melatonin has been researched along with Allodynia in 36 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Melatonin is claimed to have anti-inflammatory activity in animal models of acute and chronic inflammation." | 7.76 | Melatonin reduces hyperalgesia associated with inflammation. ( Bramanti, P; Cuzzocrea, S; Esposito, E; Mazzon, E; Paterniti, I, 2010) |
| "Pain during the BI and secondary hyperalgesia areas were defined as primary outcomes." | 6.80 | Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study. ( Andersen, LPH; Fenger, AQ; Gögenur, I; Petersen, MC; Rosenberg, J; Werner, MU, 2015) |
| "Mechanical allodynia, thermal hyperalgesia, and cold allodynia behavioral tests were performed." | 5.91 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain. ( Huang, AC; Kaur, T; Shyu, BC, 2023) |
| "This MLT-exhibited anti-allodynia is mediated by MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to induce HDAC4 dephosphorylation and nuclear import, herein increases HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1 expression in dorsal horn neurons." | 5.43 | Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription. ( Chau, YP; Chen, GD; Cheng, JK; Hsieh, MC; Lai, CY; Lin, TB; Peng, HY; Wang, HH, 2016) |
| "Melatonin is a neuroendocrine hormone that presents a wide range of physiological functions including regulating circadian rhythms and sleep, enhancing immune function, sleep improvement, and antioxidant effects." | 5.43 | Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats. ( Adachi, LN; Caumo, W; Cioato, SG; de Freitas, JS; de Macedo, IC; de Oliveira, C; de Souza, A; Medeiros, LF; Quevedo, A; Scarabelot, VL; Torres, IL, 2016) |
| "Melatonin influences the mechanical allodynia but not thermal hyperalgesia via activation of opioid system and benzodiazepine-GABAergic pathway." | 5.38 | Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism. ( Machowska, A; Nowak, L; Thor, PJ; Wordliczek, J; Zurowski, D, 2012) |
| "Melatonin has been shown to play a role in antioxidative defence." | 5.31 | Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? ( Holecek, V; Parara, S; Pekárková, I; Racek, J; Rokyta, R; Stopka, P; Trefil, L, 2001) |
| "Significant difference in erythema formation was found between areas treated with melatonin cream 12." | 5.22 | Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study. ( Gögenur, I; Pommergaard, HC; Rosenberg, J; Scheuer, C, 2016) |
| "Melatonin, the main hormone of the pineal gland, possesses analgesic properties, which were observed on various experimental models of pain and in the clinical practice." | 4.88 | [Analgesic properties of pineal hormone melatonin]. ( Arushanian, ÉB, 2012) |
| "Morphine is a widely used analgesic for various types of pain." | 3.85 | Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats. ( Fan, Y; Liang, X; Song, L; Wang, R, 2017) |
| "Previous reports suggest that melatonin may play an important role in visceral nociception and neurogenic inflammation." | 3.76 | Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process. ( Mickle, A; Miranda, A; Sengupta, JN; Shahmohammadi, G; Sood, M; Zhang, Z, 2010) |
| " Melatonin is claimed to have anti-inflammatory activity in animal models of acute and chronic inflammation." | 3.76 | Melatonin reduces hyperalgesia associated with inflammation. ( Bramanti, P; Cuzzocrea, S; Esposito, E; Mazzon, E; Paterniti, I, 2010) |
| "Previous study has shown that administration of melatonin into the anterior cingulate cortex contralateral to peripheral nerve injury prevented exacerbation of mechanical allodynia with a concurrent improvement of depression-like behavior in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats." | 3.75 | A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats. ( Chou, CW; Hernstadt, H; Lim, G; Ma, Y; Mao, J; Rusanescu, G; Sung, B; Tian, Y; Wang, S; Zhang, L, 2009) |
