propofol has been researched along with Allodynia in 24 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Excerpt | Relevance | Reference |
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"During administration, propofol significantly decreased pain scores and areas of hyperalgesia and allodynia compared with both 10% Intralipid and saline (placebo-corrected mean Numerical Rating Scale score reduction by propofol: 38 +/- 28%)." | 9.14 | Analgesic and antihyperalgesic properties of propofol in a human pain model. ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010) |
"Two hundred and fourteen women undergoing breast cancer surgery under remifentanil-based general anaesthesia were randomly included in this prospective and double-blind trial." | 9.14 | Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. ( Byeon, GJ; Cho, AR; Kim, HJ; Kim, KH; Kwon, JY; Lee, HJ; Shin, SW; Yoon, JW, 2010) |
"This study evaluated the effects of dexmedetomidine and propofol on brain-derived neurotrophic factor level in the cerebrospinal fluid (c-BDNF) and mechanical allodynia in a mild traumatic brain injury (TBI) rat model." | 8.31 | Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model. ( Baik, J; Do, W; Jeon, S; Kim, E; Kim, H; Kim, J; Lee, HJ; Lee, J, 2023) |
"During administration, propofol significantly decreased pain scores and areas of hyperalgesia and allodynia compared with both 10% Intralipid and saline (placebo-corrected mean Numerical Rating Scale score reduction by propofol: 38 +/- 28%)." | 5.14 | Analgesic and antihyperalgesic properties of propofol in a human pain model. ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010) |
"Two hundred and fourteen women undergoing breast cancer surgery under remifentanil-based general anaesthesia were randomly included in this prospective and double-blind trial." | 5.14 | Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. ( Byeon, GJ; Cho, AR; Kim, HJ; Kim, KH; Kwon, JY; Lee, HJ; Shin, SW; Yoon, JW, 2010) |
"This study evaluated the effects of dexmedetomidine and propofol on brain-derived neurotrophic factor level in the cerebrospinal fluid (c-BDNF) and mechanical allodynia in a mild traumatic brain injury (TBI) rat model." | 4.31 | Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model. ( Baik, J; Do, W; Jeon, S; Kim, E; Kim, H; Kim, J; Lee, HJ; Lee, J, 2023) |
"Intra-operative dosing of sufentanil significantly influenced post-operative morphine consumption, pain and hyperalgesia." | 2.78 | The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery. ( Fechner, J; Ihmsen, H; Jeleazcov, C; Schüttler, J, 2013) |
"Peri-incisional hyperalgesia was assessed by measuring pain threshold to pressure using an algometer before operation and at 24-48 h postoperatively." | 2.74 | [The effects of lornoxicam in preventing remifentanil-induced postoperative hyperalgesia]. ( Alper, Y; Reisli, R; Tuncer, S; Yalçin, N, 2009) |
"Pain intensities and areas of hyperalgesia were assessed before, during and after a 30 min target-controlled infusion of propofol (1." | 2.73 | Modulation of remifentanil-induced postinfusion hyperalgesia by propofol. ( Koppert, W; Manering, N; Schüttler, J; Singler, B; Tröster, A, 2007) |
"Propofol acts as an intravenous anesthetic cure which is widely used as a therapy for the craniocerebral injury that comprised surgical anesthesia as well as the sedation done in the intensive care units." | 1.62 | Propofol Alleviates Neuropathic Pain Induced by Chronic Contractile Injury by Regulating the Spinal glun2b-p38mapkepac1 Pathway. ( Li, W; Qin, C; Yan, J; Yang, Y; You, L; Zhao, Q, 2021) |
"Mechanical allodynia induced by plantar incision peaked at 1 hr and lasted for 3 days after incision." | 1.51 | Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain. ( Cheung, CW; Gu, P; Li, Q; Qiu, Q; Sun, L; Wang, XM; Wong, SS, 2019) |
