pyrazines has been researched along with Allodynia in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 22 (81.48) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Giniatullin, R; Hämäläinen, RH; Mikhailov, N; Plotnikova, L; Singh, P | 1 |
| Gao, Y; Guan, S; He, L; Huang, L; Jin, Y; Li, G; Liang, S; Liu, S; Ou, X; Shen, Y; Tan, M; Xiong, W; Xu, C; Xu, H; Yang, G | 1 |
| Araya, EI; Chichorro, JG; Dos Reis, RC; Kopruszinski, CM; Nones, CFM; Oliveira, LL; Rae, GA; Souza, RF | 1 |
| Leánez, S; Pol, O; Redondo, A; Riego, G | 1 |
| Brack, A; Hackel, D; Mousa, SA; Neumann, A; Partheil, A; Pflücke, D; Rittner, HL | 1 |
| Egashira, N; Oishi, R | 1 |
| Bennett, GJ; Bryant, L; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Ryerse, J; Salvemini, D | 1 |
| Czimmer, J; Hoffman, DC; Kehne, J; Luckey, A; Maynard, GD; Million, M; Taché, Y; Zhao, JF | 1 |
| Canta, A; Carozzi, V; Cavaletti, G; Chiorazzi, A; Meregalli, C; Monbaliu, J; Oggioni, N; Sala, B; VAN DE Velde, H | 1 |
| Cui, Y; Huang, ZZ; Li, D; Liu, XG; Pang, RP; Su, YM; Wei, JY; Xin, WJ; Xue, Z; Zhang, J | 1 |
| Andoh, T; Kitamura, R; Kuraishi, Y; Mizoguchi, S; Saito, Y; Takahata, H | 1 |
| Dougherty, PM; Robinson, CR; Zhang, H | 2 |
| Bianchi, E; Cerretani, D; Ghelardini, C; Menicacci, C | 1 |
| Balkaya, M; Boehmerle, W; Endres, M; Huehnchen, P; Peruzzaro, S | 1 |
| Carcolé, M; Castany, S; Leánez, S; Pol, O | 1 |
| Gao, Y; He, LK; Huang, LP; Liang, SD; Shen, YL; Tan, MX; Xiong, W; Yang, G | 1 |
| Gao, Y; Liang, S; Mu, S; Wan, F; Wang, Y; Xu, C; Zhang, A | 1 |
| Auguet, M; Chabrier, PE; Favre-Guilmard, C; Prevost, G; Soulard, C; Touvay, C; Zeroual-Hider, H | 1 |
| Gao, Y; Li, G; Li, X; Liang, S; Lin, J; Liu, H; Liu, S; Wan, F; Xu, C; Yu, K; Zhang, J | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X | 1 |
| Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brian Jones, A; Caldwell, T; Capitosti, S; Chenard, BL; Cortright, D; Crandall, M; Hodgetts, KJ; Krause, JE; Murphy, BA; Zheng, X | 1 |
| Horie, S; Hosoya, T; Lo, MW; Matsumoto, K; Murayama, T; Takayama, H; Tashima, K | 1 |
| Bennett, GJ; Xiao, WH; Zheng, H | 1 |
| Bristol, DR; Harrison, JE; Mark, L; Pomonis, JD; Valenzano, KJ; Walker, K | 1 |
| Hara, T; Imai, A; Kanai, Y; Sakakibara, A | 1 |
1 review(s) available for pyrazines and Allodynia
| Article | Year |
|---|---|
[Peripheral neuropathy induced by anticancer drugs].
Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cold Temperature; Drugs, Chinese Herbal; Humans; Hyperalgesia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nervous System Diseases; Pyrazines; Sensation Disorders; Vincristine; Vitamin B 12 | 2013 |
26 other study(ies) available for pyrazines and Allodynia
| Article | Year |
|---|---|
Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model.
Topics: Animals; Ganglia, Spinal; Hyperalgesia; Ion Channels; Lab-On-A-Chip Devices; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Nerve Tissue; Neurons; Pain; Peripheral Nervous System; Pyrazines; Thiadiazoles; Touch; Trigeminal Nerve | 2022 |
Inhibitory effects of tetramethylpyrazine on pain transmission of trigeminal neuralgia in CCI-ION rats.
Topics: Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; HEK293 Cells; Humans; Hyperalgesia; Male; MAP Kinase Signaling System; Membrane Potentials; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Pyrazines; Random Allocation; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; RNA, Messenger; Trigeminal Ganglion; Trigeminal Neuralgia | 2017 |
Mechanisms involved in facial heat hyperalgesia induced by endothelin-1 in female rats.
Topics: Animals; Carbazoles; Diterpenes; Endothelin-1; Face; Female; Hot Temperature; Hyperalgesia; Indole Alkaloids; Nerve Growth Factor; Oligopeptides; Peptides, Cyclic; Piperidines; Pyrazines; Pyridines; Rats; Rats, Wistar; Trigeminal Ganglion | 2017 |
Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain.
Topics: Animals; Carbon Monoxide; Central Nervous System; Gene Expression Regulation; Heme Oxygenase-1; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Organometallic Compounds; Pyrazines; Pyrroles; Sciatic Nerve; Signal Transduction | 2018 |
The molecular link between C-C-chemokine ligand 2-induced leukocyte recruitment and hyperalgesia.