| " Given that the antioxidant melatonin significantly decreased SCI-induced AQP-1 increases and that hypoxia inducible factor-1alpha was increased in acutely and chronically injured spinal cords, we propose that chronic hypoxia contributes to persistent AQP-1 increases after SCI." | 3.74 | Aquaporin 1 - a novel player in spinal cord injury. ( Hulsebosch, CE; Johnson, K; Lee, J; Nesic, O; Perez-Polo, JR; Unabia, GC; Vergara, L; Ye, Z, 2008) |
| ") melatonin on mechanical allodynia and thermal hyperalgesia in mice with partial tight ligation of the sciatic nerve, and how the nitric oxide (NO) precursor l-arginine and the opiate antagonist naloxone influence this effect." | 3.73 | Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system. ( Dokmeci, D; Guray, G; Ozyigit, F; Sapolyo, N; Tamer, M; Ulugol, A, 2006) |
| " In the present study we have evaluated the anti-inflammatory and antinociceptive activity of oxytocin and melatonin against rat paw edema induced by dried latex (DL) of C procera and compared it with that against carrageenan-induced paw edema." | 3.73 | Inhibition of Calotropis procera latex-induced inflammatory hyperalgesia by oxytocin and melatonin. ( Kumar, VL; Padhy, BM, 2005) |
| "Pain during the BI and secondary hyperalgesia areas were defined as primary outcomes." | 2.80 | Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study. ( Andersen, LPH; Fenger, AQ; Gögenur, I; Petersen, MC; Rosenberg, J; Werner, MU, 2015) |
| " Chronic administration of morphine results in analgesic tolerance, hyperalgesia, and other side effects including dependence, addiction, respiratory depression, and constipation, which limit its clinical usage." | 2.72 | Melatonin and morphine: potential beneficial effects of co-use. ( Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Mehrzadi, S; Pourhanifeh, MH; Reiter, RJ, 2021) |
| "Mechanical allodynia, thermal hyperalgesia, and cold allodynia behavioral tests were performed." | 1.91 | Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain. ( Huang, AC; Kaur, T; Shyu, BC, 2023) |
| "Neuropathic pain is a debilitating chronic pain condition and is refractory to the currently available treatments." | 1.91 | Melatonin Improves Mitochondrial Dysfunction and Attenuates Neuropathic Pain by Regulating SIRT1 in Dorsal Root Ganglions. ( Chen, J; Fang, Q; Huang, H; Liu, X; Shi, Y; Wang, Y; Wu, W; Yao, M; Zeng, Y; Zhan, H; Zhang, X; Zhong, X, 2023) |
| "The thermal nociceptive/hyperalgesia tests were performed." | 1.72 | The Combination of Zinc and Melatonin Enhanced Neuroprotection and Attenuated Neuropathy in Oxaliplatin-Induced Neurotoxicity. ( Ali, M; Aziz, T, 2022) |
| "Neuropathic pain is a severe condition with unsatisfactory treatments." | 1.46 | Single Administration of Melatonin Modulates the Nitroxidergic System at the Peripheral Level and Reduces Thermal Nociceptive Hypersensitivity in Neuropathic Rats. ( Bonazza, V; Borsani, E; Buffoli, B; Reiter, RJ; Rezzani, R; Rodella, LF, 2017) |
| "Melatonin is a neuroendocrine hormone that presents a wide range of physiological functions including regulating circadian rhythms and sleep, enhancing immune function, sleep improvement, and antioxidant effects." | 1.43 | Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats. ( Adachi, LN; Caumo, W; Cioato, SG; de Freitas, JS; de Macedo, IC; de Oliveira, C; de Souza, A; Medeiros, LF; Quevedo, A; Scarabelot, VL; Torres, IL, 2016) |
| "Morphine-induced hyperalgesia and tolerance significantly limits its clinical use in relieving acute and chronic pain." | 1.42 | Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors. ( Song, L; Wu, C; Zuo, Y, 2015) |
