Page last updated: 2024-08-21

pyrazines and Allodynia

pyrazines has been researched along with Allodynia in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (14.81)29.6817
2010's22 (81.48)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Giniatullin, R; Hämäläinen, RH; Mikhailov, N; Plotnikova, L; Singh, P1
Gao, Y; Guan, S; He, L; Huang, L; Jin, Y; Li, G; Liang, S; Liu, S; Ou, X; Shen, Y; Tan, M; Xiong, W; Xu, C; Xu, H; Yang, G1
Araya, EI; Chichorro, JG; Dos Reis, RC; Kopruszinski, CM; Nones, CFM; Oliveira, LL; Rae, GA; Souza, RF1
Leánez, S; Pol, O; Redondo, A; Riego, G1
Brack, A; Hackel, D; Mousa, SA; Neumann, A; Partheil, A; Pflücke, D; Rittner, HL1
Egashira, N; Oishi, R1
Bennett, GJ; Bryant, L; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Ryerse, J; Salvemini, D1
Czimmer, J; Hoffman, DC; Kehne, J; Luckey, A; Maynard, GD; Million, M; Taché, Y; Zhao, JF1
Canta, A; Carozzi, V; Cavaletti, G; Chiorazzi, A; Meregalli, C; Monbaliu, J; Oggioni, N; Sala, B; VAN DE Velde, H1
Cui, Y; Huang, ZZ; Li, D; Liu, XG; Pang, RP; Su, YM; Wei, JY; Xin, WJ; Xue, Z; Zhang, J1
Andoh, T; Kitamura, R; Kuraishi, Y; Mizoguchi, S; Saito, Y; Takahata, H1
Dougherty, PM; Robinson, CR; Zhang, H2
Bianchi, E; Cerretani, D; Ghelardini, C; Menicacci, C1
Balkaya, M; Boehmerle, W; Endres, M; Huehnchen, P; Peruzzaro, S1
Carcolé, M; Castany, S; Leánez, S; Pol, O1
Gao, Y; He, LK; Huang, LP; Liang, SD; Shen, YL; Tan, MX; Xiong, W; Yang, G1
Gao, Y; Liang, S; Mu, S; Wan, F; Wang, Y; Xu, C; Zhang, A1
Auguet, M; Chabrier, PE; Favre-Guilmard, C; Prevost, G; Soulard, C; Touvay, C; Zeroual-Hider, H1
Gao, Y; Li, G; Li, X; Liang, S; Lin, J; Liu, H; Liu, S; Wan, F; Xu, C; Yu, K; Zhang, J1
Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X1
Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A1
Bakthavatchalam, R; Blum, CA; Boyce, S; Brian Jones, A; Caldwell, T; Capitosti, S; Chenard, BL; Cortright, D; Crandall, M; Hodgetts, KJ; Krause, JE; Murphy, BA; Zheng, X1
Horie, S; Hosoya, T; Lo, MW; Matsumoto, K; Murayama, T; Takayama, H; Tashima, K1
Bennett, GJ; Xiao, WH; Zheng, H1
Bristol, DR; Harrison, JE; Mark, L; Pomonis, JD; Valenzano, KJ; Walker, K1
Hara, T; Imai, A; Kanai, Y; Sakakibara, A1

Reviews

1 review(s) available for pyrazines and Allodynia

ArticleYear
[Peripheral neuropathy induced by anticancer drugs].
    Fukuoka igaku zasshi = Hukuoka acta medica, 2013, Volume: 104, Issue:5

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cold Temperature; Drugs, Chinese Herbal; Humans; Hyperalgesia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nervous System Diseases; Pyrazines; Sensation Disorders; Vincristine; Vitamin B 12

2013

Other Studies

26 other study(ies) available for pyrazines and Allodynia

ArticleYear
Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model.
    International journal of molecular sciences, 2022, Jan-25, Volume: 23, Issue:3

    Topics: Animals; Ganglia, Spinal; Hyperalgesia; Ion Channels; Lab-On-A-Chip Devices; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Nerve Tissue; Neurons; Pain; Peripheral Nervous System; Pyrazines; Thiadiazoles; Touch; Trigeminal Nerve

