memantine has been researched along with Allodynia in 12 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| ", twice a week) caused mechanical allodynia in the fourth week, which was reversed by intrathecal injection of MK-801 (10 nmol) and memantine (1 μmol), NMDA receptor antagonists." | 3.77 | Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. ( Egashira, N; Ikesue, H; Kawashiri, T; Mihara, Y; Oishi, R; Sada, H; Ushio, S; Yano, T, 2011) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "Systemic treatment with the N-methyl-D-aspartate (NMDA) antagonist memantine (MEM) resulted in a decrease in mechanical hyperalgesia and mechanical allodynia in neuropathic rats." | 3.69 | Treatment with the NMDA antagonist memantine attenuates nociceptive responses to mechanical stimulation in neuropathic rats. ( Carlton, SM; Hargett, GL, 1995) |
| "Dextromethorphan and memantine have been administered to animals after spinal nerve ligation (SNL) to evaluate their antinociceptive/cognitive effects and associated molecular events, including the phosphorylation of several tyrosine (pTyr(1336), pTyr(1472)) residues in the NR2B NMDAR subunit." | 1.40 | Low doses of dextromethorphan have a beneficial effect in the treatment of neuropathic pain. ( Chalus, M; Daulhac, L; Dupuis, A; Eschalier, A; Etienne, M; Morel, V; Pickering, G; Privat, AM, 2014) |
| "Tactile allodynia, mechanical hyperalgesia and spatial memory were evaluated by von Frey, Randall & Selitto and Y-maze-tests respectively, and molecular events by western-blot analysis." | 1.39 | Memantine, a promising drug for the prevention of neuropathic pain in rat. ( Chalus, M; Daulhac, L; Dupuis, A; Eschalier, A; Etienne, M; Morel, V; Pickering, G; Privat, AM; Wattiez, AS, 2013) |
| "Methadone only treated rats had a mean paw withdrawal latency significantly lower than the corresponding values for saline on days 8, 9, 10, 11, 12, 14, and 17 (P<0." | 1.36 | Model of methadone-induced hyperalgesia in rats and effect of memantine. ( Hay, JL; Irvine, R; Kaboutari, J; Salem, A; White, JM, 2010) |
| "It is still unknown whether neuropathic pain could relate to behavioral and neurochemical alterations in the central nervous system." | 1.35 | Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain. ( Chikuma, T; Kato, T; Muramatsu, M; Takeda, K, 2009) |
| "Persistent hyperalgesia induced by chronic constrictive injury (CCI) to the sciatic nerve was significantly reduced for up to 14 days by prophylactic administration of memantine (3." | 1.29 | The clinically tested N-methyl-D-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy. ( Eisenberg, E; LaCross, S; Strassman, AM, 1995) |
| "into the right hindpaw, and exhibited hyperalgesia in the injected paw as evidenced by a significant reduction of withdrawal latencies from baseline 1, 3, 5, and 24 h following carrageenan." | 1.29 | The effects of the clinically tested NMDA receptor antagonist memantine on carrageenan-induced thermal hyperalgesia in rats. ( Eisenberg, E; LaCross, S; Strassman, AM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morel, V | 2 |
| Etienne, M | 2 |
| Wattiez, AS | 1 |
| Dupuis, A | 2 |
| Privat, AM | 2 |
| Chalus, M | 2 |
| Eschalier, A | 2 |
| Daulhac, L | 2 |
| Pickering, G | 2 |
| Chen, SR | 1 |
| Hu, YM | 1 |
| Chen, H | 1 |
| Pan, HL | 1 |
| Takeda, K | 1 |
| Muramatsu, M | 1 |
| Chikuma, T | 1 |
| Kato, T | 1 |
| Hay, JL | 1 |
| Kaboutari, J | 1 |
| White, JM | 1 |
| Salem, A | 1 |
| Irvine, R | 1 |
| Mihara, Y | 1 |
| Egashira, N | 1 |
| Sada, H | 1 |
| Kawashiri, T | 1 |
| Ushio, S | 1 |
| Yano, T | 1 |
| Ikesue, H | 1 |
| Oishi, R | 1 |
| Gil, DW | 1 |
| Cheevers, CV | 1 |
| Donello, JE | 1 |
| Harris, AC | 1 |
| Rothwell, PE | 1 |
| Gewirtz, JC | 1 |
| Eisenberg, E | 2 |
| LaCross, S | 2 |
| Strassman, AM | 2 |
| Carlton, SM | 1 |
| Hargett, GL | 1 |
| Chaplan, SR | 1 |
| Malmberg, AB | 1 |
| Yaksh, TL | 1 |
12 other studies available for memantine and Allodynia
| Article | Year |
|---|---|
Memantine, a promising drug for the prevention of neuropathic pain in rat.
Topics: Animals; Brain; Cognition; Hyperalgesia; Ligation; Male; Memantine; Neuralgia; Phosphorylation; Rats | 2013 |
Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Excitatory Postsynaptic Potentials; Hyperalgesia; Male | 2014 |
Low doses of dextromethorphan have a beneficial effect in the treatment of neuropathic pain.
Topics: Animals; Cognition; Dextromethorphan; Disease Models, Animal; Dose-Response Relationship, Drug; Exci | 2014 |
Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain.
Topics: Analgesics; Animals; Brain; CD11 Antigens; Disease Models, Animal; Excitatory Amino Acid Antagonists | 2009 |
Model of methadone-induced hyperalgesia in rats and effect of memantine.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Male; Memantine; Methadone; Rats; R | 2010 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles | 2011 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Effects of the NMDA receptor antagonist memantine on the expression and development of acute opiate dependence as assessed by withdrawal-potentiated startle and hyperalgesia.
Topics: Analgesics, Opioid; Animals; Hyperalgesia; Male; Memantine; Morphine; Morphine Dependence; Naloxone; | 2008 |
The clinically tested N-methyl-D-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Memantine; Rats; Rats, Sprague-Dawley; Receptor | 1995 |
The effects of the clinically tested NMDA receptor antagonist memantine on carrageenan-induced thermal hyperalgesia in rats.
Topics: Animals; Behavior, Animal; Carrageenan; Hot Temperature; Hyperalgesia; Male; Memantine; Pain Measure | 1994 |
Treatment with the NMDA antagonist memantine attenuates nociceptive responses to mechanical stimulation in neuropathic rats.
Topics: Analgesics; Animals; Drug Implants; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Int | 1995 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate | 1997 |