| "A mouse model of chronic neuropathic pain induced by partial sciatic nerve ligation (PSL) was employed." | 1.40 | Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain. ( Chen, CR; Chen, L; Cheng, NN; Huang, ZL; Laudon, M; Liu, YY; Qu, WM; Urade, Y; Yin, D, 2014) |
| "Morphine can induce tolerance and hyperalgesia after long-term administration." | 1.38 | Role of melatonin in the prevention of morphine-induced hyperalgesia and spinal glial activation in rats: protein kinase C pathway involved. ( Chun, W; Ling, L; Wei, W; Xin, W, 2012) |
| "Melatonin influences the mechanical allodynia but not thermal hyperalgesia via activation of opioid system and benzodiazepine-GABAergic pathway." | 1.38 | Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism. ( Machowska, A; Nowak, L; Thor, PJ; Wordliczek, J; Zurowski, D, 2012) |
| "CCI significantly caused thermal hyperalgesia, cold allodynia and oxidative damage." | 1.37 | Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats. ( Gupta, A; Kalonia, H; Kumar, A; Kumar, P; Meena, S, 2011) |
| "Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior." | 1.35 | Exacerbated mechanical allodynia in rats with depression-like behavior. ( Chang, Y; Guo, G; Lim, G; Lim, JA; Mao, J; Sung, B; Wang, S; Yang, L; Zeng, Q, 2008) |
| "The antihyperalgesia effect of MT could be significantly antagonized by i." | 1.33 | Effects of melatonin on orphanin FQ/nociceptin-induced hyperalgesia in mice. ( Chen, Q; Dai, X; Li, SR; Peng, YL; Wang, R; Wang, T, 2006) |
| "Melatonin has been shown to play a role in antioxidative defence." | 1.31 | Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? ( Holecek, V; Parara, S; Pekárková, I; Racek, J; Rokyta, R; Stopka, P; Trefil, L, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (30.56) | 29.6817 |
| 2010's | 19 (52.78) | 24.3611 |
| 2020's | 6 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Ali, M | 1 |
| Aziz, T | 1 |
| Kaur, T | 1 |
| Huang, AC | 1 |
| Shyu, BC | 1 |
| Zeng, Y | 1 |
| Fang, Q | 1 |
| Chen, J | 1 |
| Wang, Y | 1 |
| Liu, X | 1 |
| Zhang, X | 1 |
| Shi, Y | 1 |
| Zhan, H | 1 |
| Zhong, X | 1 |
| Yao, M | 1 |
| Huang, H | 1 |
| Wu, W | 1 |
| Hsieh, MC | 3 |
| Lai, CY | 3 |
| Lin, LT | 1 |
| Chou, D | 2 |
| Yeh, CM | 1 |
| Cheng, JK | 2 |
| Wang, HH | 3 |
| Lin, KH | 1 |
| Lin, TB | 3 |
| Peng, HY | 3 |
| Hemati, K | 1 |
| Pourhanifeh, MH | 1 |
| Dehdashtian, E | 1 |
| Fatemi, I | 1 |
| Mehrzadi, S | 1 |
| Reiter, RJ | 2 |
| Hosseinzadeh, A | 1 |
| Xie, SS | 1 |
| Fan, WG | 1 |
| Liu, Q | 1 |
| Li, JZ | 1 |
| Zheng, MM | 1 |
| He, HW | 1 |
| Huang, F | 1 |
| Ho, YC | 1 |
| Chen, GD | 2 |
| Galley, HF | 1 |
| McCormick, B | 1 |
| Wilson, KL | 1 |
| Lowes, DA | 1 |
| Colvin, L | 1 |
| Torsney, C | 1 |
| Fan, Y | 1 |
| Liang, X | 1 |
| Wang, R | 2 |
| Song, L | 2 |
| Borsani, E | 1 |
| Buffoli, B | 1 |
| Bonazza, V | 1 |
| Rezzani, R | 1 |
| Rodella, LF | 1 |
| Zhang, Y | 1 |
| Ji, H | 1 |
| Wang, J | 1 |
| Sun, Y | 2 |
| Qian, Z | 1 |
| Jiang, X | 1 |
| Snutch, TP | 1 |
| Tao, J | 1 |
| Liu, YY | 1 |
| Yin, D | 1 |
| Chen, L | 1 |
| Qu, WM | 1 |
| Chen, CR | 1 |
| Laudon, M | 1 |
| Cheng, NN | 1 |
| Urade, Y | 1 |
| Huang, ZL | 1 |
| Wu, C | 1 |
| Zuo, Y | 1 |
| Andersen, LPH | 1 |
| Gögenur, I | 2 |
| Fenger, AQ | 1 |
| Petersen, MC | 1 |
| Rosenberg, J | 2 |
| Werner, MU | 1 |
| Chau, YP | 1 |
| Scarabelot, VL | 2 |
| Medeiros, LF | 1 |
| de Oliveira, C | 1 |
| Adachi, LN | 1 |
| de Macedo, IC | 1 |
| Cioato, SG | 1 |
| de Freitas, JS | 1 |
| de Souza, A | 1 |
| Quevedo, A | 1 |
| Caumo, W | 2 |
| Torres, IL | 2 |
| Scheuer, C | 1 |
| Pommergaard, HC | 1 |
| Rozisky, JR | 1 |
| Oliveira, C | 1 |
| Macedo, IC | 1 |
