Compounds > win 64338
Page last updated: 2024-09-25

win 64338

Description

WIN 64338: structure given in first source; bradykinin receptor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID132927
CHEMBL ID551291
MeSH IDM0231448

Synonyms (10)

Synonym
gtpl677
win 64338
win-64338
phosphonium, ((4-((2-((bis(cyclohexylamino)methylene)amino)-3-(2-naphthalenyl)-1-oxopropyl)amino)phenyl)methyl)tributyl-, chloride, (s)-
151039-63-3
((4-((2-((bis(cyclohexylamino)methylene)amino)-3-(2-naphthyl)-1-oxopropyl)amino)phenyl)methyl)tributylphosphonium chloride monohydrochloride
CHEMBL551291 ,
tributyl-[[4-[[(2s)-2-[(n,n'-dicyclohexylcarbamimidoyl)amino]-3-naphthalen-2-ylpropanoyl]amino]phenyl]methyl]phosphanium chloride
Q27089226
tributyl-[[4-[[(2s)-2-[(n,n'-dicyclohexylcarbamimidoyl)amino]-3-naphthalen-2-ylpropanoyl]amino]phenyl]methyl]phosphanium;chloride

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1346473Human B2 receptor (Bradykinin receptors)1994Proceedings of the National Academy of Sciences of the United States of America, May-24, Volume: 91, Issue:11
The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist.
AID1346473Human B2 receptor (Bradykinin receptors)1993Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's15 (78.95)18.2507
2000's2 (10.53)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (10.53%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (89.47%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
bradykinin[no description available]medium130oligopeptidehuman blood serum metabolite;
vasodilator agent
bromfenac[no description available]medium10aromatic amino acid;
benzophenones;
organobromine compound;
substituted aniline		non-narcotic analgesic;
non-steroidal anti-inflammatory drug
icatibant[no description available]medium60
allyl isothiocyanate[no description available]medium10alkenyl isothiocyanate;
isothiocyanate		antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
lachrymator;
metabolite
cyclic gmp[no description available]medium203',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
bradykinin, des-arg(9)-[no description available]medium10oligopeptidebradykinin receptor B2 agonist
arg-3-hyp-7-phe-bradykinin[no description available]medium20oligopeptidebradykinin receptor antagonist
bradykinin, leu(8)-des-arg(9)-[no description available]medium20
kallidin[no description available]medium20peptide
fr 173657[no description available]medium20
npc 17731[no description available]medium10
fr 167344[no description available]medium10
fr 190997[no description available]medium10
dinoprostone[no description available]medium10prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
ConditionIndicatedRelationship StrengthStudiesTrials
Allodynia0low10
Allodynia, Mechanical0low10
Allodynia, Tactile0low10
Allodynia, Thermal0low10
Anesthesia0low10
Anxiety Disorders0low10
Anxiety Neuroses0low10
Anxiety States, Neurotic0low10
Blood Pressure, Low0low10
Disease Models, Animal0low10
Hyperalgesia0low10
Hyperalgesia, Mechanical0low10
Hyperalgesia, Primary0low10
Hyperalgesia, Secondary0low10
Hyperalgesia, Tactile0low10
Hyperalgesia, Thermal0low10
Hyperalgesic Sensations0low10
Hyperalgia0low10
Hyperalgia, Mechanical0low10
Hyperalgia, Primary0low10
Hyperalgia, Secondary0low10
Hypotension0low10
Hypotension, Vascular0low10
Intraocular Pressure0low10
Low Blood Pressure0low10
Mechanical Allodynia0low10
Mechanical Hyperalgesia0low10
Muscle Contraction0low30
Muscle Relaxation0low10
Neuroses, Anxiety0low10
Tactile Allodynia0low10
Thermal Allodynia0low10
Vascular Hypotension0low10