2022
Inhibitory effects of tetramethylpyrazine on pain transmission of trigeminal neuralgia in CCI-ION rats.
    Brain research bulletin, 2017, Volume: 134

    Topics: Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; HEK293 Cells; Humans; Hyperalgesia; Male; MAP Kinase Signaling System; Membrane Potentials; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Pyrazines; Random Allocation; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; RNA, Messenger; Trigeminal Ganglion; Trigeminal Neuralgia

2017
Mechanisms involved in facial heat hyperalgesia induced by endothelin-1 in female rats.
    Archives of oral biology, 2017, Volume: 83

    Topics: Animals; Carbazoles; Diterpenes; Endothelin-1; Face; Female; Hot Temperature; Hyperalgesia; Indole Alkaloids; Nerve Growth Factor; Oligopeptides; Peptides, Cyclic; Piperidines; Pyrazines; Pyridines; Rats; Rats, Wistar; Trigeminal Ganglion

2017
Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain.
    Biochemical pharmacology, 2018, Volume: 148

    Topics: Animals; Carbon Monoxide; Central Nervous System; Gene Expression Regulation; Heme Oxygenase-1; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Organometallic Compounds; Pyrazines; Pyrroles; Sciatic Nerve; Signal Transduction

2018
The molecular link between C-C-chemokine ligand 2-induced leukocyte recruitment and hyperalgesia.
    The journal of pain, 2013, Volume: 14, Issue:9

    Topics: Aldehydes; Animals; Chemokine CCL2; Ciguatoxins; Cyclophosphamide; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Immunosuppressive Agents; Leukocytes; Macrophages; Male; Pain Threshold; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Wistar; Reaction Time; Reactive Oxygen Species; Receptors, CCR2; Time Factors

2013
Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase.
    Pain, 2013, Volume: 154, Issue:11

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Axons; Boronic Acids; Bortezomib; Energy Metabolism; Hyperalgesia; Male; Mitochondria; Neoplasm Transplantation; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nerves; Peroxynitrous Acid; Physical Stimulation; Protein Processing, Post-Translational; Pyrazines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Superoxide Dismutase

2013
The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Administration, Oral; Animals; Colon; Corticotropin-Releasing Hormone; Defecation; Diarrhea; Drug Antagonism; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Intubation, Gastrointestinal; Irritable Bowel Syndrome; Male; Molecular Structure; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Stress, Physiological; Viscera

2013
Antibody against tumor necrosis factor-α reduces bortezomib-induced allodynia in a rat model.
    Anticancer research, 2013, Volume: 33, Issue:12

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Female; Hyperalgesia; Pyrazines; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2013
TNF-α-mediated JNK activation in the dorsal root ganglion neurons contributes to Bortezomib-induced peripheral neuropathy.
    Brain, behavior, and immunity, 2014, Volume: 38

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Ganglia, Spinal; Hyperalgesia; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Neurons; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2014
Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:4

    Topics: Adrenergic Neurons; Amines; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Mice; Mice, Inbred C57BL; Norepinephrine; Pyrazines; Spinal Cord

2014
Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat.
    Neuroscience, 2014, Aug-22, Volume: 274

    Topics: Animals; Antineoplastic Agents; Astrocytes; Boronic Acids; Bortezomib; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Microglia; Minocycline; Neuroprotective Agents; Organoplatinum Compounds; Oxaliplatin; Peripheral Nervous System Diseases; Pyrazines; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves

2014
Altered discharges of spinal neurons parallel the behavioral phenotype shown by rats with bortezomib related chemotherapy induced peripheral neuropathy.
    Brain research, 2014, Jul-29, Volume: 1574

    Topics: Action Potentials; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Lumbar Vertebrae; Male; Motor Activity; Neurons; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Pyrazines; Rats, Sprague-Dawley; Spinal Cord; Temperature; Touch

2014
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.
    Neuropharmacology, 2014, Volume: 86

    Topics: Analgesics; Animals; Boronic Acids; Bortezomib; Ceftriaxone; Cell Line, Tumor; Cell Survival; Central Nervous System Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hyperalgesia; Injections, Spinal; Male; Neural Conduction; Neuralgia; Peripheral Nervous System Diseases; Pyrazines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5