| Deitos, A | 1 |
| Laste, G | 1 |
| Wang, S | 2 |
| Zhang, L | 1 |
| Lim, G | 2 |
| Sung, B | 2 |
| Tian, Y | 1 |
| Chou, CW | 1 |
| Hernstadt, H | 1 |
| Rusanescu, G | 1 |
| Ma, Y | 1 |
| Mao, J | 3 |
| Negi, G | 1 |
| Kumar, A | 2 |
| Kaundal, RK | 1 |
| Gulati, A | 1 |
| Sharma, SS | 1 |
| Mickle, A | 1 |
| Sood, M | 1 |
| Zhang, Z | 1 |
| Shahmohammadi, G | 1 |
| Sengupta, JN | 1 |
| Miranda, A | 1 |
| Esposito, E | 1 |
| Paterniti, I | 1 |
| Mazzon, E | 1 |
| Bramanti, P | 1 |
| Cuzzocrea, S | 1 |
| Meena, S | 1 |
| Kalonia, H | 1 |
| Gupta, A | 1 |
| Kumar, P | 1 |
| Xin, W | 1 |
| Chun, W | 1 |
| Ling, L | 1 |
| Wei, W | 1 |
| Arushanian, ÉB | 1 |
| Zurowski, D | 1 |
| Nowak, L | 1 |
| Machowska, A | 1 |
| Wordliczek, J | 1 |
| Thor, PJ | 1 |
| Tu, Y | 1 |
| Sun, RQ | 1 |
| Willis, WD | 1 |
| Ulugol, A | 1 |
| Dokmeci, D | 1 |
| Guray, G | 1 |
| Sapolyo, N | 1 |
| Ozyigit, F | 1 |
| Tamer, M | 1 |
| Padhy, BM | 1 |
| Kumar, VL | 1 |
| Wang, T | 1 |
| Li, SR | 1 |
| Dai, X | 1 |
| Peng, YL | 1 |
| Chen, Q | 1 |
| Nesic, O | 1 |
| Lee, J | 1 |
| Unabia, GC | 1 |
| Johnson, K | 1 |
| Ye, Z | 1 |
| Vergara, L | 1 |
| Hulsebosch, CE | 1 |
| Perez-Polo, JR | 1 |
| Zeng, Q | 1 |
| Yang, L | 1 |
| Chang, Y | 1 |
| Lim, JA | 1 |
| Guo, G | 1 |
| Raghavendra, V | 1 |
| Agrewala, JN | 1 |
| Kulkarni, SK | 1 |
| Jeong, JH | 1 |
| Choi, KB | 1 |
| Yi, BC | 1 |
| Chun, CH | 1 |
| Sung, KY | 1 |
| Sung, JY | 1 |
| Gimm, YM | 1 |
| Huh, IH | 1 |
| Sohn, UD | 1 |
| Pekárková, I | 1 |
| Parara, S | 1 |
| Holecek, V | 1 |
| Stopka, P | 1 |
| Trefil, L | 1 |
| Racek, J | 1 |
| Rokyta, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Association Between Melatonin Use and Improved Sleep Quality After Total Knee Arthroplasty: A Randomized Control Trial[NCT05332717] | 176 participants (Actual) | Interventional | 2022-01-10 | Completed | |||
| Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain[NCT01269671] | Phase 1 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI has left institution) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for melatonin and Allodynia
| Article | Year |
|---|---|
Melatonin and morphine: potential beneficial effects of co-use.
Topics: Analgesics; Arachidonate 5-Lipoxygenase; Calcium; Drug Tolerance; Humans; Hyperalgesia; Melatonin; M | 2021 |
[Analgesic properties of pineal hormone melatonin].
Topics: Analgesics; Animals; Antioxidants; Humans; Hyperalgesia; Melatonin; Mice; Pain; Pineal Gland; Rats | 2012 |
2 trials available for melatonin and Allodynia
| Article | Year |
|---|---|
Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Cross-Over Studies; Dose-Response Relatio | 2015 |
Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study.
Topics: Administration, Topical; Adult; Antioxidants; Dose-Response Relationship, Radiation; Double-Blind Me | 2016 |
32 other studies available for melatonin and Allodynia
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
The Combination of Zinc and Melatonin Enhanced Neuroprotection and Attenuated Neuropathy in Oxaliplatin-Induced Neurotoxicity.
Topics: Animals; Antioxidants; Hyperalgesia; Male; Melatonin; Neural Cell Adhesion Molecules; Neuroprotectio | 2022 |
Modulation of Melatonin in Pain Behaviors Associated with Oxidative Stress and Neuroinflammation Responses in an Animal Model of Central Post-Stroke Pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation; Interleukin-6; Melatonin; Neuralgia; Ne | 2023 |
Melatonin Improves Mitochondrial Dysfunction and Attenuates Neuropathic Pain by Regulating SIRT1 in Dorsal Root Ganglions.
Topics: Analgesics; Animals; Ganglia, Spinal; Hyperalgesia; Melatonin; Mitochondria; Neuralgia; Rats; Rats, | 2023 |
Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons.
