chelerythrine has been researched along with Allodynia in 9 studies
chelerythrine : A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously developed a thrombus-induced ischemic pain (TIIP) animal model, which was characterized by chronic bilateral mechanical allodynia without thermal hyperalgesia (TH)." | 1.40 | Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain. ( Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Oh, SB; Roh, DH; Yoon, SY, 2014) |
| "Opioids can induce analgesia and also hyperalgesia in humans and in animals." | 1.35 | Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats. ( Ahmadiani, A; Esmaeili-Mahani, S; Javan, M; Koibuchi, N; Maghsoudi, N; Motamedi, F; Shimokawa, N, 2008) |
| "Our experiments show that acute thermal hyperalgesia is blocked in periaqueductal gray with the microOR antagonist CTOP, the NMDA antagonist MK801 and the protein kinase C inhibitor chelerythrine." | 1.35 | Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception. ( Bianchi, E; Galeotti, N; Ghelardini, C; Guarna, M; Norcini, M; Stefano, GB; Vivoli, E; Zhu, W, 2008) |
| "The 5-HT-induced hyperalgesia was abolished by ketanserin (5-HT2A antagonist, 10 microg, intraplantarly or i." | 1.33 | Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat. ( Bing, F; Chen, X; Dai, P; Hong, Y, 2006) |
| "In PTX-treated rats, thermal hyperalgesia was observed, and the PKCgamma content of both the synaptosomal membrane and cytosolic fractions was significantly increased." | 1.32 | D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation. ( Chang, YC; Guo, YW; Wen, ZH; Wong, CS, 2003) |
| "Magnesium (Mg)-deficient rats develop a mechanical hyperalgesia which is reversed by a N-Methyl-D-Aspartate (NMDA) receptor antagonist." | 1.31 | Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats. ( Begon, S; Dubray, C; Eschalier, A; Mazur, A; Pickering, G; Rayssiguier, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kwon, SG | 1 |
| Roh, DH | 1 |
| Yoon, SY | 1 |
| Moon, JY | 1 |
| Choi, SR | 1 |
| Choi, HS | 1 |
| Kang, SY | 1 |
| Han, HJ | 1 |
| Beitz, AJ | 1 |
| Oh, SB | 1 |
| Lee, JH | 1 |
| Bu, F | 1 |
| Tian, H | 1 |
| Gong, S | 1 |
| Zhu, Q | 1 |
| Xu, GY | 1 |
| Tao, J | 1 |
| Jiang, X | 1 |
| Wen, ZH | 1 |
| Guo, YW | 1 |
| Chang, YC | 1 |
| Wong, CS | 1 |
| Chen, X | 1 |
| Bing, F | 1 |
| Dai, P | 1 |
| Hong, Y | 1 |
| Esmaeili-Mahani, S | 1 |
| Shimokawa, N | 1 |
| Javan, M | 1 |
| Maghsoudi, N | 1 |
| Motamedi, F | 1 |
| Koibuchi, N | 1 |
| Ahmadiani, A | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Vivoli, E | 1 |
| Norcini, M | 1 |
| Zhu, W | 1 |
| Stefano, GB | 1 |
| Guarna, M | 1 |
| Bianchi, E | 1 |
| Yashpal, K | 1 |
| Pitcher, GM | 1 |
| Parent, A | 1 |
| Quirion, R | 1 |
| Coderre, TJ | 1 |
| Begon, S | 1 |
| Pickering, G | 1 |
| Eschalier, A | 1 |
| Mazur, A | 1 |
| Rayssiguier, Y | 1 |
| Dubray, C | 1 |
| Souza, AL | 1 |
| Moreira, FA | 1 |
| Almeida, KR | 1 |
| Bertollo, CM | 1 |
| Costa, KA | 1 |
| Coelho, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Magnesium Sulfate Infusion on the Quality of Recovery of Ambulatory Patients[NCT01433081] | 50 participants (Actual) | Interventional | 2011-02-28 | Completed | |||
| Does Magnesium Sulfate as a Supplement in Adductor Canal Blocks Improve Pain Control After Total Knee Arthroplasty?[NCT02581683] | Phase 4 | 130 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Opioid consumption after discharge (NCT01433081)
Timeframe: 24 hours
| Intervention | miligram morphine equivalents (Median) |
|---|---|
| Magnesium Sulfate Infusion | 10 |
| Placebo | 30 |
Quality of recovery scores post operative. Scored on a scale of 40 (poor recovery) to 200 (good recovery). (NCT01433081)
Timeframe: 24 hours post operative
| Intervention | units on scale 40 (low) - 200 (high) (Mean) |
|---|---|
| Magnesium Sulfate Infusion | 183 |
| Placebo | 159 |
9 other studies available for chelerythrine and Allodynia
| Article | Year |
|---|---|
Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain.
Topics: Acids; Acrylamides; Adenosine Diphosphate; Animals; Benzophenanthridines; Blotting, Western; Bridged | 2014 |
Phosphorylation of NR2B NMDA subunits by protein kinase C in arcuate nucleus contributes to inflammatory pain in rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Behavior, Animal; Benzophenanthridines; Disease Models, An | 2015 |
D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Cytosol; E | 2003 |
Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkaloids; Animals; Behavior, Animal; Benzophenanthridines; | 2006 |
Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats.
Topics: Alkaloids; Analgesics, Opioid; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Chan | 2008 |
Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception.
Topics: Alkaloids; Analysis of Variance; Animals; Behavior, Animal; Benzophenanthridines; Dizocilpine Maleat | 2008 |
Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Formaldehyde; Functional Laterality; | 1995 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
In vivo evidence for a role of protein kinase C in peripheral nociceptive processing.
Topics: Alkaloids; Animals; Benzophenanthridines; Bradykinin; Dose-Response Relationship, Drug; Enzyme Inhib | 2002 |