" In the three models, dose-response curves were established and their respective ED50 (50% effective dose) values were determined separately for each agent." | 1.42 | Synergistic antinociceptive interactions between fospropofol and alfentanil in mice. ( Cao, S; Cui, J; Jia, N; Li, R; Li, Y; Wang, C; Wang, L; Wen, A; Wu, Y; Zhao, C, 2015) |
"In a peripheral nerve ligation model of neuropathic pain, 2,6-DTBP and subhypnotic propofol are antihyperalgesic." | 1.39 | HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. ( Andersen, OS; Flood, PD; Goldstein, PA; Hemmings, HC; Herold, KF; Proekt, A; Rowley, TJ; Sanford, RL; Tibbs, GR, 2013) |
"The results support the hypothesis that hyperalgesia is a property of different anaesthetic agents when administered at sub-hynotic concentrations." | 1.29 | Hyperalgesia during sedation: effects of barbiturates and propofol in the rat. ( Archer, DP; Ewen, A; Roth, SH; Samanani, N, 1995) |
" Dose-response curves were monophasic and linear over this range." | 1.28 | Propofol and barbiturate depression of spinal nociceptive neurotransmission. ( Gibbs, LM; Jewett, BA; Kendig, JJ; Tarasiuk, A, 1992) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (8.33) | 18.2507 |
2000's | 5 (20.83) | 29.6817 |
2010's | 14 (58.33) | 24.3611 |
2020's | 3 (12.50) | 2.80 |
Authors | Studies |
---|---|
Li, W | 1 |
Qin, C | 1 |
Yan, J | 1 |
Zhao, Q | 1 |
You, L | 1 |
Yang, Y | 1 |
Jeon, S | 1 |
Baik, J | 1 |
Kim, J | 1 |
Lee, J | 1 |
Do, W | 1 |
Kim, E | 1 |
Lee, HJ | 2 |
Kim, H | 1 |
Su, X | 1 |
Zhu, W | 1 |
Tian, Y | 1 |
Tan, L | 1 |
Wu, H | 1 |
Wu, L | 1 |
Wong, SS | 1 |
Sun, L | 1 |
Qiu, Q | 1 |
Gu, P | 1 |
Li, Q | 1 |
Wang, XM | 1 |
Cheung, CW | 1 |
Tibbs, GR | 1 |
Rowley, TJ | 1 |
Sanford, RL | 1 |
Herold, KF | 1 |
Proekt, A | 1 |
Hemmings, HC | 1 |
Andersen, OS | 1 |
Goldstein, PA | 1 |
Flood, PD | 1 |
Corris, R | 1 |
Chou, J | 1 |
Riedel, B | 1 |
Collins, M | 1 |
Cho, AR | 2 |
Kwon, JY | 2 |
Kim, C | 1 |
Vanini, G | 1 |
Nemanis, K | 1 |
Baghdoyan, HA | 1 |
Lydic, R | 1 |
Zhao, C | 1 |
Jia, N | 1 |
Wang, C | 1 |
Li, Y | 1 |
Li, R | 1 |
Cui, J | 1 |
Cao, S | 1 |
Wang, L | 1 |
Wu, Y | 1 |
Wen, A | 1 |
Angst, MS | 1 |
Nickel, FT | 1 |
Ott, S | 1 |
Möhringer, S | 1 |
Münster, T | 1 |
Rieß, S | 1 |
Filitz, J | 2 |
Koppert, W | 3 |
Maihöfner, C | 1 |
Ben-David, B | 1 |
Chelly, JE | 1 |
Tuncer, S | 1 |
Yalçin, N | 1 |
Reisli, R | 1 |
Alper, Y | 1 |
Bandschapp, O | 1 |
Ihmsen, H | 2 |
Berset, A | 1 |
Urwyler, A | 1 |
Ruppen, W | 1 |
Shin, SW | 1 |
Kim, HJ | 1 |
Byeon, GJ | 1 |
Yoon, JW | 1 |
Kim, KH | 1 |
Echevarría, G | 1 |
Elgueta, F | 1 |
Fierro, C | 1 |
Bugedo, D | 1 |
Faba, G | 1 |
Iñiguez-Cuadra, R | 1 |
Muñoz, HR | 1 |
Cortínez, LI | 1 |
Martinez, V | 1 |
Fletcher, D | 1 |
Fechner, J | 1 |
Schüttler, J | 2 |
Jeleazcov, C | 1 |
Takechi, K | 1 |
Carstens, MI | 1 |
Klein, AH | 1 |
Carstens, E | 1 |
Chaaben, K | 1 |
Marret, E | 1 |
Lamonerie, L | 1 |
Lembert, N | 1 |
Bonnet, F | 1 |
Wang, QY | 1 |
Cao, JL | 1 |
Zeng, YM | 1 |
Dai, TJ | 1 |
Singler, B | 1 |
Tröster, A | 1 |
Manering, N | 1 |
Ewen, A | 1 |
Archer, DP | 1 |
Samanani, N | 1 |
Roth, SH | 1 |
Jewett, BA | 1 |
Gibbs, LM | 1 |
Tarasiuk, A | 1 |
Kendig, JJ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
[NCT02495363] | 50 participants (Actual) | Observational | 2015-03-31 | Completed | |||
Development of Pharmacokinetic / Pharmacodynamic (pk/pd) Model of Propofol in Patients With Severe Burns[NCT03704285] | 15 participants (Actual) | Observational | 2018-09-29 | Terminated (stopped due to Outbreak COVID 19) | |||
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938] | Phase 4 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for propofol and Allodynia
Article | Year |
---|---|
Intraoperative Use of Remifentanil for TIVA: Postoperative Pain, Acute Tolerance, and Opioid-Induced Hyperalgesia.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Drug Delivery Systems; Drug Tolerance; Humans; Hyperalg | 2015 |
7 trials available for propofol and Allodynia
Article | Year |
---|---|
Regulatory effects of propofol on high-dose remifentanil-induced hyperalgesia.
