Proteins > Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Page last updated: 2024-08-07 20:40:43
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
An ectonucleotide pyrophosphatase/phosphodiesterase family member 2 that is encoded in the genome of rat. [OMA:Q64610, PRO:DNx]
Synonyms
E-NPP 2;
EC 3.1.4.39;
Autotaxin;
Extracellular lysophospholipase D;
LysoPLD
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
Compounds (1)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pf 8380 | Rattus norvegicus (Norway rat) | IC50 | 1.0366 | 3 | 3 |
Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.Journal of medicinal chemistry, , 04-28, Volume: 65, Issue:8, 2022
Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.ACS medicinal chemistry letters, , Dec-14, Volume: 8, Issue:12, 2017
Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016