2014
Electrophysiological, behavioral and histological characterization of paclitaxel, cisplatin, vincristine and bortezomib-induced neuropathy in C57Bl/6 mice.
    Scientific reports, 2014, Sep-18, Volume: 4

    Topics: Action Potentials; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Behavior, Animal; Boronic Acids; Bortezomib; Cisplatin; Electrophysiology; Gait; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Polyneuropathies; Pyrazines; Vincristine

2014
The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1.
    Neuroscience letters, 2016, Feb-12, Volume: 614

    Topics: Analgesics, Opioid; Animals; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enzyme Induction; Heme Oxygenase-1; Hyperalgesia; Injections, Subcutaneous; Male; Mice, Inbred C57BL; Organometallic Compounds; Physical Stimulation; Pyrazines; Pyrroles; Receptors, Opioid, delta; Ruthenium

2016
[Effects of tetramethylpyrazine on trigeminal neuralgia induced by chronic constriction injury of infraorbital nerve in rats].
    Sheng li xue bao : [Acta physiologica Sinica], 2017, Feb-25, Volume: 69, Issue:1

    Topics: Animals; Constriction; Hyperalgesia; Male; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Trigeminal Neuralgia

2017
Effect of tetramethylpyrazine on primary afferent transmission mediated by P2X3 receptor in neuropathic pain states.
    Brain research bulletin, 2008, Sep-05, Volume: 77, Issue:1

    Topics: Afferent Pathways; Animals; Calcium Channel Blockers; Constriction; Electrophysiology; Female; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Male; Neuralgia; Neurons; Neurons, Afferent; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Sciatic Nerve; Spinal Cord

2008
The novel inhibitor of the heterotrimeric G-protein complex, BIM-46187, elicits anti-hyperalgesic properties and synergizes with morphine.
    European journal of pharmacology, 2008, Oct-10, Volume: 594, Issue:1-3

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Constriction, Pathologic; Cyclohexanes; Drug Synergism; Edema; Heterotrimeric GTP-Binding Proteins; Hyperalgesia; Male; Morphine; Pain Measurement; Peripheral Nervous System Diseases; Psychomotor Performance; Pyrazines; Rats; Rats, Sprague-Dawley

2008
Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn.
    Burns : journal of the International Society for Burn Injuries, 2010, Volume: 36, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Disease Models, Animal; Drug Evaluation, Preclinical; Ganglia, Spinal; Hyperalgesia; Male; Pain Threshold; Patch-Clamp Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Skin

2010
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
    Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8

    Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels

2010
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
    European journal of pharmacology, 2010, Sep-01, Volume: 641, Issue:2-3

    Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea

2010
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
    Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15

    Topics: Administration, Oral; Animals; Dogs; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Macaca mulatta; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Rats; TRPV Cation Channels

2010
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice.
    Laboratory investigation; a journal of technical methods and pathology, 2012, Volume: 92, Issue:5

    Topics: Animals; Carbolines; Dextran Sulfate; Disease Models, Animal; Electromyography; Hyperalgesia; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nociception; Pyrazines; Pyridines; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Time Factors; TRPV Cation Channels; Tryptophan Hydroxylase; Visceral Afferents

2012
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy.
    Experimental neurology, 2012, Volume: 238, Issue:2

    Topics: Acetylcarnitine; Activating Transcription Factor 3; Adenosine Triphosphate; Analysis of Variance; Animals; Antineoplastic Agents; Axons; Boronic Acids; Bortezomib; Citrate (si)-Synthase; Disease Models, Animal; Electron Transport Complex II; Ganglia, Spinal; Hyperalgesia; Male; Mitochondria; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Time Factors; Ubiquitin Thiolesterase

2012
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:1

    Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug

2003
Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:5

    Topics: Analgesics; Anilides; Animals; Cinnamates; Dose-Response Relationship, Drug; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Injections; Injections, Spinal; Male; Nerve Endings; Neurons, Afferent; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Regression Analysis; TRPV Cation Channels

2007