Topics: Adult; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Cholecystectomy, Lapar | 2020 |
Effects of Different Anesthetics on Pain Processing in an Experimental Human Pain Model.
Topics: Adult; Analgesics, Opioid; Anesthetics; Female; Humans; Hyperalgesia; Ketamine; Male; Pain; Pain Mea | 2016 |
[The effects of lornoxicam in preventing remifentanil-induced postoperative hyperalgesia].
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Analgesic and antihyperalgesic properties of propofol in a human pain model.
Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fat Emulsions, Int | 2010 |
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms | 2010 |
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms | 2010 |
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms | 2010 |
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms | 2010 |
The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Coronary Artery Bypass; Double-Blind Method | 2013 |
Modulation of remifentanil-induced postinfusion hyperalgesia by propofol.
Topics: Adult; Anesthetics; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Infusions, Intrav | 2007 |
16 other studies available for propofol and Allodynia
Article | Year |
---|---|
Propofol Alleviates Neuropathic Pain Induced by Chronic Contractile Injury by Regulating the Spinal glun2b-p38mapkepac1 Pathway.
Topics: Anesthetics, Intravenous; Animals; Computational Biology; Disease Models, Animal; Ganglia, Spinal; G | 2021 |
Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model.
Topics: Animals; Brain Concussion; Brain-Derived Neurotrophic Factor; Dexmedetomidine; Down-Regulation; Hype | 2023 |
Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Guanine Nucleoti | 2019 |
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
Topics: Algorithms; Anesthetics; Anesthetics, Intravenous; Animals; Behavior, Animal; Biological Availabilit | 2013 |
Sevoflurane and its role in the development of chronic postsurgical pain: where is the smoking gun?
Topics: Analgesics, Opioid; Anesthetics; Breast Neoplasms; Chronic Pain; Female; Humans; Hyperalgesia; Methy | 2013 |
In response.
Topics: Analgesics, Opioid; Anesthetics; Breast Neoplasms; Chronic Pain; Female; Humans; Hyperalgesia; Methy | 2013 |
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inh | 2014 |
Synergistic antinociceptive interactions between fospropofol and alfentanil in mice.
Topics: Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Animals; Dose-Response Relatio | 2015 |
Propofol alters ketamine effect on opiate-induced hyperalgesia.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Drug Interactions; Drug Tolerance; Humans; | 2009 |
Nitrous oxide (N(2)O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Lidoc | 2011 |
Prevention of opioid-induced hyperalgesia in surgical patients: does it really matter?
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Male; Nitrous Oxide; Pai | 2012 |
The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat.
Topics: Administration, Topical; Analgesics; Anesthetics, Intravenous; Animals; Behavior, Animal; Cold Tempe | 2013 |
[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhal | 2004 |
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnot | 2004 |
Hyperalgesia during sedation: effects of barbiturates and propofol in the rat.
Topics: Animals; Barbiturates; Hyperalgesia; Male; Pain; Propofol; Rats; Rats, Sprague-Dawley; Sensory Thres | 1995 |
Propofol and barbiturate depression of spinal nociceptive neurotransmission.
Topics: Animals; Animals, Newborn; Depression, Chemical; Hyperalgesia; In Vitro Techniques; Pain; Pentobarbi | 1992 |