1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with Allodynia in 12 studies
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one: structure given in first source; inhibits guanylyl cyclase
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one : A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Results VL-102-evoked acute and chronic mechanical cephalic and hind-paw allodynia in a dose-dependent manner, which was blocked by the migraine medications sumatriptan, propranolol, and topiramate." | 3.88 | Soluble guanylyl cyclase is a critical regulator of migraine-associated pain. ( Ben Aissa, M; Bennett, BM; Bertels, Z; Gaisina, IN; Gandhi, R; Lee, SH; Litosh, V; Moye, LS; Novack, M; Pradhan, AA; Thatcher, GR; Tipton, AF; Wang, Y, 2018) |
| " The objective of the present paper was to evaluate the relevance of neuronal balance of cyclic AMP and cyclic GMP concentration for functional regulation of nociceptor sensitivity during inflammation." | 3.70 | Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia. ( Cunha, FQ; Ferreira, SH; Teixeira, MM, 1999) |
| "Allodynia was also intensified by SNAP (5% or 30%) in rats pretreated with intraplantar 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ, 4 microg), a guanylate cyclase inhibitor." | 1.31 | Dual effect of local application of nitric oxide donors in a model of incision pain in rats. ( Cunha, FQ; Prado, WA; Schiavon, VF, 2002) |
| "L-NMA was also able to reverse that hyperalgesia." | 1.30 | Nitric oxide signaling in pain and nociceptor sensitization in the rat. ( Aley, KO; Levine, JD; McCarter, G, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ben Aissa, M | 1 |
| Tipton, AF | 1 |
| Bertels, Z | 1 |
| Gandhi, R | 1 |
| Moye, LS | 1 |
| Novack, M | 1 |
| Bennett, BM | 1 |
| Wang, Y | 1 |
| Litosh, V | 1 |
| Lee, SH | 1 |
| Gaisina, IN | 1 |
| Thatcher, GR | 1 |
| Pradhan, AA | 1 |
| Quiñonez-Bastidas, GN | 1 |
| Cervantes-Durán, C | 1 |
| Rocha-González, HI | 1 |
| Murbartián, J | 1 |
| Granados-Soto, V | 1 |
| Romero, TR | 1 |
| Galdino, GS | 1 |
| Silva, GC | 1 |
| Resende, LC | 1 |
| Perez, AC | 1 |
| Côrtes, SF | 1 |
| Duarte, ID | 2 |
| Vivancos, GG | 1 |
| Parada, CA | 1 |
| Ferreira, SH | 3 |
| Picolo, G | 1 |
| Cury, Y | 1 |
| Ro, JY | 1 |
| Lee, J | 1 |
| Capra, NF | 1 |
| Zhang, Y | 1 |
| Chen, GD | 1 |
| Peng, ML | 1 |
| Wang, PY | 1 |
| Lee, SD | 1 |
| Chang, HM | 1 |
| Pan, SF | 1 |
| Chen, MJ | 1 |
| Tung, KC | 1 |
| Lai, CY | 1 |
| Lin, TB | 1 |
| Aley, KO | 1 |
| McCarter, G | 1 |
| Levine, JD | 1 |
| Cunha, FQ | 2 |
| Teixeira, MM | 1 |
| Prado, WA | 1 |
| Schiavon, VF | 1 |
| Tao, YX | 1 |
| Johns, RA | 1 |
12 other studies available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and Allodynia
| Article | Year |
|---|---|
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
Topics: Adrenergic beta-Antagonists; Allosteric Regulation; Animals; Anticonvulsants; Calcitonin Gene-Relate | 2018 |
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Re | 2013 |
Ketamine activates the L-arginine/Nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats.
Topics: Analgesia; Anesthetics, Dissociative; Animals; Arginine; Cyclic AMP; Dinoprostone; Drug Synergism; E | 2011 |
Opposite nociceptive effects of the arginine/NO/cGMP pathway stimulation in dermal and subcutaneous tissues.
Topics: Animals; Arginine; Bucladesine; Cyclic GMP; Dermis; Dinoprostone; Dose-Response Relationship, Drug; | 2003 |
Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a delta- and kappa-opioid receptor agonist.
Topics: Analgesics; Animals; Crotalid Venoms; Crotalus; Dinoprostone; Drug Antagonism; Enzyme Inhibitors; Hy | 2004 |
Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity.
Topics: Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Capsaicin; Dose-Response Relation | 2007 |
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats.
Topics: Action Potentials; Anesthesia; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2008 |
Nitric oxide signaling in pain and nociceptor sensitization in the rat.
Topics: Animals; Dinoprostone; Enzyme Inhibitors; Guanylate Cyclase; Hyperalgesia; Male; Nitric Oxide; Nitri | 1998 |
Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia.
Topics: Animals; Bradykinin; Carrageenan; Cyclic AMP; Cyclic GMP; Dinoprostone; Dopamine; Hyperalgesia; Infl | 1999 |
L-NAME causes antinociception by stimulation of the arginine-NO-cGMP pathway.
Topics: Analgesics; Animals; Arginine; Carrageenan; Cyclic GMP; Dinoprostone; Hyperalgesia; Male; Methylene | 2000 |
Dual effect of local application of nitric oxide donors in a model of incision pain in rats.
Topics: Animals; Disease Models, Animal; Diuretics, Osmotic; Dose-Response Relationship, Drug; Enzyme Inhibi | 2002 |
Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw.
Topics: Animals; Behavior, Animal; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; | 2002 |