flurbiprofen has been researched along with Allodynia in 7 studies
Flurbiprofen: An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
flurbiprofen : A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pain is one of the cardinal signs accompanying inflammation." | 5.62 | Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models. ( Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A, 2021) |
| "Postoperative pain was managed by sufentanil titration in the postanesthetic care unit, followed by sufentanil infusion via patient-controlled analgesia." | 2.84 | Preoperative But Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil-induced Hyperalgesia After Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial. ( Li, Y; Shu, R; Wang, C; Wang, G; Wang, H; Yu, Y; Zhang, L; Zhao, Q, 2017) |
| "Pain is one of the cardinal signs accompanying inflammation." | 1.62 | Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models. ( Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A, 2021) |
| "Flurbiprofen was used for the first time in a rat model of REM sleep deprivation, and it provided anti-nociceptive effects in 15 mg/kg and 40 mg/kg doses." | 1.40 | Flurbiprofen in rapid eye movement sleep deprivation induced hyperalgesia. ( Gürel, EE; Öztürk, G; Öztürk, L; Ural, K, 2014) |
| "Bradykinin pretreatment (10 microM, 5 min) induced a 219 +/- 26% increase in the number of spikes evoked by noxious heat stimulation and a drop in the heat threshold by 5." | 1.31 | Bradykinin-induced nociceptor sensitization to heat is mediated by cyclooxygenase products in isolated rat skin. ( Derow, A; Pethö, G; Reeh, PW, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Voilley, N | 1 |
| de Weille, J | 1 |
| Mamet, J | 1 |
| Lazdunski, M | 1 |
| Buisseret, B | 1 |
| Guillemot-Legris, O | 1 |
| Ben Kouidar, Y | 1 |
| Paquot, A | 1 |
| Muccioli, GG | 1 |
| Alhouayek, M | 1 |
| Gürel, EE | 1 |
| Ural, K | 1 |
| Öztürk, G | 1 |
| Öztürk, L | 1 |
| Zhang, L | 2 |
| Shu, R | 2 |
| Zhao, Q | 2 |
| Li, Y | 2 |
| Wang, C | 1 |
| Wang, H | 1 |
| Yu, Y | 2 |
| Wang, G | 2 |
| Schlegel, T | 1 |
| Sauer, SK | 1 |
| Handwerker, HO | 1 |
| Reeh, PW | 2 |
| Pethö, G | 1 |
| Derow, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Postoperative Hyperalgesia Induced by Remifentanil in Patients Undergoing Lower Abdomimal Surgery[NCT02043366] | 180 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The mechanical hyperalgesia threshold was defined as the lowest force (g) necessary to bend a Von Frey filament, which was perceived to be painful by the patient and measured by Von Frey filament at 24 hours postoperatively (NCT02043366)
Timeframe: 24 hours after surgery
| Intervention | g (Mean) |
|---|---|
| Normal Saline | 60.57 |
| Flurbiprofen AxetilⅠ | 78.29 |
| Flurbiprofen AxetilⅡ | 68.50 |
| Butorphanol | 79.7 |
| Butorphanol-Flurbiprofen Axetil | 81.64 |
| Sufentanil | 89.5 |
The skin around the incision is stimulated in steps of 5 mm at intervals of 1 s starting outside of the hyperalgesic area in the direction of the incision. The distance from the incision to the first point where a 'painful', 'sore' or 'sharper' feeling occurred is measured and noted. This measurement is repeated at predefined radial lines around the incision. To eliminate the variable length of incision, this length is subtracted from the longer diameter leaving four radial distances from the end and from the middle of the incision. The normalized area of hyperalgesia is calculated by summing up the areas of the remaining four triangles measured by and Von Frey filament. (NCT02043366)
Timeframe: 24 hours after surgery
| Intervention | cm^2 (Mean) |
|---|---|
| Normal Saline | 60.46 |
| Flurbiprofen AxetilⅠ | 53.64 |
| Flurbiprofen AxetilⅡ | 56.57 |
| Butorphanol | 54.00 |
| Butorphanol-Flurbiprofen Axetil | 52.5 |
| Sufentanil | 49.89 |
2 trials available for flurbiprofen and Allodynia
| Article | Year |
|---|---|
Preoperative But Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil-induced Hyperalgesia After Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Female | 2017 |
Preoperative butorphanol and flurbiprofen axetil therapy attenuates remifentanil-induced hyperalgesia after laparoscopic gynaecological surgery: a randomized double-blind controlled trial.
Topics: Adult; Butorphanol; Double-Blind Method; Drug Therapy, Combination; Female; Flurbiprofen; Gynecologi | 2016 |
5 other studies available for flurbiprofen and Allodynia
| Article | Year |
|---|---|
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Topics: Acid Sensing Ion Channels; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; | 2001 |
Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models.
Topics: Animals; Biomarkers; Capsaicin; Carrageenan; Endocannabinoids; Flurbiprofen; Gene Expression Regulat | 2021 |
Flurbiprofen in rapid eye movement sleep deprivation induced hyperalgesia.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; Flurbiprofen; Hot Temperature; Hypera | 2014 |
Responsiveness of C-fiber nociceptors to punctate force-controlled stimuli in isolated rat skin: lack of modulation by inflammatory mediators and flurbiprofen.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Hyperalgesia; In | 2004 |
Bradykinin-induced nociceptor sensitization to heat is mediated by cyclooxygenase products in isolated rat skin.
Topics: Action Potentials; Animals; Bradykinin; Cyclooxygenase Inhibitors; Drug Interactions; Flurbiprofen; | 2001 |