Acute Tolerance, and Opioid-Induced Hyperalgesia.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Drug Delivery Systems; Drug Tolerance; Humans; Hyperalg | 2015 |
7 trials available for propofol and Allodynia
| Article | Year |
|---|---|
Regulatory effects of propofol on high-dose remifentanil-induced hyperalgesia.
Topics: Adult; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Cholecystectomy, Lapar | 2020 |
Effects of Different Anesthetics on Pain Processing in an Experimental Human Pain Model.
Topics: Adult; Analgesics, Opioid; Anesthetics; Female; Humans; Hyperalgesia; Ketamine; Male; Pain; Pain Mea | 2016 |
[The effects of lornoxicam in preventing remifentanil-induced postoperative hyperalgesia].
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Analgesic and antihyperalgesic properties of propofol in a human pain model.
Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fat Emulsions, Int | 2010 |
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms | 2010 |
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms | 2010 |
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms | 2010 |
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms | 2010 |
The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Coronary Artery Bypass; Double-Blind Method | 2013 |
Modulation of remifentanil-induced postinfusion hyperalgesia by propofol.
Topics: Adult; Anesthetics; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Infusions, Intrav | 2007 |
16 other studies available for propofol and Allodynia
| Article | Year |
|---|---|
Propofol Alleviates Neuropathic Pain Induced by Chronic Contractile Injury by Regulating the Spinal glun2b-p38mapkepac1 Pathway.
Topics: Anesthetics, Intravenous; Animals; Computational Biology; Disease Models, Animal; Ganglia, Spinal; G | 2021 |
Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model.
Topics: Animals; Brain Concussion; Brain-Derived Neurotrophic Factor; Dexmedetomidine; Down-Regulation; Hype | 2023 |
Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Guanine Nucleoti | 2019 |
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
Topics: Algorithms; Anesthetics; Anesthetics, Intravenous; Animals; Behavior, Animal; Biological Availabilit | 2013 |
Sevoflurane and its role in the development of chronic postsurgical pain: where is the smoking gun?
Topics: Analgesics, Opioid; Anesthetics; Breast Neoplasms; Chronic Pain; Female; Humans; Hyperalgesia; Methy | 2013 |
In response.
Topics: Analgesics, Opioid; Anesthetics; Breast Neoplasms; Chronic Pain; Female; Humans; Hyperalgesia; Methy | 2013 |
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inh | 2014 |
Synergistic antinociceptive interactions between fospropofol and alfentanil in mice.
Topics: Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Animals; Dose-Response Relatio | 2015 |
Propofol alters ketamine effect on opiate-induced hyperalgesia.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Drug Interactions; Drug Tolerance; Humans; | 2009 |
Nitrous oxide (N(2)O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Lidoc | 2011 |
Prevention of opioid-induced hyperalgesia in surgical patients: does it really matter?
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Male; Nitrous Oxide; Pai | 2012 |
The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat.
Topics: Administration, Topical; Analgesics; Anesthetics, Intravenous; Animals; Behavior, Animal; Cold Tempe | 2013 |
[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhal | 2004 |
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnot | 2004 |
Hyperalgesia during sedation: effects of barbiturates and propofol in the rat.
Topics: Animals; Barbiturates; Hyperalgesia; Male; Pain; Propofol; Rats; Rats, Sprague-Dawley; Sensory Thres | 1995 |
Propofol and barbiturate depression of spinal nociceptive neurotransmission.
Topics: Animals; Animals, Newborn; Depression, Chemical; Hyperalgesia; In Vitro Techniques; Pain; Pentobarbi | 1992 |