Topics: Animals; Epigenesis, Genetic; Ganglia, Spinal; Hyperalgesia; Melatonin; Neuralgia; Neurons; Rats; Re | 2023 |
Involvement of nNOS in the antinociceptive activity of melatonin in inflammatory pain at the level of sensory neurons.
Topics: Analgesics; Animals; Cell Line; Disease Models, Animal; Facial Pain; Hyperalgesia; Melatonin; Nitric | 2020 |
Melatonin impedes Tet1-dependent mGluR5 promoter demethylation to relieve pain.
Topics: Analgesics; Animals; Demethylation; Dioxygenases; DNA Methylation; Hyperalgesia; Male; Melatonin; Ne | 2017 |
Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Female; Humans; Hyperalg | 2017 |
Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Tolerance; Hyperalgesia; Male; | 2017 |
Single Administration of Melatonin Modulates the Nitroxidergic System at the Peripheral Level and Reduces Thermal Nociceptive Hypersensitivity in Neuropathic Rats.
Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Male; Melatoni | 2017 |
Melatonin-mediated inhibition of Cav3.2 T-type Ca
Topics: Animals; Calcium Channels, T-Type; Hyperalgesia; Melatonin; Membrane Potentials; Mice, Inbred ICR; P | 2018 |
Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Hypnotics and Sedatives; Indoles; Male; M | 2014 |
Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Hyperalgesia; Male; Melatonin; Morphine; Pain Measureme | 2015 |
Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription.
Topics: Animals; Histone Deacetylases; HMGB1 Protein; Hyperalgesia; Male; Matrix Metalloproteinase 15; Melat | 2016 |
Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats.
Topics: Animals; Brain Stem; Facial Pain; Freund's Adjuvant; Hyperalgesia; Melatonin; Neuroimmunomodulation; | 2016 |
Melatonin as a potential counter-effect of hyperalgesia induced by neonatal morphine exposure.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Hyperalgesia; Male; Melatonin; Morphine; Narcot | 2016 |
A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats.
Topics: Analysis of Variance; Animals; Chronic Disease; Dextromethorphan; Dose-Response Relationship, Drug; | 2009 |
Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetic Neuropathies; Disease Models, Animal; Do | 2010 |
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Topics: Analgesics; Animals; Colitis; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Melatonin; N | 2010 |
Melatonin reduces hyperalgesia associated with inflammation.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Inflammation; | 2010 |
Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats.
Topics: Animals; Antioxidants; Arginine; Catalase; Chronic Disease; Disease Models, Animal; Glutathione; Hyp | 2011 |
Role of melatonin in the prevention of morphine-induced hyperalgesia and spinal glial activation in rats: protein kinase C pathway involved.
Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Male; Melatonin; Morphine Dependence; Pai | 2012 |
Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism.
Topics: Analgesics; Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; GABA-A Receptor Ant | 2012 |
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interac | 2004 |
Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: Possible involvements of the L-arginine-NO pathway and opioid system.
Topics: Analgesics; Animals; Arginine; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricul | 2006 |
Inhibition of Calotropis procera latex-induced inflammatory hyperalgesia by oxytocin and melatonin.
Topics: Analgesics; Animals; Calotropis; Carrageenan; Edema; Hyperalgesia; Latex; Latex Hypersensitivity; Ma | 2005 |
Effects of melatonin on orphanin FQ/nociceptin-induced hyperalgesia in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions | 2006 |
Aquaporin 1 - a novel player in spinal cord injury.
Topics: Afferent Pathways; Animals; Antioxidants; Aquaporin 1; Astrocytes; Cell Size; Chronic Disease; Disea | 2008 |
Exacerbated mechanical allodynia in rats with depression-like behavior.
Topics: Animals; Depressive Disorder; Disease Models, Animal; Genetic Predisposition to Disease; Gyrus Cingu | 2008 |
Melatonin reversal of lipopolysacharides-induced thermal and behavioral hyperalgesia in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Behavior, Animal; Dexamethasone; Hyperalg | 2000 |
Effects of extremely low frequency magnetic fields on pain thresholds in mice: roles of melatonin and opioids.
Topics: Animals; Circadian Rhythm; Electromagnetic Fields; Hyperalgesia; Male; Melatonin; Mice; Mice, Inbred | 2000 |
Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat?
Topics: Animals; Free Radical Scavengers; Free Radicals; Hyperalgesia; Male; Melatonin; Oxidative Stress; Pa | 2001 |