methiothepin has been researched along with Allodynia in 4 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of oxytocin (OXT) in pain modulation has been suggested." | 3.83 | The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception. ( Condés-Lara, M; Godínez-Chaparro, B; González-Hernández, A; Manzano-García, A; Martínez-Lorenzana, G; Rodríguez-Jiménez, J; Rojas-Piloni, G, 2016) |
| "Tactile allodynia in neuropathic rats was assessed with von Frey filaments." | 1.42 | Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats. ( Avila-Rojas, SH; Barragán-Iglesias, P; Granados-Soto, V; Pineda-Farias, JB; Salinas-Abarca, AB; Velázquez-Lagunas, I, 2015) |
| "However, a similar apparent 'hyperalgesia' was seen at a non-noxious temperature of 38 degrees C." | 1.28 | Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks. ( Bervoets, K; Colpaert, FC; Millan, MJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quiñonez-Bastidas, GN | 1 |
| Cervantes-Durán, C | 1 |
| Rocha-González, HI | 1 |
| Murbartián, J | 1 |
| Granados-Soto, V | 2 |
| Avila-Rojas, SH | 1 |
| Velázquez-Lagunas, I | 1 |
| Salinas-Abarca, AB | 1 |
| Barragán-Iglesias, P | 1 |
| Pineda-Farias, JB | 1 |
| Godínez-Chaparro, B | 1 |
| Martínez-Lorenzana, G | 1 |
| Rodríguez-Jiménez, J | 1 |
| Manzano-García, A | 1 |
| Rojas-Piloni, G | 1 |
| Condés-Lara, M | 1 |
| González-Hernández, A | 1 |
| Millan, MJ | 1 |
| Bervoets, K | 1 |
| Colpaert, FC | 1 |
4 other studies available for methiothepin and Allodynia
| Article | Year |
|---|---|
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Re | 2013 |
Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Hyperalgesia; Lumbar | 2015 |
The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception.
Topics: Animals; Electric Stimulation; Formaldehyde; Hyperalgesia; Male; Methiothepin; Nociception; Oxytocin | 2016 |
Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hot Temperature; | 1989 |