Topics: Aldehydes; Animals; Chemokine CCL2; Ciguatoxins; Cyclophosphamide; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Immunosuppressive Agents; Leukocytes; Macrophages; Male; Pain Threshold; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Wistar; Reaction Time; Reactive Oxygen Species; Receptors, CCR2; Time Factors | 2013 |
Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Axons; Boronic Acids; Bortezomib; Energy Metabolism; Hyperalgesia; Male; Mitochondria; Neoplasm Transplantation; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nerves; Peroxynitrous Acid; Physical Stimulation; Protein Processing, Post-Translational; Pyrazines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Superoxide Dismutase | 2013 |
The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats.
Topics: Administration, Oral; Animals; Colon; Corticotropin-Releasing Hormone; Defecation; Diarrhea; Drug Antagonism; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Intubation, Gastrointestinal; Irritable Bowel Syndrome; Male; Molecular Structure; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Stress, Physiological; Viscera | 2013 |
Antibody against tumor necrosis factor-α reduces bortezomib-induced allodynia in a rat model.
Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Female; Hyperalgesia; Pyrazines; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2013 |
TNF-α-mediated JNK activation in the dorsal root ganglion neurons contributes to Bortezomib-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Ganglia, Spinal; Hyperalgesia; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Neurons; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2014 |
Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice.
Topics: Adrenergic Neurons; Amines; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Mice; Mice, Inbred C57BL; Norepinephrine; Pyrazines; Spinal Cord | 2014 |
Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat.
Topics: Animals; Antineoplastic Agents; Astrocytes; Boronic Acids; Bortezomib; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Microglia; Minocycline; Neuroprotective Agents; Organoplatinum Compounds; Oxaliplatin; Peripheral Nervous System Diseases; Pyrazines; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves | 2014 |
Altered discharges of spinal neurons parallel the behavioral phenotype shown by rats with bortezomib related chemotherapy induced peripheral neuropathy.
Topics: Action Potentials; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Lumbar Vertebrae; Male; Motor Activity; Neurons; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Pyrazines; Rats, Sprague-Dawley; Spinal Cord; Temperature; Touch | 2014 |
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.
Topics: Analgesics; Animals; Boronic Acids; Bortezomib; Ceftriaxone; Cell Line, Tumor; Cell Survival; Central Nervous System Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hyperalgesia; Injections, Spinal; Male; Neural Conduction; Neuralgia; Peripheral Nervous System Diseases; Pyrazines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5 | 2014 |
Electrophysiological, behavioral and histological characterization of paclitaxel, cisplatin, vincristine and bortezomib-induced neuropathy in C57Bl/6 mice.
Topics: Action Potentials; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Behavior, Animal; Boronic Acids; Bortezomib; Cisplatin; Electrophysiology; Gait; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Paclitaxel; Polyneuropathies; Pyrazines; Vincristine | 2014 |
The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1.
Topics: Analgesics, Opioid; Animals; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enzyme Induction; Heme Oxygenase-1; Hyperalgesia; Injections, Subcutaneous; Male; Mice, Inbred C57BL; Organometallic Compounds; Physical Stimulation; Pyrazines; Pyrroles; Receptors, Opioid, delta; Ruthenium | 2016 |
[Effects of tetramethylpyrazine on trigeminal neuralgia induced by chronic constriction injury of infraorbital nerve in rats].
Topics: Animals; Constriction; Hyperalgesia; Male; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion; Trigeminal Neuralgia | 2017 |
Effect of tetramethylpyrazine on primary afferent transmission mediated by P2X3 receptor in neuropathic pain states.
Topics: Afferent Pathways; Animals; Calcium Channel Blockers; Constriction; Electrophysiology; Female; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Male; Neuralgia; Neurons; Neurons, Afferent; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Sciatic Nerve; Spinal Cord | 2008 |
The novel inhibitor of the heterotrimeric G-protein complex, BIM-46187, elicits anti-hyperalgesic properties and synergizes with morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Constriction, Pathologic; Cyclohexanes; Drug Synergism; Edema; Heterotrimeric GTP-Binding Proteins; Hyperalgesia; Male; Morphine; Pain Measurement; Peripheral Nervous System Diseases; Psychomotor Performance; Pyrazines; Rats; Rats, Sprague-Dawley | 2008 |
Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Disease Models, Animal; Drug Evaluation, Preclinical; Ganglia, Spinal; Hyperalgesia; Male; Pain Threshold; Patch-Clamp Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Skin | 2010 |
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2010 |
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea | 2010 |
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
Topics: Administration, Oral; Animals; Dogs; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Macaca mulatta; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Rats; TRPV Cation Channels | 2010 |
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice.
Topics: Animals; Carbolines; Dextran Sulfate; Disease Models, Animal; Electromyography; Hyperalgesia; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nociception; Pyrazines; Pyridines; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Time Factors; TRPV Cation Channels; Tryptophan Hydroxylase; Visceral Afferents | 2012 |
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy.
Topics: Acetylcarnitine; Activating Transcription Factor 3; Adenosine Triphosphate; Analysis of Variance; Animals; Antineoplastic Agents; Axons; Boronic Acids; Bortezomib; Citrate (si)-Synthase; Disease Models, Animal; Electron Transport Complex II; Ganglia, Spinal; Hyperalgesia; Male; Mitochondria; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Time Factors; Ubiquitin Thiolesterase | 2012 |
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia.
Topics: Analgesics; Anilides; Animals; Cinnamates; Dose-Response Relationship, Drug; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Injections; Injections, Spinal; Male; Nerve Endings; Neurons, Afferent; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Regression Analysis; TRPV Cation Channels | 2007 |